Decoding corticotropin-releasing factor receptor type 1 crystal structures

Current Molecular Pharmacology

Volumn 10, Issue 4, 2017, Pages 334-344

  Doré, Andrew S ^a   Bortolato, Andrea ^a   Hollenstein, Kaspar ^b   Cheng, Robert K Y ^a   Read, Randy J ^c   Marshall, Fiona H ^a  

^a Heptares Therapeutics Ltd   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CP 376395; CRF1R; GPCR; Metadynamics; Molecular dynamics; Translational non crystallographic symmetry

Indexed keywords

CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CP 376395; UNCLASSIFIED DRUG; (3,6-DIMETHYL-2-(2,4,6-TRIMETHYLPHENOXY)PYRIDIN-4-YL)(1-ETHYLPROPYL)AMINE; AMINOPYRIDINE DERIVATIVE; CORTICOTROPIN RELEASING FACTOR RECEPTOR;

ALLOSTERIC SITE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SELECTIVITY; DYNAMICS; EXTRACELLULAR SPACE; LIGAND BINDING; METADYNAMICS; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SIMULATION; X RAY DIFFRACTION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; HUMAN; METABOLISM; PROCEDURES; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; AMINOPYRIDINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE;

EID: 85032928069     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467210666170110114727     Document Type: Article

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