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Volumn 18, Issue 3, 2016, Pages 1-9

Crohn’s Disease: Evolution, Epigenetics, and the Emerging Role of Microbiome-Targeted Therapies

Author keywords

Environmental enteropathy; Epigenetics; Inflammatory bowel disease; Microbiome; Personalized medicine; Public health

Indexed keywords

ADALIMUMAB; CERTOLIZUMAB PEGOL; EFALIZUMAB; FINGOLIMOD; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GOLIMUMAB; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR ANTIBODY; INFLIXIMAB; NATALIZUMAB; OZANIMOD; TUMOR NECROSIS FACTOR ALPHA; USTEKINUMAB; VEDOLIZUMAB; VERCIRNON; BIOLOGICAL PRODUCT;

EID: 85031991392     PISSN: 15228037     EISSN: 1534312X     Source Type: Journal    
DOI: 10.1007/s11894-016-0487-z     Document Type: Review
Times cited : (14)

References (106)
  • 1
    • 0021756017 scopus 로고
    • Landmark article Oct 15, 1932. Regional ileitis. A pathological and clinical entity. By Burril B. Crohn, Leon Ginzburg, and Gordon D. Oppenheimer
    • COI: 1:STN:280:DyaL2c%2FptVCqug%3D%3D, PID: 6361290
    • Crohn BB, Ginzburg L, Oppenheimer GD. Landmark article Oct 15, 1932. Regional ileitis. A pathological and clinical entity. By Burril B. Crohn, Leon Ginzburg, and Gordon D. Oppenheimer. JAMA. 1984;251:73–9.
    • (1984) JAMA , vol.251 , pp. 73-79
    • Crohn, B.B.1    Ginzburg, L.2    Oppenheimer, G.D.3
  • 2
    • 33646778482 scopus 로고    scopus 로고
    • The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications
    • COI: 1:STN:280:DC%2BD283mvVWrsw%3D%3D, PID: 16698746
    • Satsangi J, Silverberg MS, Vermeire S, Colombel J-F. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55:749–53.
    • (2006) Gut , vol.55 , pp. 749-753
    • Satsangi, J.1    Silverberg, M.S.2    Vermeire, S.3    Colombel, J.-F.4
  • 3
    • 84862294952 scopus 로고    scopus 로고
    • Classification of inflammatory bowel disease: the old and the new
    • PID: 22647554
    • Vermeire S, Van Assche G, Rutgeerts P. Classification of inflammatory bowel disease: the old and the new. Curr Opin Gastroenterol. 2012;28:321–6.
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 321-326
    • Vermeire, S.1    Van Assche, G.2    Rutgeerts, P.3
  • 4
    • 79955712974 scopus 로고    scopus 로고
    • Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification
    • PID: 21560194
    • Levine A, Griffiths A, Markowitz J, Wilson DC, Turner D, Russell RK, et al. Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification. Inflamm Bowel Dis. 2011;17:1314–21.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1314-1321
    • Levine, A.1    Griffiths, A.2    Markowitz, J.3    Wilson, D.C.4    Turner, D.5    Russell, R.K.6
  • 5
    • 0035044890 scopus 로고    scopus 로고
    • The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study
    • COI: 1:STN:280:DC%2BD3MzntVWguw%3D%3D, PID: 11316157
    • Bernstein CN, Blanchard JF, Rawsthorne P, Yu N. The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study. Am J Gastroenterol. 2001;96:1116–22.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1116-1122
    • Bernstein, C.N.1    Blanchard, J.F.2    Rawsthorne, P.3    Yu, N.4
  • 6
    • 40049102828 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease
    • PID: 18200656
    • Saich R, Chapman R. Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease. World J Gastroenterol. 2008;14:331–7.
    • (2008) World J Gastroenterol , vol.14 , pp. 331-337
    • Saich, R.1    Chapman, R.2
  • 7
    • 84943240073 scopus 로고    scopus 로고
    • Genetics of inflammatory bowel diseases
    • COI: 1:CAS:528:DC%2BC2MXhsFygsr3P, PID: 26255561, A thorough review and summary of the genome-wide association studies in IBD and the genetic loci that contribute to different phenotypes of the disease
    • McGovern DPB, Kugathasan S, Cho JH. Genetics of inflammatory bowel diseases. Gastroenterology. 2015;149:1163–76. A thorough review and summary of the genome-wide association studies in IBD and the genetic loci that contribute to different phenotypes of the disease.
    • (2015) Gastroenterology , vol.149 , pp. 1163-1176
    • McGovern, D.P.B.1    Kugathasan, S.2    Cho, J.H.3
  • 8
    • 44349104723 scopus 로고    scopus 로고
    • New global map of Crohn’s disease: genetic, environmental, and socioeconomic correlations
    • PID: 18095316
    • Economou M, Pappas G. New global map of Crohn’s disease: genetic, environmental, and socioeconomic correlations. Inflamm Bowel Dis. 2008;14:709–20.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 709-720
    • Economou, M.1    Pappas, G.2
  • 9
    • 84942603869 scopus 로고    scopus 로고
    • Epigenetics at the crossroads of genes and the environment
    • COI: 1:CAS:528:DC%2BC28XkslGmtw%3D%3D, PID: 26372577
    • Feinberg AP, Fallin MD. Epigenetics at the crossroads of genes and the environment. JAMA. 2015;314:1129–30.
    • (2015) JAMA , vol.314 , pp. 1129-1130
    • Feinberg, A.P.1    Fallin, M.D.2
  • 10
    • 0346734343 scopus 로고    scopus 로고
    • Crohn’s disease: the cold chain hypothesis
    • COI: 1:CAS:528:DC%2BD3sXpvVWku74%3D, PID: 14683664
    • Hugot J-P, Alberti C, Berrebi D, Bingen E, Cézard J-P. Crohn’s disease: the cold chain hypothesis. Lancet. 2003;362:2012–5.
    • (2003) Lancet , vol.362 , pp. 2012-2015
    • Hugot, J.-P.1    Alberti, C.2    Berrebi, D.3    Bingen, E.4    Cézard, J.-P.5
  • 12
    • 84937393952 scopus 로고    scopus 로고
    • Inflammatory bowel disease environmental risk factors: a population-based case–control study of Middle Eastern migration to Australia
    • PID: 25771246, e1
    • Ko Y, Kariyawasam V, Karnib M, Butcher R, Samuel D, Alrubaie A, et al. Inflammatory bowel disease environmental risk factors: a population-based case–control study of Middle Eastern migration to Australia. Clin Gastroenterol Hepatol. 2015;13:1453–63. e1.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 1453-1463
    • Ko, Y.1    Kariyawasam, V.2    Karnib, M.3    Butcher, R.4    Samuel, D.5    Alrubaie, A.6
  • 13
    • 84937965550 scopus 로고    scopus 로고
    • Environmental factors in the relapse and recurrence of inflammatory bowel disease: a review of the literature
    • COI: 1:CAS:528:DC%2BC2cXhvFyjsLfM, PID: 25407806, Reinforces Crohn’s disease as a chronic environmental enteropathy that poses public health threat
    • Martin TD, Chan SSM, Hart AR. Environmental factors in the relapse and recurrence of inflammatory bowel disease: a review of the literature. Dig Dis Sci. 2015;60:1396–405. Reinforces Crohn’s disease as a chronic environmental enteropathy that poses public health threat.
