TGFβ (transforming growth factor-β) blockade induces a human-like disease in a nondissecting mouse model of abdominal aortic aneurysm

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 37, Issue 11, 2017, Pages 2171-2181

  Lareyre, Fabien ^a,b,c   Clment, Marc ^a   Raffort, Juliette ^a,b,c   Pohlod, Stefanie ^e   Patel, Meghana ^a   Esposito, Bruno ^d   Master, Leanne ^a   Finigan, Alison ^a   Vandestienne, Marie ^d   Stergiopulos, Nikolaos ^e,f   Taleb, Soraya ^d   Trachet, Bram ^e,f   Mallat, Ziad ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c UNIVERSITY HOSPITAL OF NICE   (France)

^d PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^e EPFL   (Switzerland)

^f GHENT UNIVERSITY   (Belgium)

Author keywords

Aneurysm; Animals; Humans; Immune system; Models

Indexed keywords

ELASTASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; APOLIPOPROTEIN E; IL1B PROTEIN, MOUSE; MONOCLONAL ANTIBODY; PANCREATIC ELASTASE;

ABDOMINAL AORTIC ANEURYSM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTIC DISSECTION; AORTIC RUPTURE; AORTIC TISSUE; AORTIC WALL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; IMMUNOCOMPETENT CELL; IN VIVO STUDY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; VASCULAR SMOOTH MUSCLE CELL; ABDOMINAL AORTA; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; ECHOGRAPHY; GENETICS; IMMUNOLOGY; KINETICS; KNOCKOUT MOUSE; LESIONS AND DEFECTS; MALE; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; SYNCHROTRON; THROMBOSIS; VASCULAR REMODELING; WOUND HEALING;

ANIMALS; ANTIBODIES, MONOCLONAL; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; AORTIC RUPTURE; APOLIPOPROTEINS E; CHEMOTAXIS, LEUKOCYTE; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EXTRACELLULAR MATRIX; INTERLEUKIN-1BETA; KINETICS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; PANCREATIC ELASTASE; SYNCHROTRONS; THROMBOSIS; TRANSFORMING GROWTH FACTOR BETA; ULTRASONOGRAPHY; VASCULAR REMODELING; WOUND HEALING;

EID: 85032921750     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.117.309999     Document Type: Article

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