메뉴 건너뛰기




Volumn 17, Issue 10, 2017, Pages 889-904

Anti-GD2 immunotherapy for neuroblastoma

Author keywords

adoptive immunotherapy; anti cancer vaccines; GD2; immunotherapy; monoclonal antibodies; Neuroblastoma

Indexed keywords

ANTINEOPLASTIC AGENT; DINUTUXIMAB; GANGLIOSIDE GD2; IMMUNOCYTOKINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 14.G2A; MONOCLONAL ANTIBODY GD2; MONOCLONAL ANTIBODY HU14.18K322A; MONOCLONAL ANTIBODY HU3F8; MONOCLONAL ANTIBODY M3F8; UNCLASSIFIED DRUG; VACCINE; CANCER VACCINE; GANGLIOSIDE; GANGLIOSIDE, GD2;

EID: 85029419547     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1080/14737140.2017.1364995     Document Type: Review
Times cited : (139)

References (121)
  • 2
    • 58249093955 scopus 로고    scopus 로고
    • The International Neuroblastoma Risk Group (INRG) classification system: an INRG task force report
    • Cohn SL, Pearson AD, London WB, et al. The International Neuroblastoma Risk Group (INRG) classification system:an INRG task force report. J Clin Oncol. 2009;27(2):289-297.
    • (2009) J Clin Oncol
    • Cohn, S.L.1    Pearson, A.D.2    London, W.B.3
  • 3
    • 77957341503 scopus 로고    scopus 로고
    • Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
    • Yu AL, Gilman AL, Ozkaynak MF, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363(14):1324–1334.•• This seminal randomized clinical trial conducted by the COG established anti-GD2 mAb therapy as the new standard of care for high-risk neuroblastoma.
    • (2010) N Engl J Med , vol.363 , Issue.14 , pp. 1324-1334
    • Yu, A.L.1    Gilman, A.L.2    Ozkaynak, M.F.3
  • 4
    • 84866623753 scopus 로고    scopus 로고
    • Murine anti-GD2 monoclonal antibody 3F8 combined with granulocyte-macrophage colony-stimulating factor and 13-cis-retinoic acid in high-risk patients with stage 4 neuroblastoma in first remission
    • Cheung NK, Cheung IY, Kushner BH, et al. Murine anti-GD2 monoclonal antibody 3F8 combined with granulocyte-macrophage colony-stimulating factor and 13-cis-retinoic acid in high-risk patients with stage 4 neuroblastoma in first remission. J Clin Oncol. 2012;30(26):3264–3270.•• A summary of consecutive clinical trials of anti-GD2 mAb 3F8 conducted at MSKCC over 20 years and its curative potential.
    • (2012) J Clin Oncol , vol.30 , Issue.26 , pp. 3264-3270
    • Cheung, N.K.1    Cheung, I.Y.2    Kushner, B.H.3
  • 5
    • 84883055940 scopus 로고    scopus 로고
    • Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial
    • Kreissman SG, Seeger RC, Matthay KK, et al. Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973):a randomised phase 3 trial. Lancet Oncol. 2013;14(10):999–1008.
    • (2013) Lancet Oncol , vol.14 , Issue.10 , pp. 999-1008
    • Kreissman, S.G.1    Seeger, R.C.2    Matthay, K.K.3
  • 6
    • 40749114771 scopus 로고    scopus 로고
    • High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial
    • Pearson AD, Pinkerton CR, Lewis IJ, et al. High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma:a randomised trial. Lancet Oncol. 2008;9(3):247–256.
    • (2008) Lancet Oncol , vol.9 , Issue.3 , pp. 247-256
    • Pearson, A.D.1    Pinkerton, C.R.2    Lewis, I.J.3
  • 7
    • 77953024995 scopus 로고    scopus 로고
    • Neuroblastoma: therapeutic strategies for a clinical enigma
    • Modak S, Cheung NK., Neuroblastoma:therapeutic strategies for a clinical enigma. Cancer Treat Rev. 2010;36(4):307–317.
    • (2010) Cancer Treat Rev , vol.36 , Issue.4 , pp. 307-317
    • Modak, S.1    Cheung, N.K.2
  • 8
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature. 2013;500(7463):415–421.
    • (2013) Nature , vol.500 , Issue.7463 , pp. 415-421
    • Alexandrov, L.B.1    Nik-Zainal, S.2    Wedge, D.C.3
  • 9
    • 84923090047 scopus 로고    scopus 로고
    • Disialoganglioside GD2 as a therapeutic target for human diseases
    • Suzuki M, Cheung NK., Disialoganglioside GD2 as a therapeutic target for human diseases. Expert Opin Ther Targets. 2015;19(3):349–362.
    • (2015) Expert Opin Ther Targets , vol.19 , Issue.3 , pp. 349-362
    • Suzuki, M.1    Cheung, N.K.2
  • 10
    • 79958114113 scopus 로고    scopus 로고
    • Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells
    • Yanagisawa M, Yoshimura S, Yu RK. Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells. ASN Neuro. 2011;3(2).
    • (2011) ASN Neuro , vol.3 , Issue.2
    • Yanagisawa, M.1    Yoshimura, S.2    Yu, R.K.3
  • 11
    • 0027503907 scopus 로고
    • Ganglioside GD2 expression in the human nervous system and in neuroblastomas–an immunohistochemical study
    • Lammie GA, Cheung NKV, Gerald W, et al. Ganglioside GD2 expression in the human nervous system and in neuroblastomas–an immunohistochemical study. Int J Oncol. 1993;3:909–915.• This study demonstrated high GD2 expression on neuroblastoma tumors with restricted expression in the CNS and provided the basis for the investigation of anti-GD2 therapy using antibody 3F8.
    • (1993) Int J Oncol , vol.3 , pp. 909-915
    • Lammie, G.A.1    Cheung, N.K.V.2    Gerald, W.3
  • 12
    • 0029810887 scopus 로고    scopus 로고
    • Genomic organization and chromosomal assignment of the human beta1, 4-N-acetylgalactosaminyltransferase gene. Identification of multiple transcription units
    • Furukawa K, Soejima H, Niikawa N, et al. Genomic organization and chromosomal assignment of the human beta1, 4-N-acetylgalactosaminyltransferase gene. Identification of multiple transcription units. J Biol Chem. 1996;271(34):20836–20844.
    • (1996) J Biol Chem , vol.271 , Issue.34 , pp. 20836-20844
    • Furukawa, K.1    Soejima, H.2    Niikawa, N.3
  • 13
    • 0022559676 scopus 로고
    • Expression of GD2 ganglioside by untreated primary human neuroblastomas
    • Wu Z, Schwartz E, Seeger RC, et al. Expression of GD2 ganglioside by untreated primary human neuroblastomas. Cancer Res. 1986;46:440–443.
    • (1986) Cancer Res , vol.46 , pp. 440-443
    • Wu, Z.1    Schwartz, E.2    Seeger, R.C.3
  • 14
    • 84862896968 scopus 로고    scopus 로고
    • Essential roles of gangliosides in the formation and maintenance of membrane microdomains in brain tissues
    • Ohmi Y, Ohkawa Y, Yamauchi Y, et al. Essential roles of gangliosides in the formation and maintenance of membrane microdomains in brain tissues. Neurochem Res. 2012;37(6):1185–1191.
    • (2012) Neurochem Res , vol.37 , Issue.6 , pp. 1185-1191
    • Ohmi, Y.1    Ohkawa, Y.2    Yamauchi, Y.3
  • 15
    • 0031787323 scopus 로고    scopus 로고
    • Attachment of nontypable Haemophilus influenzae to human pharyngeal epithelial cells mediated by a ganglioside receptor
    • Kawakami K, Ahmed K, Utsunomiya Y, et al. Attachment of nontypable Haemophilus influenzae to human pharyngeal epithelial cells mediated by a ganglioside receptor. Microbiol Immunol. 1998;42(10):697–702.