    • (2015) Dig Dis Sci , vol.60 , pp. 1396-1405
    • Martin, T.D.1    Chan, S.S.M.2    Hart, A.R.3
  • 14
  • 15
    • 84928412757 scopus 로고    scopus 로고
    • Diet in the pathogenesis and treatment of inflammatory bowel diseases
    • COI: 1:CAS:528:DC%2BC2MXntVersLg%3D, PID: 25597840
    • Lee D, Albenberg L, Compher C, Baldassano R, Piccoli D, Lewis JD, et al. Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology. 2015;148:1087–106.
    • (2015) Gastroenterology , vol.148 , pp. 1087-1106
    • Lee, D.1    Albenberg, L.2    Compher, C.3    Baldassano, R.4    Piccoli, D.5    Lewis, J.D.6
  • 16
    • 84927799698 scopus 로고    scopus 로고
    • Inflammatory bowel disease in immigrants to Canada and their children: a population-based cohort study
    • PID: 25756238
    • Benchimol EI, Mack DR, Guttmann A, Nguyen GC, To T, Mojaverian N, et al. Inflammatory bowel disease in immigrants to Canada and their children: a population-based cohort study. Am J Gastroenterol. 2015;110:553–63.
    • (2015) Am J Gastroenterol , vol.110 , pp. 553-563
    • Benchimol, E.I.1    Mack, D.R.2    Guttmann, A.3    Nguyen, G.C.4    To, T.5    Mojaverian, N.6
  • 17
    • 84942565591 scopus 로고    scopus 로고
    • Gene-environment interactions in inflammatory bowel disease pathogenesis
    • PID: 26039718, Emphasizes the interplay between environmental and genetic susceptibilities in producing a variety of phenotypes of Crohn’s disease
    • Wang M-H, Achkar J-P. Gene-environment interactions in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol. 2015;31:277–82. Emphasizes the interplay between environmental and genetic susceptibilities in producing a variety of phenotypes of Crohn’s disease.
    • (2015) Curr Opin Gastroenterol , vol.31 , pp. 277-282
    • Wang, M.-H.1    Achkar, J.-P.2
  • 18
    • 84945529572 scopus 로고    scopus 로고
    • Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans
    • COI: 1:CAS:528:DC%2BC2MXhslamsrfM, PID: 26278503
    • Huang C, Haritunians T, Okou DT, Cutler DJ, Zwick ME, Taylor KD, et al. Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans. Gastroenterology. 2015;149:1575–86.
    • (2015) Gastroenterology , vol.149 , pp. 1575-1586
    • Huang, C.1    Haritunians, T.2    Okou, D.T.3    Cutler, D.J.4    Zwick, M.E.5    Taylor, K.D.6
  • 19
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC38Xhs1ajtbzP, PID: 23128233, Describes the intersection of immunogenetic patterns and signatures in determining the course of IBD
    • Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491:119–24. Describes the intersection of immunogenetic patterns and signatures in determining the course of IBD.
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3    Duerr, R.H.4    McGovern, D.P.5    Hui, K.Y.6
  • 20
    • 84856654988 scopus 로고    scopus 로고
    • Evolution, revolution and heresy in the genetics of infectious disease susceptibility
    • COI: 1:CAS:528:DC%2BC38XotVSlu74%3D, PID: 22312051
    • Hill AVS. Evolution, revolution and heresy in the genetics of infectious disease susceptibility. Philos Trans R Soc Lond B Biol Sci. 2012;367:840–9.
    • (2012) Philos Trans R Soc Lond B Biol Sci , vol.367 , pp. 840-849
    • Hill, A.V.S.1
  • 21
    • 84867619205 scopus 로고    scopus 로고
    • Innate immune gene polymorphisms in tuberculosis
    • COI: 1:CAS:528:DC%2BC38XhsVCku7jN, PID: 22825450
    • Azad AK, Sadee W, Schlesinger LS. Innate immune gene polymorphisms in tuberculosis. Infect Immun. 2012;80:3343–59.
    • (2012) Infect Immun , vol.80 , pp. 3343-3359
    • Azad, A.K.1    Sadee, W.2    Schlesinger, L.S.3
  • 22
    • 84855863560 scopus 로고    scopus 로고
    • Crohn’s disease and the mycobacterioses: a quarter century later. Causation or simple association?
    • PID: 22242906
    • Chiodini RJ, Chamberlin WM, Sarosiek J, McCallum RW. Crohn’s disease and the mycobacterioses: a quarter century later. Causation or simple association? Crit Rev Microbiol. 2012;38:52–93.
    • (2012) Crit Rev Microbiol , vol.38 , pp. 52-93
    • Chiodini, R.J.1    Chamberlin, W.M.2    Sarosiek, J.3    McCallum, R.W.4
  • 23
    • 84944156326 scopus 로고    scopus 로고
    • The zoonotic potential of Mycobacterium avium ssp. paratuberculosis: a systematic review and meta-analyses of the evidence
    • COI: 1:STN:280:DC%2BC2MflsVenuw%3D%3D, PID: 25989710
    • Waddell LA, Rajić A, Stärk KDC, McEWEN SA. The zoonotic potential of Mycobacterium avium ssp. paratuberculosis: a systematic review and meta-analyses of the evidence. Epidemiol Infect. 2015;143:3135–57.
    • (2015) Epidemiol Infect , vol.143 , pp. 3135-3157
    • Waddell, L.A.1    Rajić, A.2    Stärk, K.D.C.3    McEWEN, S.A.4
  • 24
    • 84902684907 scopus 로고    scopus 로고
    • Mycobacterium avium subspecies paratuberculosis causes Crohn’s disease in some inflammatory bowel disease patients
    • PID: 24966610
    • Naser SA, Sagramsingh SR, Naser AS, Thanigachalam S. Mycobacterium avium subspecies paratuberculosis causes Crohn’s disease in some inflammatory bowel disease patients. World J Gastroenterol. 2014;20:7403–15.
    • (2014) World J Gastroenterol , vol.20 , pp. 7403-7415
    • Naser, S.A.1    Sagramsingh, S.R.2    Naser, A.S.3    Thanigachalam, S.4
  • 25
    • 68149126054 scopus 로고    scopus 로고
    • Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide
    • COI: 1:CAS:528:DC%2BD1MXps1enu78%3D, PID: 19581406
    • Coulombe F, Divangahi M, Veyrier F, de Léséleuc L, Gleason JL, Yang Y, et al. Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. J Exp Med. 2009;206:1709–16.
