Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone

Behavioural Brain Research

Volumn 160, Issue 2, 2005, Pages 260-266

  Zhao, Chuan Sheng ^a   Puurunen, Kirsi ^a   Schallert, Timothy ^b,c   Sivenius, Juhani ^d   Jolkkonen, Jukka ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Aging; Cerebral ischemia; Functional recovery; GABA; Rats

Indexed keywords

HYPNOTIC SEDATIVE AGENT; NITROBLUE TETRAZOLIUM; ZOPICLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; COMPARATIVE STUDY; CONTROLLED STUDY; CONVALESCENCE; DISEASE PREDISPOSITION; DRUG EFFECT; HINDLIMB; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LEARNING; MALE; MAZE TEST; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; OUTCOMES RESEARCH; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SINGLE DRUG DOSE; TASK PERFORMANCE; WALKING;

EID: 18044378941     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2004.12.007     Document Type: Article

References (52)

1. R.N. Auer, M.L. Jensen, and I.Q. Whishaw Neurobehavioral deficit due to ischemic brain damage limited to half of the CA1 sector of the hippocampus J Neurosci 9 1989 1641 1647
2. C. Cohen, and D.J. Sanger Tolerance, cross-tolerance and dependence measured by operant responding in rats treated with triazolam via osmotic pumps Psychopharmacology (Berl) 115 1994 86 94
3. S. Elmstahl, I. Stenberg, L. Annerstedt, and B. Ingvad Behavioral disturbances and pharmacological treatment of patients with dementia in family caregiving: a 2-year follow-up Int Psychogeriatr 10 1998 239 252
4. E. Farkas, A. Institoris, F. Domoki, A. Mihaly, P.G. Luiten, and F. Bari Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion Brain Res 1008 2004 252 260
5. P. Gauthier, C. Arnaud, J.M. Stutzmann, and C. Gottesmann Influence of zopiclone, a new generation hypnotic, on the intermediate stage and paradoxical sleep in the rat Psychopharmacology (Berl) 130 1997 139 143
6. K.L. Goa, and R.C. Heel Zopiclone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as an hypnotic Drugs 32 1986 48 65
7. L.B. Goldstein Common drugs may influence motor recovery after stroke. The sygen in acute stroke study investigators Neurology 45 1995 865 871
8. L.B. Goldstein Prescribing of potentially harmful drugs to patients admitted to hospital after head injury J Neurol Neurosurg Psychiatry 58 1995 753 755
9. G. Hagemann, C. Redecker, T. Neumann-Haefelin, H.J. Freund, and O.W. Witte Increased long-term potentiation in the surround of experimentally induced focal cortical infarction Ann Neurol 44 1998 255 258
10. E.D. Hall, P.K. Andrus, T.J. Fleck, J.A. Oostveen, D.B. Carter, and E.J. Jacobsen Neuroprotective properties of the benzodiazepine receptor, partial agonist PNU-101017 in the gerbil forebrain ischemia model J Cereb Blood Flow Metab 17 1997 875 883
11. T.D. Hernandez, and T. Schallert Seizures and recovery from experimental brain damage Exp Neurol 102 1988 318 324
12. T.D. Hernandez, G.H. Jones, and T. Schallert Co-administration of Ro 15-1788 prevents diazepam-induced retardation of recovery of function Brain Res 487 1989 89 95
13. T.D. Hernandez, and L.C. Holling Disruption of behavioral recovery by the anti-convulsant phenobarbital Brain Res 635 1994 300 306
14. F.F. Johansen, and N.H. Diemer Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells Acta Neurol Scand 84 1991 1 6
15. R.A. Lasser, and T. Sunderland Newer psychotropic medication use in nursing home residents J Am Geriatr Soc 46 1998 202 207
