Neuroplasticity and behavioral effects of fluoxetine after experimental stroke

Restorative Neurology and Neuroscience

Volumn 35, Issue 5, 2017, Pages 457-468

  Sun, Yefei ^a   Sun, Xiaoyu ^b   Qu, Huiling ^b   Zhao, Shanshan ^a   Xiao, Ting ^a,c   Zhao, Chuansheng ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b the People's Hospital of Liaoning Province   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

behavioral recovery; Fluoxetine; neuroplasticity; stroke

Indexed keywords

FLUOXETINE; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGING; ARTICLE; BEHAVIOR; BRAIN; CONVALESCENCE; DRUG EFFECT; DRUG MEGADOSE; EXPERIMENTAL STROKE; HUMAN; LOW DRUG DOSE; NEOVASCULARIZATION (PATHOLOGY); NERVE CELL DIFFERENTIATION; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CEREBROVASCULAR ACCIDENT; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY;

AGING; ANIMALS; BRAIN; FLUOXETINE; HUMANS; NEUROGENESIS; NEURONAL PLASTICITY; NEURONS; SEROTONIN UPTAKE INHIBITORS; STROKE;

EID: 85030786163     PISSN: 09226028     EISSN: 18783627     Source Type: Journal    
DOI: 10.3233/RNN-170725     Document Type: Article

References (108)

1. Acler, M., Robol, E., Fiaschi, A., & Manganotti, P. (2009). A double blind placebo RCT to investigate the effects of serotonergic modulation on brain excitability and motorrecovery in stroke patients. Journal of Neurology, 256(7), 1152-1158.
2. Adamczak, J., Aswendt, M., Kreutzer, C., Rotheneichner, P., Riou, A., Selt, M., Hoehn, M. (2016). Neurogenesis upregulation on the healthy hemisphere after stroke enhances compensation for age-dependent decrease of basal neurogenesis. Neurobiology of Disease, 99, 47-57.
3. Andrade, C., Sandarsh, S., Chethan, K. B., & Nagesh, K. S. (2010). Serotonin reuptake inhibitor antidepressants and abnormal bleeding: A review for clinicians and a reconsideration of mechanisms. The Journal of Clinical Psychiatry, 71(12), 1565-1575.
4. Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002). Neuronal replacement from endogenous precursors in the adult brain after stroke. Nature Medicine, 8(9), 963-970.
5. Badan, I., Buchhold, B., Hamm, A., Gratz, M., Walker, L. C., Platt, D., & Popa-Wagner, A. (2003). Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery. Journal of Cerebral Blood Flow & Metabolism, 23(7), 845-854.
6. Barkho, B. Z., Munoz, A. E., Li, X., Li, L., Cunningham, L. A., & Zhao, X. (2008). Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells, 26(12), 3139-3149.
7. Bergami, M., Rimondini, R., Santi, S., Blum, R., Gotz, M., & Canossa, M. (2008). Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior. Proceedings of the National Academy of Sciences, 105(40), 15570-15575.
8. Biernaskie, J., Corbett, D., Peeling, J., Wells, J., & Lei, H. (2001). A serial MR study of cerebral blood flow changes and lesion development following endothelin-1-induced ischemia in rats. Magn Reson Med, 46(4), 827-830.
9. Bondolfi, L., Ermini, F., Long, J. M., Ingram, D. K., & Jucker, M. (2004). Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiology of Aging, 25(3), 333-340.
10. Bovetti, S., Hsieh, Y. C., Bovolin, P., Perroteau, I., Kazunori, T., & Puche, A. C. (2007). Blood vessels form a scaffold for neuroblast migration in the adult olfactory bulb. The Journal of Neuroscience, 27(22), 5976-5980.
11. Buga, A. M., Ciobanu, O., Badescu, G. M., Bogdan, C., Weston, R., Slevin, M., Popa-Wagner, A. (2016). Up-regulation of serotonin receptor 2BmRNAand protein in the peri-infarcted area of aged rats and stroke patients. Oncotarget, 7(14), 17415-17430.
12. Chang, Y. C., Tzeng, S. F., Yu, L., Huang, A. M., Lee, H. T., Huang, C. C., & Ho, C. J. (2006). Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pups. Neurobiology of Disease, 24(1), 101-113.
