An Fc Double-Engineered CD20 Antibody with Enhanced Ability to Trigger Complement-Dependent Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity

Transfusion Medicine and Hemotherapy

Volumn 44, Issue 5, 2017, Pages 292-300

  Wirt, Tim ^a   Rosskopf, Sophia ^a   Rösner, Thies ^a   Eichholz, Klara Marie ^a   Kahrs, Anne ^a   Lutz, Sebastian ^a   Kretschmer, Anna ^a   Valerius, Thomas ^a   Klausz, Katja ^a   Otte, Anna ^a   Gramatzki, Martin ^a   Peipp, Matthias ^a   Kellner, Christian ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

ADCC; Antibody therapy; CD20; CDC; Fc engineering

Indexed keywords

CD20 ANTIBODY; FC RECEPTOR; FC RECEPTOR RIIIA; FRUCTOSE; IMMUNOGLOBULIN G1 ANTIBODY; RITUXIMAB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY ENGINEERING; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; FUCOSYLATION; GLYCO ENGINEERING; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN ENGINEERING; PROTEIN PROCESSING;

EID: 85029451742     PISSN: 16603796     EISSN: 16603818     Source Type: Journal    
DOI: 10.1159/000479978     Document Type: Article

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