Salicylate-based phytopharmaceuticals induce adaptive cytokine and chemokine network responses in human fibroblast cultures

Phytomedicine

Volumn 34, Issue , 2017, Pages 202-211

  Ulrich Merzenich, Gudrun ^a   Hartbrod, Frederik ^a   Kelber, Olaf ^b   Müller, Jürgen ^b   Koptina, Anna ^a,c   Zeitler, Heike ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Steigerwald Arzneimittelwerk GmbH   (Germany)

^c VOLGA STATE UNIVERSITY OF TECHNOLOGY   (Russian Federation)

Author keywords

Cytokine networks; Fibroblasts; Immunomodulation; Inflammation; Salicylates

Indexed keywords

ACETYLSALICYLIC ACID; CHEMOKINE; CYTOKINE; FRAXINUS EXCELSIOR EXTRACT; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRO ALPHA PROTEIN; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 3; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LYMPHOTOXIN; MONOCYTE CHEMOTACTIC PROTEIN 1; POPULUS TREMULA EXTRACT; RANTES; RNA; SALICYLIC ACID; SOLIDAGO VIRGAUREA EXTRACT; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; INTERLEUKIN DERIVATIVE; PLANT EXTRACT; SALICYLIC ACID DERIVATIVE;

ARTICLE; CELL LYSATE; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST CULTURE; FRAXINUS; FRAXINUS EXCELSIOR; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; POPULUS TREMULA; PRIORITY JOURNAL; RNA ISOLATION; SKIN; SOLIDAGO; SOLIDAGO VIRGAUREA; CELL CULTURE; DRUG EFFECTS; FIBROBLAST; METABOLISM;

ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CHEMOKINES; CYTOKINES; FIBROBLASTS; HUMANS; INTERLEUKINS; LIPOPOLYSACCHARIDES; PLANT EXTRACTS; SALICYLATES;

EID: 85028760054     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2017.08.002     Document Type: Article

References (53)

