Investigation of the mechanism of the SpnF-catalyzed [4+2]-cycloaddition reaction in the biosynthesis of spinosyn A

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 39, 2017, Pages 10408-10413

  Jeon, Byung sun ^a   Ruszczycky, Mark W ^b   Russell, William K ^c   Lin, Geng Min ^a   Kim, Namho ^b   Choi, Sei hyun ^a   Wang, Shao An ^a   Liu, Yung nan ^b   Patrick, John W ^c   Russell, David H ^c   Liu, Hung wen ^a,b  

^a University of Texas at Austin   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Bayesian analysis; Diels Alderase; Enzyme; Isotope effect; Spinosyn

Indexed keywords

ENZYME; SPINOSYN A; SPNF ENZYME; UNCLASSIFIED DRUG; MACROLIDE; METHYLTRANSFERASE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CYCLIZATION; CYCLOADDITION; DIELS ALDER REACTION; ELECTROSPRAY; ENZYME ACTIVE SITE; ENZYME MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACROLACTONIZATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROPOLYSPORA; SACCHAROPOLYSPORA SPINOSA; STILLE REACTION; ENZYMOLOGY; METABOLISM; PHYSIOLOGY;

CATALYTIC DOMAIN; CYCLOADDITION REACTION; MACROLIDES; METHYLTRANSFERASES; SACCHAROPOLYSPORA;

EID: 85029915740     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1710496114     Document Type: Article

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