    • (1998) Microbiol Immunol , vol.42 , Issue.10 , pp. 697-702
    • Kawakami, K.1    Ahmed, K.2    Utsunomiya, Y.3
  • 16
    • 0022458959 scopus 로고
    • Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins
    • Cheresh DA, Pierschbacher MD, Herzig MA, et al. Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins. J Cell Biol. 1986;102:688.
    • (1986) J Cell Biol , vol.102 , pp. 688
    • Cheresh, D.A.1    Pierschbacher, M.D.2    Herzig, M.A.3
  • 17
    • 84861801520 scopus 로고    scopus 로고
    • Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis
    • Battula VL, Shi Y, Evans KW, et al. Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest. 2012;122(6):2066–2078.
    • (2012) J Clin Invest , vol.122 , Issue.6 , pp. 2066-2078
    • Battula, V.L.1    Shi, Y.2    Evans, K.W.3
  • 18
    • 84923082345 scopus 로고    scopus 로고
    • How do gangliosides regulate RTKs signaling?
    • Julien S, Bobowski M, Steenackers A, et al. How do gangliosides regulate RTKs signaling? Cells. 2013;2(4):751–767.
    • (2013) Cells , vol.2 , Issue.4 , pp. 751-767
    • Julien, S.1    Bobowski, M.2    Steenackers, A.3
  • 19
    • 84865713189 scopus 로고    scopus 로고
    • Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3
    • Shibuya H, Hamamura K, Hotta H, et al. Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3. Cancer Sci. 2012;103(9):1656–1664.
    • (2012) Cancer Sci , vol.103 , Issue.9 , pp. 1656-1664
    • Shibuya, H.1    Hamamura, K.2    Hotta, H.3
  • 20
    • 84907495445 scopus 로고    scopus 로고
    • Gangliosides drive the tumor infiltration and function of myeloid-derived suppressor cells
    • Wondimu A, Liu Y, Su Y, et al. Gangliosides drive the tumor infiltration and function of myeloid-derived suppressor cells. Cancer Res. 2014;74(19):5449–5457.
    • (2014) Cancer Res , vol.74 , Issue.19 , pp. 5449-5457
    • Wondimu, A.1    Liu, Y.2    Su, Y.3
  • 21
    • 0028286056 scopus 로고
    • Ganglioside conjugate vaccines. Immunotherapy against tumors of neuroectodermal origin
    • Helling F, Livingston PO. Ganglioside conjugate vaccines. Immunotherapy against tumors of neuroectodermal origin. Mol Chem Neuropathol. 1994;21(2–3):299–309.
    • (1994) Mol Chem Neuropathol , vol.21 , Issue.2-3 , pp. 299-309
    • Helling, F.1    Livingston, P.O.2
  • 22
    • 84983287303 scopus 로고    scopus 로고
    • Oncotargets GD2 and GD3 are highly expressed in sarcomas of children, adolescents, and young adults
    • Dobrenkov K, Ostrovnaya I, Gu J, et al. Oncotargets GD2 and GD3 are highly expressed in sarcomas of children, adolescents, and young adults. Pediatr Blood Cancer. 2016;63(10):1780–1785.
    • (2016) Pediatr Blood Cancer , vol.63 , Issue.10 , pp. 1780-1785
    • Dobrenkov, K.1    Ostrovnaya, I.2    Gu, J.3
  • 23
    • 69049089548 scopus 로고    scopus 로고
    • The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research
    • Cheever MA, Allison JP, Ferris AS, et al. The prioritization of cancer antigens:a national cancer institute pilot project for the acceleration of translational research. Clin Cancer Res. 2009;15(17):5323–5337.
    • (2009) Clin Cancer Res , vol.15 , Issue.17 , pp. 5323-5337
    • Cheever, M.A.1    Allison, J.P.2    Ferris, A.S.3
  • 24
    • 0034746989 scopus 로고    scopus 로고
    • Disaloganglioside GD2 loss following monoclonal antibody therapy is rare in neuroblastoma
    • Kramer K, Gerald WL, Kushner BH, et al. Disaloganglioside GD2 loss following monoclonal antibody therapy is rare in neuroblastoma. Med Pediatr Oncol. 2001;36(1):194–196.
    • (2001) Med Pediatr Oncol , vol.36 , Issue.1 , pp. 194-196
    • Kramer, K.1    Gerald, W.L.2    Kushner, B.H.3
  • 25
    • 0021726250 scopus 로고
    • Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients
    • Schulz G, Cheresh DA, Varki NM, et al. Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients. Cancer Res. 1984;44:5914–5920.
    • (1984) Cancer Res , vol.44 , pp. 5914-5920
    • Schulz, G.1    Cheresh, D.A.2    Varki, N.M.3
  • 26
    • 84961392036 scopus 로고    scopus 로고
    • Dinutuximab for the treatment of pediatric patients with high-risk neuroblastoma
    • Mora J. Dinutuximab for the treatment of pediatric patients with high-risk neuroblastoma. Expert Rev Clin Pharmacol. 2016;9(5):647–653.
    • (2016) Expert Rev Clin Pharmacol , vol.9 , Issue.5 , pp. 647-653
    • Mora, J.1
  • 27
    • 0023525839 scopus 로고
    • Ganglioside GD2 specific monoclonal antibody 3F8: a phase I study in patients with neuroblastoma and malignant melanoma
    • Cheung NK, Lazarus H, Miraldi FD, et al. Ganglioside GD2 specific monoclonal antibody 3F8:a phase I study in patients with neuroblastoma and malignant melanoma. J Clin Oncol. 1987;5(9):1430–1440.
    • (1987) J Clin Oncol , vol.5 , Issue.9 , pp. 1430-1440
    • Cheung, N.K.1    Lazarus, H.2    Miraldi, F.D.3
  • 28
    • 0031686971 scopus 로고    scopus 로고
    • Anti-G(D2) antibody treatment of minimal residual stage 4 neuroblastoma diagnosed at more than 1 year of age
    • Cheung NK, Kushner BH, Cheung IY, et al. Anti-G(D2) antibody treatment of minimal residual stage 4 neuroblastoma diagnosed at more than 1 year of age. J Clin Oncol. 1998;16(9):3053–3060.
    • (1998) J Clin Oncol , vol.16 , Issue.9 , pp. 3053-3060
    • Cheung, N.K.1    Kushner, B.H.2    Cheung, I.Y.3
  • 29
    • 0035890643 scopus 로고    scopus 로고
    • Phase II trial of the anti-G(D2) monoclonal antibody 3F8 and granulocyte-macrophage colony-stimulating factor for neuroblastoma
    • Kushner BH, Kramer K, Cheung NKV. Phase II trial of the anti-G(D2) monoclonal antibody 3F8 and granulocyte-macrophage colony-stimulating factor for neuroblastoma. J Clin Oncol. 2001;19:4189–4194.
    • (2001) J Clin Oncol , vol.19 , pp. 4189-4194
    • Kushner, B.H.1    Kramer, K.2    Cheung, N.K.V.3
  • 30
    • 84906234428 scopus 로고    scopus 로고
    • Key role for myeloid cells: phase II results of anti-G(D2) antibody 3F8 plus granulocyte-macrophage colony-stimulating factor for chemoresistant osteomedullary neuroblastoma
    • Cheung NK, Cheung IY, Kramer K, et al. Key role for myeloid cells:phase II results of anti-G(D2) antibody 3F8 plus granulocyte-macrophage colony-stimulating factor for chemoresistant osteomedullary neuroblastoma. Int J Cancer Oncol. 2014;135(9):2199–2205.
    • (2014) Int J Cancer Oncol , vol.135 , Issue.9 , pp. 2199-2205
    • Cheung, N.K.1    Cheung, I.Y.2    Kramer, K.3
  • 31
    • 84923091515 scopus 로고    scopus 로고
    • Structure based refinement of a humanized monoclonal antibody that targets tumor antigen disialoganglioside GD2
    • Ahmed M, Hu J, Cheung NK. Structure based refinement of a humanized monoclonal antibody that targets tumor antigen disialoganglioside GD2. Front Immunol. 2014;5:372.