    • (2009) J Exp Med , vol.206 , pp. 1709-1716
    • Coulombe, F.1    Divangahi, M.2    Veyrier, F.3    de Léséleuc, L.4    Gleason, J.L.5    Yang, Y.6
  • 26
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease
    • COI: 1:CAS:528:DC%2BD3MXksVShur8%3D, PID: 11385577
    • Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature. 2001;411:603–6.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3    Nicolae, D.L.4    Chen, F.F.5    Ramos, R.6
  • 27
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn’s disease
    • COI: 1:CAS:528:DyaK2sXmvVKjsrs%3D, PID: 9321530
    • Targan SR, Hanauer SB, van Deventer SJH, Mayer L, Present DH, Braakman T, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn’s disease. N Engl J Med. 1997;337:1029–36.
    • (1997) N Engl J Med , vol.337 , pp. 1029-1036
    • Targan, S.R.1    Hanauer, S.B.2    van Deventer, S.J.H.3    Mayer, L.4    Present, D.H.5    Braakman, T.6
  • 28
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    • COI: 1:CAS:528:DyaK1MXitlalsro%3D, PID: 10204494
    • Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity. 1999;10:387–98.
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3    Cominelli, F.4    Kollias, G.5
  • 29
    • 0035846326 scopus 로고    scopus 로고
    • Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent
    • COI: 1:CAS:528:DC%2BD3MXnsFShsr0%3D, PID: 11596589
    • Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, et al. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med. 2001;345:1098–104.
    • (2001) N Engl J Med , vol.345 , pp. 1098-1104
    • Keane, J.1    Gershon, S.2    Wise, R.P.3    Mirabile-Levens, E.4    Kasznica, J.5    Schwieterman, W.D.6
  • 30
    • 84956943463 scopus 로고    scopus 로고
    • Polymorphisms in the toll-like receptor and the IL-23/IL-17 pathways were associated with susceptibility to inflammatory bowel disease in a Danish cohort
    • PID: 26698117, Examines the role of IL-23/IL-17 and interferon gamma pathways in the pathogenesis of Crohn’s disease
    • Bank S, Andersen PS, Burisch J, Pedersen N, Roug S, Galsgaard J, et al. Polymorphisms in the toll-like receptor and the IL-23/IL-17 pathways were associated with susceptibility to inflammatory bowel disease in a Danish cohort. PLoS One. 2015;10:e0145302. Examines the role of IL-23/IL-17 and interferon gamma pathways in the pathogenesis of Crohn’s disease.
    • (2015) PLoS One , vol.10 , pp. e0145302
    • Bank, S.1    Andersen, P.S.2    Burisch, J.3    Pedersen, N.4    Roug, S.5    Galsgaard, J.6
  • 31
    • 67449147595 scopus 로고    scopus 로고
    • Interleukin-23/Th17 pathways and inflammatory bowel disease
    • PID: 19253307
    • Abraham C, Cho J. Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:1090–100.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1090-1100
    • Abraham, C.1    Cho, J.2
  • 32
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn’s disease
    • COI: 1:CAS:528:DC%2BD1cXht12lur3E, PID: 18706417
    • Sandborn WJ, Feagan BG, Fedorak RN, Scherl E, Fleisher MR, Katz S, et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn’s disease. Gastroenterology. 2008;135:1130–41.
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3    Scherl, E.4    Fleisher, M.R.5    Katz, S.6
  • 33
    • 84883591833 scopus 로고    scopus 로고
    • Combined blockade of IL-17A and IL-17F may prevent the development of experimental colitis
    • COI: 1:CAS:528:DC%2BC3sXhtlKrt77L, PID: 23998727
    • McLean LP, Cross RK, Shea-Donohue T. Combined blockade of IL-17A and IL-17F may prevent the development of experimental colitis. Immunotherapy. 2013;5:923–5.
    • (2013) Immunotherapy , vol.5 , pp. 923-925
    • McLean, L.P.1    Cross, R.K.2    Shea-Donohue, T.3
  • 34
    • 84944675546 scopus 로고    scopus 로고
    • Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability
    • COI: 1:CAS:528:DC%2BC2MXhsFyqt7vO, PID: 26431948
    • Lee JS, Tato CM, Joyce-Shaikh B, Gulan F, Cayatte C, Chen Y, et al. Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability. Immunity. 2015;43:727–38.
    • (2015) Immunity , vol.43 , pp. 727-738
    • Lee, J.S.1    Tato, C.M.2    Joyce-Shaikh, B.3    Gulan, F.4    Cayatte, C.5    Chen, Y.6
  • 35
    • 84936892270 scopus 로고    scopus 로고
    • Innate lymphoid cells in the initiation, regulation and resolution of inflammation
    • COI: 1:CAS:528:DC%2BC2MXhtFeisrvE, PID: 26121198
    • Sonnenberg GF, Artis D. Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nat Med. 2015;21:698–708.
    • (2015) Nat Med , vol.21 , pp. 698-708
    • Sonnenberg, G.F.1    Artis, D.2
  • 36
    • 0033799851 scopus 로고    scopus 로고
    • Specific targeting of IL-6 signalling pathway: a new way to treat IBD?
    • COI: 1:STN:280:DC%2BD3M%2FksFynsg%3D%3D, PID: 10986204
    • Desreumaux P. Specific targeting of IL-6 signalling pathway: a new way to treat IBD? Gut. 2000;47:465–6.
    • (2000) Gut , vol.47 , pp. 465-466
    • Desreumaux, P.1
  • 37
    • 84882433613 scopus 로고    scopus 로고
    • Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3sXhsV2ms7vP, PID: 23827161
    • Coskun M, Salem M, Pedersen J, Nielsen OH. Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease. Pharmacol Res. 2013;76:1–8.
    • (2013) Pharmacol Res , vol.76 , pp. 1-8
    • Coskun, M.1    Salem, M.2    Pedersen, J.3    Nielsen, O.H.4
  • 38
    • 84865494677 scopus 로고    scopus 로고
    • Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC38Xhs1CqtbjL, PID: 22827693
    • Anderson JL, Edney RJ, Whelan K. Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease. Aliment Pharmacol Ther. 2012;36:503–16.
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 503-516
    • Anderson, J.L.1    Edney, R.J.2    Whelan, K.3
  • 39
    • 84924787273 scopus 로고    scopus 로고
    • IBD and the gut microbiota—from bench to personalized medicine
    • Bellaguarda E, Chang EB. IBD and the gut microbiota—from bench to personalized medicine. wCurr Gastroenterol Rep. 2015;17:15.
    • (2015) wCurr Gastroenterol Rep , vol.17 , pp. 15
    • Bellaguarda, E.1    Chang, E.B.2
  • 40
    • 84896092821 scopus 로고    scopus 로고
    • The treatment-naive microbiome in new-onset Crohn’s disease
    • COI: 1:CAS:528:DC%2BC2cXks1Omu7Y%3D, PID: 24629344, Unexplained heterogeneity in Crohn’s disease phenotypes may be explained by differences in the microbiome among affected individuals
    • Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van Treuren W, Ren B, et al. The treatment-naive microbiome in new-onset Crohn’s disease. Cell Host Microbe. 2014;15:382–92. Unexplained heterogeneity in Crohn’s disease phenotypes may be explained by differences in the microbiome among affected individuals.
