메뉴 건너뛰기




Volumn 27, Issue 11, 2017, Pages 754-768

Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway

Author keywords

Britanin; Keap1; Nrf2; ROS; stroke

Indexed keywords

ALPHA TOCOPHEROL; BRITANIN; CASPASE 3; CYSTEINE; GLUCOSE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LACTATE DEHYDROGENASE; MESSENGER RNA; NATURAL PRODUCT; NEUROPROTECTIVE AGENT; OXYGEN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; BRITANNIN; LACTONE; NFE2L2 PROTEIN, RAT; SESQUITERPENE;

EID: 85028817942     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2016.6885     Document Type: Article
Times cited : (75)

References (43)
  • 1
    • 84884493497 scopus 로고    scopus 로고
    • Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke
    • Alfieri A, Srivastava S, Siow RC, Cash D, Modo M, Duchen MR, Fraser PA, Williams SC, and Mann GE. Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke. Free Radic Biol Med 65: 1012-1022, 2013.
    • (2013) Free Radic Biol Med , vol.65 , pp. 1012-1022
    • Alfieri, A.1    Srivastava, S.2    Siow, R.C.3    Cash, D.4    Modo, M.5    Duchen, M.R.6    Fraser, P.A.7    Williams, S.C.8    Mann, G.E.9
  • 2
    • 40549121572 scopus 로고    scopus 로고
    • Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription ac-Tivation function of Nrf2 in IMR-32 neuroblastoma cells
    • Apopa PL, He X, and Ma Q. Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription ac-Tivation function of Nrf2 in IMR-32 neuroblastoma cells. J Biochem Mol Toxicol 22: 63-76, 2008.
    • (2008) J Biochem Mol Toxicol , vol.22 , pp. 63-76
    • Apopa, P.L.1    He, X.2    Ma, Q.3
  • 4
    • 84921047168 scopus 로고    scopus 로고
    • Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: An overview
    • Bomprezzi R. Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: An overview. Ther Adv Neurol Disord 8: 20-30, 2015.
    • (2015) Ther Adv Neurol Disord , vol.8 , pp. 20-30
    • Bomprezzi, R.1
  • 6
    • 29644437160 scopus 로고    scopus 로고
    • 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
    • Chen Z-H, Saito Y, Yoshida Y, Sekine A, Noguchi N, and Niki E. 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2. J Biol Chem 280: 41921-41927, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 41921-41927
    • Chen, Z.-H.1    Saito, Y.2    Yoshida, Y.3    Sekine, A.4    Noguchi, N.5    Niki, E.6
  • 8
    • 18844412788 scopus 로고    scopus 로고
    • Reactive oxygen species and the modulation of stroke
    • Crack PJ and Taylor JM. Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 38: 1433-1444, 2005.
    • (2005) Free Radic Biol Med , vol.38 , pp. 1433-1444
    • Crack, P.J.1    Taylor, J.M.2
  • 14
    • 24744453945 scopus 로고    scopus 로고
    • Specific patterns of electrophile adduction trigger Keap1 Ubiquitination and Nrf2 activation
    • Hong F, Sekhar KR, Freeman ML, and Liebler DC. Specific patterns of electrophile adduction trigger Keap1 Ubiquitination and Nrf2 activation. J Biol Chem 280: 31768-31775, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 31768-31775
    • Hong, F.1    Sekhar, K.R.2    Freeman, M.L.3    Liebler, D.C.4
  • 15
    • 0033731182 scopus 로고    scopus 로고
    • Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
    • Huang H-C, Nguyen T, and Pickett CB. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci U S A 97: 12475-12480, 2000.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12475-12480
    • Huang, H.-C.1    Nguyen, T.2    Pickett, C.B.3
  • 16
    • 0034717329 scopus 로고    scopus 로고
    • Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in Macrophages