    • (2014) Front Immunol , vol.5 , pp. 372
    • Ahmed, M.1    Hu, J.2    Cheung, N.K.3
  • 32
    • 84925328665 scopus 로고    scopus 로고
    • Bone marrow minimal residual disease was an early response marker and a consistent independent predictor of survival after anti-GD2 immunotherapy
    • Cheung NK, Ostrovnaya I, Kuk D, et al. Bone marrow minimal residual disease was an early response marker and a consistent independent predictor of survival after anti-GD2 immunotherapy. J Clin Oncol. 2015;33(7):755–763.
    • (2015) J Clin Oncol , vol.33 , Issue.7 , pp. 755-763
    • Cheung, N.K.1    Ostrovnaya, I.2    Kuk, D.3
  • 33
    • 79952762286 scopus 로고    scopus 로고
    • Successful multifold dose escalation of anti-GD2 monoclonal antibody 3F8 in patients with neuroblastoma: a phase I study
    • Kushner BH, Kramer K, Modak S, et al. Successful multifold dose escalation of anti-GD2 monoclonal antibody 3F8 in patients with neuroblastoma:a phase I study. J Clin Oncol. 2011;29(9):1168–1174.
    • (2011) J Clin Oncol , vol.29 , Issue.9 , pp. 1168-1174
    • Kushner, B.H.1    Kramer, K.2    Modak, S.3
  • 34
    • 84886945545 scopus 로고    scopus 로고
    • Anti-GD2 antibody 3F8 and barley-derived (1 –> 3),(1 –> 4)-beta-D-glucan: a phase I study in patients with chemoresistant neuroblastoma
    • Modak S, Kushner BH, Kramer K, et al. Anti-GD2 antibody 3F8 and barley-derived (1 –> 3),(1 –> 4)-beta-D-glucan:a phase I study in patients with chemoresistant neuroblastoma. Oncoimmunology. 2013;2(3):e23402.
    • (2013) Oncoimmunology , vol.2 , Issue.3 , pp. e23402
    • Modak, S.1    Kushner, B.H.2    Kramer, K.3
  • 35
    • 85029453776 scopus 로고    scopus 로고
    • Phase I study of combination of anti-GD2 antibody 3F8 and soluble yeast-derived beta glucan for resistant neuroblastoma
    • Modak S, Kushner B, Kramer K, et al. Phase I study of combination of anti-GD2 antibody 3F8 and soluble yeast-derived beta glucan for resistant neuroblastoma. Proc ANR Meeting (Abs). 2008;169.
    • (2008) Proc ANR Meeting (Abs) , vol.169
    • Modak, S.1    Kushner, B.2    Kramer, K.3
  • 36
    • 85029448713 scopus 로고    scopus 로고
    • Phase I trial of murine anti-ganglioside (GD2) monoclonal antibody (Mab) 14G2A in cancer patients
    • Murray JL, Cunningham JE, Brewer HM, et al. Phase I trial of murine anti-ganglioside (GD2) monoclonal antibody (Mab) 14G2A in cancer patients. J Biol Resp Modif. Abs.1991;135.
    • J Biol Resp Modif
    • Murray, J.L.1    Cunningham, J.E.2    Brewer, H.M.3
  • 37
    • 0027145882 scopus 로고
    • Phase I trial of murine monoclonal antibody 14G2a administered by prolonged intravenous infusion in patients with neuroectodermal tumors
    • Murray JL, Cunningham JE, Brewer H, et al. Phase I trial of murine monoclonal antibody 14G2a administered by prolonged intravenous infusion in patients with neuroectodermal tumors. J Clin Oncol. 1994;12(1):184–193.
    • (1994) J Clin Oncol , vol.12 , Issue.1 , pp. 184-193
    • Murray, J.L.1    Cunningham, J.E.2    Brewer, H.3
  • 38
    • 0028946423 scopus 로고
    • A phase I study of human/mouse chimeric antiganglioside GD2 antibody ch 14.18 in patients with neuroblastoma
    • Handgretinger R, Anderson K, Lang P, et al. A phase I study of human/mouse chimeric antiganglioside GD2 antibody ch 14.18 in patients with neuroblastoma. Eur J Cancer. 1995;31:261–267.
    • (1995) Eur J Cancer , vol.31 , pp. 261-267
    • Handgretinger, R.1    Anderson, K.2    Lang, P.3
  • 39
    • 0031750167 scopus 로고    scopus 로고
    • Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma
    • Yu A, Uttenreuther-Fischer M, Huang C-S, et al. Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma. J Clin Oncol. 1998;16:2169–2180.
    • (1998) J Clin Oncol , vol.16 , pp. 2169-2180
    • Yu, A.1    Uttenreuther-Fischer, M.2    Huang, C.-S.3
  • 40
    • 58149329110 scopus 로고    scopus 로고
    • Phase I study of ch14.18 with granulocyte-macrophage colony-stimulating factor and interleukin-2 in children with neuroblastoma after autologous bone marrow transplantation or stem-cell rescue: a report from the Children’s Oncology Group
    • Gilman AL, Ozkaynak MF, Matthay KK, et al. Phase I study of ch14.18 with granulocyte-macrophage colony-stimulating factor and interleukin-2 in children with neuroblastoma after autologous bone marrow transplantation or stem-cell rescue:a report from the Children’s Oncology Group. J Clin Oncol. 2009;27(1):85–91.
    • (2009) J Clin Oncol , vol.27 , Issue.1 , pp. 85-91
    • Gilman, A.L.1    Ozkaynak, M.F.2    Matthay, K.K.3
  • 41
    • 78651428141 scopus 로고    scopus 로고
    • Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy
    • Simon T, Hero B, Faldum A, et al. Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy. BMC Cancer. 2011;11:21.
    • (2011) BMC Cancer , vol.11 , pp. 21
    • Simon, T.1    Hero, B.2    Faldum, A.3
  • 42
    • 85019589496 scopus 로고    scopus 로고
    • Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial
    • Mody R, Naranjo A, van Ryn C, et al. Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221):an open-label, randomised, phase 2 trial. Lancet Oncol. 2017;18(7):946–957.
    • (2017) Lancet Oncol , vol.18 , Issue.7 , pp. 946-957
    • Mody, R.1    Naranjo, A.2    van Ryn, C.3
  • 43
    • 84883875530 scopus 로고    scopus 로고
    • Ch14.18 antibody produced in CHO cells in relapsed or refractory stage 4 neuroblastoma patients: a SIOPEN phase 1 study
    • Ladenstein R, Weixler S, Baykan B, et al. Ch14.18 antibody produced in CHO cells in relapsed or refractory stage 4 neuroblastoma patients:a SIOPEN phase 1 study. MAbs. 2013;5(5):801–809.
    • (2013) MAbs , vol.5 , Issue.5 , pp. 801-809
    • Ladenstein, R.1    Weixler, S.2    Baykan, B.3
  • 44
    • 84961589310 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2
    • Siebert N, Eger C, Seidel D, et al. Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2. MAbs. 2016;8(3):604–616.
    • (2016) MAbs , vol.8 , Issue.3 , pp. 604-616
    • Siebert, N.1    Eger, C.2    Seidel, D.3
  • 45
    • 85014665209 scopus 로고    scopus 로고
    • Toxicity and outcome of anti-GD2 antibody ch14.18/CHO in front-line, high-risk patients with neuroblastoma: final results of the phase III immunotherapy randomisation (HR-NBL1/SIOPEN trial)
    • Abstr 10500
    • Ladenstein R, Poetschger U, Gray JA, et al. Toxicity and outcome of anti-GD2 antibody ch14.18/CHO in front-line, high-risk patients with neuroblastoma:final results of the phase III immunotherapy randomisation (HR-NBL1/SIOPEN trial). J Clin Oncol (Suppl) 2016;34. Abstr 10500.
