Nuclear translocation of adeno-associated virus type 2 capsid proteins for virion assembly

Journal of General Virology

Volumn 93, Issue PART 9, 2012, Pages 1887-1898

  Popa Wagner, Ruth ^a   Sonntag, Florian ^b   Schmidt, Kristin ^a   King, Jason ^c   Kleinschmidt, Jürgen A ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Rentschler Biotechnologie GmbH   (Germany)

^c Roslin Cellab Roslin BioCentre ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN VP1; PROTEIN VP2; PROTEIN VP3;

ADENO ASSOCIATED VIRUS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOPLASM; FRAGMENTATION REACTION; MUTATION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; STOICHIOMETRY; VIRION; VIRUS GENOME;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CAPSID PROTEINS; CELL NUCLEUS; DEPENDOVIRUS; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PARVOVIRIDAE INFECTIONS; SEQUENCE ALIGNMENT; VIRION; VIRUS ASSEMBLY;

EID: 84865152525     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.043232-0     Document Type: Article

References (34)

1. Becerra, S. P., Rose, J. A., Hardy, M., Baroudy, B. M. & Anderson, C. W. (1985). Direct mapping of adeno-associated virus capsid proteins B and C: a possible ACG initiation codon. Proc Natl Acad Sci U S A 82, 7919-7923.
2. Becerra, S. P., Koczot, F., Fabisch, P. & Rose, J. A. (1988). Synthesis of adeno-associated virus structural proteins requires both alternative mRNA splicing and alternative initiations from a single transcript. J Virol 62, 2745-2754.
3. Buller, R. M. & Rose, J. A. (1978). Characterization of adenovirusassociated virus-induced polypeptides in KB cells. J Virol 25, 331-338.
4. Cassinotti, P., Weitzand, M. & Tratschin, J. D. (1988). Organization of the adeno-associated virus (AAV) capsid gene: mapping of a minor spliced mRNA coding for virus capsid protein. Virology 167, 176-184.
5. Cokol, M., Nair, R. & Rost, B. (2000). Finding nuclear localization signals. EMBO Rep 1, 411-415.
6. Dingwall, C. & Laskey, R. A. (1991). Nuclear targeting sequences -a consensus? Trends Biochem Sci 16, 478-481.
7. Fried, H. & Kutay, U. (2003). Nucleocytoplasmic transport: taking an inventory. Cell Mol Life Sci 60, 1659-1688.
8. Garcia-Bustos, J., Heitman, J. & Hall, M. N. (1991). Nuclear protein localization. Biochim Biophys Acta 1071, 83-101.
9. Grieger, J. C., Snowdy, S. & Samulski, R. J. (2006). Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly. J Virol 80, 5199-5210.
10. Grimm, D., Kern, A., Pawlita, M., Ferrari, F., Samulski, R. & Kleinschmidt, J. (1999). Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2. Gene Ther 6, 1322-1330.
11. Heilbronn, R., Bürkle, A., Stephan, S. & zur Hausen, H. (1990). The adeno-associated virus rep gene suppresses herpes simplex virusinduced DNA amplification. J Virol 64, 3012-3018.
12. Hoque, M., Ishizu, K., Matsumoto, A., Han, S.-I., Arisaka, F., Takayama, M., Suzuki, K., Kato, K., Kanda, T. & other authors (1999). Nuclear transport of the major capsid protein is essential for adeno-associated virus capsid formation. J Virol 73, 7912-7915.
13. Kerr, J. R., Cotmore, S. F., Bloom, M. E., Linden, R. M. & Parrish, C. R. (editors) (2006). Parvoviruses. London: Hodder Arnold.
14. Kleinschmidt, J. A. & King, J. A. (2006). Molecular interactions involved in assembling the viral particle and packaging the genome. In Parvoviruses, pp. 305-319. Edited by J. R. Kerr, S. F. Cotmore, M. E. Bloom, R. M. Linden & C. R. Parrish. London: Hodder Arnold.
15. Kronenberg, S., Kleinschmidt, J. A. & Böttcher, B. (2001). Electron cryo-microscopy and image reconstruction of adeno-associated virus type 2 empty capsids. EMBO Rep 2, 997-1002.
