Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis

Arthritis and Rheumatology

Volumn 68, Issue 5, 2016, Pages 1251-1261

  Sun, Huanxing ^a   Zhu, Yangyang ^a   Pan, Hongyi ^a   Chen, Xiaosong ^a   Balestrini, Jenna L ^a   Lam, Tukiet T ^a   Kanyo, Jean E ^a   Eichmann, Anne ^a   Gulati, Mridu ^a   Fares, Wassim H ^a   Bai, Hanwen ^a   Feghali Bostwick, Carol A ^b   Gan, Ye ^a   Peng, Xueyan ^a   Moore, Meagan W ^a   White, Eric S ^c   Sava, Parid ^d   Gonzalez, Anjelica L ^d   Cheng, Yuwei ^d   Niklason, Laura E ^a   Herzog, Erica L ^a   more..

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; COLLAGEN; COLLAGEN TYPE 1 ALPHA; NETRIN 1; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; CD45 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE I, ALPHA 1 CHAIN; NERVE GROWTH FACTOR; NETRIN-1; PTPRC PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL COMPOSITION; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CELL CULTURE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROCYTE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNODETECTION; INTERSTITIAL LUNG DISEASE; LEUKOCYTE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMIC SCLEROSIS; TISSUE SCAFFOLD; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOMECHANICS; CASE CONTROL STUDY; CELL DIFFERENTIATION; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HETEROZYGOTE; KNOCKOUT MOUSE; LUNG; LUNG DISEASES, INTERSTITIAL; LUNG FIBROSIS; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD45; BIOMECHANICAL PHENOMENA; BLEOMYCIN; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; COLLAGEN; COLLAGEN TYPE I; FIBROSIS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HETEROZYGOTE; HUMANS; LEUKOCYTES, MONONUCLEAR; LUNG; LUNG DISEASES, INTERSTITIAL; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, SCANNING; NERVE GROWTH FACTORS; PROTEOMICS; PULMONARY FIBROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCLERODERMA, SYSTEMIC; TISSUE SCAFFOLDS; TUMOR SUPPRESSOR PROTEINS;

EID: 84962892510     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39575     Document Type: Article

References (42)

