Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFβ1

Cancer Immunology, Immunotherapy

Volumn 62, Issue 10, 2013, Pages 1637-1648

  Xu, Yibing ^a   Sun, Jianping ^a   Sheard, Michael A ^a   Tran, Hung C ^a,b   Wan, Zesheng ^a   Liu, Wei Yao ^a   Asgharzadeh, Shahab ^a,b   Sposto, Richard ^a,b   Wu, Hong Wei ^a   Seeger, Robert C ^a,b  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

ADCC; IL 6; Lenalidomide; Neuroblastoma; NK cells; TGF 1

Indexed keywords

GAMMA INTERFERON; GRANZYME A; GRANZYME B; INTERLEUKIN 2; INTERLEUKIN 6; LENALIDOMIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CH14.18; PERFORIN; SMAD2 PROTEIN; SMAD3 PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CELL MEDIATED CYTOTOXICITY; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; DRUG POTENTIATION; ENZYME RELEASE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOMODULATION; MONOCYTE; MOUSE; NATURAL KILLER CELL; NEUROBLASTOMA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CULTURE MEDIA, CONDITIONED; FEMALE; HUMANS; INTERLEUKIN-6; KILLER CELLS, NATURAL; MICE; MICE, INBRED NOD; MICE, SCID; NEUROBLASTOMA; THALIDOMIDE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR MICROENVIRONMENT;

EID: 84885856402     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1466-y     Document Type: Article

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