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Volumn 15, Issue 6, 2015, Pages 361-370

Building better monoclonal antibody-based therapeutics

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; BISPECIFIC ANTIBODY; CHIMERIC ANTIGEN RECEPTOR; COMPLEMENT; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR; ANTINEOPLASTIC AGENT;

EID: 84929885314     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3930     Document Type: Review
Times cited : (548)

References (114)
  • 2
    • 0033793926 scopus 로고    scopus 로고
    • Passive immunity in prevention and treatment of infectious diseases
    • Keller, M. A. & Stiehm, E. R. Passive immunity in prevention and treatment of infectious diseases. Clin. Microbiol. Rev. 13, 602-614 (2000).
    • (2000) Clin. Microbiol. Rev. , vol.13 , pp. 602-614
    • Keller, M.A.1    Stiehm, E.R.2
  • 3
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler, G. & Milstein, C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495 (1975).
    • (1975) Nature , vol.256 , pp. 495
    • Kohler, G.1    Milstein, C.2
  • 4
    • 0021878121 scopus 로고
    • From the structure of antibodies to the diversification of the immune response
    • 8 December 1984. Biosci. Rep
    • Milstein, C. From the structure of antibodies to the diversification of the immune response. Nobel lecture, 8 December 1984. Biosci. Rep. 5, 275-297 (1985).
    • (1985) Nobel Lecture , vol.5 , pp. 275-297
    • Milstein, C.1
  • 5
    • 0021602942 scopus 로고
    • The clusters of differentiation (CD) defined by the First International Workshop on Human Leucocyte Differentiation Antigens
    • Bernard, A. & Boumsell, L. The clusters of differentiation (CD) defined by the First International Workshop on Human Leucocyte Differentiation Antigens. Hum. Immunol. 11, 1-10 (1984).
    • (1984) Hum. Immunol. , vol.11 , pp. 1-10
    • Bernard, A.1    Boumsell, L.2
  • 6
    • 0025784952 scopus 로고
    • Overview of monoclonal antibodies in the diagnosis and therapy of cancer
    • Vaickus, L. & Foon, K. A. Overview of monoclonal antibodies in the diagnosis and therapy of cancer. Cancer Invest. 9, 195-209 (1991).
    • (1991) Cancer Invest. , vol.9 , pp. 195-209
    • Vaickus, L.1    Foon, K.A.2
  • 7
    • 0021795011 scopus 로고
    • A clinical trial of anti-idiotype therapy for B cell malignancy
    • Meeker, T. C. et al. A clinical trial of anti-idiotype therapy for B cell malignancy. Blood 65, 1349-1363 (1985).
    • (1985) Blood , vol.65 , pp. 1349-1363
    • Meeker, T.C.1
  • 8
    • 0342530626 scopus 로고
    • Mouse/human chimeric monoclonal antibody in man: Kinetics and immune response
    • LoBuglio, A. F. et al. Mouse/human chimeric monoclonal antibody in man: kinetics and immune response. Proc. Natl Acad. Sci. USA 86, 4220-4224 (1989).
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 4220-4224
    • Lobuglio, A.F.1
  • 9
    • 1842368507 scopus 로고    scopus 로고
    • Idec-C2b8 (Rituximab) anti-CD20 monoclonal antibody therapy patients with relapsed low-grade non-Hodgkins lymphoma
    • Maloney, D. G. et al. Idec-C2b8 (Rituximab) anti-CD20 monoclonal antibody therapy patients with relapsed low-grade non-Hodgkins lymphoma. Blood 90, 2188-2195 (1997).
    • (1997) Blood , vol.90 , pp. 2188-2195
    • Maloney, D.G.1
  • 11
    • 0032530929 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of B cell lymphoma: Signaling activity on tumor cells appears more important than recruitment of effectors
    • Tutt, A. L. et al. Monoclonal antibody therapy of B cell lymphoma: signaling activity on tumor cells appears more important than recruitment of effectors. J. Immunol. 161, 3176-3185 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 3176-3185
    • Tutt, A.L.1
  • 12
    • 33745604637 scopus 로고    scopus 로고
    • Of mice and mechanisms: Identifying the role of complement in monoclonal antibody-based immunotherapy
    • Taylor, R. P. Of mice and mechanisms: identifying the role of complement in monoclonal antibody-based immunotherapy. Haematologica 91, 146a (2006).
