Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children

Leukemia

Volumn 21, Issue 2, 2007, Pages 238-247

  Dufourg, M N ^a   Landman Parker, J ^a   Auclerc, M F ^b   Schmitt, C ^c   Perel, Y ^d   Michel, G ^e   Levy, P ^f   Couillault, G ^g   Gandemer, V ^h   Tabone, M D ^a   Demeocq, F ⁱ   Vannier, J P ^j   Leblanc, T ^b   Leverger, G ^a   Baruchel, A ^b  

^a ARMAND TROUSSEAU HOSPITAL   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c Hospital d'Enfant Vandoeuvre les Nancy   (France)

^d Section of Radiology   (France)

^e TIMONE HOSPITAL   (France)

^f HÔPITAL TENON   (France)

^g LIMOGES UNIVERSITY HOSPITAL   (France)

^h RENNES UNIVERSITY HOSPITAL   (France)

ⁱ UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^j ROUEN UNIVERSITY HOSPITAL   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ASPARAGINASE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; FOLINIC ACID; MERCAPTOPURINE; METHOTREXATE; METHYLPREDNISOLONE; PREDNISONE; STEROID; TIOGUANINE; VINCRISTINE; VINDESINE;

ACUTE BRAIN DISEASE; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGE; ALLOGENEIC STEM CELL TRANSPLANTATION; ARACHNOIDITIS; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CANCER RESISTANCE; CEREBROVASCULAR ACCIDENT; CHILD; CHILDHOOD LEUKEMIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; FEMALE; FLACCID PARALYSIS; GAIT DISORDER; HIGH RISK PATIENT; HUMAN; INFANT; LOW DRUG DOSE; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROTOXICITY; OCCLUSIVE CEREBROVASCULAR DISEASE; PARAPLEGIA; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; QUADRIPLEGIA; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK FACTOR; SEIZURE; SENSORIMOTOR NEUROPATHY; SENSORY DYSFUNCTION; SKULL IRRADIATION; SPINAL CORD DISEASE; STATISTICAL SIGNIFICANCE;

EID: 33846554822     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404495     Document Type: Article

References (47)