1. Gabrielli A, Avvedimento EV, Krieg T., Scleroderma. N Engl J Med 2009; 360: 1989-2003.
2. Herzog EL, Mathur A, Tager AM, Feghali-Bostwick C, Schneider F, Varga J., Interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct? [review]. Arthritis Rheumatol 2014; 66: 1967-78.
3. Galligan CL, Fish EN., The role of circulating fibrocytes in inflammation and autoimmunity. J Leukoc Biol 2013; 93: 45-50.
4. Reilkoff RA, Bucala R, Herzog EL., Fibrocytes: emerging effector cells in chronic inflammation. Nat Rev Immunol 2011; 11: 427-35.
5. Borie R, Quesnel C, Phin S, Debray MP, Marchal-Somme J, Tiev K, et al., Detection of alveolar fibrocytes in idiopathic pulmonary fibrosis and systemic sclerosis. PloS One 2013; 8: e53736.
6. Mathai SK, Gulati M, Peng X, Russell TR, Shaw AC, Rubinowitz AN, et al., Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Lab Invest 2010; 90: 812-23.
7. Tourkina E, Bonner M, Oates J, Hofbauer A, Richard M, Znoyko S, et al., Altered monocyte and fibrocyte phenotype and function in scleroderma interstitial lung disease: reversal by caveolin-1 scaffolding domain peptide. Fibrogenesis Tissue Repair 2011; 4: 15.
8. Hynes RO, Naba A., Overview of the matrisome: an inventory of extracellular matrix constituents and functions. Cold Spring Harb Perspect Biol 2012; 4: a004903.
9. Petersen TH, Calle EA, Zhao L, Lee EJ, Gui L, Raredon MB, et al., Tissue-engineered lungs for in vivo implantation. Science 2010; 329: 538-41.
10. Cortiella J, Niles J, Cantu A, Brettler A, Pham A, Vargas G, et al., Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation. Tissue Eng Part A 2010; 16: 2565-80.
11. Booth AJ, Hadley R, Cornett AM, Dreffs AA, Matthes SA, Tsui JL, et al., Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. Am J Respir Crit Care Med 2012; 186: 866-76.
12. Parker MW, Rossi D, Peterson M, Smith K, Sikstrom K, White ES, et al., Fibrotic extracellular matrix activates a profibrotic positive feedback loop. J Clin Invest 2014; 124: 1622-35.
13. Wagner DE, Bonenfant NR, Parsons CS, Sokocevic D, Brooks EM, Borg ZD, et al., Comparative decellularization and recellularization of normal versus emphysematous human lungs. Biomaterials 2014; 35: 3281-97.
14. Sorokin L., The impact of the extracellular matrix on inflammation. Nat Rev Immunol 2010; 10: 712-23.
15. Jaalouk DE, Lammerding J., Mechanotransduction gone awry. Nat Rev Mol Cell Biol 2009; 10: 63-73.
16. Moore SW, Zhang X, Lynch CD, Sheetz MP., Netrin-1 attracts axons through FAK-dependent mechanotransduction. J Neurosci 2012; 32: 11574-85.
17. Duman-Scheel M., Netrin and DCC: axon guidance regulators at the intersection of nervous system development and cancer. Curr Drug Targets 2009; 10: 602-10.
18. Yebra M, Montgomery AM, Diaferia GR, Kaido T, Silletti S, Perez B, et al., Recognition of the neural chemoattractant Netrin-1 by integrins α6β4 and α3β1 regulates epithelial cell adhesion and migration. Dev Cell 2003; 5: 695-707.
19. Rajasekharan S, Kennedy TE., The netrin protein family. Genome Biol 2009; 10: 239.
20. Cirulli V, Yebra M., Netrins: beyond the brain. Nat Rev Mol Cell Biol 2007; 8: 296-306.
21. Mirakaj V, Dalli J, Granja T, Rosenberger P, Serhan CN., Vagus nerve controls resolution and pro-resolving mediators of inflammation. J Exp Med 2014; 211: 1037-48.
22. Herazo-Maya JD, Noth I, Duncan SR, Kim S, Ma SF, Tseng GC, et al., Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. Sci Transl Med 2013; 5: 205ra136.
23. Karmouty-Quintana H, Philip K, Acero LF, Chen NY, Weng T, Molina JG, et al., Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension. FASEB J 2015; 29: 50-60.
24. Tadagavadi RK, Wang W, Ramesh G., Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. J Immunol 2010; 185: 3750-8.
25. Wang W, Reeves WB, Pays L, Mehlen P, Ramesh G., Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis. Am J Pathol 2009; 175: 1010-8.
26. Sun H, Calle E, Chen X, Mathur A, Zhu Y, Mendez J, et al., Fibroblast engraftment in the decellularized mouse lung occurs via a β1-integrin-dependent, FAK-dependent pathway that is mediated by ERK and opposed by AKT. Am J Physiol Lung Cell Mol Physiol 2014; 306: L463-75.
27. Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, et al., Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in mammalian lung fibrosis. Sci Transl Med 2014; 6: 240ra76.
28. Tse JR, Engler AJ., Preparation of hydrogel substrates with tunable mechanical properties. Curr Protoc Cell Biol 2010; 10: 10.16.
29. Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, et al., The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004; 432: 179-86.
30. Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, et al., Early growth response gene 1-mediated apoptosis is essential for transforming growth factor β1-induced pulmonary fibrosis. J Exp Med 2004; 200: 377-89.
31. Gan Y, Reilkoff R, Peng X, Russell T, Chen Q, Mathai SK, et al., Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease. Arthritis Rheum 2011; 63: 2484-94.
32. Hubner RH, Gitter W, El Mokhtari NE, Mathiak M, Both M, Bolte H, et al., Standardized quantification of pulmonary fibrosis in histological samples. Biotechniques 2008; 44: 507-11, 14-7.
33. Hecker L, Logsdon NJ, Kurundkar D, Kurundkar A, Bernard K, Hock T, et al., Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med 2014; 6: 231ra47.
34. Liu F, Mih JD, Shea BS, Kho AT, Sharif AS, Tager AM, et al., Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol 2010; 190: 693-706.
35. Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A., Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1994; 1: 71-81.
36. Bitterman PB, Wewers MD, Rennard SI, Adelberg S, Crystal RG., Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. J Clin Invest 1986; 77: 700-8.
37. Pilling D, Zheng Z, Vakil V, Gomer RH., Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis. Proc Natl Acad Sci U S A 2014; 111: 18291-6.
38. Humphrey JD, Dufresne ER, Schwartz MA., Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol 2014; 15: 802-12.
39. Balestrini JL, Chaudhry S, Sarrazy V, Koehler A, Hinz B., The mechanical memory of lung myofibroblasts. Integ Biol (Camb) 2012; 4: 410-21.
40. Wang JH, Reinherz EL., The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function. Immunol Rev 2012; 250: 102-19.
41. Ramkhelawon B, Hennessy EJ, Menager M, Ray TD, Sheedy FJ, Hutchison S, et al., Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med 2014; 20: 377-84.
42. Ramkhelawon B, Yang Y, van Gils JM, Hewing B, Rayner KJ, Parathath S, et al., Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival. Arterioscler Thromb Vasc Biol 2013; 33: 1180-8.