Kaposi's sarcoma-associated herpesvirus ORF54/dutpase downregulates a ligand for the NK activating receptor NKp44

Journal of Virology

Volumn 86, Issue 16, 2012, Pages 8693-8704

  Madrid, Alexis Spain ^a,b   Ganem, Don ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; INTERLEUKIN 23 RECEPTOR; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2; VIRUS PROTEIN;

ARTICLE; CELL KILLING; CELL PROTECTION; CELL SURFACE; DISEASE ASSOCIATION; EMBRYO; ENZYME ACTIVITY; GENETIC SCREENING; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IMMUNOREGULATION; INTRACELLULAR SIGNALING; MOLECULAR EVOLUTION; NATURAL KILLER CELL; NONHUMAN; ORF54 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS LATENCY; VIRUS RELEASE;

CELL LINE; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNE EVASION; KILLER CELLS, NATURAL; LIGANDS; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2; PYROPHOSPHATASES; VIRAL PROTEINS;

EID: 84865094730     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00252-12     Document Type: Article

References (48)

1. Ambroziak JA, et al. 1995. Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients. Science 268:582-583.
2. Barabas O, Pongracz V, Kovari J, Wilmanns M, Vertessy BG. 2004. Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase. J. Biol. Chem. 279:42907-42915.
3. Bechtel J, Grundhoff A, Ganem D. 2005. RNAs in the virion of Kaposi's sarcoma-associated herpesvirus. J. Virol. 79:10138-10146.
4. Bechtel JT, Liang Y, Hvidding J, Ganem D. 2003. Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells. J. Virol. 77:6474-6481.
5. Bergman AC, Nyman PO, Larsson G. 1998. Kinetic properties and stereospecificity of the monomeric dUTPase from herpes simplex virus type 1. FEBS Lett. 441:327-330.
6. Bisson SA, Page AL, Ganem D. 2009. A Kaposi's sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins, and blocks interferonmediated signal transduction. J. Virol. 83:5056-5066.
7. Bjornberg O, et al. 1993. dUTPase from herpes simplex virus type 1; purification from infected green monkey kidney (Vero) cells and from an overproducing Escherichia coli strain. Protein Expr. Purif. 4:149-159.
8. Byrd A, Hoffmann SC, Jarahian M, Momburg F, Watzl C. 2007. Expression analysis of the ligands for the natural killer cell receptors NKp30 and NKp44. PLoS One 2:e1339. doi:10.1371/journal.pone. 0001339.
9. Cantoni C, et al. 1999. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J. Exp. Med. 189:787-796.
10. Caposio P, Riera L, Hahn G, Landolfo S, Gribaudo G. 2004. Evidence that the human cytomegalovirus 46-kDa UL72 protein is not an active dUTPase but a late protein dispensable for replication in fibroblasts. Virology 325:264-276.
11. Carbone A, Gloghini A. 2008. KSHV/HHV8-associated lymphomas. Br. J. Haematol. 140:13-24.
12. Carpenter G, Liao HJ. 2009. Trafficking of receptor tyrosine kinases to the nucleus. Exp. Cell Res. 315:1556-1566.
13. Chalupny N, Rein-Weston A, Dosch S, Cosman D. 2006. Downregulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142. Biochem. Biophys. Res. Commun. 346:175-181.
14. Coscoy L, Ganem D. 2000. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display ofMHCclass I chains by enhancing their endocytosis. Proc. Natl. Acad. Sci. U. S. A. 97:8051-8056.
15. Coscoy L, Sanchez D, Ganem D. 2001. A novel class of herpesvirusencoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. J. Cell Biol. 155:1265-1273.
16. Cosman D, et al. 2001. ULBPs, novelMHCclass I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14:123-133.
17. Davison AJ, Stow ND. 2005. New genes from old: redeployment of dUTPase by herpesviruses. J. Virol. 79:12880-12892.
18. Fausther-Bovendo H, et al. 2009. HIV escape from natural killer cytotoxicity: nef inhibits NKp44L expression on CD4+T cells. AIDS 23:1077-1087.
19. Ganem D. 2006. KSHV infection and the pathogenesis of Kaposi's sarcoma. Annu. Rev. Pathol. 1:273-296.
20. Glaunsinger B, Ganem D. 2004. Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover. Mol. Cell 13:713-723.
21. Harris JM, McIntosh EM, Muscat GE. 1999. Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target. J. Mol. Biol. 288:275-287.
22. Ishido S, et al. 2000. Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein. Immunity 13: 365-374.
23. Ishido S, Wang C, Lee B, Cohen G, Jung J. 2000. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcomaassociated herpesvirus K3 and K5 proteins. J. Virol. 74:5300-5309.
24. Kremmer E, et al. 1999. Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) ORF54 encodes a functional dUTPase expressed in the lytic replication cycle. J. Gen. Virol. 80(Pt 5):1305-1310.
25. Krishnan H, et al. 2004. Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J. Virol. 78:3601-3620.
26. Kubin M, et al. 2001. ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activateNKcells. Eur. J. Immunol. 31:1428-1437.
27. Leang RS, et al. 2011. The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. PLoS Pathog. 7:e1002292. doi:10.1371/journal.ppat.1002292.
28. Lenac T, et al. 2006. The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. J. Exp. Med. 203:1843-1850.
29. Liao HJ, Carpenter G. 2007. Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol. Biol. Cell 18:1064-1072.
30. Lilley B, Ploegh H. 2005. Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond. Immunol. Rev. 207: 126-144.
31. Lin SY, et al. 2001. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat. Cell Biol. 3:802-808.
32. Lodoen M, Lanier L. 2005. Viral modulation of NK cell immunity. Nat. Rev. Microbiol. 3:59-69.
33. Lodoen M, et al. 2003. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J. Exp. Med. 197:1245-1253.
34. Lodoen MB, et al. 2004. The cytomegalovirus m155 gene product sub-verts natural killer cell antiviral protection by disruption of H60-NKG2D interactions. J. Exp. Med. 200:1075-1081.
35. Lukac DM, Renne R, Kirshner JR, Ganem D. 1998. Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R protein. Virology 252:304-312.
36. Mansouri M, et al. 2009. Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus. J. Virol. 83:9672-9681.
37. Moretta L, et al. 2006. Surface NK receptors and their ligands on tumor cells. Semin. Immunol. 18:151-158.
38. Moretta L, Moretta A. 2004. Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J. 23:255-259.
39. Myoung J, Ganem D. 2011. Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: maintenance of tight latency with efficient reactivation upon induction. J. Virol. Methods 174:12-21.
40. Nachmani D, Stern-Ginossar N, Sarid R, Mandelboim O. 2009. Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells. Cell Host Microbe 5:376-385.
41. Orange J, Ballas Z. 2006. Natural killer cells in human health and disease. Clin. Immunol. 118:1-10.
42. Shah AH, et al. 2010. Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu. Cell Host Microbe 8:397-409.
43. Sun R, et al. 1998. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. U. S. A. 95:10866-10871.
44. Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP. 2005. The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases. Structure 13:1299-1310.
45. Thomas M, et al. 2008. Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity. Proc. Natl. Acad. Sci. U. S. A. 105:1656-1661.
46. Tomasec P, et al. 2005. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nat. Immunol. 6:181-188.
47. Vieira J, O'Hearn P. 2004. Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression. Virology 325:225-240.
48. Vitale M, et al. 1998. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in nonmajor histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 187: 2065-2072.