    • (2016) J Clin Oncol (Suppl) , vol.34
    • Ladenstein, R.1    Poetschger, U.2    Gray, J.A.3
  • 46
    • 33645679838 scopus 로고    scopus 로고
    • A phase I clinical trial of the hu14.18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children’s Oncology Group
    • Osenga KL, Hank JA, Albertini MR, et al. A phase I clinical trial of the hu14.18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma:a study of the Children’s Oncology Group. Clin Cancer Res. 2006;12(6):1750–1759.
    • (2006) Clin Cancer Res , vol.12 , Issue.6 , pp. 1750-1759
    • Osenga, K.L.1    Hank, J.A.2    Albertini, M.R.3
  • 47
    • 85029425823 scopus 로고    scopus 로고
    • Phase I study of anti-GD2 humanized 3F8 plus GM-CSF: high dosing and major responses in patients with resistant high-risk neuroblastoma
    • Abs 57
    • Kushner B, Cheung IY, Basu E, et al. Phase I study of anti-GD2 humanized 3F8 plus GM-CSF:high dosing and major responses in patients with resistant high-risk neuroblastoma. Adv Neuroblastoma Res 2016;2016. Abs 57.
    • (2016) Adv Neuroblastoma Res , vol.2016
    • Kushner, B.1    Cheung, I.Y.2    Basu, E.3
  • 48
    • 79951886003 scopus 로고    scopus 로고
    • Antitumor activity of hu14.18-IL2 in patients with relapsed/refractory neuroblastoma: a Children’s Oncology Group (COG) phase II study
    • Shusterman S, London WB, Gillies SD, et al. Antitumor activity of hu14.18-IL2 in patients with relapsed/refractory neuroblastoma:a Children’s Oncology Group (COG) phase II study. J Clin Oncol. 2010;28(33):4969–4975.
    • (2010) J Clin Oncol , vol.28 , Issue.33 , pp. 4969-4975
    • Shusterman, S.1    London, W.B.2    Gillies, S.D.3
  • 49
    • 0033554684 scopus 로고    scopus 로고
    • Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children’s Cancer Group
    • Matthay KK, Villablanca JG, Seeger RC, et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children’s Cancer Group. N Engl J Med. 1999;341(16):1165–1173.
    • (1999) N Engl J Med , vol.341 , Issue.16 , pp. 1165-1173
    • Matthay, K.K.1    Villablanca, J.G.2    Seeger, R.C.3
  • 50
    • 0035174256 scopus 로고    scopus 로고
    • N7: a novel multi-modality therapy of high risk neuroblastoma (NB) in children diagnosed over 1 year of age
    • Cheung NK, Kushner BH, LaQuaglia M, et al. N7:a novel multi-modality therapy of high risk neuroblastoma (NB) in children diagnosed over 1 year of age. Med Pediatr Oncol. 2001;36(1):227–230.
    • (2001) Med Pediatr Oncol , vol.36 , Issue.1 , pp. 227-230
    • Cheung, N.K.1    Kushner, B.H.2    LaQuaglia, M.3
  • 51
    • 85029423138 scopus 로고    scopus 로고
    • Combined radioimmunotherapy and anti-angiogenic therapy for resistant neuroblastoma
    • Modak S, Kushner B, Kramer K, et al. Combined radioimmunotherapy and anti-angiogenic therapy for resistant neuroblastoma. Proc ANR Meeting (Abs). 2010;137.
    • (2010) Proc ANR Meeting (Abs) , vol.137
    • Modak, S.1    Kushner, B.2    Kramer, K.3
  • 52
    • 85029416548 scopus 로고    scopus 로고
    • Phase I study of haploidentical NK cells plus monoclonal antibody 3F8 for resistant high-risk neuroblastoma
    • Modak S, Cheung NK, Kushner B, et al. Phase I study of haploidentical NK cells plus monoclonal antibody 3F8 for resistant high-risk neuroblastoma. Proc ANR Meeting (Abs). 2014.
    • (2014) Proc ANR Meeting (Abs)
    • Modak, S.1    Cheung, N.K.2    Kushner, B.3
  • 53
    • 55549145071 scopus 로고    scopus 로고
    • Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
    • Pule MA, Savoldo B, Myers GD, et al. Virus-specific T cells engineered to coexpress tumor-specific receptors:persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 2008;14(11):1264–1270.
    • (2008) Nat Med , vol.14 , Issue.11 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3
  • 54
    • 0033958915 scopus 로고    scopus 로고
    • Clinical and immune responses in advanced melanoma patients immunized with an anti-idiotype antibody mimicking disialoganglioside GD2
    • Foon KA, Lutzky J, Baral RN, et al. Clinical and immune responses in advanced melanoma patients immunized with an anti-idiotype antibody mimicking disialoganglioside GD2. J Clin Oncol. 2000;18:376–384.
    • (2000) J Clin Oncol , vol.18 , pp. 376-384
    • Foon, K.A.1    Lutzky, J.2    Baral, R.N.3
  • 55
    • 10744226998 scopus 로고    scopus 로고
    • Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21
    • Ragupathi G, Livingston PO, Hood C, et al. Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21. Clin Cancer Res. 2003;9(14):5214–5220.
    • (2003) Clin Cancer Res , vol.9 , Issue.14 , pp. 5214-5220
    • Ragupathi, G.1    Livingston, P.O.2    Hood, C.3
  • 56
    • 84878251843 scopus 로고    scopus 로고
    • Neuroblastoma: developmental biology, cancer genomics and immunotherapy
    • Cheung NK, Dyer MA. Neuroblastoma:developmental biology, cancer genomics and immunotherapy. Nat Rev Cancer. 2013;13(6):397–411.
    • (2013) Nat Rev Cancer , vol.13 , Issue.6 , pp. 397-411
    • Cheung, N.K.1    Dyer, M.A.2
  • 57
    • 84907980704 scopus 로고    scopus 로고
    • In situ modulation of dendritic cells by injectable thermosensitive hydrogels for cancer vaccines in mice
    • Liu Y, Xiao L, Joo KI, et al. In situ modulation of dendritic cells by injectable thermosensitive hydrogels for cancer vaccines in mice. Biomacromolecules. 2014;15(10):3836–3845.
    • (2014) Biomacromolecules , vol.15 , Issue.10 , pp. 3836-3845
    • Liu, Y.1    Xiao, L.2    Joo, K.I.3
  • 58
    • 28544440831 scopus 로고    scopus 로고
    • Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer
    • Imai M, Landen C, Ohta R, et al. Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer. Cancer Res. 2005;65(22):10562–10568.
    • (2005) Cancer Res , vol.65 , Issue.22 , pp. 10562-10568
    • Imai, M.1    Landen, C.2    Ohta, R.3
  • 59
    • 0030792278 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor improves immunological parameters in patients with refractory solid tumours receiving second-line chemotherapy: correlation with clinical responses
    • Baxevanis CN, Tsavaris NB, Papadhimitriou SI, et al. Granulocyte-macrophage colony-stimulating factor improves immunological parameters in patients with refractory solid tumours receiving second-line chemotherapy:correlation with clinical responses. Eur J Cancer. 1997;33(8):1202–1208.
    • (1997) Eur J Cancer , vol.33 , Issue.8 , pp. 1202-1208
    • Baxevanis, C.N.1    Tsavaris, N.B.2    Papadhimitriou, S.I.3
  • 60
    • 84973098657 scopus 로고    scopus 로고
    • Role of IL-2 in cancer immunotherapy
    • Jiang T, Zhou C, Ren S. Role of IL-2 in cancer immunotherapy. Oncoimmunology. 2016;5(6):e1163462.
