Pseudorabies virus dUTPase UL50 induces lysosomal degradation of type I interferon receptor 1 and antagonizes the alpha interferon response

Journal of Virology

Volumn 91, Issue 21, 2017, Pages

  Zhang, Rui ^a   Xu, Aotian ^a   Qin, Chao ^a   Zhang, Qiong ^a   Chen, Shifan ^a   Lang, Yue ^a   Wang, Mengdong ^a   Li, Chuang ^a   Feng, Wenhai ^a   Jiang, Zhengfan ^b   Tang, Jun ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b Peking University   (China)

Author keywords

Alphaherpesviruses; DUTPase UL50; Interferon signaling; Pseudorabies virus; Type I interferon receptor 1

Indexed keywords

ALPHA INTERFERON; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; INTERFERON RECEPTOR; INTERFERON RECEPTOR 1; STAT1 PROTEIN; UL50 PROTEIN; UNCLASSIFIED DRUG; VIRUS ENZYME; ALPHA BETA INTERFERON RECEPTOR; ANTIVIRUS AGENT; DUTP PYROPHOSPHATASE; IFNAR1 PROTEIN, HUMAN; INORGANIC PYROPHOSPHATASE; INTERFERON; VIRAL PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE RESPONSE; DELETION MUTANT; ECTOPIC EXPRESSION; ENZYME ACTIVITY; GENE DELETION; HUMAN ALPHAHERPESVIRUS 1; IMMUNE EVASION; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PSEUDORABIES VIRUS; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HELA CELL LINE; HUMAN; KIDNEY; METABOLISM; PHOSPHORYLATION; PIG; PSEUDORABIES; SEQUENCE HOMOLOGY; VIROLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; HELA CELLS; HERPESVIRUS 1, SUID; HUMANS; IMMUNE EVASION; INTERFERON TYPE I; KIDNEY; LYSOSOMES; PHOSPHORYLATION; PROTEOLYSIS; PSEUDORABIES; PYROPHOSPHATASES; RECEPTOR, INTERFERON ALPHA-BETA; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SWINE; VIRAL PROTEINS;

EID: 85031119584     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01148-17     Document Type: Article

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