Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 40, 2017, Pages E8478-E8487

  Konishi, Masahiro ^a   Sakaguchi, Masaji ^a   Lockhart, Samuel M ^a   Cai, Weikang ^a   Li, Mengyao Ella ^a   Homan, Erica P ^a   Rask Madsen, Christian ^a   Kahn, C Ronald ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Brain insulin action; Endothelial cells; Feeding behavior; Insulin receptor; Insulin resistance

Indexed keywords

C PEPTIDE; FLUORESCEIN ISOTHIOCYANATE; GLUCOSE; INSULIN; INSULIN RECEPTOR; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROOPIOMELANOCORTIN; PROTEIN KINASE B; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; AREA POSTREMA; ARTICLE; BODY WEIGHT; BRAIN BLOOD VESSEL; BRAIN THIRD VENTRICLE; BRAIN TISSUE; BROWN ADIPOSE TISSUE; CHOROID PLEXUS; CONTROLLED STUDY; ENDOTHELIUM CELL; FATTY ACID LEVEL; FOOD INTAKE; GENE INACTIVATION; GENETIC RECOMBINATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HIPPOCAMPUS; HYPERINSULINEMIA; HYPOTHALAMUS; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN SIGNALING; INSULIN TOLERANCE TEST; LIPID DIET; LOXP SITE; MEDIAN EMINENCE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OVERNUTRITION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SATIETY; SKELETAL MUSCLE; TARGET TISSUE; TISSUE BLOOD FLOW; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BRAIN; C57BL MOUSE; KINETICS; KNOCKOUT MOUSE; LIVER; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD GLUCOSE; BRAIN; GLUCOSE INTOLERANCE; INSULIN; INSULIN RESISTANCE; KINETICS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; OBESITY; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 85030221998     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1710625114     Document Type: Article

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