    • (2016) Oncoimmunology , vol.5 , Issue.6 , pp. e1163462
    • Jiang, T.1    Zhou, C.2    Ren, S.3
  • 61
    • 0026425705 scopus 로고
    • Nonoxidative lysis of human solid tumor cells by neutrophils armed with GD2 specific monoclonal antibody 3F8
    • Kushner BH, Cheung NKV. Nonoxidative lysis of human solid tumor cells by neutrophils armed with GD2 specific monoclonal antibody 3F8. Blood. 1991;51(18):4865-4870.
    • (1991) Blood
    • Kushner, B.H.1    Cheung, N.K.V.2
  • 62
    • 67349260735 scopus 로고    scopus 로고
    • The GD2-specific 14G2a monoclonal antibody induces apoptosis and enhances cytotoxicity of chemotherapeutic drugs in IMR-32 human neuroblastoma cells
    • Kowalczyk A, Gil M, Horwacik I, et al. The GD2-specific 14G2a monoclonal antibody induces apoptosis and enhances cytotoxicity of chemotherapeutic drugs in IMR-32 human neuroblastoma cells. Cancer Lett. 2009;281(2):171–182.
    • (2009) Cancer Lett , vol.281 , Issue.2 , pp. 171-182
    • Kowalczyk, A.1    Gil, M.2    Horwacik, I.3
  • 63
    • 0026425705 scopus 로고
    • Clinically effective monoclonal antibody 3F8 mediates nonoxidative lysis of human neuroectodermal tumor cells by polymorphonuclear leukocytes
    • Kushner BH, Cheung NK. Clinically effective monoclonal antibody 3F8 mediates nonoxidative lysis of human neuroectodermal tumor cells by polymorphonuclear leukocytes. Cancer Res. 1991;51(18):4865–4870.
    • (1991) Cancer Res , vol.51 , Issue.18 , pp. 4865-4870
    • Kushner, B.H.1    Cheung, N.K.2
  • 64
    • 0022399764 scopus 로고
    • Eradication of neuroblastoma cells in vitro by monoclonal antibody and human complement: method for purging autologous bone marrow
    • Saarinen UM, Coccia PF, Gerson SL, et al. Eradication of neuroblastoma cells in vitro by monoclonal antibody and human complement:method for purging autologous bone marrow. Cancer Res. 1985;45:5969–5975.
    • (1985) Cancer Res , vol.45 , pp. 5969-5975
    • Saarinen, U.M.1    Coccia, P.F.2    Gerson, S.L.3
  • 65
    • 0035999738 scopus 로고    scopus 로고
    • Oral (1–>3),(1–>4)-beta-D-glucan synergizes with antiganglioside GD2 monoclonal antibody 3F8 in the therapy of neuroblastoma
    • Cheung NK, Modak S. Oral (1–>3),(1–>4)-beta-D-glucan synergizes with antiganglioside GD2 monoclonal antibody 3F8 in the therapy of neuroblastoma. Clin Cancer Res. 2002;8(5):1217–1223.
    • (2002) Clin Cancer Res , vol.8 , Issue.5 , pp. 1217-1223
    • Cheung, N.K.1    Modak, S.2
  • 66
    • 14844365464 scopus 로고    scopus 로고
    • Antibody-based targeted radiation to pediatric tumors
    • Modak S, Cheung NK. Antibody-based targeted radiation to pediatric tumors. J Nucl Med. 2005;46(Suppl 1):157S–163S.
    • (2005) J Nucl Med , vol.46 , pp. 157S-163S
    • Modak, S.1    Cheung, N.K.2
  • 67
    • 0024358410 scopus 로고
    • GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma
    • Kushner BH, Cheung NK. GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma. Blood. 1989;73(7):1936–1941.
    • (1989) Blood , vol.73 , Issue.7 , pp. 1936-1941
    • Kushner, B.H.1    Cheung, N.K.2
  • 68
    • 61449106633 scopus 로고    scopus 로고
    • Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a Children’s Oncology Group study
    • Matthay KK, Reynolds CP, Seeger RC, et al. Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid:a Children’s Oncology Group study. J Clin Oncol. 2009;27(7):1007–1013.
    • (2009) J Clin Oncol , vol.27 , Issue.7 , pp. 1007-1013
    • Matthay, K.K.1    Reynolds, C.P.2    Seeger, R.C.3
  • 69
    • 84958012724 scopus 로고    scopus 로고
    • Lack of survival advantage with autologous stem-cell transplantation in high-risk neuroblastoma consolidated by anti-GD2 immunotherapy and isotretinoin
    • Kushner BH, Ostrovnaya I, Cheung IY, et al. Lack of survival advantage with autologous stem-cell transplantation in high-risk neuroblastoma consolidated by anti-GD2 immunotherapy and isotretinoin. Oncotarget. 2016;7(4):4155–4166.
    • (2016) Oncotarget , vol.7 , Issue.4 , pp. 4155-4166
    • Kushner, B.H.1    Ostrovnaya, I.2    Cheung, I.Y.3
  • 70
    • 84944449153 scopus 로고    scopus 로고
    • Prolonged progression-free survival after consolidating second or later remissions of neuroblastoma with Anti-GD2 immunotherapy and isotretinoin: a prospective phase II study
    • Kushner BH, Ostrovnaya I, Cheung IY, et al. Prolonged progression-free survival after consolidating second or later remissions of neuroblastoma with Anti-GD2 immunotherapy and isotretinoin:a prospective phase II study. Oncoimmunology. 2015;4(7):e1016704.
    • (2015) Oncoimmunology , vol.4 , Issue.7 , pp. e1016704
    • Kushner, B.H.1    Ostrovnaya, I.2    Cheung, I.Y.3
  • 71
    • 0028286938 scopus 로고
    • Antibody response to murine anti-GD2 monoclonal antibodies: correlation with patient survival
    • Cheung NK, Cheung IY, Canete A, et al. Antibody response to murine anti-GD2 monoclonal antibodies:correlation with patient survival. Cancer Res. 1994;54(8):2228–2233.
    • (1994) Cancer Res , vol.54 , Issue.8 , pp. 2228-2233
    • Cheung, N.K.1    Cheung, I.Y.2    Canete, A.3
  • 72
    • 85029440934 scopus 로고    scopus 로고
    • Suppression of human anti-mouse antibody response by rituximab plus cyclophosphamide permits continuation of anti-GD2 immunotherapy
    • Modak S, Kushner B, Kramer K, et al. Suppression of human anti-mouse antibody response by rituximab plus cyclophosphamide permits continuation of anti-GD2 immunotherapy. Proc ANR Meeting (Abs). 2010;104.
    • (2010) Proc ANR Meeting (Abs) , pp. 104
    • Modak, S.1    Kushner, B.2    Kramer, K.3
  • 73
    • 0033928328 scopus 로고    scopus 로고
    • Induction of Ab3 and Ab3ʹ antibody was associated with long-term survival after anti-G(D2) antibody therapy of stage 4 neuroblastoma
    • Cheung NK, Guo HF, Heller G, et al. Induction of Ab3 and Ab3ʹ antibody was associated with long-term survival after anti-G(D2) antibody therapy of stage 4 neuroblastoma. Clin Cancer Res. 2000;6(7):2653–2660.
    • (2000) Clin Cancer Res , vol.6 , Issue.7 , pp. 2653-2660
    • Cheung, N.K.1    Guo, H.F.2    Heller, G.3
  • 74
    • 0024382410 scopus 로고
    • Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18
    • Mujoo K, Kipps TJ, Yang HM, et al. Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18. Cancer Res. 1989;49:2857–2861.
    • (1989) Cancer Res , vol.49 , pp. 2857-2861
    • Mujoo, K.1    Kipps, T.J.2    Yang, H.M.3
  • 75
    • 0029148798 scopus 로고
    • Pharmacokinetics of anti-ganglioside GD2 mAb 14G2a in a phase I trial in pediatric cancer patients
    • Uttenreuther-Fischer MM, Huang CS, Reisfeld RA, et al. Pharmacokinetics of anti-ganglioside GD2 mAb 14G2a in a phase I trial in pediatric cancer patients. Cancer Immunol Immunother. 1995;41(1):29–36.