16. R.M. Lazar, B.F. Fitzsimmons, R.S. Marshall, M.F. Berman, M.A. Bustillo, and W.L. Young Reemergence of stroke deficits with midazolam challenge Stroke 33 2002 283 285
17. R.M. Lazar, B.F. Fitzsimmons, R.S. Marshall, J.P. Mohr, and M.F. Berman Midazolam challenge reinduces neurological deficits after transient ischemic attack Stroke 34 2003 794 796
18. T. Linjakumpu, S. Hartikainen, T. Klaukka, H. Koponen, S.L. Kivela, and R. Isoaho Psychotropics among the home-dwelling elderly - increasing trends Int J Geriatr Psychiatry 17 2002 874 883
19. V.G. Longo, M. Massotti, D. DeMedici, and A. Valerio Modifications of brain electrical activity after activation of the benzodiazepine receptor types in rats and rabbits Pharmacol Biochem Behav 29 1988 785 790
20. P.D. Lyden GABA and neuroprotection Int Rev Neurobiol 40 1997 233 258
21. M. Margallo-Lana, A. Swann, J. O'Brien, A. Fairbairn, K. Reichelt, and D. Potkins Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia sufferers living in care environments Int J Geriatr Psychiatry 16 2001 39 44
22. T. Miyakawa, T. Yagi, A. Kagiyama, and H. Niki Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: further evidence for increased fearfulness Brain Res Mol Brain Res 37 1996 145 150
23. B. Musch, and F. Maillard Zopiclone, the third generation hypnotic: a clinical overview Int Clin Psychopharmacol 5 Suppl. 2 1990 147 158
24. M.M. Nachlas, K.C. Tsou, E. De Souza, C.S. Cheng, and A.M. Seligman Cytochemical demonstration of succinic dehydrogenase by the use of a new p-nitrophenyl substituted ditetrazole J Histochem Cytochem 5 1957 420 436
25. T. Neumann-Haefelin, J.F. Staiger, C. Redecker, K. Zilles, J.M. Fritschy, and H. Mohler Immunohistochemical evidence for dysregulation of the GABAergic system ipsilateral to photochemically induced cortical infarcts in rats Neuroscience 87 1998 871 879
26. G. Paxinos, and C.R. Watson The rat atlas in stereotaxic coordinates 4th ed. 1998 Academic Press San Diego, CA
27. M. Qu, I. Buchkremer-Ratzmann, K. Schiene, M. Schroeter, O.W. Witte, and K. Zilles Bihemispheric reduction of GABAA receptor binding following focal cortical photothrombotic lesions in the rat brain Brain Res 813 1998 374 380
28. M. Que, K. Schiene, O.W. Witte, and K. Zilles Widespread up-regulation of N-methyl-d-aspartate receptors after focal photothrombotic lesion in rat brain Neurosci Lett 273 1999 77 80
29. M. Saji, and D.J. Reis Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist Science 235 1987 66 69
30. T. Schallert, T.D. Hernandez, and T.M. Barth Recovery of function after brain damage: severe and chronic disruption by diazepam Brain Res 379 1986 104 111
31. T. Schallert, T.A. Jones, and M.D. Lindner Multilevel transneuronal degeneration after brain damage. Behavioral events and effects of anticonvulsant gamma-aminobutyric acid-related drugs Stroke 21 1990 III143 III146
32. T. Schallert, and M.D. Lindner Rescuing neurons from trans-synaptic degeneration after brain damage: helpful, harmful, or neutral in recovery of function? Can J Psychol 44 1990 276 292
33. T. Schallert, and T.D. Hernandez GABAergic drugs and neuroplasticity after brain injury: impact on functional recovery L.B. Goldstein Restorative neurology: advances in pharmacotherapy after stroke 1998 Futura Publishing Armonk, NY 91 120
34. T. Schallert, M.T. Woodlee, and S.M. Fleming Disentangling multiple types of recovery from brain injury J. Krieglstein S. Klumpp Pharmacology of cerebral ischemia 2002 2002 Medpharm Scientific Publishers Stuttgart 201 216
