The microbiome and the hallmarks of cancer

PLoS Pathogens

Volumn 13, Issue 9, 2017, Pages

  Fulbright, Laura E ^a   Ellermann, Melissa ^a   Arthur, Janelle C ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; APC PROTEIN; BETA CATENIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FRAGILYSIN; INTERLEUKIN 10; INTERLEUKIN 17; LIPOPOLYSACCHARIDE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; POLYSACCHARIDE; PROGRAMMED DEATH 1 LIGAND 1; STAT3 PROTEIN; UVOMORULIN;

ANGIOGENESIS; BACTEROIDES FRAGILIS; CARCINOGENESIS; CELL ENERGY; CELL PROLIFERATION; CHROMOSOME SEGREGATION; DNA DAMAGE; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; INTESTINE FLORA; MICROBIOME; MICROFLORA; NEOPLASM; NONHUMAN; REVIEW; TUMOR GROWTH; TUMOR MICROENVIRONMENT; WNT SIGNALING; ANIMAL; MICROBIOLOGY;

ANIMALS; HUMANS; MICROBIOTA; NEOPLASMS;

EID: 85030456226     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006480     Document Type: Review

References (23)

1. Hanahan D, Weinberg RA, Hallmarks of cancer: the next generation. Cell. Elsevier; 2011;144: 646–674. doi: 10.1016/j.cell.2011.02.013 21376230
2. Marshall BJ, The 1995 Albert Lasker Medical Research Award. Helicobacter pylori. The etiologic agent for peptic ulcer. JAMA: The Journal of the American Medical Association. 1995;274: 1064–1066. doi: 10.1001/jama.274.13.1064 7563460
3. Rhee KJ, Wu S, Wu X, Huso DL, Karim B, Franco AA, et al. Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice. Infect Immun. 2009;77: 1708–1718. doi: 10.1128/IAI.00814-08 19188353
4. Rubinstein MR, Wang X, Liu W, Hao Y, Cai G, Han YW, Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe. 2013;14: 195–206. doi: 10.1016/j.chom.2013.07.012 23954158
5. Cougnoux A, Dalmasso G, Martinez R, Buc E, Delmas J, Gibold L, et al. Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype. Gut. BMJ Publishing Group; 2014;63: 1932–1942. doi: 10.1136/gutjnl-2013-305257 24658599
6. Donohoe DR, Holley D, Collins LB, Montgomery SA, Whitmore AC, Hillhouse A, et al. A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner. Cancer Discovery. American Association for Cancer Research; 2014;4: 1387–1397. doi: 10.1158/2159-8290.CD-14-0501 25266735
7. Stappenbeck TS, Hooper LV, Gordon JI, Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci USA. National Acad Sciences; 2002;99: 15451–15455. doi: 10.1073/pnas.202604299 12432102
8. Osherov N, Ben-Ami R, Sheppard DC, Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic Target. PLoS Pathog. 2016;12: e1005479–8. doi: 10.1371/journal.ppat.1005479 27078259
9. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012;10: 789–15. doi: 10.1038/nature11465
10. Wu S, Rhee K-J, Albesiano E, Rabizadeh S, Wu X, Yen H-R, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. Nature Publishing Group; 2009;: 1–8. doi: 10.1038/nm0109-1
11. Housseau F, Wu S, Wick EC, Fan H, Wu X, Llosa NJ, et al. Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis. Cancer Research. American Association for Cancer Research; 2016;76: 2115–2124. doi: 10.1158/0008-5472.CAN-15-0749 26880802
12. Moschen AR, Gerner RR, Wang J, Klepsch V, Adolph TE, Reider SJ, et al. Lipocalin 2 protects from inflammation and tumorigenesis associated with gut microbiota alterations. Cell Host Microbe. 2016;19: 455–469. doi: 10.1016/j.chom.2016.03.007 27078067
13. Gur C, Ibrahim Y, Isaacson B, Yamin R, Abed J, Gamliel M, et al. Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack. Immunity. 2015;42: 344–355. doi: 10.1016/j.immuni.2015.01.010 25680274
14. Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, et al. Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment. Cell Host Microbe. 2013;14: 207–215. doi: 10.1016/j.chom.2013.07.007 23954159
15. Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. American Association for the Advancement of Science; 2015;350: 1084–1089. doi: 10.1126/science.aac4255 26541606
16. Vetizou M, Pitt JM, Daillere R, Lepage P, Waldschmitt N, Flament C, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015;350: 1079–1084. doi: 10.1126/science.aad1329 26541610
17. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL, An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System. Cell. 2005;122: 107–118. doi: 10.1016/j.cell.2005.05.007 16009137
18. Mazmanian SK, Round JL, Kasper DL, A microbial symbiosis factor prevents intestinal inflammatory disease. Nature. 2008;453: 620–625. doi: 10.1038/nature07008 18509436
19. Nougayrède J-P, Homburg S, Taieb F, Boury M, Brzuszkiewicz E, Gottschalk G, et al. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science. 2006;313: 848–851. doi: 10.1126/science.1127059 16902142
20. Arthur JC, Perez-Chanona E, Mühlbauer M, Tomkovich S, Uronis JM, Fan T-J, et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science. American Association for the Advancement of Science; 2012;338: 120–123. doi: 10.1126/science.1224820 22903521
21. Goodwin AC, DeStefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, et al. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proceedings of the National Academy of Sciences. National Acad Sciences; 2011;108: 15354–15359. doi: 10.1073/pnas.1010203108 21876161
22. Wang X, Yang Y, Huycke MM, Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect. Gut. BMJ Publishing Group; 2015;64: 459–468. doi: 10.1136/gutjnl-2014-307213 24906974
23. Arthur JC, Gharaibeh RZ, Mühlbauer M, Perez-Chanona E, Uronis JM, McCafferty J, et al. Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer. Nature Communications. 2014;5: 4724. doi: 10.1038/ncomms5724 25182170