    • (1995) Cancer Immunol Immunother , vol.41 , Issue.1 , pp. 29-36
    • Uttenreuther-Fischer, M.M.1    Huang, C.S.2    Reisfeld, R.A.3
  • 76
    • 0024791484 scopus 로고
    • High-level expression of chimeric antibodies using adapted cDNA variable region cassettes
    • Gillies SD, Lo K-M, Wesolowski J. High-level expression of chimeric antibodies using adapted cDNA variable region cassettes. J Immunol Methods. 1989;125:191–202.
    • (1989) J Immunol Methods , vol.125 , pp. 191-202
    • Gillies, S.D.1    Lo, K.-M.2    Wesolowski, J.3
  • 77
    • 0025021639 scopus 로고
    • Enhancement of antibody-dependent cytotoxicity with a chimeric anti-GD2 antibody
    • Mueller BM, Romerdahl CA, Gillies SD, et al. Enhancement of antibody-dependent cytotoxicity with a chimeric anti-GD2 antibody. J Immunol. 1990;144(4):1382–1386.
    • (1990) J Immunol , vol.144 , Issue.4 , pp. 1382-1386
    • Mueller, B.M.1    Romerdahl, C.A.2    Gillies, S.D.3
  • 78
    • 0034671441 scopus 로고    scopus 로고
    • Phase I study of chimeric human/murine anti-ganglioside G(D2) monoclonal antibody (ch14.18) with granulocyte-macrophage colony-stimulating factor in children with neuroblastoma immediately after hematopoietic stem-cell transplantation: a Children’s Cancer Group study
    • Ozkaynak MF, Sondel PM, Krailo MD, et al. Phase I study of chimeric human/murine anti-ganglioside G(D2) monoclonal antibody (ch14.18) with granulocyte-macrophage colony-stimulating factor in children with neuroblastoma immediately after hematopoietic stem-cell transplantation:a Children’s Cancer Group study. J Clin Oncol. 2000;18(24):4077–4085.
    • (2000) J Clin Oncol , vol.18 , Issue.24 , pp. 4077-4085
    • Ozkaynak, M.F.1    Sondel, P.M.2    Krailo, M.D.3
  • 79
    • 85029428079 scopus 로고    scopus 로고
    • Update of outcome for high-risk neuroblastoma treated on a randomized trial of chimeric anti-GD2 antibody (ch14.18)+GMCSF-IL2 immunotherapy in 1st response: a Children’s Oncology Group study
    • Yu A, Gilman A, Ozkaynak MF, et al. Update of outcome for high-risk neuroblastoma treated on a randomized trial of chimeric anti-GD2 antibody (ch14.18)+GMCSF-IL2 immunotherapy in 1st response:a Children’s Oncology Group study. Proc ANR Meeting (Abs). 2014;108.
    • (2014) Proc ANR Meeting (Abs) , vol.108
    • Yu, A.1    Gilman, A.2    Ozkaynak, M.F.3
  • 80
    • 84885856402 scopus 로고    scopus 로고
    • Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFbeta1
    • Xu Y, Sun J, Sheard MA, et al. Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFbeta1. Cancer Immunol Immunother. 2013;62(10):1637–1648.
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.10 , pp. 1637-1648
    • Xu, Y.1    Sun, J.2    Sheard, M.A.3
  • 81
    • 20444400586 scopus 로고    scopus 로고
    • Anti-neuroblastoma effect of ch14.18 antibody produced in CHO cells is mediated by NK-cells in mice
    • Zeng Y, Fest S, Kunert R, et al. Anti-neuroblastoma effect of ch14.18 antibody produced in CHO cells is mediated by NK-cells in mice. Mol Immunol. 2005;42(11):1311–1319.
    • (2005) Mol Immunol , vol.42 , Issue.11 , pp. 1311-1319
    • Zeng, Y.1    Fest, S.2    Kunert, R.3
  • 82
    • 0031750167 scopus 로고    scopus 로고
    • Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma
    • Yu AL, Uttenreuther-Fischer MM, Huang CS, et al. Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma. J Clin Oncol. 1998;16(6):2169–2180.
    • (1998) J Clin Oncol , vol.16 , Issue.6 , pp. 2169-2180
    • Yu, A.L.1    Uttenreuther-Fischer, M.M.2    Huang, C.S.3
  • 83
    • 17644384446 scopus 로고    scopus 로고
    • SDR grafting–a new approach to antibody humanization
    • Kashmiri SV, De Pascalis R, Gonzales NR, et al. SDR grafting–a new approach to antibody humanization. Methods. 2005;36(1):25–34.
    • (2005) Methods , vol.36 , Issue.1 , pp. 25-34
    • Kashmiri, S.V.1    De Pascalis, R.2    Gonzales, N.R.3
  • 84
    • 84877799310 scopus 로고    scopus 로고
    • Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo
    • Cheung NK, Guo H, Hu J, et al. Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo. Oncoimmunology. 2012;1(4):477–486.
    • (2012) Oncoimmunology , vol.1 , Issue.4 , pp. 477-486
    • Cheung, N.K.1    Guo, H.2    Hu, J.3
  • 85
    • 85029432715 scopus 로고    scopus 로고
    • Phase I study of humanized 3F8 monoclonal antibody in patients with relapsed or refractory neuroblastoma
    • Basu EM, Kushner BH, Modak S, et al. Phase I study of humanized 3F8 monoclonal antibody in patients with relapsed or refractory neuroblastoma. Proc ANR Meeting (Abs). 2012;115.
    • (2012) Proc ANR Meeting (Abs) , pp. 115
    • Basu, E.M.1    Kushner, B.H.2    Modak, S.3
  • 86
    • 85029423348 scopus 로고    scopus 로고
    • Pharmacokinetics of humanized anti-GD2 monoclonal antibody hu3F8 in patients with metastatic GD2-positive tumors
    • Cheung I, Basu E, Modak S, et al. Pharmacokinetics of humanized anti-GD2 monoclonal antibody hu3F8 in patients with metastatic GD2-positive tumors. Proc ANR Meeting (Abs). 2014;243.
    • (2014) Proc ANR Meeting (Abs) , vol.243
    • Cheung, I.1    Basu, E.2    Modak, S.3
  • 87
    • 84902962349 scopus 로고    scopus 로고
    • Phase I trial of a novel anti-GD2 monoclonal antibody, Hu14.18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma
    • Navid F, Sondel PM, Barfield R, et al. Phase I trial of a novel anti-GD2 monoclonal antibody, Hu14.18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma. J Clin Oncol. 2014;32(14):1445–1452.
    • (2014) J Clin Oncol , vol.32 , Issue.14 , pp. 1445-1452
    • Navid, F.1    Sondel, P.M.2    Barfield, R.3
  • 88
    • 84927518131 scopus 로고    scopus 로고
    • Comparison of pain outcomes between two anti-GD2 antibodies in patients with neuroblastoma
    • Anghelescu DL, Goldberg JL, Faughnan LG, et al. Comparison of pain outcomes between two anti-GD2 antibodies in patients with neuroblastoma. Pediatr Blood Cancer. 2015;62(2):224–228.
    • (2015) Pediatr Blood Cancer , vol.62 , Issue.2 , pp. 224-228
    • Anghelescu, D.L.1    Goldberg, J.L.2    Faughnan, L.G.3
  • 89
    • 0030007139 scopus 로고    scopus 로고
    • Eradication of established hepatic human neuroblastoma metastases in mice with severe combined immunodeficiency by antibody-targeted interleukin-2
    • Pancook JD, Becker JC, Gillies SD, et al. Eradication of established hepatic human neuroblastoma metastases in mice with severe combined immunodeficiency by antibody-targeted interleukin-2. Cancer Immunol Immunother. 1996;42(2):88–92.