13. Chen, H. F., Pan, X. L., Wang, J. W., Kong, H. M., &Fu, Y. M. (2014). Protein-drug interactome analysis of SSRI-mediated neurorecovery following stroke. Biosystems, 120, 1-9.
14. Chiou, S. H., Chen, S. J., Peng, C. H., Chang, Y. L., Ku, H. H., Hsu, W. M., Lee, C. H. (2006). Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPSinduced apoptosis in hippocampus-derived neural stem cell. Biochemical and Biophysical Research Communications, 343(2), 391-400.
15. Chollet, F., Tardy, J., Albucher, J. F., Thalamas, C., Berard, E., Lamy, C., Loubinoux, I. (2011). Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): A randomised placebo-controlled trial. The Lancet Neurology, 10(2), 123-130.
16. Cornelisse, L. N., Van der Harst, J. E., Lodder, J. C., Baarendse, P. J., Timmerman, A. J., Mansvelder, H. D., Brussaard, A. B. (2007). Reduced 5-HT1A-and GABAB receptor function in dorsal raphe neurons upon chronic fluoxetine treatment of socially stressed rats. Journal of Neurophysiology, 98(1), 196-204.
17. Couillard-Despres, S., Wuertinger, C., Kandasamy, M., Caioni, M., Stadler, K., Aigner, R., Aigner, L. (2009). Ageing abolishes the effects of fluoxetine on neurogenesis. Molecular Psychiatry, 14(9), 856-864.
18. Dam, M., Tonin, P., De Boni, A., Pizzolato, G., Casson, S., Ermani, M., Battistin, L. (1996). Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy. Stroke, 27(7), 1211-1214.
19. David, D. J., Samuels, B. A., Rainer, Q., Wang, J. W., Marsteller, D., Mendez, I., Hen, R. (2009). Neurogenesis-dependent and-independent effects of fluoxetine in an animal model of anxiety/ depression. Neuron, 62(4), 479-493.
20. de Abajo, F. J., Rodriguez, L. A., &Montero, D. (1999). Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: Population based case-control study. British Medical Journal, 319(7217), 1106-1109.
21. Dobkin, B. H. (2008). Training and exercise to drive poststroke recovery. Nature Clinical Practice Neurology, 4(2), 76-85.
22. Donnan, G. A., Fisher, M., Macleod, M., & Davis, S. M. (2008). Stroke. Lancet, 371(9624), 1612-1623.
23. Donovan, M. H., Yamaguchi, M., & Eisch, A. J. (2008). Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus. Hippocampus, 18(5), 435-439.
24. Duman, R. S., Nakagawa, S., & Malberg, J. (2001). Regulation of adult neurogenesis by antidepressant treatment. Neuropsychopharmacology, 25(6), 836-844.
25. Encinas, J. M., Vaahtokari, A., & Enikolopov, G. (2006). Fluoxetine targets early progenitor cells in the adult brain. Proceedings of the National Academy of Sciences, 103(21), 8233-8238.
26. Espinera, A. R., Ogle, M. E., Gu, X., &Wei, L. (2013). Citalopram enhances neurovascular regeneration and sensorimotor functional recovery after ischemic stroke in mice. Neuroscience, 247, 1-11.
27. Gainotti, G., Antonucci, G., Marra, C., &Paolucci, S. (2001). Relation between depression after stroke, antidepressant therapy, and functional recovery. Journal of Neurology, Neurosurgery, and Psychiatry, 71(2), 258-261.
28. Greenberg, D. A. (1998). Angiogenesis and stroke. Drug News Perspect, 11(5), 265-270.
29. Guo, Y. J., Zhang, Z. J., Wang, S. H., Sui, Y. X., & Sun, Y. (2009). Notch1 signaling, hippocampal neurogenesis and behavioral responses to chronic unpredicted mild stress in adult ischemic rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(4), 688.
30. Hartmann, M., Heumann, R., & Lessmann, V. (2001). Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses. The EMBO Journal, 20(21), 5887-5897.
31. He, J., & Crews, F. T. (2007). Neurogenesis decreases during brain maturation from adolescence to adulthood. Pharmacology, Biochemistry and Behavior, 86(2), 327-333.
