A double blind placebo RCT to investigate the effects of serotonergic modulation on brain excitability and motor recovery in stroke patients

Journal of Neurology

Volumn 256, Issue 7, 2009, Pages 1152-1158

  Acler, Michele ^a   Robol, E ^a   Fiaschi, A ^a   Manganotti, P ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

Drugs; Motor recovery; Rehabilitation; Stroke; TMS

Indexed keywords

CITALOPRAM; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HEMISPHERE; HUMAN; MALE; MOTOR CORTEX; MOTOR PERFORMANCE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NERVE EXCITABILITY; NEUROPHYSIOLOGY; PHYSIOTHERAPY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEROTONINERGIC SYSTEM; SINGLE DRUG DOSE; STROKE PATIENT; TRANSCRANIAL MAGNETIC STIMULATION;

ADMINISTRATION, ORAL; AGED; BRAIN; CITALOPRAM; DOMINANCE, CEREBRAL; DOUBLE-BLIND METHOD; EVOKED POTENTIALS, MOTOR; EXTREMITIES; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MALE; MIDDLE AGED; MOVEMENT DISORDERS; PARESIS; RECOVERY OF FUNCTION; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; STROKE; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME;

EID: 67650451084     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-009-5093-7     Document Type: Article

References (36)

1. G Andersen K Vestergaard L Lauritzen 1994 Effective treatment of post-stroke depression with the selective serotonin reuptake inhibitor citalopram Stroke 25 1099 1104 (Pubitemid 24164745)
2. ML Berthier J Hinojosa MC Martin I Fernandez 2003 Open-label study of donezepil in chronic post-stroke aplasia Neurology 60 1218 1219 (Pubitemid 36418800)
3. ML Berthier J Pujol A Gironell J Kulisevsky J Deus J Hinojosa 2003 Beneficial effect of donezepil on sensorimotor function after stroke Am J Phys Med Rehabil 82 725 729 (Pubitemid 37022523)
4. Bobath B (1970) Adult hemiplegia: evaluation and treatment, 2nd edn. William Heinemann Medical Books, London
5. E Chemerinski RG Robinson JT Kosier 2001 Improved recovery in activities of daily living associated with remission of poststroke depression Stroke 32 113 117 (Pubitemid 32063833)
6. F Chollet V DiPiero RJS Wise DJ Brooks RJ Dolan RSJ Frackowiak 1991 The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography Ann Neurol 26 63 71
7. LG Cohen U Ziemann R Chen J Classen M Hallett C Gerloff C Butefisch 1998 Studies of neuroplasticity with transcranial magnetic stimulation J Clin Neurophysiol 15 305 324 (review) (Pubitemid 28402029)
8. SC Cramer G Nelles RR Benson JD Kaplan RA Parker KK Kwong 1997 A fMRI study of subjects recovered from hemiparetic stroke Stroke 28 2518 2527 (Pubitemid 28007661)
9. M Dam P Tonin A De Boni G Pizzolato S Casson M Ermani 1996 Effects of fluoxetine and maptroline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy Stroke 27 1211 1214 (Pubitemid 26226957)
10. G Gainotti G Antonucci C Marra S Paolucci 2001 Relation between depression after stroke, antidepressant therapy, and functional recovery J Neurol Neurosurg Psychiatry 71 258 261 (Pubitemid 32675158)
11. M Hamilton 1960 A rating scale for depression J Neurol Neurosurg Psychiatry 23 58 62
12. T Kujirai MD Caramia JC Rothwell BL Day PD Thompson A Ferbert 1993 Corticocortical inhibition in human motor cortex J Physiol 471 501 519 (Pubitemid 23345592)
13. J Liepert P Storch A Fritsch C Weiller 2000 Motor cortex disinhibition in acute stroke Clin Neurophysiol 111 671 676 (Pubitemid 30155989)
14. B Lindmark E Hamrin 1988 Evaluation of functional capacity after stroke as a basis for active intervention. Presentation of a modified chart for motor capacity assessment and its reliability Scand J Rehabil Med 3 103 109 (Pubitemid 18246083)
15. P Lyden T Brott B Tilley KMA Welch EJ Maascha 1994 Improved reliability of the NIH stroke scale using video training. NINDS TPA Stroke study group Stroke 25 2220 2226