    • (1996) Cancer Immunol Immunother , vol.42 , Issue.2 , pp. 88-92
    • Pancook, J.D.1    Becker, J.C.2    Gillies, S.D.3
  • 90
    • 0030470861 scopus 로고    scopus 로고
    • Activation of human effector cells by a tumor reactive recombinant anti-ganglioside GD2 interleukin-2 fusion protein (ch 14.18-IL2)
    • Hank JA, Surfus JE, Gan J, et al. Activation of human effector cells by a tumor reactive recombinant anti-ganglioside GD2 interleukin-2 fusion protein (ch 14.18-IL2). Clin Cancer Res. 1996;2:1951–1959.
    • (1996) Clin Cancer Res , vol.2 , pp. 1951-1959
    • Hank, J.A.1    Surfus, J.E.2    Gan, J.3
  • 91
    • 0000230036 scopus 로고    scopus 로고
    • Usefulness of a chimeric anti-GD2 (ch14.18) and GM-CSF for refractory neuroblastoma: a POG phase II study
    • Yu AL, Batova A, Alvarado C, et al. Usefulness of a chimeric anti-GD2 (ch14.18) and GM-CSF for refractory neuroblastoma:a POG phase II study. Proc ASCO. 1997;16:1846.
    • (1997) Proc ASCO , vol.16 , pp. 1846
    • Yu, A.L.1    Batova, A.2    Alvarado, C.3
  • 92
    • 36849018928 scopus 로고    scopus 로고
    • Phase I study of targeted radioimmunotherapy for leptomeningeal cancers using intra-Ommaya 131-I-3F8
    • Kramer K, Humm JL, Souweidane MM, et al. Phase I study of targeted radioimmunotherapy for leptomeningeal cancers using intra-Ommaya 131-I-3F8. J Clin Oncol. 2007;25(34):5465–5470.
    • (2007) J Clin Oncol , vol.25 , Issue.34 , pp. 5465-5470
    • Kramer, K.1    Humm, J.L.2    Souweidane, M.M.3
  • 93
    • 77953288400 scopus 로고    scopus 로고
    • Compartmental intrathecal radioimmunotherapy: results for treatment for metastatic CNS neuroblastoma
    • Kramer K, Kushner BH, Modak S, et al. Compartmental intrathecal radioimmunotherapy:results for treatment for metastatic CNS neuroblastoma. J Neurooncol. 2010;97(3):409–418.• Intrathecal administration of anti-GD2 antibodies could improve the cure rate after CNS neuroblastoma metastases.
    • (2010) J Neurooncol , vol.97 , Issue.3 , pp. 409-418
    • Kramer, K.1    Kushner, B.H.2    Modak, S.3
  • 94
    • 84865960648 scopus 로고    scopus 로고
    • Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment
    • Tarek N, Le Luduec JB, Gallagher MM, et al. Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment. J Clin Invest. 2012;122(9):3260–3270.
    • (2012) J Clin Invest , vol.122 , Issue.9 , pp. 3260-3270
    • Tarek, N.1    Le Luduec, J.B.2    Gallagher, M.M.3
  • 95
    • 78649968328 scopus 로고    scopus 로고
    • Genotypes of NK cell KIR receptors, their ligands, and Fcgamma receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy
    • Delgado DC, Hank JA, Kolesar J, et al. Genotypes of NK cell KIR receptors, their ligands, and Fcgamma receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res. 2010;70(23):9554–9561.
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9554-9561
    • Delgado, D.C.1    Hank, J.A.2    Kolesar, J.3
  • 96
    • 84978221332 scopus 로고    scopus 로고
    • KIR3DL1 allelic polymorphism and HLA-B epitopes modulate response to anti-GD2 monoclonal antibody in patients with neuroblastoma
    • Forlenza CJ, Boudreau JE, Zheng J, et al. KIR3DL1 allelic polymorphism and HLA-B epitopes modulate response to anti-GD2 monoclonal antibody in patients with neuroblastoma. J Clin Oncol. 2016;34(21):2443–2451.
    • (2016) J Clin Oncol , vol.34 , Issue.21 , pp. 2443-2451
    • Forlenza, C.J.1    Boudreau, J.E.2    Zheng, J.3
  • 97
    • 82955207691 scopus 로고    scopus 로고
    • Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
    • Louis CU, Savoldo B, Dotti G, et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood. 2011;118(23):6050–6056.
    • (2011) Blood , vol.118 , Issue.23 , pp. 6050-6056
    • Louis, C.U.1    Savoldo, B.2    Dotti, G.3
  • 98
    • 84944072257 scopus 로고    scopus 로고
    • Activated T cells armed with bispecific antibodies kill tumor targets
    • Bhutani D, Lum LG. Activated T cells armed with bispecific antibodies kill tumor targets. Curr Opin Hematol. 2015;22(6):476–483.
    • (2015) Curr Opin Hematol , vol.22 , Issue.6 , pp. 476-483
    • Bhutani, D.1    Lum, L.G.2
  • 99
    • 0027336381 scopus 로고
    • Disialoganglioside GD2 anti-idiotypic monoclonal antibodies
    • Cheung NK, Canete A, Cheung IY, et al. Disialoganglioside GD2 anti-idiotypic monoclonal antibodies. Int J Cancer Oncol. 1993;54(3):499–505.
    • (1993) Int J Cancer Oncol , vol.54 , Issue.3 , pp. 499-505
    • Cheung, N.K.1    Canete, A.2    Cheung, I.Y.3
  • 100
    • 84895814045 scopus 로고    scopus 로고
    • Phase I trial of a bivalent gangliosides vaccine in combination with beta-glucan for high-risk neuroblastoma in second or later remission
    • Kushner BH, Cheung IY, Modak S, et al. Phase I trial of a bivalent gangliosides vaccine in combination with beta-glucan for high-risk neuroblastoma in second or later remission. Clin Cancer Res. 2014;20(5):1375–1382.• Active immunity elicited by anti-GD2 (and anti-GD3) vaccine when combined with the immune adjuvant QS21 and oral glucan appears to improve survival rates for NB patients in second CR.
    • (2014) Clin Cancer Res , vol.20 , Issue.5 , pp. 1375-1382
    • Kushner, B.H.1    Cheung, I.Y.2    Modak, S.3
  • 101
    • 84877805975 scopus 로고    scopus 로고
    • In silico driven redesign of a clinically relevant antibody for the treatment of GD2 positive tumors
    • Ahmed M, Goldgur Y, Hu J, et al. In silico driven redesign of a clinically relevant antibody for the treatment of GD2 positive tumors. PloS One. 2013;8(5):e63359.
    • (2013) PloS One , vol.8 , Issue.5 , pp. e63359
    • Ahmed, M.1    Goldgur, Y.2    Hu, J.3
  • 102
    • 84979729500 scopus 로고    scopus 로고
    • Antitumor efficacy of anti-GD2 IgG1 is enhanced by Fc glyco-engineering
    • Xu H, Guo H, Cheung IY, et al. Antitumor efficacy of anti-GD2 IgG1 is enhanced by Fc glyco-engineering. Cancer Immunol Res. 2016;4(7):631–638.
    • (2016) Cancer Immunol Res , vol.4 , Issue.7 , pp. 631-638
    • Xu, H.1    Guo, H.2    Cheung, I.Y.3
  • 103
    • 2642527143 scopus 로고    scopus 로고
    • Single-chain Fv-streptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2
    • Cheung NK, Modak S, Lin Y, et al. Single-chain Fv-streptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2. J Nucl Med. 2004;45(5):867–877.
    • (2004) J Nucl Med , vol.45 , Issue.5 , pp. 867-877
    • Cheung, N.K.1    Modak, S.2    Lin, Y.3
  • 104
    • 84904174507 scopus 로고    scopus 로고
    • Preclinical evaluation of multistep targeting of diasialoganglioside GD2 using an IgG-scFv bispecific antibody with high affinity for GD2 and DOTA metal complex
    • Cheal SM, Xu H, Guo HF, et al. Preclinical evaluation of multistep targeting of diasialoganglioside GD2 using an IgG-scFv bispecific antibody with high affinity for GD2 and DOTA metal complex. Mol Cancer Ther. 2014;13(7):1803–1812.• A pretargeting strategy using an anti-GD2 bispecific antibody substantially improves therapeutic index.
