Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells

Cancer Letters

Volumn 260, Issue 1-2, 2008, Pages 88-95

  Kim, Hae Jong ^a   Oh, Ji Eun ^a   Kim, Sang Woo ^a   Chun, Young Jin ^a   Kim, Mie Young ^a  

^a Chung Ang University   (South Korea)

Author keywords

Akt; Apoptosis; Bax; Ceramide; HL 60 cells; p38 MAPK

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CERAMIDE; DNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BAX; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CELL VIABILITY; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA DAMAGE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CERAMIDES; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; IMIDAZOLES; LEUKEMIA, PROMYELOCYTIC, ACUTE; MITOCHONDRIA; MUTATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 38149129507     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.10.030     Document Type: Article

References (39)

1. Obeid L.M., Linardic C.M., Karolak L.A., and Hannun Y.A. Programmed cell death by ceramide. Science 259 (1993) 1769-1771
2. Hannun Y.A. Functions of ceramide in coordinating cellular responses to stress. Science 274 (1996) 1855-1859
3. Hannun Y.A., and Obeid L.M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 277 (2002) 25847-25850
4. Kim M.Y., Linardic C., Obeid L., and Hannun Y.A. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor-α and γ-interferon. J. Biol. Chem. 266 (1991) 484-489
5. Jaffrezou J.-P., Levade T., Bettaieb A., Andrieu N., Bezombes C., Maestre N., Vermeersch S., Rousse A., and Laurent B. Daunorubicin induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J. 15 (1996) 2417-2424
6. Herr I., Wilhelm D., Bohler T., Angel P., and Debatin K. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16 (1997) 6200-6208
7. Martin S.J., Newmeyer D.D., Mathias S., Farschon D.M., Wang H.G., Reed J.C., Kolesnick R.N., and Green D.R. Cell-free reconstitution of Fas-, UV radiation-, and ceramide-induced apoptosis. EMBO J. 14 (1995) 5191-5200
8. Verhei M., Bose R., Lin X.H., Yao B., Jarvis W.D., Grant S., Birrer M.J., Szabo E., Zon L.I., Kyriakis J.M., Haimovitz-Friedman A., Füks Z., and Kolesnick R. Requirement for ceramide-induced SAPK/JNK signaling in stress-induced apoptosis. Nature 380 (1996) 75-79
9. Chalfant C.E., Kishikawa K., Mumby M.C., Kamibaya C., Bielawska A., and Hannun Y.A. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A activation is stereospecific and regulated by phosphatidic acid. J. Biol. Chem. 274 (1999) 20313-20317
10. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 309-1312
11. Gross A., McDonnell J.M., and Korsmeyer S.J. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 13 (1999) 1899-1911
12. Kuwana T., and Newmeyer D.D. Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr. Opin. Cell Biol. 15 (2003) 691-699
13. Stoica B.A., Movsesyan V.A., Knoblach S.M., and Faden A.I. Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol. Cell. Neurosci. 29 (2005) 355-371
14. Kim H.J., Mun J.Y., Chun Y.J., Choi K.H., and Kim M.Y. Bax-dependent apoptosis induced by ceramide in HL-60 cells. FEBS Lett. 505 (2001) 264-268
15. Kong J.Y., Klassen S.S., and Rabkin S.W. Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis. Mol. Cell. Biochem. 278 (2006) 39-51
16. von Haefen C., Wieder T., Gillissen B., Starck L., Graupner V., Dorken B., and Daniel P.T. Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells. Oncogene 21 (2002) 4009-4019
17. Birbes H., Luberto C., Hsu Y.T., Bawab S.E., Hannun Y.A., and Obeid L.M. A mitochondrial pool of sphinogomyelin is involved in TNFα-induced Bax translocation to mitochondrial. Biochem. J. 386 (2005) 445-451
