Effect of methotrexate/Vitamin B12 on DNA methylation as a potential factor in leukemia treatment-related neurotoxicity

Epigenomics

Volumn 9, Issue 9, 2017, Pages 1205-1218

  Forster, Victoria J ^a   McDonnell, Alex ^a   Theobald, Rachel ^a   McKay, Jill A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

childhood acute lymphoblastic leukemia; epigenetic; late effects; methotrexate; neurocognition; neurotoxicity; one carbon metabolism; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; METHOTREXATE; ANTINEOPLASTIC AGENT; FK 506 BINDING PROTEIN; TACROLIMUS BINDING PROTEIN 5;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CARBON METABOLISM; CELL POPULATION; CELL PROLIFERATION; CHILDHOOD LEUKEMIA; COMBINATION DRUG THERAPY; CONCENTRATION (PARAMETERS); DAOY CELL LINE; DNA EXTRACTION; DNA METHYLATION; EPIGENETICS; FKBP5 GENE; GENE; HOXA4 GENE; LINE1 GENE; MO3.13 CELL LINE; MONOTHERAPY; NEURONAL CELL LINE; NEUROTOXICITY; OLIGODENDROCYTE CELL LINE; PRIORITY JOURNAL; SH-SY5Y CELL LINE; TREATMENT RESPONSE; DRUG EFFECTS; GENETICS; HUMAN; LONG INTERSPERSED REPEAT; METABOLISM; NERVE CELL; TOXICITY AND INTOXICATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA METHYLATION; HUMANS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; METHOTREXATE; NEURONS; NEUROTOXICITY SYNDROMES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TACROLIMUS BINDING PROTEINS; VITAMIN B 12;

EID: 85028827519     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi-2016-0165     Document Type: Article

References (44)