    • (2006) Haematologica , vol.91 , pp. 146a
    • Taylor, R.P.1
  • 14
    • 58149162030 scopus 로고    scopus 로고
    • Type II (tositumomab) anti-CD20 monoclonal antibody out performs type i (rituximab-like) reagents in B-cell depletion regardless of complement activation
    • Beers, S. A. et al. Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood 112, 4170-4177 (2008).
    • (2008) Blood , vol.112 , pp. 4170-4177
    • Beers, S.A.1
  • 15
    • 0032030699 scopus 로고    scopus 로고
    • Apoptosis of malignant human B cells by ligation of CD20 monoclonal antibodies
    • Shan, D. , Ledbetter, J. A. & Press, O. W. Apoptosis of malignant human B cells by ligation of CD20 monoclonal antibodies. Blood 91, 1644-1652 (1998).
    • (1998) Blood , vol.91 , pp. 1644-1652
    • Shan, D.1    Ledbetter, J.A.2    Press, O.W.3
  • 16
    • 0037082469 scopus 로고    scopus 로고
    • The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism
    • Pedersen, I. M. , Buhl, A. M. , Klausen, P. , Geisler, C. H. & Jurlander, J. The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism. Blood 99, 1314-1319 (2002).
    • (2002) Blood , vol.99 , pp. 1314-1319
    • Pedersen, I.M.1    Buhl, A.M.2    Klausen, P.3    Geisler, C.H.4    Jurlander, J.5
  • 17
    • 77950332103 scopus 로고    scopus 로고
    • Rituximab: Mechanism of action
    • Weiner, G. J. Rituximab: mechanism of action. Semin. Hematol. 47, 115-123 (2010).
    • (2010) Semin. Hematol. , vol.47 , pp. 115-123
    • Weiner, G.J.1
  • 18
    • 0034104375 scopus 로고    scopus 로고
    • Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells
    • Shan, D. , Ledbetter, J. A. & Press, O. W. Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells. Cancer Immunol. Immunother. 48, 673-683 (2000).
    • (2000) Cancer Immunol. Immunother. , vol.48 , pp. 673-683
    • Shan, D.1    Ledbetter, J.A.2    Press, O.W.3
  • 19
    • 84921377658 scopus 로고    scopus 로고
    • Targeting HER2 for the treatment of breast cancer
    • Rimawi, M. F. , Schiff, R. & Osborne, C. K. Targeting HER2 for the treatment of breast cancer. Annu. Rev. Med. 66, 111-128 (2015).
    • (2015) Annu. Rev. Med. , vol.66 , pp. 111-128
    • Rimawi, M.F.1    Schiff, R.2    Osborne, C.K.3
  • 20
    • 84905817234 scopus 로고    scopus 로고
    • Strategies to overcome trastuzumab resistance in HER2-overexpressing breast cancers: Focus on new data from clinical trials
    • Lavaud, P. & Andre, F. Strategies to overcome trastuzumab resistance in HER2-overexpressing breast cancers: focus on new data from clinical trials. BMC Med. 12, 132 (2014).
    • (2014) BMC Med. , vol.12 , pp. 132
    • Lavaud, P.1    Andre, F.2
  • 22
    • 84864367360 scopus 로고    scopus 로고
    • The ERBB network: At last, cancer therapy meets systems biology
    • Yarden, Y. & Pines, G. The ERBB network: at last, cancer therapy meets systems biology. Nature Rev. Cancer 12, 553-563 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 553-563
    • Yarden, Y.1    Pines, G.2
  • 23
    • 1842605531 scopus 로고    scopus 로고
    • Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
    • Franklin, M. C. et al. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 5, 317-328 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 317-328
    • Franklin, M.C.1
  • 24
    • 0034235598 scopus 로고    scopus 로고
    • Differential signaling by an anti-p185HER2 antibody and heregulin
    • Le, X. F. et al. Differential signaling by an anti-p185HER2 antibody and heregulin. Cancer Res. 60, 3522-3531 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 3522-3531
    • Le, X.F.1
  • 25
    • 84876970810 scopus 로고    scopus 로고
    • Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, Phase 3 study
    • Swain, S. M. et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, Phase 3 study. Lancet Oncol. 14, 461-471 (2013).
    • (2013) Lancet Oncol. , vol.14 , pp. 461-471
    • Swain, S.M.1
  • 26
    • 85025410832 scopus 로고
    • Snake venom in relation to haemolysis, bacteriolysis, and toxicity
    • Flexner, S. & Noguchi, H. Snake venom in relation to haemolysis, bacteriolysis, and toxicity. J. Exp. Med. 6, 277-301 (1902).
