Epigenetics at the crossroads of genes and the environment

JAMA - Journal of the American Medical Association

Volumn 314, Issue 11, 2015, Pages 1129-1130

  Feinberg, Andrew P ^a   Daniele Fallin, M ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI GENE; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOME; GENOTYPE ENVIRONMENT INTERACTION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; NOTE; NUTRITION; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; GENETIC EPIGENESIS; HUMAN; MOUSE; RISK ASSESSMENT;

ANIMALS; EPIGENESIS, GENETIC; EPIGENOMICS; GENE-ENVIRONMENT INTERACTION; HUMANS; MICE; RISK ASSESSMENT;

EID: 84942603869     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2015.10414     Document Type: Note

References (10)

1. Wolff GL, Kodell RL, Moore SR, Cooney CA. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/amice. FASEB J. 1998;12(11):949-957.
2. Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet. 2007;8(4):253-262.
3. Pembrey ME, Bygren LO, Kaati G, et al; ALSPAC Study Team. Sex-specific, male-line transgenerational responses in humans. Eur J Hum Genet. 2006;14(2):159-166.
4. Tobi EW, Goeman JJ, Monajemi R, et al. DNA methylation signatures link prenatal famine exposure to growth and metabolism. Nat Commun. 2014;5:5592.
5. Radford EJ, Ito M, Shi H, et al. In utero effects: in utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. Science. 2014;345(6198):1255903.
6. Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.
7. Joubert BR, Håberg SE, Nilsen RM, et al. 450K Epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 2012;120(10):1425-1431.
8. Liu Y, Aryee MJ, Padyukov L, et al. Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol. 2013;31(2): 142-147.
9. Multhaup ML, Seldin MM, Jaffe AE, et al. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab. 2015;21(1):138-149.
10. Barrès R, Yan J, Egan B, et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012;15(3):405-411.