    • (2014) Mol Cancer Ther , vol.13 , Issue.7 , pp. 1803-1812
    • Cheal, S.M.1    Xu, H.2    Guo, H.F.3
  • 105
    • 0037401058 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor activity of liposomal fenretinide targeted to human neuroblastoma
    • Raffaghello L, Pagnan G, Pastorino F, et al. In vitro and in vivo antitumor activity of liposomal fenretinide targeted to human neuroblastoma. Int J Cancer Oncol. 2003;104(5):559–567.
    • (2003) Int J Cancer Oncol , vol.104 , Issue.5 , pp. 559-567
    • Raffaghello, L.1    Pagnan, G.2    Pastorino, F.3
  • 106
    • 3543119461 scopus 로고    scopus 로고
    • Immune cell-mediated antitumor activities of GD2-targeted liposomal c-myb antisense oligonucleotides containing CpG motifs
    • Brignole C, Pastorino F, Marimpietri D, et al. Immune cell-mediated antitumor activities of GD2-targeted liposomal c-myb antisense oligonucleotides containing CpG motifs. J Natl Cancer Inst. 2004;96(15):1171–1180.
    • (2004) J Natl Cancer Inst , vol.96 , Issue.15 , pp. 1171-1180
    • Brignole, C.1    Pastorino, F.2    Marimpietri, D.3
  • 107
    • 84861473531 scopus 로고    scopus 로고
    • Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles
    • Tivnan A, Orr WS, Gubala V, et al. Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PloS One. 2012;7(5):e38129.
    • (2012) PloS One , vol.7 , Issue.5 , pp. e38129
    • Tivnan, A.1    Orr, W.S.2    Gubala, V.3
  • 108
    • 84885124167 scopus 로고    scopus 로고
    • Enhanced anti-tumor and anti-angiogenic efficacy of a novel liposomal fenretinide on human neuroblastoma
    • Di Paolo D, Pastorino F, Zuccari G, et al. Enhanced anti-tumor and anti-angiogenic efficacy of a novel liposomal fenretinide on human neuroblastoma. J Control Release. 2013;170(3):445–451.
    • (2013) J Control Release , vol.170 , Issue.3 , pp. 445-451
    • Di Paolo, D.1    Pastorino, F.2    Zuccari, G.3
  • 109
    • 67849086444 scopus 로고    scopus 로고
    • In vitro photothermal destruction of neuroblastoma cells using carbon nanotubes conjugated with GD2 monoclonal antibody
    • Wang CH, Huang YJ, Chang CW, et al. In vitro photothermal destruction of neuroblastoma cells using carbon nanotubes conjugated with GD2 monoclonal antibody. Nanotechnology. 2009;20(31):315101.
    • (2009) Nanotechnology , vol.20 , Issue.31 , pp. 315101
    • Wang, C.H.1    Huang, Y.J.2    Chang, C.W.3
  • 110
    • 0036191537 scopus 로고    scopus 로고
    • Effective targeted cytotoxicity of neuroblastoma cells
    • Thomas PB, Delatte SJ, Sutphin A, et al. Effective targeted cytotoxicity of neuroblastoma cells. J Pediatr Surg. 2002;37(3):539–544.
    • (2002) J Pediatr Surg , vol.37 , Issue.3 , pp. 539-544
    • Thomas, P.B.1    Delatte, S.J.2    Sutphin, A.3
  • 111
    • 84877964989 scopus 로고    scopus 로고
    • Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency
    • Vincent M, Bessard A, Cochonneau D, et al. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. Int J Cancer Oncol. 2013;133(3):757–765.
    • (2013) Int J Cancer Oncol , vol.133 , Issue.3 , pp. 757-765
    • Vincent, M.1    Bessard, A.2    Cochonneau, D.3
  • 113
    • 84930765209 scopus 로고    scopus 로고
    • 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
    • Long AH, Haso WM, Shern JF, et al. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med. 2015;21(6):581–590.
    • (2015) Nat Med , vol.21 , Issue.6 , pp. 581-590
    • Long, A.H.1    Haso, W.M.2    Shern, J.F.3
  • 114
    • 84964317521 scopus 로고    scopus 로고
    • GD2-specific CAR T cells undergo potent activation and deletion following antigen encounter but can be protected from activation-induced cell death by PD-1 blockade
    • Gargett T, Yu W, Dotti G, et al. GD2-specific CAR T cells undergo potent activation and deletion following antigen encounter but can be protected from activation-induced cell death by PD-1 blockade. Mol Ther. 2016;24(6):1135–1149.
    • (2016) Mol Ther , vol.24 , Issue.6 , pp. 1135-1149
    • Gargett, T.1    Yu, W.2    Dotti, G.3
  • 115
    • 84890850147 scopus 로고    scopus 로고
    • Advances in chimeric antigen receptor immunotherapy for neuroblastoma
    • Heczey A, Louis CU. Advances in chimeric antigen receptor immunotherapy for neuroblastoma. Discov Med. 2013;16(90):287–294.
    • (2013) Discov Med , vol.16 , Issue.90 , pp. 287-294
    • Heczey, A.1    Louis, C.U.2
  • 116
    • 0028979935 scopus 로고
    • GD2 oligosaacharide: target for cytotoxic T-lymphocyte (CTL)
    • Zhao XJ. GD2 oligosaacharide:target for cytotoxic T-lymphocyte (CTL). Cancer Res. 1995;182(1);67-74.
    • (1995) Cancer Res
    • Zhao, X.J.1
  • 117
    • 84974785082 scopus 로고    scopus 로고
    • Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors
    • Cheng M, Santich BH, Xu H, et al. Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors. Oncoimmunology. 2016;5(6):e1168557.
    • (2016) Oncoimmunology , vol.5 , Issue.6 , pp. e1168557
    • Cheng, M.1    Santich, B.H.2    Xu, H.3
  • 118
    • 84895759475 scopus 로고    scopus 로고
    • Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects as therapeutic ch14.18 antibody to GD2 without antibody induced allodynia
    • Terme M, Dorvillius M, Cochonneau D, et al. Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects as therapeutic ch14.18 antibody to GD2 without antibody induced allodynia. PloS One. 2014;9(2):e87210.
    • (2014) PloS One , vol.9 , Issue.2 , pp. e87210
    • Terme, M.1    Dorvillius, M.2    Cochonneau, D.3
  • 119
    • 79960215653 scopus 로고    scopus 로고
    • Anti-galactose-alpha-1,3-galactose IgE from allergic patients does not bind alpha-galactosylated glycans on intact therapeutic antibody Fc domains
    • Lammerts van Bueren JJ, Rispens T, Verploegen S, et al. Anti-galactose-alpha-1,3-galactose IgE from allergic patients does not bind alpha-galactosylated glycans on intact therapeutic antibody Fc domains. Nat Biotechnol. 2011;29(7):574–576.
    • (2011) Nat Biotechnol , vol.29 , Issue.7 , pp. 574-576
    • Lammerts van Bueren, J.J.1    Rispens, T.2    Verploegen, S.3
  • 120
    • 84892369775 scopus 로고    scopus 로고
    • Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy
    • Ahmed M, Cheung NK. Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy. FEBS Lett. 2014;588(2):288-297.
    • (2014) FEBS Lett
    • Ahmed, M.1    Cheung, N.K.2
  • 121
    • 84904097189 scopus 로고    scopus 로고
    • Current concepts in the diagnosis and management of cytokine release syndrome
    • Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood. 2014;124(2):188–195.
    • (2014) Blood , vol.124 , Issue.2 , pp. 188-195
    • Lee, D.W.1    Gardner, R.2    Porter, D.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.