    • (1902) J. Exp. Med. , vol.6 , pp. 277-301
    • Flexner, S.1    Noguchi, H.2
  • 27
    • 45549086969 scopus 로고    scopus 로고
    • Complement and cellular cytotoxicity in antibody therapy of cancer
    • Wang, S. Y. & Weiner, G. Complement and cellular cytotoxicity in antibody therapy of cancer. Expert Opin. Biol. Ther. 8, 759-768 (2008).
    • (2008) Expert Opin. Biol. Ther. , vol.8 , pp. 759-768
    • Wang, S.Y.1    Weiner, G.2
  • 28
    • 33745324686 scopus 로고    scopus 로고
    • The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
    • Teeling, J. L. et al. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J. Immunol. 177, 362-371 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 362-371
    • Teeling, J.L.1
  • 29
    • 79955979273 scopus 로고    scopus 로고
    • Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies
    • Alduaij, W. et al. Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies. Blood 117, 4519-4529 (2011).
    • (2011) Blood , vol.117 , pp. 4519-4529
    • Alduaij, W.1
  • 30
    • 70649095045 scopus 로고    scopus 로고
    • Engineered anti-CD20 antibodies with enhanced complement-activating capacity mediate potent anti-lymphoma activity
    • Natsume, A. , Shimizu-Yokoyama, Y. , Satoh, M. , Shitara, K. & Niwa, R. Engineered anti-CD20 antibodies with enhanced complement-activating capacity mediate potent anti-lymphoma activity. Cancer Sci. 100, 2411-2418 (2009).
    • (2009) Cancer Sci. , vol.100 , pp. 2411-2418
    • Natsume, A.1    Shimizu-Yokoyama, Y.2    Satoh, M.3    Shitara, K.4    Niwa, R.5
  • 31
    • 77951561987 scopus 로고    scopus 로고
    • Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity
    • Mossner, E. et al. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity. Blood 115, 4393-4402 (2010).
    • (2010) Blood , vol.115 , pp. 4393-4402
    • Mossner, E.1
  • 32
    • 68949129063 scopus 로고    scopus 로고
    • Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): Considerably higher levels of CDC are induced by OFA than by RTX
    • Pawluczkowycz, A. W. et al. Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX. J. Immunol. 183, 749-758 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 749-758
    • Pawluczkowycz, A.W.1
  • 33
    • 80053080677 scopus 로고    scopus 로고
    • Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells
    • Beum, P. V. et al. Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells. J. Immunol. 187, 3438-3447 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 3438-3447
    • Beum, P.V.1
  • 34
    • 73949123455 scopus 로고    scopus 로고
    • Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model
    • Wang, S. Y. et al. Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model. Blood 114, 5322-5330 (2009).
    • (2009) Blood , vol.114 , pp. 5322-5330
    • Wang, S.Y.1
  • 35
    • 3042743884 scopus 로고    scopus 로고
    • Rituximab-dependent cytotoxicity by natural killer cells: Influence of FCGR3A polymorphism on the concentration-effect relationship
    • Dall'Ozzo, S. et al. Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship. Cancer Res. 64, 4664-4669 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4664-4669
    • Dall'ozzo, S.1
  • 36
    • 33747880652 scopus 로고    scopus 로고
    • Ex vivo-activated human macrophages kill chronic lymphocytic leukemia cells in the presence of rituximab: Mechanism of antibody-dependent cellular cytotoxicity and impact of human serum
    • Lefebvre, M. L. , Krause, S. W. , Salcedo, M. & Nardin, A. Ex vivo-activated human macrophages kill chronic lymphocytic leukemia cells in the presence of rituximab: mechanism of antibody-dependent cellular cytotoxicity and impact of human serum. J. Immunother. 29, 388-397 (2006).
    • (2006) J. Immunother. , vol.29 , pp. 388-397
    • Lefebvre, M.L.1    Krause, S.W.2    Salcedo, M.3    Nardin, A.4
  • 37
    • 0347447283 scopus 로고    scopus 로고
    • Neutrophils contribute to the biological antitumor activity of rituximab in a non-Hodgkin's lymphoma severe combined immunodeficiency mouse model
    • Hernandez-Ilizaliturri, F. J. et al. Neutrophils contribute to the biological antitumor activity of rituximab in a non-Hodgkin's lymphoma severe combined immunodeficiency mouse model. Clin. Cancer Res. 9, 5866-5873 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5866-5873
    • Hernandez-Ilizaliturri, F.J.1
  • 38
    • 84888234973 scopus 로고    scopus 로고
    • Neutrophils: "neu players" in antibody therapy
    • Beers, S. A. & Glennie, M. J. Neutrophils: "neu players" in antibody therapy? Blood 122, 3093-3094 (2013).
