P38 MAP kinase is involved in oleuropein-induced apoptosis in A549 cells by a mitochondrial apoptotic cascade

Biomedicine and Pharmacotherapy

Volumn 95, Issue , 2017, Pages 1425-1435

  Cao, Shasha ^a   Zhu, Xixi ^a   Du, Linfang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

A549 cells; Apoptosis; Mitochondrial apoptotic cascade; Oleuropein; p38MAPK

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 9; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; OLEUROPEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; IRIDOID; PROTEIN KINASE INHIBITOR;

A-549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CELL VIABILITY ASSAY; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LUNG CANCER; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL CYCLE CHECKPOINT; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; DRUG EFFECT; METABOLISM; MITOCHONDRION;

A549 CELLS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; G2 PHASE; HUMANS; IRIDOIDS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 85029512570     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.09.072     Document Type: Article

References (44)

1. Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D.M., Forman, D., Bray, F., Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 136:5 (2015), E359–E386.
2. Lehtiö, J., De Petris, L., Lung cancer proteomics, clinical and technological considerations. J. Proteomics 73:10 (2010), 1851–1863.
3. Indovina, P., Marcelli, E., Pentimalli, F., Tanganelli, P., Tarro, G., Giordano, A., Mass spectrometry‐based proteomics: the road to lung cancer biomarker discovery. Mass Spectrom. Rev. 32:2 (2013), 129–142.
4. Gikas, F.N., Conformation of oleuropein, the major bioactive compound of Olea europea. J. Mol. Struct. THEOCHEM 821:1 (2007), 125–132.
5. Omar, S.H., Cardioprotective and neuroprotective roles of oleuropein in olive. Saudi Pharmaceutical Journal 18:3 (2010), 111–121.
6. Cicerale, S., Lucas, L., Keas, R., Antimicrobial antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil. Curr. Opin. Biotechnol. 23:2 (2012), 129–135.
7. Yao, J., Wu, J., Yang, X., Yang, J., Zhang, Y., Du, L., Oleuropein induced apoptosis in HeLa cells via a mitochondrial apoptotic cascade associated with activation of the c-Jun NH2-terminal kinase. J. Pharmacol. Sci. 125:3 (2014), 300–311.
8. Rust, C., Gores, G.J., Apoptosis and liver disease. Am. J. Med. 108:7 (2000), 567–574.
9. Callsen, D., Brüne, B., Role of mitogen-activated protein kinases in S-nitrosoglutathione-induced macrophage apoptosis. Biochemistry 38:8 (1999), 2279–2286.
10. Zhang, W., Liu, H.T., MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 12:1 (2002), 9–18.
11. Han, J., Sun, P., The pathways to tumor suppression via route p38. Trends Biochem. Sci. 32:8 (2007), 364–371.
12. Shimizu, S., Narita, M., Tsujimoto, Y., Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399:6735 (1999), 483–487.
13. Pan, J., Xu, G., Yeung, S.-C.J., Cytochrome c release is upstream to activation of caspase-9, caspase-8, and caspase-3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel. J. Clin. Endocrinol. Metab. 86:10 (2001), 4731–4740.
14. Thornton, T.M., Rincon, M., Non-classical p38 map kinase functions: cell cycle checkpoints and survival. Int. J. Biol. Sci. 5:1 (2009), 44–51.
15. Kirazov, L.P., Venkov, L.G., Kirazov, E.P., Comparison of the Lowry and the Bradford protein assays as applied for protein estimation of membrane-containing fractions. Anal. Biochem. 208:1 (1993), 44–48.
16. Darzynkiewicz, Z., Bruno, S., Del Bino, G., Gorczyca, W., Hotz, M., Lassota, P., Traganos, F., Features of apoptotic cells measured by flow cytometry. Cytometry 13:8 (1992), 795–808.
17. Soliman, A.S., Samadi, S., Banerjee, M., Chamberlain, R.M., Aziz, Z., Brief continuing medical education (CME) module raises knowledge of developing country physicians. Int. Electronic J. Health Educ. 9 (2006), 31–41.
18. Elamin, M.H., Daghestani, M.H., Omer, S.A., Elobeid, M.A., Virk, P., Al-Olayan, E.M., Hassan, Z.K., Mohammed, O.B., Aboussekhra, A., Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells. Food Chem. Toxicol. 53 (2013), 310–316.
19. Babich, H., Visioli, F., In vitro cytotoxicity to human cells in culture of some phenolics from olive oil. Il Farmaco 58:5 (2003), 403–407.
20. Deacon, K., Mistry, P., Chernoff, J., Blank, J.L., Patel, R., p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol. Biol. Cell 14:5 (2003), 2071–2087.
