Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells

Molecular Therapy

Volumn 25, Issue 12, 2017, Pages 2661-2675

  Kondratov, Oleksandr ^a   Marsic, Damien ^a   Crosson, Sean M ^a   Mendez Gomez, Hector R ^a   Moskalenko, Oleksandr ^a   Mietzsch, Mario ^a,c   Heilbronn, Regine ^c   Allison, Jonathan R ^b   Green, Kari B ^b   Agbandje McKenna, Mavis ^a   Zolotukhin, Sergei ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b University of Florida   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

AAV; gene therapy; obesity

Indexed keywords

ADENO ASSOCIATED VIRUS VECTOR; CAPSID PROTEIN; PROTEIN VP1; PROTEIN VP2; PROTEIN VP3; SINGLE STRANDED DNA; VIRUS DNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DNA SEQUENCE; GENE CASSETTE; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSECT CELL; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NEXT GENERATION SEQUENCING; NONHUMAN; PARTICLE SIZE; PROTEIN FOLDING; SEQUENCE ANALYSIS; STOICHIOMETRY; VIRAL GENE DELIVERY SYSTEM; VIRUS GENE; VIRUS GENOME; ANIMAL; CELL CULTURE TECHNIQUE; CELL LINE; CHEMISTRY; CLASSIFICATION; DEPENDOPARVOVIRUS; GENE EXPRESSION; GENE ORDER; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; PHYSIOLOGY; REPORTER GENE; SF9 CELL LINE; TISSUE DISTRIBUTION; VIRUS LOAD; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMALS; CAPSID PROTEINS; CELL CULTURE TECHNIQUES; CELL LINE; DEPENDOVIRUS; GENE EXPRESSION; GENE ORDER; GENES, REPORTER; GENETIC VECTORS; HEK293 CELLS; HUMANS; MICE; SF9 CELLS; TISSUE DISTRIBUTION; TRANSDUCTION, GENETIC; VIRAL LOAD; VIRUS REPLICATION;

EID: 85031020157     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1016/j.ymthe.2017.08.003     Document Type: Article

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