    • (2013) Blood , vol.122 , pp. 3093-3094
    • Beers, S.A.1    Glennie, M.J.2
  • 39
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes, R. A. , Towers, T. L. , Presta, L. G. & Ravetch, J. V. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nature Med. 6, 443-446 (2000).
    • (2000) Nature Med. , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 40
    • 24344468297 scopus 로고    scopus 로고
    • CD16 polymorphisms and NK activation induced by monoclonal antibody-coated target cells
    • Bowles, J. A. & Weiner, G. J. CD16 polymorphisms and NK activation induced by monoclonal antibody-coated target cells. J. Immunol. Methods 304, 88-99 (2005).
    • (2005) J. Immunol. Methods , vol.304 , pp. 88-99
    • Bowles, J.A.1    Weiner, G.J.2
  • 41
    • 0030783298 scopus 로고    scopus 로고
    • The high-affinity FcRI on PMN: Regulation of expression and signal transduction
    • Hoffmeyer, F. , Witte, K. & Schmidt, R. E. The high-affinity FcRI on PMN: regulation of expression and signal transduction. Immunology 92, 544-552 (1997).
    • (1997) Immunology , vol.92 , pp. 544-552
    • Hoffmeyer, F.1    Witte, K.2    Schmidt, R.E.3
  • 42
    • 34548221347 scopus 로고    scopus 로고
    • Mechanisms of killing by anti-CD20 monoclonal antibodies
    • Glennie, M. J. , French, R. R. , Cragg, M. S. & Taylor, R. P. Mechanisms of killing by anti-CD20 monoclonal antibodies. Mol. Immunol. 44, 3823-3837 (2007).
    • (2007) Mol. Immunol. , vol.44 , pp. 3823-3837
    • Glennie, M.J.1    French, R.R.2    Cragg, M.S.3    Taylor, R.P.4
  • 43
    • 84905749267 scopus 로고    scopus 로고
    • Complement in monoclonal antibody therapy of cancer
    • Rogers, L. M. , Veeramani, S. & Weiner, G. J. Complement in monoclonal antibody therapy of cancer. Immunol. Res. 59, 203-210 (2014).
    • (2014) Immunol. Res. , vol.59 , pp. 203-210
    • Rogers, L.M.1    Veeramani, S.2    Weiner, G.J.3
  • 44
    • 38949121647 scopus 로고    scopus 로고
    • NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement
    • Wang, S. Y. , Racila, E. , Taylor, R. P. & Weiner, G. J. NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement. Blood 111, 1456-1463 (2008).
    • (2008) Blood , vol.111 , pp. 1456-1463
    • Wang, S.Y.1    Racila, E.2    Taylor, R.P.3    Weiner, G.J.4
  • 45
    • 34248213007 scopus 로고    scopus 로고
    • Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance
    • Harbers, S. O. et al. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J. Clin. Invest. 117, 1361-1369 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 1361-1369
    • Harbers, S.O.1
  • 46
    • 84894078151 scopus 로고    scopus 로고
    • Inhibitory FcRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity
    • Vaughan A.T.et al. Inhibitory FcRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity. Blood 123, 669-677 (2014).
    • (2014) Blood , vol.123 , pp. 669-677
    • Vaughan, A.T.1
  • 47
    • 0034682589 scopus 로고    scopus 로고
    • Trastuzumab in the treatment of metastatic breast cancer: Anticancer therapy versus cardiotoxicity
    • Feldman, A. M. , Lorell, B. H. & Reis, S. E. Trastuzumab in the treatment of metastatic breast cancer: anticancer therapy versus cardiotoxicity. Circulation 102, 272-274 (2000).
    • (2000) Circulation , vol.102 , pp. 272-274
    • Feldman, A.M.1    Lorell, B.H.2    Reis, S.E.3
  • 48
    • 0018971622 scopus 로고
    • Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen
    • Nadler, L. M. et al. Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res. 40, 3147-3154 (1980).
    • (1980) Cancer Res. , vol.40 , pp. 3147-3154
    • Nadler, L.M.1
  • 49
    • 84896539427 scopus 로고    scopus 로고
    • HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design
    • de Goeij, B. E. et al. HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design. mAbs 6, 392-402 (2014).
    • (2014) MAbs , vol.6 , pp. 392-402
    • De Goeij, B.E.1
  • 50
    • 33750622479 scopus 로고    scopus 로고
    • Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab
    • Bowles, J. A. et al. Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab. Blood 108, 2648-2654. (2006).
