IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Nature

Volumn 551, Issue 7678, 2017, Pages 110-114

  Molgora, Martina ^a   Bonavita, Eduardo ^a,g   Ponzetta, Andrea ^a   Riva, Federica ^b   Barbagallo, Marialuisa ^a   Jaillon, Sébastien ^a,c   Popović, Branka ^d   Bernardini, Giovanni ^e,f   Magrini, Elena ^a   Gianni, Francesca ^a   Zelenay, Santiago ^g   Jonjić, Stipan ^d   Santoni, Angela ^e,f   Garlanda, Cecilia ^a,c   Mantovani, Alberto ^a,c,h  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c HUMANITAS UNIVERSITY   (Italy)

^d UNIVERSITY OF RIJEKA   (Croatia)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f IRCCS NEUROMED   (Italy)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

^h QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD27 ANTIGEN; CXCL1 CHEMOKINE; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR 8; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NATURAL KILLER CELL RECEPTOR NKG2D; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ACTIVATION ENERGY; CARCINOGEN; CELLS AND CELL COMPONENTS; GENETIC ANALYSIS; IMMUNE RESPONSE; MATURATION; PATHOGEN; PROTEIN; TUMOR;

ADOPTIVE TRANSFER; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL RESISTANCE; ARTICLE; CANCER RESISTANCE; CELL MATURATION; COLON CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DENDRITIC CELL; EFFECTOR CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOREGULATION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER METASTASIS; LIVER TISSUE; LUNG METASTASIS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MALE; MOUSE; MURINE CYTOMEGALOVIRUS; NATURAL KILLER CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR IMMUNITY; UPREGULATION; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; HERPES VIRUS INFECTION; IMMUNOLOGY; LIVER TUMOR; LYMPHOCYTE ACTIVATION; METABOLISM; METASTASIS; MUROMEGALOVIRUS;

CYTOMEGALOVIRUS;

ANIMALS; CELL DIFFERENTIATION; FEMALE; HERPESVIRIDAE INFECTIONS; HUMANS; KILLER CELLS, NATURAL; LIVER NEOPLASMS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MUROMEGALOVIRUS; NEOPLASM METASTASIS;

EID: 85032826485     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature24293     Document Type: Article

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