1. Balsom WR, Bleyer WA, Robison LL, Heyn RM, Meadows AT, Sitarz A et al. Intellectual function in long-term survivors of childhood acute lymphoblastic leukemia: Protective effect of preirradiation methotrexate? A Childrens Cancer Study Group study. Med Pediatr Oncol 1991; 19: 486-492.
2. Bleyer WA. Central nervous system leukemia. Pediatr Clin North Am 1988; 35: 789-814.
3. Pui CH. Acute leukemia in children. Curr Opin Hematol 1996; 3: 249-258.
4. Lauer SJ, Kirchner PA, Camitta BM. Identification of leukemic cells in the cerebrospinal fluid from children with acute lymphoblastic leukemia: advances and dilemmas. Am J Pediatr Hematol Oncol 1989; 11: 64-73.
5. Evans AE, Gilbert ES, Zandstra R. The increasing incidence of central nervous system leukemia in children. (Children's Cancer Study Group A). Cancer 1970; 26: 404-409.
6. George SL, Ochs JJ, Mauer AM, Simone JV. The importance of an isolated central nervous system relapse in children with acute lymphoblastic leukemia. J Clin Oncol 1985; 3: 776-781.
7. Unal S, Yetgin S, Cetin M, Gumruk F, Arslan D, Ozyurek E et al. The prognosis and survival of childhood acute lymphoblastic leukemia with central nervous system relapse. Pediatr Hematol Oncol 2004; 21: 279-289.
8. Barredo JC, Devidas M, Lauer SJ, Billett A, Marymont M, Pullen J et al. Isolated CNS relapse of acute lymphoblastic leukemia treated with intensive systemic chemotherapy and delayed CNS radiation: A pediatric oncology group study. J Clin Oncol 2006; 24: 3142-3149.
9. Krance RA, Newman EM, Ravindranath Y, Harris MB, Brecher M, Wimmer R et al. A pilot study of intermediate-dose methotrexate and cytosine arabinoside, 'spread-out' or 'up-front, 'in continuation therapy for childhood non-T, non-B acute lymphoblastic leukemia. A Pediatric Oncology Group study. Cancer 1991; 67: 550-556.
10. Pui CH, Relling MV, Campana D, Evans WE. Childhood acute lymphoblastic leukemia. Rev Clin Exp Hematol 2002; 6: 161-180; discussion 200-202.
11. Ochs JJ. Neurotoxicity due to central nervous system therapy for childhood leukemia. Am J Pediatr Hematol Oncol 1989; 11: 93-105.
12. Reinders-Messelink HA, Van Weerden TW, Fock JM, Gidding CE, Vingerhoets HM, Schoemaker MM et al. Mild axonal neuropathy of children during treatment for acute lymphoblastic leukaemia. Eur J Paediatr Neurol 2000; 4: 225-233.
13. Herzig RH, Hines JD, Herzig GP, Wolff SN, Cassileth PA, Lazarus HM et al. Cerebellar toxicity with high-dose cytosine arabinoside. J Clin Oncol 1987; 5: 927-932.
14. Resar LM, Phillips PC, Kastan MB, Leventhal BG, Bowman PW, Civin CI. Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type. Cancer 1993; 71: 117-123.
15. Mitchell LG, Sutor AH, Andrew M. Hemostasis in childhood acute lymphoblastic leukemia: Coagulopathy induced by disease and treatment. Semin Thromb Hemost 1995; 21: 390-401.
16. Nowak-Gottl U, Ahlke E, Fleischhack G, Schwabe D, Schobess R, Schumann C et al. Thromboembolic events in children with acute lymphoblastic leukemia (BFM protocols): Prednisone versus dexamethasone administration. Blood 2003; 101: 2529-2533.
17. Yim YS, Mahoney Jr DH, Oshman DG. Hemiparesis and ischemic changes of the white matter after intrathecal therapy for children with acute lymphocytic leukemia. Cancer 1991; 67: 2058-2061.
18. Ray M, Marwaha RK, Trehan A. Chemotherapy related fatal neurotoxicity during induction in acute lymphoblastic leukemia. Indian J Pediatr 2002; 69: 185-187.
19. Kubo M, Azuma E, Arai S, Komada Y, Ito M, Sakurai M. Transient encephalopathy following a single exposure of high-dose methotrexate in a child with acute lymphoblastic leukemia. Pediatr Hematol Oncol 1992; 9: 157-165.
20. Garcia-Tena J, Lopez-Andreu JA, Ferris J, Menor F, Mulas F, Millet E et al. Intrathecal chemotherapy-related myeloencephalopathy in a young child with acute lymphoblastic leukemia. Pediatr Hematol Oncol 1995; 12: 377-385.
21. Gerrard MP, Eden OB, Lilleyman JS. Acute encephalopathy during induction therapy for acute lymphoblastic leukemia. Pediatr Hematol Oncol 1986; 3: 49-58.
22. DiMario Jr FJ, Packer RJ. Acute mental status changes in children with systemic cancer. Pediatrics 1990; 85: 353-360.
23. Winick NJ, Bowman WP, Kamen BA, Roach ES, Rollins N, Jacaruso D et al. Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia. J Natl Cancer Inst 1992; 84: 252-256.
24. Pullen J, Boyett J, Shuster J, Crist W, Land V, Frankel L et al. Extended triple intrathecal chemotherapy trial for prevention of CNS relapse in good-risk and poor-risk patients with B-progenitor acute lymphoblastic leukemia: A Pediatric Oncology Group study. J Clin Oncol 1993; 11: 839-849.