    • (2006) Blood , vol.108 , pp. 2648-2648
    • Bowles, J.A.1
  • 51
    • 78751564397 scopus 로고    scopus 로고
    • Preclinical studies on the mechanism of action and the anti-lymphoma activity of the novel anti-CD20 antibody GA101. Mol
    • Dalle, S. et al. Preclinical studies on the mechanism of action and the anti-lymphoma activity of the novel anti-CD20 antibody GA101. Mol. Cancer Ther. 10, 178-185 (2011).
    • (2011) Cancer Ther. , vol.10 , pp. 178-185
    • Dalle, S.1
  • 52
    • 84861835530 scopus 로고    scopus 로고
    • Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients
    • Salles, G. et al. Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients. Blood 119, 5126-5132 (2012).
    • (2012) Blood , vol.119 , pp. 5126-5132
    • Salles, G.1
  • 53
    • 84907698941 scopus 로고    scopus 로고
    • Obinutuzumab (GA101) in relapsed/ refractory chronic lymphocytic leukemia: Final data from the Phase 1/2 GAUGUIN study
    • Cartron, G. et al. Obinutuzumab (GA101) in relapsed/ refractory chronic lymphocytic leukemia: final data from the Phase 1/2 GAUGUIN study. Blood 124, 2196-2202 (2014).
    • (2014) Blood , vol.124 , pp. 2196-2202
    • Cartron, G.1
  • 54
    • 79953220116 scopus 로고    scopus 로고
    • Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing
    • Lohse, S. et al. Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing. J. Immunol. 186, 3770-3778 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 3770-3778
    • Lohse, S.1
  • 55
    • 84886943480 scopus 로고    scopus 로고
    • Approaching untargetable tumor-associated antigens with antibodies
    • Dao, T. , Liu, C. & Scheinberg, D. A. Approaching untargetable tumor-associated antigens with antibodies. Oncoimmunology 2, e24678 (2013).
    • (2013) Oncoimmunology , vol.2 , pp. e24678
    • Dao, T.1    Liu, C.2    Scheinberg, D.A.3
  • 56
    • 84903174180 scopus 로고    scopus 로고
    • A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias
    • Dubrovsky, L. et al. A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias. Blood 123, 3296-3304 (2014).
    • (2014) Blood , vol.123 , pp. 3296-3304
    • Dubrovsky, L.1
  • 57
    • 79955966609 scopus 로고    scopus 로고
    • An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells
    • Sergeeva, A. et al. An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells. Blood 117, 4262-4272 (2011).
    • (2011) Blood , vol.117 , pp. 4262-4272
    • Sergeeva, A.1
  • 58
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186 (1971).
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 59
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara, N. , Hillan, K. J. , Gerber, H. P. & Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nature Rev. Drug Discov. 3, 391-400 (2004).
    • (2004) Nature Rev. Drug Discov. , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 60
    • 84866693927 scopus 로고    scopus 로고
    • Controlling escape from angiogenesis inhibitors
    • Sennino, B. & McDonald, D. M. Controlling escape from angiogenesis inhibitors. Nature Rev. Cancer 12, 699-709 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 699-709
    • Sennino, B.1    McDonald, D.M.2
  • 61
    • 79960992697 scopus 로고    scopus 로고
    • Addition of bevacizumab to chemotherapy in advanced non-small cell lung cancer: A systematic review and meta-analysis
    • Lima, A. B. , Macedo, L. T. & Sasse, A. D. Addition of bevacizumab to chemotherapy in advanced non-small cell lung cancer: a systematic review and meta-analysis. PLoS ONE 6, e22681 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e22681
    • Lima, A.B.1    Macedo, L.T.2    Sasse, A.D.3
  • 62
    • 77951625266 scopus 로고    scopus 로고
    • Updated response assessment criteria for high-grade gliomas: Response assessment in neuro-oncology working group
    • Wen, P. Y. et al. Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J. Clin. Oncol. 28, 1963-1972 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1963-1972
    • Wen, P.Y.1
  • 64
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nature Rev. Cancer 12, 252-264 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 66
    • 33644659256 scopus 로고    scopus 로고
    • Principles and use of anti-CTLA4 antibody in human cancer immunotherapy
    • Peggs, K. S. , Quezada, S. A. , Korman, A. J. & Allison, J. P. Principles and use of anti-CTLA4 antibody in human cancer immunotherapy. Curr. Opin. Immunol. 18, 206-213 (2006).