    • Ishii T. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in Macrophages. J Biol Chem 275: 16023-16029, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 16023-16029
    • Ishii, T.1
  • 17
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-Terminal Neh2 domain
    • Itoh K, WakabayashiN, Katoh Y, Ishii T, IgarashiK, Engel JD, and Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-Terminal Neh2 domain. Genes Dev 13: 76-86, 1999.
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashin Katoh, Y.2    Ishii, T.3    Igarashik Engel, J.D.4    Yamamoto, M.5
  • 18
    • 84897395747 scopus 로고    scopus 로고
    • Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis
    • Jiang Z-Y, Lu M-C, Yang T-T, Xi M-Y, Xu X-L, Guo X-K, Zhang X-J, You Q-D, and Sun H-P. Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis. J Med Chem 57: 2736-2745, 2014.
    • (2014) J Med Chem , vol.57 , pp. 2736-2745
    • Jiang, Z.-Y.1    Lu, M.-C.2    Yang, T.-T.3    Xi, M.-Y.4    Xu, X.-L.5    Guo, X.-K.6    Zhang, X.-J.7    You, Q.-D.8    Sun, H.-P.9
  • 19
    • 0346157306 scopus 로고    scopus 로고
    • Effects of estrone on Nmethyl-D-Aspartic acid-And staurosporine-induced changes in caspase-3-like protease activity and lactate dehydrogenaserelease: Time-And tissue-dependent effects in neuronal primary cultures
    • Kajta M, Lasoń W, and Kupiec T. Effects of estrone on Nmethyl-D-Aspartic acid-And staurosporine-induced changes in caspase-3-like protease activity and lactate dehydrogenaserelease: Time-And tissue-dependent effects in neuronal primary cultures. Neuroscience 123: 515-526, 2004.
    • (2004) Neuroscience , vol.123 , pp. 515-526
    • Kajta, M.1    Lasoń, W.2    Kupiec, T.3
  • 21
    • 33748052967 scopus 로고    scopus 로고
    • Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
    • Kobayashi M and Yamamoto M. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul 46: 113-140, 2006.
    • (2006) Adv Enzyme Regul , vol.46 , pp. 113-140
    • Kobayashi, M.1    Yamamoto, M.2
  • 22
    • 77953648503 scopus 로고    scopus 로고
    • A critical assessment of edaravone acute ischemic stroke efficacy trials: Is edaravone an effective neuroprotective therapy
    • Lapchak PA. A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy? Expert Opin Pharmacother 11: 1753-1763, 2010.
    • (2010) Expert Opin Pharmacother , vol.11 , pp. 1753-1763
    • Lapchak, P.A.1
  • 23
    • 21744445077 scopus 로고    scopus 로고
    • Nrf2 a multi-organ protector
    • Lee J-M. Nrf2, a multi-organ protector? FASEB J 19: 1061-1066, 2005.
    • (2005) FASEB J , vol.19 , pp. 1061-1066
    • Lee, J.-M.1
  • 24
    • 0141621061 scopus 로고    scopus 로고
    • NF-E2-related Factor-2 mediates neuroprotection against mitochondrial complex i inhibitors and increased concentrations of intracellular Calcium in primary cortical neurons
    • Lee J-M, Shih AY, Murphy TH, and Johnson JA. NF-E2-related Factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular Calcium in primary cortical neurons. J Biol Chem 278: 37948-37956, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 37948-37956
    • Lee, J.-M.1    Shih, A.Y.2    Murphy, T.H.3    Johnson, J.A.4
  • 25
    • 13644268144 scopus 로고    scopus 로고
    • Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
    • Li J. Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. Toxicol Sci 83: 313-328, 2004.
    • (2004) Toxicol Sci , vol.83 , pp. 313-328
    • Li, J.1
  • 26
    • 0024494427 scopus 로고
    • Reversible middle cerebral artery occlusion without craniectomy in rats
    • Longa EZ, Weinstein PR, Carlson S, and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91, 1989.
    • (1989) Stroke , vol.20 , pp. 84-91
    • Longa, E.Z.1    Weinstein, P.R.2    Carlson, S.3    Cummins, R.4
