Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Cell

Volumn 171, Issue 6, 2017, Pages 1259-1271.e11

  McGranahan, Nicholas ^a,e   Rosenthal, Rachel ^a   Hiley, Crispin T ^a,b   Rowan, Andrew J ^c   Watkins, Thomas B K ^c   Wilson, Gareth A ^a,c   Birkbak, Nicolai J ^a,c   Veeriah, Selvaraju ^a   Van Loo, Peter ^c,d   Herrero, Javier ^a   Swanton, Charles ^a,c   Jamal Hanjani, Mariam ^e   Shafi, Seema ^e   Czyzewska Khan, Justyna ^e   Johnson, Diana ^e   Laycock, Joanne ^e   Bosshard Carter, Leticia ^e   Gorman, Pat ^e   Hynds, Robert E ^e   Horswell, Stuart ^e   Mitter, Richard ^e   Escudero, Mickael ^e   Stewart, Aengus ^e   Xu, Hang ^e   Turajlic, Samra ^e   Abbosh, Christopher ^e   Goldman, Jacki ^e   Stone, Richard Kevin ^e   Denner, Tamara ^e   Matthews, Nik ^e   Elgar, Greg ^e   Ward, Sophia ^e   Costa, Marta ^e   Begum, Sharmin ^e   Phillimore, Ben ^e   Chambers, Tim ^e   Nye, Emma ^e   Graca, Sofia ^e   Al Bakir, Maise ^e   Joshi, Kroopa ^e   Furness, Andrew ^e   Ben Aissa, Assma ^e   Wong, Yien Ning Sophia ^e   Georgiou, Andy ^e   Quezada, Sergio ^e   Hartley, John A ^e   Lowe, Helen L ^e   Lawrence, David ^e   Hayward, Martin ^e   Panagiotopoulos, Nikolaos ^e   Kolvekar, Shyam ^e   Falzon, Mary ^e   Borg, Elaine ^e   Marafioti, Teresa ^e   Simeon, Celia ^e   Hector, Gemma ^e   Smith, Amy ^e   Aranda, Marie ^e   Novelli, Marco ^e   Oukrif, Dahmane ^e   Janes, Sam M ^e   Thakrar, Ricky ^e   Forster, Martin ^e   Ahmad, Tanya ^e   Lee, Siow Ming ^e   Papadatos Pastos, Dionysis ^e   Carnell, Dawn ^e   Mendes, Ruheena ^e   George, Jeremy ^e   Navani, Neal ^e   Ahmed, Asia ^e   Taylor, Magali ^e   Choudhary, Junaid ^e   Summers, Yvonne ^e   Califano, Raffaele ^e   Taylor, Paul ^e   Shah, Rajesh ^e   Krysiak, Piotr ^e   Rammohan, Kendadai ^e   Fontaine, Eustace ^e   Booton, Richard ^e   Evison, Matthew ^e   Crosbie, Phil ^e   Moss, Stuart ^e   Idries, Faiza ^e   Joseph, Leena ^e   Bishop, Paul ^e   Chaturved, Anshuman ^e   Quinn, Anne Marie ^e   Doran, Helen ^e   Leek, Angela ^e   Harrison, Phil ^e   Moore, Katrina ^e   Waddington, Rachael ^e   Novasio, Juliette ^e   Blackhall, Fiona ^e   Rogan, Jane ^e   Smith, Elaine ^e   Dive, Caroline ^e   Tugwood, Jonathan ^e   Brady, Ged ^e   Rothwell, Dominic G ^e   Chemi, Francesca ^e   Pierce, Jackie ^e   Gulati, Sakshi ^e   Naidu, Babu ^e   Langman, Gerald ^e   Trotter, Simon ^e   Bellamy, Mary ^e   Bancroft, Hollie ^e   Kerr, Amy ^e   Kadiri, Salma ^e   Webb, Joanne ^e   Middleton, Gary ^e   Djearaman, Madava ^e   Fennell, Dean ^e   Shaw, Jacqui A ^e   Le Quesne, John ^e   Moore, David ^e   Nakas, Apostolos ^e   Rathinam, Sridhar ^e   Monteiro, William ^e   Marshall, Hilary ^e   Nelson, Louise ^e   Bennett, Jonathan ^e   Riley, Joan ^e   Primrose, Lindsay ^e   Martinson, Luke ^e   Anand, Girija ^e   Khan, Sajid ^e   Amadi, Anita ^e   Nicolson, Marianne ^e   Kerr, Keith ^e   Palmer, Shirley ^e   