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 206-213
    • Peggs, K.S.1    Quezada, S.A.2    Korman, A.J.3    Allison, J.P.4
  • 67
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi, F. S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1
  • 68
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert, C. et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364, 2517-2526 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2517-2526
    • Robert, C.1
  • 70
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer, J. R. et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366, 2455-2465 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1
  • 71
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a Phase 1 trial
    • Robert, C. et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a Phase 1 trial. Lancet 384, 1109-1117 (2014).
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1
  • 72
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok, J. D. et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369, 122-133 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 122-133
    • Wolchok, J.D.1
  • 73
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 74
    • 84925221855 scopus 로고    scopus 로고
    • PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
    • Ansell, S. M. et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N. Engl. J. Med. 372, 311-319 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 311-319
    • Ansell, S.M.1
  • 75
    • 0016900126 scopus 로고
    • The history and progress of serologic immunotherapy and radiodiagnosis
    • Order, S. E. The history and progress of serologic immunotherapy and radiodiagnosis. Radiology 118, 219-223 (1976).
    • (1976) Radiology , vol.118 , pp. 219-223
    • Order, S.E.1
  • 76
    • 84929917515 scopus 로고
    • Radiolabeled antibody in the treatment of primary and metastatic liver malignancies
    • Order, S. E. et al. Radiolabeled antibody in the treatment of primary and metastatic liver malignancies. Recent Results Cancer Res. 1986, 100307-100314 (1986).
    • (1986) Recent Results Cancer Res. 1986 , pp. 100307-100314
    • Order, S.E.1
  • 77
    • 82555170240 scopus 로고    scopus 로고
    • Clinical radioimmunotherapy-The role of radiobiology
    • Pouget, J. P. et al. Clinical radioimmunotherapy-the role of radiobiology. Nature Rev. Clin. Oncol. 8, 720-734 (2011).
    • (2011) Nature Rev. Clin. Oncol. , vol.8 , pp. 720-734
    • Pouget, J.P.1
  • 78
    • 33947385483 scopus 로고    scopus 로고
    • Optimization of radioimmunotherapy of solid tumors: Biological impediments and their modulation
    • Jain, M. , Venkatraman, G. & Batra, S. K. Optimization of radioimmunotherapy of solid tumors: biological impediments and their modulation. Clin. Cancer Res. 13, 1374-1382 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1374-1382
    • Jain, M.1    Venkatraman, G.2    Batra, S.K.3
  • 79
    • 20144363581 scopus 로고    scopus 로고
    • Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer
    • Chen, S. et al. Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer. J. Clin. Oncol. 23, 1538-1547 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1538-1547
    • Chen, S.1
  • 80
    • 0037093241 scopus 로고    scopus 로고
    • Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma
    • Witzig, T. E. et al. Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma. J. Clin. Oncol. 20, 2453-2463 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2453-2463
    • Witzig, T.E.1
  • 81
    • 0027208577 scopus 로고
    • Radioimmunotherapy of B-cell lymphoma with 131I anti-B1 (anti-CD20) antibody
    • Kaminski, M. S. et al. Radioimmunotherapy of B-cell lymphoma with 131I anti-B1 (anti-CD20) antibody. N. Engl. J. Med. 329, 459-465 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , pp. 459-465
    • Kaminski, M.S.1
  • 82
    • 84900442345 scopus 로고    scopus 로고
    • Nordic MCL3 study: 90Y-ibritumomab-tiuxetan added to BEAM/C in non-CR patients before transplant in mantle cell lymphoma
    • Kolstad, A. et al. Nordic MCL3 study: 90Y-ibritumomab-tiuxetan added to BEAM/C in non-CR patients before transplant in mantle cell lymphoma. Blood 123, 2953-2959 (2014).
    • (2014) Blood , vol.123 , pp. 2953-2959
    • Kolstad, A.1
  • 83
    • 84929886657 scopus 로고    scopus 로고
    • A Phase i trial of immunostimulatory CpG 7909 oligodeoxynucleotide and yttrium ibritumomab tiuxetan radioimmunotherapy for relapsed B-cell non-Hodgkin lymphoma
    • Witzig, T. E. et al. A Phase I trial of immunostimulatory CpG 7909 oligodeoxynucleotide and yttrium ibritumomab tiuxetan radioimmunotherapy for relapsed B-cell non-Hodgkin lymphoma. Am. J. Hematol. 53, 211-217 (2012).