    • (2014) Cell Host Microbe , vol.15 , pp. 382-392
    • Gevers, D.1    Kugathasan, S.2    Denson, L.A.3    Vázquez-Baeza, Y.4    Van Treuren, W.5    Ren, B.6
  • 41
    • 84875293765 scopus 로고    scopus 로고
    • Microbial manipulation as primary therapy for Crohn’s disease
    • PID: 23539531
    • Longman RS, Swaminath A. Microbial manipulation as primary therapy for Crohn’s disease. World J Gastroenterol. 2013;19:1513–6.
    • (2013) World J Gastroenterol , vol.19 , pp. 1513-1516
    • Longman, R.S.1    Swaminath, A.2
  • 42
    • 84925622906 scopus 로고    scopus 로고
    • Dogan B, Suzuki H, Herlekar D, Sartor RB, Campbell BJ, Roberts CL, et al. Inflammation-associated adherent-invasive Escherichia coli are enriched in pathways for use of propanediol and iron and M-cell translocation. Inflamm Bowel Dis. 2014;20:1919–32. Examines the dysbiosis and the role of adherent-invasive E. coli in promoting intestinal inflammation and potential therapeutic targets.
    • Dogan B, Suzuki H, Herlekar D, Sartor RB, Campbell BJ, Roberts CL, et al. Inflammation-associated adherent-invasive Escherichia coli are enriched in pathways for use of propanediol and iron and M-cell translocation. Inflamm Bowel Dis. 2014;20:1919–32. Examines the dysbiosis and the role of adherent-invasiveE. coliin promoting intestinal inflammation and potential therapeutic targets.
  • 43
    • 34548483459 scopus 로고    scopus 로고
    • Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn’s disease involving the ileum
    • COI: 1:CAS:528:DC%2BD2sXht1Kht7fP, PID: 18043660
    • Baumgart M, Dogan B, Rishniw M, Weitzman G, Bosworth B, Yantiss R, et al. Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn’s disease involving the ileum. ISME J. 2007;1:403–18.
    • (2007) ISME J , vol.1 , pp. 403-418
    • Baumgart, M.1    Dogan, B.2    Rishniw, M.3    Weitzman, G.4    Bosworth, B.5    Yantiss, R.6
  • 44
    • 84879109909 scopus 로고    scopus 로고
    • A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice
    • COI: 1:CAS:528:DC%2BC3sXpsFSjtbg%3D, PID: 23768495
    • Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, et al. A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice. Cell Host Microbe. 2013;13:711–22.
    • (2013) Cell Host Microbe , vol.13 , pp. 711-722
    • Hayashi, A.1    Sato, T.2    Kamada, N.3    Mikami, Y.4    Matsuoka, K.5    Hisamatsu, T.6
  • 45
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • COI: 1:CAS:528:DC%2BC3MXmsVCjsw%3D%3D, PID: 21205640
    • Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science. 2011;331:337–41.
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3    Imaoka, A.4    Kuwahara, T.5    Momose, Y.6
  • 46
    • 84918804221 scopus 로고    scopus 로고
    • Microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs
    • PID: 25469017
    • Honneffer JB, Minamoto Y, Suchodolski JS. Microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs. World J Gastroenterol. 2014;20:16489–97.
    • (2014) World J Gastroenterol , vol.20 , pp. 16489-16497
    • Honneffer, J.B.1    Minamoto, Y.2    Suchodolski, J.S.3
  • 48
    • 84943639694 scopus 로고    scopus 로고
    • Th17 cell induction by adhesion of microbes to intestinal epithelial cells
    • COI: 1:CAS:528:DC%2BC2MXhsFKqsb%2FN, PID: 26411289
    • Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, et al. Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell. 2015;163:367–80.
    • (2015) Cell , vol.163 , pp. 367-380
    • Atarashi, K.1    Tanoue, T.2    Ando, M.3    Kamada, N.4    Nagano, Y.5    Narushima, S.6
  • 50
    • 84865041023 scopus 로고    scopus 로고
    • Majority of patients with inflammatory bowel disease in clinical remission have mucosal inflammation
    • PID: 22069022
    • Baars JE, Nuij VJAA, Oldenburg B, Kuipers EJ, van der Woude CJ. Majority of patients with inflammatory bowel disease in clinical remission have mucosal inflammation. Inflamm Bowel Dis. 2012;18:1634–40.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1634-1640
    • Baars, J.E.1    Nuij, V.J.A.A.2    Oldenburg, B.3    Kuipers, E.J.4    van der Woude, C.J.5
  • 51
    • 84864832613 scopus 로고    scopus 로고
    • Crucial steps in the natural history of inflammatory bowel disease
    • PID: 22876029
    • Latella G, Papi C. Crucial steps in the natural history of inflammatory bowel disease. World J Gastroenterol. 2012;18:3790–9.
    • (2012) World J Gastroenterol , vol.18 , pp. 3790-3799
    • Latella, G.1    Papi, C.2
  • 52
    • 0026708247 scopus 로고
    • Medical treatment of inflammatory bowel disease
    • COI: 1:STN:280:DyaK383lsFaktA%3D%3D, PID: 1580577
    • Shanahan F, Targan S. Medical treatment of inflammatory bowel disease. Annu Rev Med. 1992;43:125–33.
    • (1992) Annu Rev Med , vol.43 , pp. 125-133
    • Shanahan, F.1    Targan, S.2
  • 53
    • 0023912898 scopus 로고
    • Sulfasalazine: II. Some notes on the discovery and development of salazopyrin
    • COI: 1:CAS:528:DyaL1cXktVGkt7k%3D, PID: 2896459
    • Svartz N. Sulfasalazine: II. Some notes on the discovery and development of salazopyrin. Am J Gastroenterol. 1988;83:497–503.
    • (1988) Am J Gastroenterol , vol.83 , pp. 497-503
    • Svartz, N.1
  • 54
    • 84887323708 scopus 로고    scopus 로고
    • Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
    • PID: 24192039
    • Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife. 2013;2:e01202.
    • (2013) eLife , vol.2 , pp. e01202
    • Scher, J.U.1    Sczesnak, A.2    Longman, R.S.3    Segata, N.4    Ubeda, C.5    Bielski, C.6
  • 55
    • 0013898813 scopus 로고
    • Corticosteroids and corticotrophin in the treatment of Crohn’s disease
    • COI: 1:STN:280:DyaF287ivFyjsQ%3D%3D, PID: 4286707
    • Jones JH, Lennard-Jones JE. Corticosteroids and corticotrophin in the treatment of Crohn’s disease. Gut. 1966;7:181–7.