Remmen, Hardy ^e   Miller, Joy ^e   Buchan, Keith ^e   Chetty, Mahendran ^e   Gomersall, Lesley ^e   Lester, Jason ^e   Edwards, Alison ^e   Morgan, Fiona ^e   Adams, Haydn ^e   Davies, Helen ^e   Kornaszewska, Malgorzata ^e   Attanoos, Richard ^e   Lock, Sara ^e   Verjee, Azmina ^e   MacKenzie, Mairead ^e   Wilcox, Maggie ^e   Bell, Harriet ^e   Hackshaw, Allan ^e   Ngai, Yenting ^e   Smith, Sean ^e   Gower, Nicole ^e   Ottensmeier, Christian ^e   Chee, Serena ^e   Johnson, Benjamin ^e   Alzetani, Aiman ^e   Shaw, Emily ^e   Lim, Eric ^e   De Sousa, Paulo ^e   Barbosa, Monica Tavares ^e   Bowman, Alex ^e   Jordan, Simon ^e   Rice, Alexandra ^e   Raubenheimer, Hilgardt ^e   Proli, Chiara ^e   Cufari, Maria Elena ^e   Ronquillo, John Carlo ^e   Kwayie, Angela ^e   Bhayani, Harshil ^e   Hamilton, Morag ^e   Bakar, Yusura ^e   Mensah, Natalie ^e   Ambrose, Lyn ^e   Devaraj, Anand ^e   Buderi, Silviu ^e   Finch, Jonathan ^e   Azcarate, Leire ^e   Chavan, Hema ^e   Green, Sophie ^e   Mashinga, Hillaria ^e   Nicholson, Andrew G ^e   Lau, Kelvin ^e   Sheaff, Michael ^e   Schmid, Peter ^e   Conibear, John ^e   Ezhil, Veni ^e   Ismail, Babikir ^e   Irvin sellers, Melanie ^e   Prakash, Vineet ^e   Russell, Peter ^e   Light, Teresa ^e   Horey, Tracey ^e   Danson, Sarah ^e   Bury, Jonathan ^e   Edwards, John ^e   Hill, Jennifer ^e   Matthews, Sue ^e   Kitsanta, Yota ^e   Suvarna, Kim ^e   Fisher, Patricia ^e   Keerio, Allah Dino ^e   Shackcloth, Michael ^e   Gosney, John ^e   Postmus, Pieter ^e   Feeney, Sarah ^e   Asante Siaw, Julius ^e   Aerts, Hugo J W L ^e   Dentro, Stefan ^e   Dessimoz, Christophe ^e   more..

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e NONE

Author keywords

bioinformatics; cancer evolution; chromosomal instability; copy number; heterogeneity; immune editing; immune escape; loss of heterozygosity; lung cancer; neoantigen

Indexed keywords

APOLIPOPROTEIN B MRNA EDITING ENZYME CATALYTIC POLYPEPTIDE LIKE; HLA ANTIGEN; PROGRAMMED DEATH 1 LIGAND 1;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; HAPLOTYPE; HETEROZYGOSITY; HETEROZYGOSITY LOSS; HLA SYSTEM; HOMOZYGOSITY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR EVOLUTION; MUTAGENESIS; NEXT GENERATION SEQUENCING; NON SMALL CELL LUNG CANCER; PHYLOGENETIC TREE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; RANK SUM TEST; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR ESCAPE; TUMOR MICROENVIRONMENT; VERY ELDERLY; ANTIGEN PRESENTATION; COHORT ANALYSIS; GENETICS; IMMUNOLOGY; LUNG TUMOR; MUTATION; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGEN PRESENTATION; CARCINOMA, NON-SMALL-CELL LUNG; COHORT STUDIES; FEMALE; HLA ANTIGENS; HUMANS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; TUMOR ESCAPE;

EID: 85032583704     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.10.001     Document Type: Article

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