32. Horsfield, S. A., Rosse, R. B., Tomasino, V., Schwartz, B. L., Mastropaolo, J., & Deutsch, S. I. (2002). Fluoxetine's effects on cognitive performance in patients with traumatic brain injury. The International Journal of Psychiatry in Medicine, 32(4), 337-344.
33. Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Kageyama, R. (2008). Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature Neuroscience, 11(10), 1153-1161.
34. Iwai, M., Abe, K., Kitagawa, H., & Hayashi, T. (2001). Gene therapy with adenovirus-mediated glial cell line-derived neurotrophic factor and neural stem cells activation after ischemic brain injury. Human Cell, 14(1), 27-38.
35. Jin, K., Wang, X., Xie, L., Mao, X. O., Zhu, W., Wang, Y., Greenberg, D. A. (2006). Evidence for stroke-induced neurogenesis in the human brain. Proceedings of the National Academy of Sciences, 103(35), 13198-13202.
36. Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., & Greenberg, D. A. (2002). Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proceedings of the National Academy of Sciences, 99(18), 11946-11950.
37. Jolkkonen, J., Puurunen, K., Rantakomi, S., Sirvio, J., Haapalinna, A., & Sivenius, J. (2000). Effects-of fluoxetine on sensorimotor and spatial learning deficits following focal cerebral ischemia in rats. Restorative Neurology and Neuroscience, 17(4), 211-216.
38. Jorge, R. E., Robinson, R. G., Arndt, S., & Starkstein, S. (2003). Mortality and poststroke depression: A placebo-controlled trial of antidepressants. The American Journal of Psychiatry, 160(10), 1823-1829.
39. Karpova, N. N., Pickenhagen, A., Lindholm, J., Tiraboschi, E., Kulesskaya, N., Agustsdottir, A., Castren, E. (2011). Fear erasure in mice requires synergy between antidepressant drugs and extinction training. Science, 334(6063), 1731-1734.
40. Kawaguchi, Y., & Kubota, Y. (1997). GABAergic cell subtypes and their synaptic connections in rat frontal cortex. Cerebral Cortex, 7(6), 476-486.
41. Kee, N. J., Preston, E., & Wojtowicz, J. M. (2001). Enhanced neurogenesis after transient global ischemia in the dentate gyrus of the rat. Experimental Brain Research, 136(3), 313-320.
42. Kelly-Hayes, M., Beiser, A., Kase, C. S., Scaramucci, A., D'Agostino, R. B., & Wolf, P. A. (2003). The influence of gender and age on disability following ischemic stroke: The Framingham study. Journal of Stroke&Cerebrovascular Diseases, 12(3), 119-126.
43. Khodanovich, M. Y., Kisel, A. A., Chernysheva, G. A., Smol'yakova, V. I., Savchenko, R. R., & Plotnikov, M. B. (2016). Effect of fluoxetine on neurogenesis in hippocampal dentate gyrus after global transient cerebral ischemia in rats. Bulletin of Experimental Biology and Medicine, 161(3), 351-354.
44. Kim, D. H., Li, H., Yoo, K. Y., Lee, B. H., Hwang, I. K., &Won, M. H. (2007). Effects of fluoxetine on ischemic cells and expressions in BDNF and some antioxidants in the gerbil hippocampal CA1 region induced by transient ischemia. Experimental Neurology, 204(2), 748-758.
45. Kodama, M., Fujioka, T., & Duman, R. S. (2004). Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biological Psychiatry, 56(8), 570-580.
46. Kojima, T., Hirota, Y., Ema, M., Takahashi, S., Miyoshi, I., Okano, H., &Sawamoto, K. (2010). Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum. Stem Cells, 28(3), 545-554.
47. Kraglund, K. L., Mortensen, J. K., Grove, E. L., Johnsen, S. P., & Andersen, G. (2015). TALOS: A multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. International Journal of Stroke, 10(6), 985-987.
48. Labos, C., Dasgupta, K., Nedjar, H., Turecki, G., & Rahme, E. (2011). Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction. Canadian Medical Association Journal, 183(16), 1835-1843.
49. Lee, S. R., Kim, H. Y., Rogowska, J., Zhao, B. Q., Bhide, P., Parent, J. M., & Lo, E. H. (2006). Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. Journal of Neuroscience, 26(13), 3491-3495.