    • (2012) Am. J. Hematol. , vol.53 , pp. 211-217
    • Witzig, T.E.1
  • 84
    • 79953828095 scopus 로고    scopus 로고
    • Can radioimmunotherapy increase efficacy for the systemic control of cancer?
    • Allen, B. J. Can radioimmunotherapy increase efficacy for the systemic control of cancer? Immunotherapy 3, 455-458 (2011).
    • (2011) Immunotherapy , vol.3 , pp. 455-458
    • Allen, B.J.1
  • 85
    • 79959430516 scopus 로고    scopus 로고
    • Astatine-211: Production and availability
    • Zalutsky, M. R. & Pruszynski, M. Astatine-211: production and availability. Curr. Radiopharm. 4, 177-185 (2011).
    • (2011) Curr. Radiopharm. , vol.4 , pp. 177-185
    • Zalutsky, M.R.1    Pruszynski, M.2
  • 86
    • 80052230219 scopus 로고    scopus 로고
    • Actinium-225 in targeted particle therapeutic applications
    • Scheinberg, D. A. & McDevitt, M. R. Actinium-225 in targeted particle therapeutic applications. Curr. Radiopharm. 4, 306-320 (2011).
    • (2011) Curr. Radiopharm. , vol.4 , pp. 306-320
    • Scheinberg, D.A.1    McDevitt, M.R.2
  • 87
    • 0028062734 scopus 로고
    • Immunotoxins in the therapy of cancer: From bench to clinic
    • Ghetie, V. & Vitetta, E. Immunotoxins in the therapy of cancer: from bench to clinic. Pharmacol. Ther. 63, 209-234 (1994).
    • (1994) Pharmacol. Ther. , vol.63 , pp. 209-234
    • Ghetie, V.1    Vitetta, E.2
  • 89
    • 84946208600 scopus 로고    scopus 로고
    • Picking the optimal target for antibody-drug conjugates
    • Mathur, R. & Weiner, G. J. Picking the optimal target for antibody-drug conjugates. American Society of Clinical Oncology [online], http://meetinglibrary. asco. org/content/17-132 (2013).
    • (2013) American Society of Clinical Oncology
    • Mathur, R.1    Weiner, G.J.2
  • 90
    • 0027194197 scopus 로고
    • Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: A novel and potent family of antitumor antibiotics
    • Hinman, L. M. et al. Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics. Cancer Res. 53, 3336-3342 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 3336-3342
    • Hinman, L.M.1
  • 91
    • 0028826495 scopus 로고
    • Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications
    • Pettit, G. R. et al. Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications. Anticancer Drug Des. 10, 529-544 (1995).
    • (1995) Anticancer Drug Des. , vol.10 , pp. 529-544
    • Pettit, G.R.1
  • 92
    • 0015520389 scopus 로고
    • Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus
    • Kupchan, S. M. et al. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. J. Am. Chem. Soc. 94, 1354-1356 (1972).
    • (1972) J. Am. Chem. Soc. , vol.94 , pp. 1354-1356
    • Kupchan, S.M.1
  • 93
    • 0036055430 scopus 로고    scopus 로고
    • Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents
    • Cooper, N. et al. Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents. Chem. Commun. 21, 1764-1765 (2002).
    • (2002) Chem. Commun. , vol.21 , pp. 1764-1765
    • Cooper, N.1
  • 94
    • 84873053339 scopus 로고    scopus 로고
    • Antibody-drug conjugates in cancer therapy
    • Sievers, E. L. & Senter, P. D. Antibody-drug conjugates in cancer therapy. Annu. Rev. Med. 64, 15-29 (2013).
    • (2013) Annu. Rev. Med. , vol.64 , pp. 15-29
    • Sievers, E.L.1    Senter, P.D.2
  • 95
    • 84863012529 scopus 로고    scopus 로고
    • Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
    • Shen, B. Q. et al. Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Nature Biotech. 30, 184-189 (2012).
    • (2012) Nature Biotech. , vol.30 , pp. 184-189
    • Shen, B.Q.1
  • 96
    • 84863676500 scopus 로고    scopus 로고
    • Results of a pivotal Phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma
    • Younes, A. et al. Results of a pivotal Phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. J. Clin. Oncol. 30, 2183-2189 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2183-2189
    • Younes, A.1
  • 97
    • 84923319448 scopus 로고    scopus 로고
    • Durable remissions in a pivotal Phase 2 study of brentuximab vedotin in relapsed or refractory Hodgkin lymphoma
    • Gopal, A. K. et al. Durable remissions in a pivotal Phase 2 study of brentuximab vedotin in relapsed or refractory Hodgkin lymphoma. Blood 125, 1236-1243 (2015).