1. Mckay JA, Mathers JC. Diet induced epigenetic changes and their implications for health. Acta Physiol. (Oxf.) 202(2), 103-118 (2011).
2. Dufourg MN, Landman-Parker J, Auclerc MF et al. Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children. Leukemia 21(2), 238-247 (2007).
3. Lobel U, Trah J, Escherich G. Severe neurotoxicity following intrathecal methotrexate with nitrous oxide sedation in a child with acute lymphoblastic leukemia. Pediatr. Blood Cancer 62(3), 539-541 (2015).
4. Cheung YT, Krull KR. Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review. Neurosci. Biobehav. Rev. 53, 108-120 (2015).
5. Van Der Plas E, Nieman BJ, Butcher DT et al. Neurocognitive late effects of chemotherapy in survivors of acute lymphoblastic leukemia: focus on methotrexate. J. Can. Acad. Child Adolesc. Psychiatry 24(1), 25-32 (2015).
6. Forster VJ, Van Delft FW, Baird SF, Mair S, Skinner R, Halsey C. Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients. Cancer Chemother. Pharmacol. 78(5), 1093-1096 (2016).
7. Kroes AC, Lindemans J, Schoester M, Abels J. Enhanced therapeutic effect of methotrexate in experimental rat leukemia after inactivation of cobalamin (vitamin B12) by nitrous oxide. Cancer Chemother. Pharmacol. 17(2), 114-120 (1986).
8. Spyridopoulou KP, Dimou NL, Hamodrakas SJ, Bagos PG. Methylene tetrahydrofolate reductase gene polymorphisms and their association with methotrexate toxicity: a meta-analysis. Pharmacogenet. Genomics 22(2), 117-133 (2012).
9. Mathers JC, Strathdee G, Relton CL. Induction of epigenetic alterations by dietary and other environmental factors. Adv. Genet. 71, 3-39 (2010).
10. Rudenko A, Tsai LH. Epigenetic modifications in the nervous system and their impact upon cognitive impairments. Neuropharmacology 80, 70-82 (2014).
11. Varela-Rey M, Iruarrizaga-Lejarreta M, Lozano JJ et al. S-adenosylmethionine levels regulate the schwann cell DNA methylome. Neuron 81(5), 1024-1039 (2014).
12. Landgrave-Gomez J, Mercado-Gomez O, Guevara-Guzman R. Epigenetic mechanisms in neurological and neurodegenerative diseases. Front. Cell. Neurosci. 9, 58 (2015).
13. Cribbs AP, Kennedy A, Penn H et al. Methotrexate restores regulatory T cell function through demethylation of the FoxP3 upstream enhancer in patients with rheumatoid arthritis. Arthritis Rheumatol. (Hoboken, N.J.) 67(5), 1182-1192 (2015).
14. De Andres MC, Perez-Pampin E, Calaza M et al. Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate. Arthritis Res. Ther. 17, 233 (2015).
15. Kim YI, Logan JW, Mason JB, Roubenoff R. DNA hypomethylation in inflammatory arthritis: reversal with methotrexate. J. Lab. Clin. Med. 128(2), 165-172 (1996).
16. Bollati V, Baccarelli A, Hou L et al. Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res. 67(3), 876-880 (2007).
17. Strathdee G, Sim A, Parker A, Oscier D, Brown R. Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL. Leukemia 20(7), 1326-1329 (2006).
18. Van Otterdijk SD, Norden J, Dickinson AM et al. Aberrations in DNA methylation are detectable during remission of acute lymphoblastic leukemia and predict patient outcome. Epigenomics 7(1), 35-45 (2015).
19. Klengel T, Mehta D, Anacker C et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat. Neurosci. 16(1), 33-41 (2013).
20. Bagur J, Massoubre C, Casagranda L, Faure-Conter C, Trombert-Paviot B, Berger C. Psychiatric disorders in 130 survivors of childhood cancer: preliminary results of a semi-standardized interview. Pediatr. Blood Cancer 62(5), 847-853 (2015).
21. Kunin-Batson AS, Lu X, Balsamo L et al. Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: a prospective longitudinal study. Cancer 122(10), 1608-1617 (2016).
22. Prasad PK, Hardy KK, Zhang N et al. Psychosocial and neurocognitive outcomes in adult survivors of adolescent and early young adult cancer: a report from the childhood cancer survivor study. J. Clin. Oncol. 33(23), 2545-2552 (2015).
23. Jones MJ, Farre P, Mcewen LM et al. Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in down syndrome. BMC Med. Genomics 6, 58 (2013).
24. Lazarus J, Mather KA, Armstrong NJ et al. DNA methylation in the apolipoprotein-A1 gene is associated with episodic memory performance in healthy older individuals. J. Alzheimers Dis. 44(1), 175-182 (2015).
25. Marioni RE, Shah S, Mcrae AF et al. The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936. Int. J. Epidemiol. 44(4), 1388-1396 (2015).
26. Lockwood LE, Su S, Youssef NA. The role of epigenetics in depression and suicide: a platform for gene-environment interactions. Psychiatry Res. 228(3), 235-242 (2015).
27. Murphy TM, O'donovan A, Mullins N, O'Farrelly C, Mccann A, Malone K. Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes. Psychiatr. Genet. 25(2), 71-78 (2015).
28. Nagy C, Suderman M, Yang J et al. Astrocytic abnormalities and global DNA methylation patterns in depression and suicide. Mol. Psychiatry 20(3), 320-328 (2015).
29. Tseng PT, Lin PY, Lee Y et al. Age-associated decrease in global DNA methylation in patients with major depression. Neuropsychiatr. Dis. Treat. 10, 2105-2114 (2014).
30. Varela-Moreiras G, Ragel C, Perez De Miguelsanz J. Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats. J. Am. Coll. Nutr. 14(5), 480-485 (1995).
31. Vezmar S, Schusseler P, Becker A, Bode U, Jaehde U. Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity. Pediatr. Blood Cancer 52(1), 26-32 (2009).
32. Wang YC, Chiang EP. Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo. Mol. Med. 18, 423-432 (2012).
33. Bermingham EN, Bassett SA, Young W et al. Post-weaning selenium and folate supplementation affects gene and protein expression and global DNA methylation in mice fed high-fat diets. BMC Med. Genomics 6, 7 (2013).
34. Cordero P, Campion J, Milagro FI, Martinez JA. Transcriptomic and epigenetic changes in early liver steatosis associated to obesity: effect of dietary methyl donor supplementation. Mol. Genet. Metab. 110(3), 388-395 (2013).
35. Mckay JA, Adriaens M, Evelo CT, Ford D, Mathers JC. Gene promoter DNA methylation patterns have a limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy. Mol. Nutr. Food Res. 60(9), 2031-2042 (2016).
36. Mckay JA, Xie L, Adriaens M, Evelo CT, Ford D, Mathers JC. Maternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring. Mol. Nutr. Food Res. 61(4), 1600713 (2017).
37. Sramek M, Neradil J, Sterba J, Veselska R. Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation. Cancer Cell Int. 16, 14 (2016).
38. Wang X, Guan Z, Chen Y et al. Genomic DNA hypomethylation is associated with neural tube defects induced by methotrexate inhibition of folate metabolism. PLoS ONE 10(3), e0121869 (2015).
39. Mckay JA, Xie L, Adriaens M, Evelo CT, Ford D, Mathers JC. Organ-specific gene expression changes in the fetal liver and placenta in response to maternal folate depletion. Nutrients 8(10), 661 (2016).
40. Evans WE, Hutson PR, Stewart CF et al. Methotrexate cerebrospinal fluid and serum concentrations after intermediate-dose methotrexate infusion. Clin. Pharmacol. Ther. 33(3), 301-307 (1983).
41. Mckay JA, Groom A, Potter C et al. Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. PLoS ONE 7(3), e33290 (2012).
42. Kok DE, Dhonukshe-Rutten RA, Lute C et al. The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects. Clin. Epigenetics 7, 121 (2015).
43. Niemann A, Muhlisch J, Fruhwald MC, Gerss J, Hempel G, Boos J. Therapeutic drug monitoring of methotrexate in cerebrospinal fluid after systemic high-dose infusion in children: can the burden of intrathecal methotrexate be reduced? Ther. Drug Monit. 32(4), 467-475 (2010).
44. Moorman AV, Enshaei A, Schwab C et al. A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia. Blood 124(9), 1434-1444 (2014).