Accumulation of smooth muscle 22α protein accelerates senescence of vascular smooth muscle cells via stabilization of p53 in vitro and in vivo

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 37, Issue 10, 2017, Pages 1849-1859

  Miao, Sui Bing ^a   Xie, Xiao Li ^a   Yin, Ya Juan ^a   Zhao, Li Li ^a   Zhang, Fan ^a   Shu, Ya Nan ^a   Chen, Rong ^a   Chen, Peng ^a   Dong, Li Hua ^a   Lin, Yan Ling ^a   Lv, Pin ^a   Zhang, Dan Dan ^a   Nie, Xi ^a   Xue, Zhen Ying ^a   Han, Mei ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Actin cytoskeleton; Angiotensin II; Blood pressure; Phosphorylation; Ubiquitination

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANGIOTENSIN II; BETA GALACTOSIDASE; CYCLINE; F ACTIN; GAMMA H2AX; HISTONE H2AX; JASPAMIDE; MUSCLE PROTEIN; NUTLIN 3; PHALLOIDIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P16; PROTEIN P21; PROTEIN P53; SMOOTH MUSCLE 22ALPHA PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; MDM2 PROTEIN, MOUSE; TAGLN PROTEIN, MOUSE;

ACTIN FILAMENT; AORTA; ARTICLE; CELL AGING; CELL LYSATE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA DAMAGE; GENE KNOCKDOWN; GENE OVEREXPRESSION; HYPERTENSION; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE; UBIQUITINATION; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; ANIMAL MODEL; CYTOLOGY; DRUG EFFECTS; METABOLISM; PATHOPHYSIOLOGY; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ACTIN CYTOSKELETON; ANGIOTENSIN II; ANIMALS; AORTA; CELL AGING; HYPERTENSION; MICE; MICROFILAMENT PROTEINS; MODELS, ANIMAL; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION; UP-REGULATION;

EID: 85031099715     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.117.309378     Document Type: Article

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