    • (1966) Gut , vol.7 , pp. 181-187
    • Jones, J.H.1    Lennard-Jones, J.E.2
  • 56
    • 0025322362 scopus 로고
    • Glucocorticoid treatment in ileal Crohn’s disease: relief of symptoms but not of endoscopically viewed inflammation
    • COI: 1:STN:280:DyaK3c3hsFentw%3D%3D, PID: 2323598
    • Olaison G, Sjödahl R, Tagesson C. Glucocorticoid treatment in ileal Crohn’s disease: relief of symptoms but not of endoscopically viewed inflammation. Gut. 1990;31:325–8.
    • (1990) Gut , vol.31 , pp. 325-328
    • Olaison, G.1    Sjödahl, R.2    Tagesson, C.3
  • 57
    • 0014966572 scopus 로고
    • Azathioprine in Crohn’s disease
    • COI: 1:STN:280:DyaE3M%2Fjt1agtg%3D%3D, PID: 4097954
    • Rhodes J, Bainton D, Beck P. Azathioprine in Crohn’s disease. Lancet. 1970;2:1142.
    • (1970) Lancet , vol.2 , pp. 1142
    • Rhodes, J.1    Bainton, D.2    Beck, P.3
  • 58
    • 84881273549 scopus 로고    scopus 로고
    • Azathioprine or 6-mercaptopurine for induction of remission in Crohn’s disease
    • PID: 23633304
    • Chande N, Tsoulis DJ, MacDonald JK. Azathioprine or 6-mercaptopurine for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2013;4:CD000545.
    • (2013) Cochrane Database Syst Rev , vol.4 , pp. CD000545
    • Chande, N.1    Tsoulis, D.J.2    MacDonald, J.K.3
  • 59
    • 0018888679 scopus 로고
    • Treatment of Crohn’s disease with 6-mercaptopurine. A long-term, randomized, double-blind study
    • COI: 1:STN:280:DyaL3c7msFelsw%3D%3D, PID: 6102739
    • Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS. Treatment of Crohn’s disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med. 1980;302:981–7.
    • (1980) N Engl J Med , vol.302 , pp. 981-987
    • Present, D.H.1    Korelitz, B.I.2    Wisch, N.3    Glass, J.L.4    Sachar, D.B.5    Pasternack, B.S.6
  • 61
    • 13744255984 scopus 로고    scopus 로고
    • Safety and efficacy of adalimumab (D2E7) in Crohn’s disease patients with an attenuated response to infliximab
    • COI: 1:CAS:528:DC%2BD2MXht12rur4%3D, PID: 15654784
    • Papadakis KA, Shaye OA, Vasiliauskas EA, Ippoliti A, Dubinsky MC, Birt J, et al. Safety and efficacy of adalimumab (D2E7) in Crohn’s disease patients with an attenuated response to infliximab. Am J Gastroenterol. 2005;100:75–9.
    • (2005) Am J Gastroenterol , vol.100 , pp. 75-79
    • Papadakis, K.A.1    Shaye, O.A.2    Vasiliauskas, E.A.3    Ippoliti, A.4    Dubinsky, M.C.5    Birt, J.6
  • 62
    • 32044451548 scopus 로고    scopus 로고
    • Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn’s disease: the CLASSIC-I trial
    • COI: 1:CAS:528:DC%2BD28Xit1alu7o%3D, PID: 16472588, quiz 591
    • Hanauer SB, Sandborn WJ, Rutgeerts P, Fedorak RN, Lukas M, MacIntosh D, et al. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn’s disease: the CLASSIC-I trial. Gastroenterology. 2006;130:323–33. quiz 591.
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.B.1    Sandborn, W.J.2    Rutgeerts, P.3    Fedorak, R.N.4    Lukas, M.5    MacIntosh, D.6
  • 63
    • 84905723625 scopus 로고    scopus 로고
    • Update on anti-tumor necrosis factor agents in Crohn disease
    • PID: 25110253
    • Singh S, Pardi DS. Update on anti-tumor necrosis factor agents in Crohn disease. Gastroenterol Clin North Am. 2014;43:457–78.
    • (2014) Gastroenterol Clin North Am , vol.43 , pp. 457-478
    • Singh, S.1    Pardi, D.S.2
  • 64
    • 58149388237 scopus 로고    scopus 로고
    • Effects of adalimumab maintenance therapy on health-related quality of life of patients with Crohn’s disease: patient-reported outcomes of the CHARM trial
    • PID: 18853973
    • Loftus EV, Feagan BG, Colombel J-F, Rubin DT, Wu EQ, Yu AP, et al. Effects of adalimumab maintenance therapy on health-related quality of life of patients with Crohn’s disease: patient-reported outcomes of the CHARM trial. Am J Gastroenterol. 2008;103:3132–41.
    • (2008) Am J Gastroenterol , vol.103 , pp. 3132-3141
    • Loftus, E.V.1    Feagan, B.G.2    Colombel, J.-F.3    Rubin, D.T.4    Wu, E.Q.5    Yu, A.P.6
  • 66
    • 84920675807 scopus 로고    scopus 로고
    • Treatment of IBD: where we are and where we are going
    • PID: 25488896
    • Bernstein CN. Treatment of IBD: where we are and where we are going. Am J Gastroenterol. 2015;110:114–26.
    • (2015) Am J Gastroenterol , vol.110 , pp. 114-126
    • Bernstein, C.N.1
  • 67
    • 84926162527 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: the efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failed
    • COI: 1:CAS:528:DC%2BC2MXjvVOgsrY%3D, PID: 25652884
    • Gisbert JP, Marín AC, McNicholl AG, Chaparro M. Systematic review with meta-analysis: the efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failed. Aliment Pharmacol Ther. 2015;41:613–23.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 613-623
    • Gisbert, J.P.1    Marín, A.C.2    McNicholl, A.G.3    Chaparro, M.4
  • 68
    • 0036726041 scopus 로고    scopus 로고
    • Predictors of response to infliximab in patients with Crohn’s disease
    • COI: 1:CAS:528:DC%2BD38Xntl2mtbc%3D, PID: 12198696
    • Parsi MA, Achkar J-P, Richardson S, Katz J, Hammel JP, Lashner BA, et al. Predictors of response to infliximab in patients with Crohn’s disease. Gastroenterology. 2002;123:707–13.
    • (2002) Gastroenterology , vol.123 , pp. 707-713
    • Parsi, M.A.1    Achkar, J.-P.2    Richardson, S.3    Katz, J.4    Hammel, J.P.5    Lashner, B.A.6
  • 69
    • 84872050633 scopus 로고    scopus 로고
    • Impact of antibodies to infliximab on clinical outcomes and serum infliximab levels in patients with inflammatory bowel disease (IBD): a meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXktFWlsw%3D%3D, PID: 23147525
    • Nanda KS, Cheifetz AS, Moss AC. Impact of antibodies to infliximab on clinical outcomes and serum infliximab levels in patients with inflammatory bowel disease (IBD): a meta-analysis. Am J Gastroenterol. 2013;108:40–7.