21. Avisetti, D.R., Babu, K.S., Kalivendi, S.V., Activation of p38/JNK pathway is responsible for embelin induced apoptosis in lung cancer cells: transitional role of reactive oxygen species. PLoS One, 9(1), 2014, e87050.
22. Shimizu, T., Nakazato, T., Xian, M.J., Sagawa, M., Ikeda, Y., Kizaki, M., Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways. Biochem. Pharmacol. 71:6 (2006), 742–750.
23. Sirianni, R., Chimento, A., De Luca, A., Casaburi, I., Rizza, P., Onofrio, A., Iacopetta, D., Puoci, F., Andò, S., Maggiolini, M., Oleuropein and hydroxytyrosol inhibit MCFò7 breast cancer cell proliferation interfering with ERK1/2 activation. Mol. Nutr. Food Res. 54:6 (2010), 833–840.
24. Yu, X., Guo, Z.S., Marcu, M.G., Neckers, L., Nguyen, D.M., Chen, G.A., Schrump, D.S., Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228. J. Natl. Cancer Inst. 94:7 (2002), 504–513.
25. Dhanasekaran, D.N., Reddy, E.P., JNK signaling in apoptosis. Oncogene 27:48 (2008), 6245–6251.
26. Bulotta, S., Corradino, R., Celano, M., Maiuolo, J., D'Agostino, M., Oliverio, M., Procopio, A., Filetti, S., Russo, D., Antioxidant and antigrowth action of peracetylated oleuropein in thyroid cancer cells. J. Mol. Endocrinol. 51:1 (2013), 181–189.
27. Cárdeno, A., Sánchez-Hidalgo, M., Rosillo, M.A., de la Lastra, C.A., Oleuropein a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1α. Nutr. Cancer 65:1 (2013), 147–156.
28. Gomez-Lazaro, M., Galindo, M., De Mera, R.M.-F., Fernandez-Gomez, F., Concannon, C., Segura, M., Comella, J., Prehn, J., Jordan, J., Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate. Mol. Pharmacol. 71:3 (2007), 736–743.
29. Sakamuru, S., Li, X., Attene-Ramos, M.S., Huang, R., Lu, J., Shou, L., Shen, M., Tice, R.R., Austin, C.P., Xia, M., Application of a homogenous membrane potential assay to assess mitochondrial function. Physiol. Genomics 44:9 (2012), 495–503.
30. Antonsson, B., Martinou, J.-C., The bcl-2 protein family. Exp. Cell Res. 256:1 (2000), 50–57.
31. Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., Armstrong, R.C., Augeri, D.J., Belli, B.A., Bruncko, M., Deckwerth, T.L., Dinges, J., Hajduk, P.J., An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435:7042 (2005), 677–681.
32. Gross, A., Jockel, J., Wei, M.C., Korsmeyer, S.J., Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 17:14 (1998), 3878–3885.
33. ANTONSSON, B., MONTESSUIT, S., LAUPER, S., ESKES, R., MARTINOU, J.-C., Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem. J 345:2 (2000), 271–278.
34. Porter, A.G., Jänicke, R.U., Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6:2 (1999), 99–104.
35. Yang, J., Liu, X., Bhalla, K., Kim, C.N., Ibrado, A.M., Cai, J., Peng, T.-I., Jones, D.P., Wang, X., Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:5303 (1997), 1129–1132.
36. Lazebnik, Y.A., Kaufmann, S.H., Desnoyers, S., Poirier, G., Earnshaw, W., Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371:6495 (1994), 346–347.
37. Seo, S.-K., Lee, H.-C., Woo, S.-H., Jin, H.-O., Yoo, D.-H., Lee, S.-J., An, S., Choe, T.-B., Park, M.-J., Hong, S.-I., Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. Apoptosis 12:1 (2007), 195–209.
38. Owens, T., Valentijn, A., Upton, J., Keeble, J., Zhang, L., Lindsay, J., Zouq, N., Gilmore, A., Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK. Cell Death Differ. 16:11 (2009), 1551–1562.
39. Park, H.S., Hwang, H.J., Kim, G.-Y., Cha, H.-J., Kim, W.-J., Kim, N.D., Yoo, Y.H., Choi, Y.H., Induction of apoptosis by fucoidan in human leukemia U937 cells through activation of p38 MAPK and modulation of Bcl-2 family. Mar. Drugs 11:7 (2013), 2347–2364.
40. Van Laethem, A., Van Kelst, S., Lippens, W., Declercq, P., Vandenabeele, S., Janssens, J.R., Vandenheede, M., Agostinis, P., Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes. FASEB J. 18:15 (2004), 1946–1948.
41. Goping, S., Gross, A., Lavoie, J.N., Nguyen, M., Jemmerson, R., Roth, K., Korsmeyer, S.J., Shore, G.C., Regulated targeting of BAX to mitochondria. J. Cell Biol. 143:1 (1998), 207–215.
42. Nechushtan, C.L., Smith, Y.T., Conformation of the Bax C‐terminus regulates subcellular location and cell death. EMBO J. 18:9 (1999), 2330–2341.
43. Kim, H.J., Oh, J.E., Kim, S.W., Chun, Y.J., Kim, M.Y., Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer Lett. 260:1 (2008), 88–95.
44. Yang, X., Yao, J., Luo, Y., Han, Y., Wang, Z., Du, L., P38 MAP kinase mediates apoptosis after genipin treatment in non–Small-Cell lung cancer H1299Cells via a mitochondrial apoptotic cascade. J. Pharmacol. Sci. 121:4 (2013), 272–281.