Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure

Circulation

Volumn 136, Issue 16, 2017, Pages 1528-1544

  Meder, Benjamin ^a,d   Haas, Jan ^a,d   Sedaghat Hamedani, Farbod ^a,d   Kayvanpour, Elham ^a,d   Frese, Karen ^a,d   Lai, Alan ^a,d   Nietsch, Rouven ^a   Scheiner, Christina ^a   Mester, Stefan ^a   Bordalo, Diana Martins ^a   Amr, Ali ^a   Dietrich, Carsten ^b   Pils, Dietmar ^f,g   Siede, Dominik ^a,d   Hund, Hauke ^a   Bauer, Andrea ^e   Holzer, Daniel Benjamin ^a   Ruhparwar, Arjang ^a   Mueller Hennessen, Matthias ^a,d   Weichenhan, Dieter ^e   Plass, Christoph ^e   Weis, Tanja ^a,d   Backs, Johannes ^a,d   Wuerstle, Maximilian ^b   Keller, Andreas ^c   Katus, Hugo A ^a,d   Posch, Andreas E ^b   more..

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SIEMENS AG   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^e GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^f SIEMENS AG ÖSTERREICH   (Austria)

^g MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

biomarker; dilated cardiomyopathy; DNA methylation; epigenetics; heart failure; natriuretic peptides

Indexed keywords

BIOLOGICAL MARKER; CYTOSINE; CYTOSINE PHOSPHATE GUANINE; GUANINE; MESSENGER RNA; PHOSPHATE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; GENETIC MARKER;

ARTICLE; COHORT ANALYSIS; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION PROFILING; GENE LOCUS; GENE MAPPING; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE BIOPSY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RNA SEQUENCE; SYSTOLIC HEART FAILURE; TRANSCRIPTION REGULATION; WHOLE GENOME SEQUENCING; BLOOD; CARDIOMYOPATHY, DILATED; CASE CONTROL STUDY; CHEMISTRY; CPG ISLAND; GENETIC EPIGENESIS; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; HEART VENTRICLE; HIGH THROUGHPUT SEQUENCING; PROCEDURES; SEQUENCE ANALYSIS;

CARDIOMYOPATHY, DILATED; CASE-CONTROL STUDIES; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; GENE EXPRESSION PROFILING; GENETIC LOCI; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HEART FAILURE; HEART VENTRICLES; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; PHENOTYPE; RNA, MESSENGER; SEQUENCE ANALYSIS, RNA;

EID: 85031938231     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.117.027355     Document Type: Article

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