35. T. Schallert, T.A. Jones, M.S. Weaver, L.E. Shapiro, D. Crippens, and R. Fulton Pharmacologic and anatomic considerations in recovery of function D.M. Tucker Neuropsychological assessment - physical medicine and rehabilitation 6 1992 375 393
36. K. Schiene, C. Bruehl, K. Zilles, M. Qu, G. Hagemann, and M. Kraemer Neuronal hyperexcitability and reduction of GABAA-receptor expression in the surround of cerebral photothrombosis J Cereb Blood Flow Metab 16 1996 906 914
37. R.D. Schwartz, R.A. Huff, X. Yu, M.L. Carter, and M. Bishop Postischemic diazepam is neuroprotective in the gerbil hippocampus Brain Res 647 1994 153 160
38. R.D. Schwartz, X. Yu, M.R. Katzman, D.M. Hayden-Hixson, and J.M. Perry Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum J Neurosci 15 1995 529 539
39. R.D. Schwartz-Bloom, K.J. McDonough, P.J. Chase, L.E. Chadwick, J.R. Inglefield, and E.D. Levin Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected] J Cereb Blood Flow Metab 18 1998 548 558
40. A. Shuaib, S. Ijaz, S. Hasan, and J. Kalra Gamma-vinyl GABA prevents hippocampal and substantia nigra reticulata damage in repetitive transient forebrain ischemia Brain Res 590 1992 13 17
41. A. Shuaib, R. Mazagri, and S. Ijaz GABA agonist muscimol is neuroprotective in repetitive transient forebrain ischemia in gerbils Exp Neurol 123 1993 284 288
42. A. Shuaib, S. Ijaz, and R. Kanthan Clomethiazole protects the brain in transient forebrain ischemia when used up to 4 h after the insult Neurosci Lett 197 1995 109 112
43. L.L. Sternau, W.D. Lust, A.J. Ricci, and R. Ratcheson Role for gamma-aminobutyric acid in selective vulnerability in gerbils Stroke 20 1989 281 287
44. S.G. Sydserff, A.J. Cross, and A.R. Green The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat Neurodegeneration 4 1995 323 328
45. S.G. Sydserff, A.J. Cross, K.J. West, and A.R. Green The effect of chlormethiazole on neuronal damage in a model of transient focal ischaemia Br J Pharmacol 114 1995 1631 1635
46. K. Troy Harker, and I.Q. Whishaw Place and matching-to-place spatial learning affected by rat inbreeding (Dark-Agouti, Fischer 344) and albinism (Wistar, Sprague-Dawley) but not domestication (wild rat vs. Long-Evans, Fischer-Norway) Behav Brain Res 134 2002 467 477
47. A.N. Wadworth, and D. McTavish Zopiclone. A review of its pharmacological properties and therapeutic efficacy as an hypnotic Drugs Aging 3 1993 441 459
48. B.D. Watson, W.D. Dietrich, R. Busto, M.S. Wachtel, and M.D. Ginsberg Induction of reproducible brain infarction by photochemically initiated thrombosis Ann Neurol 17 1985 497 504
49. T. Yamamoto, Y. Kumasaka, and S. Ueki Behavioral analysis of zopiclone on the basis of their discriminative stimulus properties in the rat Jpn J Pharmacol 51 1989 337 345
50. J.L.W. Yau, J. Noble, C. Hibberd, W.B. Rowe, M.J. Meaney, and R.G.M. Morris Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats J Neurosci 22 2002 1436 1442
51. C.S. Zhao, K. Puurunen, T. Schallert, J. Sivenius, and J. Jolkkonen Effect of cholinergic medication, before and after focal photothrombotic ischemic cortical injury, on histological and functional outcome in aged and young adult rats Behav Brain Res 156 2005 85 94
52. Zhao CS, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. Behavioral and histological effects of chronic antipsychotic and antidepressant drug treatment in aged rats with focal ischemic brain injury. Behav Brain Res, in press.