    • (2015) Blood , vol.125 , pp. 1236-1243
    • Gopal, A.K.1
  • 98
    • 84868520609 scopus 로고    scopus 로고
    • Trastuzumab emtansine for HER2-positive advanced breast cancer
    • Verma, S. et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N. Engl. J. Med. 367, 1783-1791 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1783-1791
    • Verma, S.1
  • 99
    • 84877310777 scopus 로고    scopus 로고
    • Maturing antibody-drug conjugate pipeline hits 30
    • Mullard, A. Maturing antibody-drug conjugate pipeline hits 30. Nature Rev. Drug Discov. 12, 329-332 (2013).
    • (2013) Nature Rev. Drug Discov. , vol.12 , pp. 329-332
    • Mullard, A.1
  • 100
    • 84911872687 scopus 로고    scopus 로고
    • Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with locally advanced or metastatic breast cancer
    • Bendell, J. et al. Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with locally advanced or metastatic breast cancer. J. Clin. Oncol. 32, 3619-3625 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 3619-3625
    • Bendell, J.1
  • 101
    • 84911933928 scopus 로고    scopus 로고
    • Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with advanced melanoma
    • Ott, P. A. et al. Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with advanced melanoma. J. Clin. Oncol. 32, 3659-3666 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 3659-3666
    • Ott, P.A.1
  • 102
    • 77957341503 scopus 로고    scopus 로고
    • Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
    • Yu, A. L. et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N. Engl. J. Med. 363, 1324-1334 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1324-1334
    • Yu, A.L.1
  • 103
    • 79951886003 scopus 로고    scopus 로고
    • Antitumor activity of hu14. 18-IL2 in patients with relapsed/refractory neuroblastoma: A Children's Oncology Group (COG) Phase II study
    • Shusterman, S. et al. Antitumor activity of hu14. 18-IL2 in patients with relapsed/refractory neuroblastoma: a Children's Oncology Group (COG) Phase II study. J. Clin. Oncol. 28, 4969-4975 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4969-4975
    • Shusterman, S.1
  • 104
    • 84902962349 scopus 로고    scopus 로고
    • Phase i trial of a novel anti-GD2 monoclonal antibody, Hu14. 18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma
    • Navid, F. et al. Phase I trial of a novel anti-GD2 monoclonal antibody, Hu14. 18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma. J. Clin. Oncol. 32, 1445-1452 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1445-1452
    • Navid, F.1
  • 106
    • 68449086890 scopus 로고    scopus 로고
    • Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab
    • Nagorsen, D. et al. Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab. Leukemia Lymphoma 50, 886-891 (2009).
    • (2009) Leukemia Lymphoma , vol.50 , pp. 886-891
    • Nagorsen, D.1
  • 107
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • Topp, M. S. et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J. Clin. Oncol. 29, 2493-2498 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2493-2498
    • Topp, M.S.1
  • 110
    • 84923019006 scopus 로고    scopus 로고
    • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A Phase 1 dose-escalation trial
    • Lee, D. W. et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a Phase 1 dose-escalation trial. Lancet 385, 517-528 (2014).
    • (2014) Lancet , vol.385 , pp. 517-528
    • Lee, D.W.1
  • 111
    • 84908073316 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells for sustained remissions in leukemia
    • Maude, S. L. et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N. Engl. J. Med. 371, 1507-1517 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 1507-1517
    • Maude, S.L.1
  • 112
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos, M. et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci. Transl Med. 3, 95ra73 (2011).
    • (2011) Sci. Transl Med. , vol.3 , pp. 95ra73
    • Kalos, M.1
  • 113
    • 84897568616 scopus 로고    scopus 로고
    • Managing cytokine release syndrome associated with novel T cell-engaging therapies
    • Maude, S. L. , Barrett, D. , Teachey, D. T. & Grupp, S. A. Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J. 20, 119-122 (2014).
    • (2014) Cancer J. , vol.20 , pp. 119-122
    • Maude, S.L.1    Barrett, D.2    Teachey, D.T.3    Grupp, S.A.4
  • 114
    • 84908138667 scopus 로고    scopus 로고
    • CAR-T cell therapy seeks strategies to harness cytokine storm
    • DeFrancesco, L. CAR-T cell therapy seeks strategies to harness cytokine storm. Nature Biotech. 32, 604 (2014).
    • (2014) Nature Biotech. , vol.32 , pp. 604
    • Defrancesco, L.1


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