  • 27
    • 84888864147 scopus 로고    scopus 로고
    • Hydrogen sulfide prevents OGD/Rinduced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons
    • Luo Y, Yang X, Zhao S, Wei C, Yin Y, Liu T, Jiang S, Xie J, Wan X, Mao M, et al. Hydrogen sulfide prevents OGD/Rinduced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons. Neurochem Int 63: 826-831, 2013.
    • (2013) Neurochem Int , vol.63 , pp. 826-831
    • Luo, Y.1    Yang, X.2    Zhao, S.3    Wei, C.4    Yin, Y.5    Liu, T.6    Jiang, S.7    Xie, J.8    Wan, X.9    Mao, M.10
  • 29
    • 78650952230 scopus 로고    scopus 로고
    • Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen-glucose deprivation) models
    • Meloni BP, Meade AJ, Kitikomolsuk D, and Knuckey NW. Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen-glucose deprivation) models. J Neurosci Methods 195: 67-74, 2011.
    • (2011) J Neurosci Methods , vol.195 , pp. 67-74
    • Meloni, B.P.1    Meade, A.J.2    Kitikomolsuk, D.3    Knuckey, N.W.4
  • 32
    • 77649261371 scopus 로고    scopus 로고
    • Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-Terminal domains
    • Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, and Yamamoto M. Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-Terminal domains. Proc Natl Acad Sci U S A 107: 2842-2847, 2010.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2842-2847
    • Ogura, T.1    Tong, K.I.2    Mio, K.3    Maruyama, Y.4    Kurokawa, H.5    Sato, C.6    Yamamoto, M.7
  • 33
    • 84861112895 scopus 로고    scopus 로고
    • Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-jB activation in a cerebral ischemia mouse model
    • Qian Y, Guan T, Huang M, Cao L, li Y, Cheng H, Jin H, and Yu D. Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-jB activation in a cerebral ischemia mouse model. Neurochem Int 60: 759-767, 2012.
    • (2012) Neurochem Int , vol.60 , pp. 759-767
    • Qian, Y.1    Guan, T.2    Huang, M.3    Cao, L.Y.4    Cheng, H.5    Jin, H.6    Yu, D.7
  • 34
    • 41149134840 scopus 로고    scopus 로고
    • GSK-3b downregulates the transcription factor Nrf2 after oxidant damage: Relevance to exposure of neuronal cells to oxidative stress
    • Rojo AI, Sagarra MR de, and Cuadrado A. GSK-3b downregulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress. J Neurochem 105: 192-202, 2008.
    • (2008) J Neurochem , vol.105 , pp. 192-202
    • Rojo, A.I.1    Sagarra, M.R.D.E.2    Cuadrado, A.3
  • 38
    • 56249106571 scopus 로고    scopus 로고
    • Nrf2 as aMasterRedox Switch in Turning on the Cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
    • Surh Y-J, Kundu J, and Na H-K. Nrf2 as aMasterRedox Switch in Turning on the Cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 74: 1526-1539, 2008.
    • (2008) Planta Med , vol.74 , pp. 1526-1539
    • Surh, Y.-J.1    Kundu, J.2    Na, H.-K.3
  • 42
    • 33748358379 scopus 로고    scopus 로고
    • Mechanism of action of isothiocyanates: The induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation ofNrf2
    • Xu C. Mechanism of action of isothiocyanates: The induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation ofNrf2. Mol Cancer Ther 5: 1918-1926, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1918-1926
    • Xu, C.1
  • 43
    • 29244479186 scopus 로고    scopus 로고
    • Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents
    • Zhao J, Kobori N, Aronowski J, and Dash PK. Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 393: 108-112, 2006.
    • (2006) Neurosci Lett , vol.393 , pp. 108-112
    • Zhao, J.1    Kobori, N.2    Aronowski, J.3    Dash, P.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.