16. FI Mahoney DW Barthel 1965 Functional evaluation: the Barthel index Md State Med J 14 61 85
17. P Manganotti LG Bongiovanni G Zanette A Fiaschi 1999 Cortical excitability in patients after loading doses of lamotrigine: a brain magnetic stimulation study Epilepsia 40 316 321 (Pubitemid 29164796)
18. P Manganotti M Bortolomasi G Zanette T Pawelzik M Giacopuzzi A Fiaschi 2001 Intravenous clomipramine decreases excitability of human motor cortex. A study with paired magnetic stimulation J Neurol Sci 184 27 32 (Pubitemid 32166722)
19. P Manganotti S Patuzzo F Cortese A Palermo N Smania A Fiaschi 2002 Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke Clin Neurophysiol 113 936 943 (Pubitemid 34621201)
20. P Manganotti M Acler GP Zanette N Smania A Fiaschi 2008 Motor cortical disinhibition during early and late recovery after stroke Neurorehabil Neural Repair 22 4 396 403 (Pubitemid 351852638)
21. Martinsson L, Wahlgren NG, Hardemark HG (2003) Amphetamines for improving recovery after stroke. Cochrane Database Syst Rev (3):CD002090
22. T Mittman HJ Luhmann R Schmidt-Kastner UT Eysel H Weigel U Heinemann 1994 Lesion induced transient suppression of inhibitory function in rat neocortex in vitro Neuroscience 60 891 906
23. S Paolucci G Antonucci MG Grasso D Morelli E Troisi S Coiro M Ermani 2001 Post-stroke depression, antidepressant treatment and rehabilitation results: a case-control study Cerebrovasc Dis 12 264 271 (Pubitemid 32973960)
24. J Pariente I Loubinoux C Carel JF Albucher A Leger C Manelfe 2001 Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke Ann Neurol 55 454 456
25. E Robol A Fiaschi P Manganotti 2004 Effects of citalopram on the excitability of the human motor cortex: a paired magnetic stimulation study J Neurol Sci 221 41 46 (Pubitemid 38724167)
26. PM Rossini AT Barker A Berardelli MD Caramia G Caruso RQ Cracco 1994 Noninvasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee Electroencephalogr Clin Neurophysiol 91 79 92 (Pubitemid 24246462)
27. MR Salkind 1969 Beck depression inventory in general practice J R Coll Gen Pract 18 267 271
28. K Schiene C Bruehl K Zilles M Qu G Hagemann M Kraemer OW Witte 1996 Neuronal hyperexcitability and reduction of GABA receptor expression in the surround of cerebral photothrombosis J Cereb Blood Flow Metab 16 906 914 (Pubitemid 26292057)
29. RP Stroemer TA Kent CE Hulsebosch 1998 Enhanced neocortical neural sprouting, synaptogenesis, and behavioral recovery with d-amphetamine therapy after neocortical infarction in rats Stroke 29 2381 2393
30. P Talelli RJ Greenwood JC Rothwwell 2006 Arm function after stroke: Neurophysiological correlates and recovery mechanism assessed by transcranial magnetic stimulation Clin Neurophysiol 117 1641 1659 (review) (Pubitemid 44094245)
31. D Tombari MC Ricciardi N Bonaffini M Pasquini M Cecconi V DiPiero GL Lenzi 2006 Functional MRI, drugs, and poststroke recovery Clin Exp Hypertens 28 301 307 (Pubitemid 44178503)
32. NS Ward MM Brown AJ Thompson RSJ Frackowiak 2003 Neural correlates of outcome after stroke: a cross-sectional fMRI study Brain 126 1430 1448 (Pubitemid 36644387)
33. NS Ward MM Brown AJ Thompson RSJ Frackowiak 2004 The influence of time after stroke on brain activations during a motor task Ann Neurol 6 829 834 (Pubitemid 38702577)
34. KJ Werhahn S Forderreuther A Straube 1998 Effects of the serotonin1B/1D receptor agonist zolmitriptan on motor cortical excitability in humans Neurology 51 896 898 (Pubitemid 28449286)
35. U Ziemann JC Rothwell MC Ridding 1996 Interaction between intracortical inhibition and facilitation in human motor cortex J Physiol 496 873 881 (Pubitemid 26387868)
36. U Ziemann 2004 TMS and drugs Clin Neurophysiol 115 1717 1729 (review) (Pubitemid 38952939)