    • (2013) Am J Gastroenterol , vol.108 , pp. 40-47
    • Nanda, K.S.1    Cheifetz, A.S.2    Moss, A.C.3
  • 70
    • 84925367939 scopus 로고    scopus 로고
    • Levels of drug and antidrug antibodies are associated with outcome of interventions after loss of response to infliximab or adalimumab
    • COI: 1:CAS:528:DC%2BC2cXhsVOiu7bN, PID: 25066837, e2
    • Yanai H, Lichtenstein L, Assa A, Mazor Y, Weiss B, Levine A, et al. Levels of drug and antidrug antibodies are associated with outcome of interventions after loss of response to infliximab or adalimumab. Clin Gastroenterol Hepatol. 2015;13:522–30. e2.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 522-530
    • Yanai, H.1    Lichtenstein, L.2    Assa, A.3    Mazor, Y.4    Weiss, B.5    Levine, A.6
  • 71
    • 34247884424 scopus 로고    scopus 로고
    • Natalizumab for the treatment of active Crohn’s disease: results of the ENCORE Trial
    • COI: 1:CAS:528:DC%2BD2sXmsVymsrc%3D, PID: 17484865
    • Targan SR, Feagan BG, Fedorak RN, Lashner BA, Panaccione R, Present DH, et al. Natalizumab for the treatment of active Crohn’s disease: results of the ENCORE Trial. Gastroenterology. 2007;132:1672–83.
    • (2007) Gastroenterology , vol.132 , pp. 1672-1683
    • Targan, S.R.1    Feagan, B.G.2    Fedorak, R.N.3    Lashner, B.A.4    Panaccione, R.5    Present, D.H.6
  • 72
    • 84882785930 scopus 로고    scopus 로고
    • Inhibition of leukocyte trafficking in inflammatory bowel disease
    • PID: 23964940
    • Cominelli F. Inhibition of leukocyte trafficking in inflammatory bowel disease. N Engl J Med. 2013;369:775–6.
    • (2013) N Engl J Med , vol.369 , pp. 775-776
    • Cominelli, F.1
  • 73
    • 84882749768 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for Crohn’s disease
    • COI: 1:CAS:528:DC%2BC3sXhtlCrsrbO, PID: 23964933
    • Sandborn WJ, Feagan BG, Rutgeerts P, Hanauer S, Colombel J-F, Sands BE, et al. Vedolizumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2013;369:711–21.
    • (2013) N Engl J Med , vol.369 , pp. 711-721
    • Sandborn, W.J.1    Feagan, B.G.2    Rutgeerts, P.3    Hanauer, S.4    Colombel, J.-F.5    Sands, B.E.6
  • 74
    • 84882769357 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for ulcerative colitis
    • COI: 1:CAS:528:DC%2BC3sXhtlCrsrbN, PID: 23964932
    • Feagan BG, Rutgeerts P, Sands BE, Hanauer S, Colombel J-F, Sandborn WJ, et al. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2013;369:699–710.
    • (2013) N Engl J Med , vol.369 , pp. 699-710
    • Feagan, B.G.1    Rutgeerts, P.2    Sands, B.E.3    Hanauer, S.4    Colombel, J.-F.5    Sandborn, W.J.6
  • 75
    • 84890928365 scopus 로고    scopus 로고
    • Leukocyte traffic blockade as a therapeutic strategy in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3sXhsl2jsLfP, PID: 23621509
    • Bamias G, Clark DJ, Rivera-Nieves J. Leukocyte traffic blockade as a therapeutic strategy in inflammatory bowel disease. Curr Drug Targets. 2013;14:1490–500.
    • (2013) Curr Drug Targets , vol.14 , pp. 1490-1500
    • Bamias, G.1    Clark, D.J.2    Rivera-Nieves, J.3
  • 76
    • 79959690272 scopus 로고    scopus 로고
    • Efalizumab, a human monoclonal anti-CD11a antibody, in the treatment of moderate to severe Crohn’s disease: an open-label pilot study
    • COI: 1:CAS:528:DC%2BC3MXmtlyqu7g%3D, PID: 21170755
    • James DG, Seo DH, Chen J, Vemulapalli C, Stone CD. Efalizumab, a human monoclonal anti-CD11a antibody, in the treatment of moderate to severe Crohn’s disease: an open-label pilot study. Dig Dis Sci. 2011;56:1806–10.
    • (2011) Dig Dis Sci , vol.56 , pp. 1806-1810
    • James, D.G.1    Seo, D.H.2    Chen, J.3    Vemulapalli, C.4    Stone, C.D.5
  • 77
    • 80051791145 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy associated with efalizumab use in psoriasis patients
    • COI: 1:CAS:528:DC%2BC3MXhtVais7nL, PID: 21514689
    • Kothary N, Diak I-L, Brinker A, Bezabeh S, Avigan M, Dal PG. Progressive multifocal leukoencephalopathy associated with efalizumab use in psoriasis patients. J Am Acad Dermatol. 2011;65:546–51.
    • (2011) J Am Acad Dermatol , vol.65 , pp. 546-551
    • Kothary, N.1    Diak, I.-L.2    Brinker, A.3    Bezabeh, S.4    Avigan, M.5    Dal, P.G.6
  • 78
    • 84894589499 scopus 로고    scopus 로고
    • Review article: anti-adhesion therapies for inflammatory bowel disease
    • PID: 24479980
    • Lobatón T, Vermeire S, Van Assche G, Rutgeerts P. Review article: anti-adhesion therapies for inflammatory bowel disease. Aliment Pharmacol Ther. 2014;39:579–94.
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 579-594
    • Lobatón, T.1    Vermeire, S.2    Van Assche, G.3    Rutgeerts, P.4
  • 79
    • 84940606889 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor modulators in multiple sclerosis
    • COI: 1:CAS:528:DC%2BC2MXhtlSjt7jP, PID: 26239599
    • Subei AM, Cohen JA. Sphingosine 1-phosphate receptor modulators in multiple sclerosis. CNS Drugs. 2015;29:565–75.
    • (2015) CNS Drugs , vol.29 , pp. 565-575
    • Subei, A.M.1    Cohen, J.A.2
  • 80
    • 76149140914 scopus 로고    scopus 로고
    • Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
    • COI: 1:CAS:528:DC%2BC3cXhvVWrsbk%3D, PID: 20089954
    • Cohen JA, Barkhof F, Comi G, Hartung H-P, Khatri BO, Montalban X, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010;362:402–15.
    • (2010) N Engl J Med , vol.362 , pp. 402-415
    • Cohen, J.A.1    Barkhof, F.2    Comi, G.3    Hartung, H.-P.4    Khatri, B.O.5    Montalban, X.6
  • 82
    • 33846804162 scopus 로고    scopus 로고
    • A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn’s disease
    • COI: 1:CAS:528:DC%2BD2sXjtlKjsrg%3D, PID: 17296530
    • Yacyshyn B, Chey WY, Wedel MK, Yu RZ, Paul D, Chuang E. A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with active Crohn’s disease. Clin Gastroenterol Hepatol. 2007;5:215–20.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 215-220
    • Yacyshyn, B.1    Chey, W.Y.2    Wedel, M.K.3    Yu, R.Z.4    Paul, D.5    Chuang, E.6
  • 83
    • 84865013186 scopus 로고    scopus 로고
    • Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis
    • COI: 1:CAS:528:DC%2BC38Xht1Chu77K, PID: 22894574
    • Sandborn WJ, Ghosh S, Panes J, Vranic I, Su C, Rousell S, et al. Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis. N Engl J Med. 2012;367:616–24.