16. Lee, B. J., Cansizoglu, A. E., Süel, K. E., Louis, T. H., Zhang, Z. & Chook, Y. M. (2006). Rules for nuclear localization sequence recognition by karyopherin beta 2. Cell 126, 543-558.
17. Lombardo, E., Ramírez, J. C., Agbandje-McKenna, M. & Almendral, J. M. (2000). A b-stranded motif drives capsid protein oligomers of the parvovirus minute virus of mice into the nucleus for viral assembly. J Virol 74, 3804-3814.
18. Lombardo, E., Ramírez, J. C., Garcia, J. & Almendral, J. M. (2002). Complementary roles of multiple nuclear targeting signals in the capsid proteins of the parvovirus minute virus of mice during assembly and onset of infection. J Virol 76, 7049-7059.
19. Muralidhar, S., Becerra, S. P. & Rose, J. A. (1994). Site-directed mutagenesis of adeno-associated virus type 2 structural protein initiation codons: effects on regulation of synthesis and biological activity. J Virol 68, 170-176.
20. Nigg, E. A. (1997). Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386, 779-787.
21. Ruffing, M., Zentgraf, H. & Kleinschmidt, J. A. (1992). Assembly of viruslike particles by recombinant structural proteins of adenoassociated virus type 2 in insect cells. J Virol 66, 6922-6930.
22. Sayle, R. A. & Milner-White, E. J. (1995). RASMOL: Biomolecular graphics for all. Trends Biochem Sci 20, 374-376.
23. Sonntag, F., Bleker, S., Leuchs, B., Fischer, R. & Kleinschmidt, J. A. (2006). Adeno-associated virus type 2 capsids with externalized VP1/ VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus. J Virol 80, 11040-11054.
24. Sonntag, F., Schmidt, K. & Kleinschmidt, J. A. (2010). A viral assembly factor promotes AAV2 capsid formation in the nucleolus. Proc Natl Acad Sci U S A 107, 10220-10225.
25. Tran, E. J. & Wente, S. R. (2006). Dynamic nuclear pore complexes: life on the edge. Cell 125, 1041-1053.
26. Trempe, J. P. & Carter, B. J. (1988). Alternate mRNA splicing is required for synthesis of adeno-associated virus VP1 capsid protein. J Virol 62, 3356-3363.
27. Valle, N., Riolobos, L. & Almendral, J. M. (2006). Synthesis, posttranslational modification and trafficking of the parvovirus structural polypeptides. In Parvoviruses, pp. 344-358. Edited by J. R. Kerr, S. F. Cotmore, M. E. Bloom, R. M. Linden & C. R. Parrish. London: Hodder Arnold.
28. Vihinen-Ranta, M., Kakkola, L., Kalela, A., Vilja, P. & Vuento, M. (1997). Characterization of a nuclear localization signal of canine parvovirus capsid proteins. Eur J Biochem 250, 389-394.
29. Wistuba, A., Weger, S., Kern, A. & Kleinschmidt, J. A. (1995). Intermediates of adeno-associated virus type 2 assembly: identification of soluble complexes containing Rep and Cap proteins. J Virol 69, 5311-5319.
30. Wistuba, A., Kern, A., Weger, S., Grimm, D. & Kleinschmidt, J. A. (1997). Subcellular compartmentalization of adeno-associated virus type 2 assembly. J Virol 71, 1341-1352.
31. Wobus, C. E., Hü gle-Dörr, B., Girod, A., Petersen, G., Hallek, M. & Kleinschmidt, J. A. (2000). Monoclonal antibodies against the adenoassociated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection. J Virol 74, 9281-9293.
32. Wu, P., Xiao, W., Conlon, T., Hughes, J., Agbandje-McKenna, M., Ferkol, T., Flotte, T. & Muzyczka, N. (2000). Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism. J Virol 74, 8635-8647.
33. Xie, Q., Bu, W., Bhatia, S., Hare, J., Somasundaram, T., Azzi, A. & Chapman, M. S. (2002). The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy. Proc Natl Acad Sci U S A 99, 10405-10410.
34. Yuan, W. & Parrish, C. R. (2001). Canine parvovirus capsid assembly and differences in mammalian and insect cells. Virology 279, 546-557.