50. Li, W. L., Cai, H. H., Wang, B., Chen, L., Zhou, Q. G., Luo, C. X., Zhu, D. Y. (2009). Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke. Journal of Neuroscience Research, 87(1), 112-122.
51. Lim, C. M., Kim, S. W., Park, J. Y., Kim, C., Yoon, S. H., & Lee, J. K. (2009). Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect. Journal of Neuroscience Research, 87(4), 1037-1045.
52. Liu, M., Counsell, C., Wardlaw, J., & Sandercock, P. (1998). A systematic review of randomized evidence for fibrinogendepleting agents in acute ischemic stroke. Journal of Stroke & Cerebrovascular Diseases, 7(1), 63-69.
53. Liu, M., Jiang, Q. H., Hao, J. L., & Zhou, L. L. (2009). Protective effect of total flavones of Abelmoschus manihot L. Medic against poststroke depression injury in mice and its action mechanism. Anatomical Record, 292(3), 412-422.
54. Liu, X., Zhang, J., Sun, D., Fan, Y., Zhou, H., & Fu, B. (2014). Effects of fluoxetine on brain-derived neurotrophic factor serum concentration and cognition in patients with vascular dementia. Clinical Interventions in Aging, 9, 411-418.
55. Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. Journal of Neuroscience, 20(24), 9104-9110.
56. Marcussen, A. B., Flagstad, P., Kristjansen, P. E., Johansen, F. F., & Englund, U. (2008). Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats. Acta Neurologica Scandinavica, 117(2), 94-100.
57. Mccann, S. K., Irvine, C., Mead, G. E., Sena, E. S., Currie, G. L., Egan, K. E., Howells, D. W. (2014). Efficacy of antidepressants in animal models of ischemic stroke: A systematic review and meta-analysis. Stroke, 45(10), 3055.
58. Mead, G. E., Dennis, M., Lundstrom, E., Murray, V., Hackett, M., &Hankey, G. J. (2013). Letter by Mead et al. regarding article, "Selective serotonin reuptake inhibitors for stroke: More trials are needed". Stroke, 44(4), e40-41.
59. Mead, G. E., Hsieh, C. F., Lee, R., Kutlubaev, M. A., Claxton, A., Hankey, G. J., & Hackett, M. L. (2012). Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery. Cochrane Database of Systematic Reviews, 11, Cd009286.
60. Mikami, K., Jorge, R. E., Adams Jr, H. P., Davis, P. H., Leira, E. C., Jang, M., & Robinson, R. G. (2011). Effect of antidepressants on the course of disability following stroke. The American Journal of Geriatric Psychiatry, 19(12), 1007-1015.
61. Mortensen, J. K., & Andersen, G. (2015). Safety of selective serotonin reuptake inhibitor treatment in recovering stroke patients. Expert Opinion Drug Safety, 14(6), 911-919.
62. Mukherjee, J., & Yang, Z. Y. (1999). Monoamine oxidase A inhibition by fluoxetine: An in vitro and in vivo study. Synapse, 31(4), 285-289.
63. Murase, N., Duque, J., Mazzocchio, R., & Cohen, L. G. (2004). Influence of interhemispheric interactions on motor function in chronic stroke. Annals of Neurology, 55(3), 400-409.
64. Nakata, N., Kato, H., & Kogure, K. (1992). Protective effects of serotonin reuptake inhibitors, citalopram and clomipramine, against hippocampal CA1 neuronal damage following transient ischemia in the gerbil. Brain Research, 590(1-2), 48-52.
65. Nasrallah, H. A., Hopkins, T., & Pixley, S. K. (2010). Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats. Brain Research, 1354, 23-29.
66. Niv, F., Keiner, S., Krishna, Witte, O. W., Lie, D. C., &Redecker, C. (2012). Aberrant neurogenesis after stroke: A retroviral cell labeling study. Stroke, 43(9), 2468-2475.
67. Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006). A neurovascular niche for neurogenesis after stroke. Journal of Neuroscience, 26(50), 13007-13016.
68. Ohira, K., & Miyakawa, T. (2011). Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice. Molecular Brain Research, 4, 10.
69. Pan, A., Sun, Q., Okereke, O. I., Rexrode, K. M., & Hu, F. B. (2011). Depression and risk of stroke morbidity and mortality: A meta-analysis and systematic review. JAMA, 306(11), 1241-1249.