    • (2012) N Engl J Med , vol.367 , pp. 616-624
    • Sandborn, W.J.1    Ghosh, S.2    Panes, J.3    Vranic, I.4    Su, C.5    Rousell, S.6
  • 84
    • 84875241315 scopus 로고    scopus 로고
    • Ustekinumab for moderate-to-severe Crohn’s disease
    • PID: 23462132
    • Konijeti GG, Chan AT. Ustekinumab for moderate-to-severe Crohn’s disease. Gastroenterology. 2013;144:846–8.
    • (2013) Gastroenterology , vol.144 , pp. 846-848
    • Konijeti, G.G.1    Chan, A.T.2
  • 85
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn’s disease
    • COI: 1:CAS:528:DC%2BC38XhsFGqsrjN, PID: 23075178
    • Sandborn WJ, Gasink C, Gao L-L, Blank MA, Johanns J, Guzzo C, et al. Ustekinumab induction and maintenance therapy in refractory Crohn’s disease. N Engl J Med. 2012;367:1519–28.
    • (2012) N Engl J Med , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.-L.3    Blank, M.A.4    Johanns, J.5    Guzzo, C.6
  • 87
    • 84931379420 scopus 로고    scopus 로고
    • Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn’s disease
    • COI: 1:CAS:528:DC%2BC2MXhtlehs7rK, PID: 26083213
    • Monteleone G, Pallone F. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn’s disease. N Engl J Med. 2015;372:2461.
    • (2015) N Engl J Med , vol.372 , pp. 2461
    • Monteleone, G.1    Pallone, F.2
  • 88
    • 78650150602 scopus 로고    scopus 로고
    • Intestinal growth factors: potential use in the treatment of inflammatory bowel disease and their role in mucosal healing
    • PID: 20848489
    • Krishnan K, Arnone B, Buchman A. Intestinal growth factors: potential use in the treatment of inflammatory bowel disease and their role in mucosal healing. Inflamm Bowel Dis. 2011;17:410–22.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 410-422
    • Krishnan, K.1    Arnone, B.2    Buchman, A.3
  • 89
    • 0037048904 scopus 로고    scopus 로고
    • Treatment of active Crohn’s disease with recombinant human granulocyte-macrophage colony-stimulating factor
    • PID: 12433518
    • Dieckgraefe BK, Korzenik JR. Treatment of active Crohn’s disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet. 2002;360:1478–80.
    • (2002) Lancet , vol.360 , pp. 1478-1480
    • Dieckgraefe, B.K.1    Korzenik, J.R.2
  • 90
    • 19444363154 scopus 로고    scopus 로고
    • Sargramostim in Crohn’s Disease Study Group. Sargramostim for active Crohn’s disease
    • COI: 1:CAS:528:DC%2BD2MXksFOlsro%3D, PID: 15917384
    • Korzenik JR, Dieckgraefe BK, Valentine JF, Hausman DF, Gilbert MJ. Sargramostim in Crohn’s Disease Study Group. Sargramostim for active Crohn’s disease. N Engl J Med. 2005;352:2193–201.
    • (2005) N Engl J Med , vol.352 , pp. 2193-2201
    • Korzenik, J.R.1    Dieckgraefe, B.K.2    Valentine, J.F.3    Hausman, D.F.4    Gilbert, M.J.5
  • 91
    • 14644404938 scopus 로고    scopus 로고
    • An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn’s disease
    • COI: 1:CAS:528:DC%2BD2MXisFCrsbo%3D, PID: 15709989
    • Korzenik JR, Dieckgraefe BK. An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn’s disease. Aliment Pharmacol Ther. 2005;21:391–400.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 391-400
    • Korzenik, J.R.1    Dieckgraefe, B.K.2
  • 92
    • 0347987896 scopus 로고    scopus 로고
    • An open-label pilot study of granulocyte colony-stimulating factor for the treatment of severe endoscopic postoperative recurrence in Crohn’s disease
    • COI: 1:CAS:528:DC%2BD2cXisFyquw%3D%3D, PID: 14581762
    • Dejaco C, Lichtenberger C, Miehsler W, Oberhuber G, Herbst F, Vogelsang H, et al. An open-label pilot study of granulocyte colony-stimulating factor for the treatment of severe endoscopic postoperative recurrence in Crohn’s disease. Digestion. 2003;68:63–70.
    • (2003) Digestion , vol.68 , pp. 63-70
    • Dejaco, C.1    Lichtenberger, C.2    Miehsler, W.3    Oberhuber, G.4    Herbst, F.5    Vogelsang, H.6
  • 93
    • 0344457371 scopus 로고    scopus 로고
    • A controlled trial comparing ciprofloxacin with mesalazine for the treatment of active Crohn’s disease. Groupe d’Etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID)
    • COI: 1:CAS:528:DyaK1MXitV2ku7s%3D, PID: 10086650
    • Colombel JF, Lémann M, Cassagnou M, Bouhnik Y, Duclos B, Dupas JL, et al. A controlled trial comparing ciprofloxacin with mesalazine for the treatment of active Crohn’s disease. Groupe d’Etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID). Am J Gastroenterol. 1999;94:674–8.
    • (1999) Am J Gastroenterol , vol.94 , pp. 674-678
    • Colombel, J.F.1    Lémann, M.2    Cassagnou, M.3    Bouhnik, Y.4    Duclos, B.5    Dupas, J.L.6
  • 94
    • 84859918761 scopus 로고    scopus 로고
    • Probiotics in the management of inflammatory bowel disease: a systematic review of intervention studies in adult patients
    • PID: 22512365
    • Jonkers D, Penders J, Masclee A, Pierik M. Probiotics in the management of inflammatory bowel disease: a systematic review of intervention studies in adult patients. Drugs. 2012;72:803–23.
    • (2012) Drugs , vol.72 , pp. 803-823
    • Jonkers, D.1    Penders, J.2    Masclee, A.3    Pierik, M.4
  • 95
    • 84910613451 scopus 로고    scopus 로고
    • Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC2cXhvF2qu7jN, PID: 25356041
    • Wang Z-K, Yang Y-S, Chen Y, Yuan J, Sun G, Peng L-H. Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease. World J Gastroenterol. 2014;20:14805–20.