25. Mahoney Jr DH, Camitta BM, Leventhal BG, Shuster JJ, Civin CJ, Ganick DJ et al. Repetitive low dose oral methotrexate and intravenous mercaptopurine treatment for patients with lower risk B-lineage acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study. Cancer 1995; 75: 2623-2631.
26. Bowman WP, Shuster JJ, Cook B, Griffin T, Behm F, Pullen J et al. Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small noncleaved-cell lymphoma: A pediatric oncology group study. J Clin Oncol 1996; 14: 1252-1261.
27. Mahoney Jr DH, Shuster JJ, Nitschke R, Lauer SJ, Steuber CP, Winick N et al. Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: An association with intermediate-dose intravenous methotrexate and intrathecal triple therapy-a Pediatric Oncology Group study. J Clin Oncol 1998; 16: 1712-1722.
28. Rubnitz JE, Relling MV, Harrison PL, Sandlund JT, Ribeiro RC, Rivera GK et al. Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia. Leukemia 1998; 12: 1176-1181.
29. Shuper A, Stark B, Kornreich L, Cohen IJ, Aviner S, Steinmetz A et al. Methotrexate treatment protocols and the central nervous system: significant cure with significant neurotoxicity. J Child Neurol 2000; 15: 573-580.
30. Lo Nigro L, Di Cataldo A, Schiliro G. Acute neurotoxicity in children with B-lineage acute lymphoblastic leukemia (B-ALL) treated with intermediate risk protocols. Med Pediatr Oncol 2000; 35: 449-455.
31. Packer RJ, Grossman RI, Belasco JB. High dose systemic methotrexate-associated acute neurologic dysfunction. Med Pediatr Oncol 1983; 11: 159-161.
32. Allen JC, Rosen G, Mehta BM, Horten B. Leukoencephalopathy following high-dose iv methotrexate chemotherapy with leucovorin rescue. Cancer Treat Rep 1980; 64: 1261-1273.
33. Quinn CT, Kamen BA. A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities. J Investig Med 1996; 44: 522-530.
34. Drachtman RA, Cole PD, Golden CB, James SJ, Melnyk S, Aisner J et al. Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatr Hematol Oncol 2002; 19: 319-327.
35. Kishi S, Griener J, Cheng C, Das S, Cook EH, Pei D et al. Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia. J Clin Oncol 2003; 21: 3084-3091.
36. Jaffe N, Takaue Y, Anzai T, Robertson R. Transient neurologic disturbances induced by high-dose methotrexate treatment. Cancer 1985; 56: 1356-1360.
37. Defresne P, Hollenberg H, Husson B, Tabarki B, Landrieu P, Huault G et al. Acute transverse myelitis in children: Clinical course and prognostic factors. J Child Neurol 2003; 18: 401-406.
38. Ozon A, Topaloglu H, Cila A, Gunay M, Cetin M. Acute ascending myelitis and encephalopathy after intrathecal cytosine arabinoside and methotrexate in an adolescent boy with acute lymphoblastic leukemia. Brain Dev 1994; 16: 246-248.
39. Wolff L, Zighelboim J, Gale RP. Paraplegia following intrathecal cytosine arabinoside. Cancer 1979; 43: 83-85.
40. Watterson J, Toogood I, Nieder M, Morse M, Frierdich S, Lee Y et al. Excessive spinal cord toxicity from intensive central nervous system-directed therapies. Cancer 1994; 74: 3034-3041.
41. Pui CH, Mahmoud HH, Rivera GK, Hancock ML, Sandlund JT, Behm FG et al. Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia. Blood 1998; 92: 411-415.
42. Matloub Y, Lindemulder S, Gaynon PS, Sather H, La M, Broxson E et al. Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: Results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Children's Oncology Group. Blood 2006; 108: 1165-1173.
43. Nicholson JC, Darmady JM, Kohler JA. Superior sagittal sinus thrombosis complicating maintenance treatment for acute lymphoblastic leukemia. Pediatr Hematol Oncol 1996; 13: 287-291.
44. Chen CY, Zimmerman RA, Faro S, Bilaniuk LT, Chou TY, Molloy PT. Childhood leukemia: Central nervous system abnormalities during and after treatment. AJNR Am J Neuroradiol 1996; 17: 295-310.
45. Santoro N, Giordano P, Del Vecchio GC, Guido G, Rizzari C, Varotto S et al. Ischemic stroke in children treated for acute lymphoblastic leukemia: A retrospective study. J Pediatr Hematol Oncol 2005; 27: 153-157.
46. deVeber G, Andrew M, Adams C, Bjornson B, Booth F, Buckley DJ et al. Cerebral sinovenous thrombosis in children. N Engl J Med 2001; 345: 417-423.
47. Nowak-Gottl U, Schlegel N, Brenner B. New insights into paediatric haemostasis: Thrombosis and bleeding issues. Thromb Haemost 2004; 92: 676-677.