70. Parent, J. M., Vexler, Z. S., Gong, C., Derugin, N., & Ferriero, D. M. (2002). Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Annals of Neurology, 52(6), 802-813.
71. Pariente, J., Loubinoux, I., Carel, C., Albucher, J. F., Leger, A., Manelfe, C., Chollet, F. (2001). Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Annals of Neurology, 50(6), 718-729.
72. Peters, R. (2006). Ageing and the brain. Postgraduate Medical Journal, 82(964), 84-88.
73. Popa-Wagner, A., Buga, A. M., &Kokaia, Z. (2011). Perturbed cellular response to brain injury during aging. Ageing Research Reviews, 10(1), 71-79.
74. Popa-Wagner, A., Buga, A. M., Turner, R. C., Rosen, C. L., & Toescu, E. (2012). Cerebrovascular disorders: Role of aging. Journal of Aging Research, 2012, 128146.
75. Rosen, C. L., Dinapoli, V. A., Nagamine, T., & Crocco, T. (2005). Influence of age on stroke outcome following transient focal ischemia. Journal of Neurosurgery, 103(4), 687-694.
76. Ruan, L., Wang, B., ZhuGe, Q., & Jin, K. (2015). Coupling of neurogenesis and angiogenesis after ischemic stroke. Brain Research, 1623, 166-173.
77. Ruiz de Almodovar, C., Lambrechts, D., Mazzone, M., & Carmeliet, P. (2009). Role and therapeutic potential of VEGF in the nervous system. Physiological Reviews, 89(2), 607-648.
78. Samuels, B. A., Mendez-David, I., Faye, C., David, S. A., Pierz, K. A., Gardier, A. M., David, D. J. (2016). Serotonin 1A and serotonin 4 receptors: Essential mediators of the neurogenic and behavioral actions of antidepressants. Neuroscientist, 22(1), 26-45.
79. Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Hen, R. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science, 301(5634), 805-809.
80. Schinder, A. F., &Poo, M. (2000). The neurotrophin hypothesis for synaptic plasticity. Trends Neuroscience, 23(12), 639-645.
81. Schmidt, W., & Reymann, K. G. (2002). Proliferating cells differentiate into neurons in the hippocampal CA1 region of gerbils after global cerebral ischemia. Neuroscience Letters, 334(3), 153-156.
82. Shibuya, M. (2009). Brain angiogenesis in developmental and pathological processes: Therapeutic aspects of vascular endothelial growth factor. FEBS Journal, 276(17), 4636-4643.
83. Singhal, A. B., Caviness, V. S., Begleiter, A. F., Mark, E. J., Rordorf, G., &Koroshetz, W. J. (2002). Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology, 58(1), 130-133.
84. Sobreviela, T., Pagcatipunan, M., Kroin, J. S., & Mufson, E. J. (1996). Retrograde transport of brain-derived neurotrophic factor (BDNF) following infusion in neo-and limbic cortex in rat: Relationship to BDNF mRNA expressing neurons. Journal of Comparative Neurology, 375(3), 417-444.
85. Storkebaum, E., Lambrechts, D., & Carmeliet, P. (2004). VEGF: Once regarded as a specific angiogenic factor, nowimplicated in neuroprotection. Bioessays, 26(9), 943-954.
86. Sugiura, S., Kitagawa, K., Tanaka, S., Todo, K., Omura-Matsuoka, E., Sasaki, T., Hori, M. (2005). Adenovirus-mediated gene transfer of heparin-binding epidermal growth factor-like growth factor enhances neurogenesis and angiogenesis after focal cerebral ischemia in rats. Stroke, 36(4), 859-864.
87. Sun, X., Sun, X., Liu, T., Zhao, M., Zhao, S., Xiao, T., Zhao, C. (2015). Fluoxetine enhanced neurogenesis is not translated to functional outcome in stroke rats. Neuroscience Letters, 603, 31-36.
88. Sun, X., Zhou, Z., Liu, T., Zhao, M., Zhao, S., Xiao, T., Zhao, C. (2016). Fluoxetine Enhances Neurogenesis in Aged Rats with Cortical Infarcts, but This is not Reflected in a Behavioral Recovery. Journal of Molecular Neuroscience, 58(2), 233-242.