    • (2014) World J Gastroenterol , vol.20 , pp. 14805-14820
    • Wang, Z.-K.1    Yang, Y.-S.2    Chen, Y.3    Yuan, J.4    Sun, G.5    Peng, L.-H.6
  • 96
    • 84919624382 scopus 로고    scopus 로고
    • Fecal microbiota transplantation through mid-gut for refractory Crohn’s disease: safety, feasibility, and efficacy trial results
    • COI: 1:CAS:528:DC%2BC2MXhvVWrtLbO, PID: 25168749
    • Cui B, Feng Q, Wang H, Wang M, Peng Z, Li P, et al. Fecal microbiota transplantation through mid-gut for refractory Crohn’s disease: safety, feasibility, and efficacy trial results. J Gastroenterol Hepatol. 2015;30:51–8.
    • (2015) J Gastroenterol Hepatol , vol.30 , pp. 51-58
    • Cui, B.1    Feng, Q.2    Wang, H.3    Wang, M.4    Peng, Z.5    Li, P.6
  • 97
    • 0025887076 scopus 로고
    • Effect of faecal stream diversion on recurrence of Crohn’s disease in the neoterminal ileum
    • COI: 1:STN:280:DyaK38%2Fhs1Olsw%3D%3D, PID: 1681159
    • Rutgeerts P, Goboes K, Peeters M, Hiele M, Penninckx F, Aerts R, et al. Effect of faecal stream diversion on recurrence of Crohn’s disease in the neoterminal ileum. Lancet. 1991;338:771–4.
    • (1991) Lancet , vol.338 , pp. 771-774
    • Rutgeerts, P.1    Goboes, K.2    Peeters, M.3    Hiele, M.4    Penninckx, F.5    Aerts, R.6
  • 98
    • 20844445090 scopus 로고    scopus 로고
    • Long-term outcome of surgically treated Crohn’s colitis: a prospective study
    • PID: 15785882
    • Fichera A, McCormack R, Rubin MA, Hurst RD, Michelassi F. Long-term outcome of surgically treated Crohn’s colitis: a prospective study. Dis Colon Rectum. 2005;48:963–9.
    • (2005) Dis Colon Rectum , vol.48 , pp. 963-969
    • Fichera, A.1    McCormack, R.2    Rubin, M.A.3    Hurst, R.D.4    Michelassi, F.5
  • 99
    • 0036141470 scopus 로고    scopus 로고
    • Clinical aspects and pathophysiology of inflammatory bowel disease
    • PID: 11781268
    • Hendrickson BA, Gokhale R, Cho JH. Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev. 2002;15:79–94.
    • (2002) Clin Microbiol Rev , vol.15 , pp. 79-94
    • Hendrickson, B.A.1    Gokhale, R.2    Cho, J.H.3
  • 100
    • 84900390806 scopus 로고    scopus 로고
    • Towards personalized care in IBD
    • COI: 1:CAS:528:DC%2BC3sXhvFCjsL3F, PID: 24345887
    • Gerich ME, McGovern DPB. Towards personalized care in IBD. Nat Rev Gastroenterol Hepatol. 2014;11:287–99.
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , pp. 287-299
    • Gerich, M.E.1    McGovern, D.P.B.2
  • 101
    • 40749155783 scopus 로고    scopus 로고
    • Perinuclear antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies as serological markers are not specific in the identification of Crohn’s disease and ulcerative colitis
    • PID: 18209778
    • Anand V, Russell AS, Tsuyuki R, Fedorak R. Perinuclear antineutrophil cytoplasmic autoantibodies and anti-Saccharomyces cerevisiae antibodies as serological markers are not specific in the identification of Crohn’s disease and ulcerative colitis. Can J Gastroenterol. 2008;22:33–6.
    • (2008) Can J Gastroenterol , vol.22 , pp. 33-36
    • Anand, V.1    Russell, A.S.2    Tsuyuki, R.3    Fedorak, R.4
  • 102
    • 84920971302 scopus 로고    scopus 로고
    • Systematic review: new serological markers (anti-glycan, anti-GP2, anti-GM-CSF Ab) in the prediction of IBD patient outcomes
    • COI: 1:CAS:528:DC%2BC2cXhvFCiu7jM, PID: 25462578, Describes serological markers and their role in personalizing therapeutic and management decisions in patients with Crohn’s disease
    • Bonneau J, Dumestre-Perard C, Rinaudo-Gaujous M, Genin C, Sparrow M, Roblin X, et al. Systematic review: new serological markers (anti-glycan, anti-GP2, anti-GM-CSF Ab) in the prediction of IBD patient outcomes. Autoimmun Rev. 2015;14:231–45. Describes serological markers and their role in personalizing therapeutic and management decisions in patients with Crohn’s disease.
    • (2015) Autoimmun Rev , vol.14 , pp. 231-245
    • Bonneau, J.1    Dumestre-Perard, C.2    Rinaudo-Gaujous, M.3    Genin, C.4    Sparrow, M.5    Roblin, X.6
  • 103
    • 84889677565 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease
    • PID: 24145675
    • Däbritz J, Bonkowski E, Chalk C, Trapnell BC, Langhorst J, Denson LA, et al. Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease. Am J Gastroenterol. 2013;108:1901–10.
    • (2013) Am J Gastroenterol , vol.108 , pp. 1901-1910
    • Däbritz, J.1    Bonkowski, E.2    Chalk, C.3    Trapnell, B.C.4    Langhorst, J.5    Denson, L.A.6
  • 104
    • 84903940383 scopus 로고    scopus 로고
    • Toward a personalized medicine approach to the management of inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC2cXhtFWisbjK, PID: 24842338
    • Mosli MH, Sandborn WJ, Kim RB, Khanna R, Al-Judaibi B, Feagan BG. Toward a personalized medicine approach to the management of inflammatory bowel disease. Am J Gastroenterol. 2014;109:994–1004.
    • (2014) Am J Gastroenterol , vol.109 , pp. 994-1004
    • Mosli, M.H.1    Sandborn, W.J.2    Kim, R.B.3    Khanna, R.4    Al-Judaibi, B.5    Feagan, B.G.6
  • 105
    • 84948132349 scopus 로고    scopus 로고
    • The effect of breathing, movement, and meditation on psychological and physical symptoms and inflammatory biomarkers in inflammatory bowel disease: a randomized controlled trial
    • PID: 26426148
    • Gerbarg PL, Jacob VE, Stevens L, Bosworth BP, Chabouni F, DeFilippis EM, et al. The effect of breathing, movement, and meditation on psychological and physical symptoms and inflammatory biomarkers in inflammatory bowel disease: a randomized controlled trial. Inflamm Bowel Dis. 2015;21:2886–96.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 2886-2896
    • Gerbarg, P.L.1    Jacob, V.E.2    Stevens, L.3    Bosworth, B.P.4    Chabouni, F.5    DeFilippis, E.M.6
  • 106
    • 84857051275 scopus 로고    scopus 로고
    • Shared decision making in inflammatory bowel disease: helping patients understand the tradeoffs between treatment options
    • PID: 22187072
    • Siegel CA. Shared decision making in inflammatory bowel disease: helping patients understand the tradeoffs between treatment options. Gut. 2012;61:459–65.
    • (2012) Gut , vol.61 , pp. 459-465
    • Siegel, C.A.1


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