18. Ghatan S., Lamer S., Kinoshta Y., Helman M., Patel L., Xia Z., Youle R.J., and Morrison R.S. p38 MAP kinase mediates Bax translocation in nitric oxide-induced apoptosis in neurons. J. Cell Biol. 150 (2000) 335-347
19. Chang L., and Karin M. Mammalian MAP kinase signaling cascades. Nature 410 (2001) 37-40
20. Grethe S., Ares M.P.S., Andersson T., and Pörn-Ares M.I. p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-xL. Exp. Cell Res. 298 (2004) 632-642
21. Cowan J.J., and Storey K.B. Mitogen-activated protein kinases: New signaling pathways functioning in cellular responses to environmental stress. J. Exp. Biol. 206 (2003) 1107-1115
22. Tsuruta F., Masuyama N., and Gotoh Y. The phosphatidylinositol 3-kinase (PI3)-Akt pathway suppresses Bax translocation to mitochondria. J. Biol. Chem. 277 (2002) 14040-14047
23. Kennedy S.G., Kandel E.S., Cross T.K., and Hay N. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell. Biol. 19 (1999) 5800-5810
24. Kennedy S.G., Wagner A.J., Conzen S.D., Jordan J., Bellacosa A., Tsichlis P.N., and Hay N. The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11 (1997) 701-713
25. Zhou H., Li X.-M., Meinkoth J., and Pittman R.N. Akt regulates cell survival and apoptosis at a postmitochondrial level. J. Cell Biol. 151 (2000) 483-494
26. Testa J.R., and Bellacosa A. Akt plays a central role in tumorigenesis. Proc. Natl. Acad. Sci. USA 98 (2001) 10983-10985
27. Willaime S., Vanhoutte P., Cahoche J., Lemaigre-Dubreuil Y., Mariani J., and Brugg B. Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. Eur. J. Neurosci. 13 (2001) 2037-2046
28. Zhou H.Z., Summers S.A., Birnbaum M.J., and Pittman R.N. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J. Biol. Chem. 273 (1998) 16568-16575
29. Bourbon N.A., Sandirasegarane L., and Kester M. Ceramide-induced inhibition of Akt is mediated through protein kinase Cζ, Implications for growth arrest. J. Biol. Chem. 277 (2002) 3286-3292
30. Kim D., Kim S., Koh H., Yoon S., Chung A., Cho K.S., and Chung J. Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J. 15 (2001) 1953-1962
31. Gratton J.P., Morales-Ruiz M., Kureishi Y., Fulton D., Walsh K., and Sessa W.C. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J. Biol. Chem. 276 (2001) 20359-20365
32. Horowitz J.C., Lee D.Y., Waghray M., Keshamouni V.G., Thomas P.E., Zhang H., Cui Z., and Thannickal V.J. Activation of the pro-survival phosphatidylinositol 3-kinase/Akt pathway by transforming growth factor-β1 in mesenchymeal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. J. Biol. Chem. 279 (2004) 1359-1367
33. Anter E., Thomas S.R., Schulz E., Shapira O.M., Vita J.A., and Keaney Jr. J.F. Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols. J. Biol. Chem. 279 (2004) 46637-46643
34. Tavarini S., Colombaioni L., and Garcia-Gil M. Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. Neurosci. Lett. 285 (2000) 185-188
35. Hida H., Nagano S., Takeda M., and Soliven B. Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes. J. Neurosci. 19 (1999) 7458-7467
36. Jane R.G., Meredith M.J., and Pekala P.H. Tumor necrosis factor-α mediated activation of signal transduction cascades and transcription factors in 3T3-L1 adipocytes. Adv. Enzyme Regul. 38 (1998) 333-347
37. Hsu Y.W., Chi K.H., Huang W.C., and Lin W.W. Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: Effects on protein kinases and transcription factors. J. Immunol. 166 (2001) 5338-5397
38. Clarke C.J., Truong T.G., and Hannun Y.A. Role for neutral sphingomyelinase-2 (nSMase2) in TNF-α-stimulated expression of VCAM and ICAM in lung epithelial cells: p38 MAPK is an upstream regulator of nSMse2. J. Biol. Chem. 282 (2007) 1384-1396
39. Xin M., and Deng X. Nicotine inactivation of the proapototic function of Bax through phosphorylation. J. Biol. Chem. 280 (2005) 10781-10789