89. Surget, A., Saxe, M., Leman, S., Ibarguen-Vargas, Y., Chalon, S., Griebel, G., & Belzung, C. (2008). Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biological Psychiatry, 64(4), 293-301.
90. Takagi, Y., Nozaki, K., Takahashi, J., Yodoi, J., Ishikawa, M., & Hashimoto, N. (1999). Proliferation of neuronal precursorcells in the dentate gyrus is accelerated after transient forebrain ischemia in mice. Brain Research, 831(1-2), 283-287.
91. Teramoto, T., Qiu, J., Plumier, J. C., & Moskowitz, M. A. (2003). EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia. Journal of Clinical Investigation, 111(8), 1125-1132.
92. Thored, P., Arvidsson, A., Cacci, E., Ahlenius, H., Kallur, T., Darsalia, V., Lindvall, O. (2006). Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells, 24(3), 739-747.
93. Thored, P., Wood, J., Arvidsson, A., Cammenga, J., Kokaia, Z., & Lindvall, O. (2007). Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke. Stroke, 38(11), 3032-3039.
94. Tonchev, A. B., Yamashima, T., Guo, J., Chaldakov, G. N., & Takakura, N. (2007). Expression of angiogenic and neurotrophic factors in the progenitor cell niche of adult monkey subventricular zone. Neuroscience, 144(4), 1425-1435.
95. Traboulsie, A., Chemin, J., Kupfer, E., Nargeot, J., & Lory, P. (2006). T-type calcium channels are inhibited by fluoxetine and its metabolite norfluoxetine. Molecular Pharmacology, 69(6), 1963-1968.
96. van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002). Functional neurogenesis in the adult hippocampus. Nature, 415(6875), 1030-1034.
97. Wang, J. W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008). Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. Journal of Neuroscience, 28(6), 1374-1384.
98. Wang, L., Zhang, Z., Wang, Y., Zhang, R., & Chopp, M. (2004). Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke, 35(7), 1732-1737.
99. Wee, T. C. (2017). Gastrointestinal hemorrhage related to fluoxetine in a patient with stroke. American Journal of Physical Medicine & Rehabilitation.
100. Wetmore, C., Cao, Y. H., Pettersson, R. F., & Olson, L. (1991). Brain-derived neurotrophic factor: Subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies. Proceedings of the National Academy of Sciences, 88(21), 9843-9847.
101. Windle, V., &Corbett, D. (2005). Fluoxetine and recovery of motor function after focal ischemia in rats. Brain Research, 1044(1), 25-32.
102. Yagita, Y., Kitagawa, K., Ohtsuki, T., Takasawa, K., Miyata, T., Okano, H., Matsumoto, M. (2001). Neurogenesis by progenitor cells in the ischemic adult rat hippocampus. Stroke, 32(8), 1890-1896.
103. Yamashita, T., Ninomiya, M., Hernandez Acosta, P., Garcia-Verdugo, J. M., Sunabori, T., Sakaguchi, M. Sawamoto, K. (2006). Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. Journal of Neuroscience, 26(24), 6627-6636.
104. Yu, S. W., Friedman, B., Cheng, Q., & Lyden, P. D. (2007). Strokeevoked angiogenesis results in a transient population of microvessels. Journal of Cerebral Blood Flow&Metabolism, 27(4), 755-763.
105. Yuan, J., &Yankner, B. A. (2000). Apoptosis in the nervous system. Nature, 407(6805), 802-809.
106. Zhang, R. L., Chopp, M., Gregg, S. R., Toh, Y., Roberts, C., Letourneau, Y., Zhang, Z. G. (2009). Patterns and dynamics of subventricular zone neuroblast migration in the ischemic striatum of the adult mouse. Journal of Cerebral Blood Flow & Metabolism, 29(7), 1240-1250.
107. Zhao, C. S., Puurunen, K., Schallert, T., Sivenius, J., &Jolkkonen, J. (2005). Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone. Behavioural Brain Research, 160(2), 260-266.
108. Zhong, P., & Yan, Z. (2011). Differential regulation of the excitability of prefrontal cortical fast-spiking interneurons and pyramidal neurons by serotonin and fluoxetine. PLoS One, 6(2), e16970.