1. Baggiolini, M., CXCL8 – the first chemokine. Front. Immunol., 6, 2015, 285, 10.3389/fimmu.2015.00285.
2. Bossaller, L., Rothe, A., Monoclonal antibody treatments for rheumatoid arthritis. Exp. Opin. Biol. Ther. 13 (2013), 1257–1272.
3. Brennan, F.M., Zachariae, C.O., Chantry, D., Larsen, C.G., Turner, M., Maini, R.N., Matsushima, K., Feldmann, M., Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells. Eur. J. Immunol. 20 (1990), 2141–2144.
4. Cameron, M., Gagnier, J.J., Chrubasik, S., 2011. Herbal therapy for treating rheumatoid arthritis. The Cochrane database of systematic reviews, CD002948.
5. Campbell, L.M., Maxwell, P.J., Waugh, D.J., Rationale and means to target pro-inflammatory interleukin-8 (CXCL8) signaling in cancer. Pharmaceuticals 6 (2013), 929–959.
6. Castor, C.W., Smith, E.M., Bignall, M.C., Hossler, P.A., Connective tissue activation. XXXVII. Effects of cytokine combinations, implications for an integrated cytokine network. J. Rheumatol. 24 (1997), 2080–2089.
7. Cuzick, J., Thorat, M.A., Bosetti, C., Brown, P.H., Burn, J., Cook, N.R., et al. Estimates of benefits and harms of phrophylactic use of aspirin in the general population. Ann. Oncol. 26 (2015), 47–57.
8. Daien, C.I., Morel, J., Predictive factors of response to biological disease modifying antirheumatic drugs: towards personalized medicine. Mediators Inflammation, 2014, vol 2014, Article ID 386148, 11 pages. doi: 10.1155/2014/386148.
9. David, J.M., Dominguez, C., Hamilton, D.H., Palena, C., The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance. Vaccines (Basel) 24;, 4(3), 2016 pii: E22, doi: 10.3390/vaccines4030022.
10. Dethlefsen, C., Hojfeldt, G., Hojman, P., The role of intratumoral and systemic IL-6 in breast cancer. Breast Cancer Res. Treatment 138 (2013), 657–664.
11. Dorner, T., Giesecke, C., Lipsky, P.E., Mechanisms of B cell autoimmunity in SLE. Arthritis Res. Ther., 13, 2011, 243.
12. Ernst, E., Pittler, M.H., Wider, B., (eds.) The Desktop Guide to Complementary and Alternative Medicine, 2006, Elsevier Ltd.
13. Grimm, M.C., Elsbury, S.K., Pavli, P., Doe, W.F., Interleukin 8: cells of origin in inflammatory bowel disease. Gut 38 (1996), 90–98.
14. Gundermann, K.J., Müller, J., Phytodolor ®- effect and efficiency of a herbal medicine. Wien. Med. Wochenschr. 157/13-14 (2007), 343–347.
15. Habiel, D.M., Hogaboam, C., Heterogeneity in fibroblast proliferation and survival in idiopathic pulmonary fibrosis. Front. Pharmacol., 5, 2014, 2.
16. Hur, S.J., Kay, S.H., Jung, H.S., Kim, S.C., Jeon, H.S., Kim, I.H., Lee, J.D., Review of natural products actions on cytokines in inflammatory bowel disease. Nutr. Res. 32:11 (2012), 801–816.
17. Ivanovska, N., Yossifova, T., Vassileva, E., Kostova, I., Effect of some hydroxycoumarins on complement-mediated hemolysis in human serum. Methods Find Exp. Clin. Pharmacol. 16 (1994), 557–562.
18. Jorken, S., Okpanyi, S.N., Pharmakologische Grundlagen pflanzlicher Arzneimittel. Loew, D., Reitbrock, N., (eds.) Phytotherapheutika: Forschung und Klinische Anwendung, 1996, Steinkopf Verlag, GmbH, Darmstadt.
19. Khayyal, M.T., El-Ghazaly, M.A., Abdallah, D.M., Okpanyi, S.N., Kelber, O., Weiser, D., Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittelforschung 55 (2005), 677–687.
20. Klein-Galczinsky, C., Pharmacological and clinical effectiveness of a fixed phytogenic combination trembling poplar (Populus tremula), true goldenrod (Solidago virgaurea) and ash (Fraxinus excelsior) in mild to moderate rheumatic complaints. Wien. Med. Wochenschr. 149 (1999), 248–253.
21. Knuth, S., Abdelsalam, R.M., Khayyal, M.T., Schweda, F., Heilmann, J., Kees, M.G., et al. Catechol conjugates are in vivo metabolites of Salicis cortex. Planta Med. 79:16 (2013), 1489–1494.
22. Kumar, S., Kishimoto, H., Chua, H.L., Badve, S., Miller, K.D., Bigsby, R.M., Nakshatri, H., Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer. Am. J. Pathol. 163 (2003), 2531–2541.
23. Lee, W., Ku, S.K., Bae, J.S., Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo. Food Chem. Toxicol. 50 (2012), 3048–3055.
24. Lund, S., Christensen, K.V., Hedtjärn, M., Mortensen, A.L., Hagberg, H., Falsig, J., Hasseldam, H., Schrattenholz, A., Pörzgen, P., Leist, M., The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions. J. Neuroimmunol. 180:1–2 (2006), 71–87.
25. Maini, R.N., Anti-TNF therapy from the bench to the clinic: a paradigm of translational research. ClinMed 10 (2010), 161–162.
26. Manach, C., Scalbert, A., Morand, C., Remesy, C., Jimenez, L., Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr. 79 (2004), 727–747.
27. Matsushima, K., Morishita, K., Yoshimura, T., Lavu, S., Kobayashi, Y., Lew, W., Appella, E., Kung, H.F., Leonard, E.J., Oppenheim, J.J., Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J. Exp. Med. 167 (1988), 1883–1893.
28. Mazzucchelli, L., Hauser, C., Zgraggen, K., Wagner, H., Hess, M., Laissue, J.A., Mueller, C., Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. Am. J. Pathol. 144 (1994), 997–1007.
29. Nahrstedt, A., Schmidt, M., Jaggi, R., Metz, J., Khayyal, M.T., Willow bark extract: the contribution of polyphenols to the overall effect. Wiener. Med. Wochenschr. 157 (2007), 348–351.
30. Panossian, A., Hamm, R., Kadioglu, O., Wikmann, G., Efferth, T, Synergy and antagonism of active constituents of ADAPT-232 on transcriptional level of metabolic regulation of isolated neuroglia cells. Front. Neurosci., 2013 Feb. 2007:16. doi: 10.3389/fnins.
31. Paya, M., Goodwin, P.A., De Las Heras, B., Hoult, J.R., Superoxide scavenging activity in leukocytes and absence of cellular toxicity of a series of coumarins. Biochem. Pharmacol. 48 (1994), 445–451.
32. Pedersen, B.K., The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Essays Biochem. 42 (2006), 105–117.
33. Riegsecker, S., Wiczynski, D., Kaplan, M.J., Ahmed, S., Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis. Life Sci. 93 (2013), 307–312.
34. Rothwell, A.J., Urpi-Sarda, M., Odonez, M.B., Llorach, R., Farran-Codina, A., Barupal, D.K., Neveu, V., Manach, C., Anderes-Lacueva, C.A., Scalbert, A, Systemic analysis of the polyphenol metablome using the phenol-explorer database. Mol. Nutr 60 (2016), 203–211.
35. Schaser, J., Bonaterram, G.A., Kelberm, O., Weiser, D., Kinscherf, R., Metz, J., Untersuchungen antiinflammatorischer Effekte des Phytopharmakons Phytodolor und seiner Einzelkomponenten in einem Monozyten-Testmodell. Perfusion 19 (2006), 76–77.
36. Schempp, H., Weiser, D., Elstner, E.F., Biochemical model reactions indicative of inflammatory processes. Activities of extracts from Fraxinus excelsior and Populus tremula. Arzneimittelforschung 50 (2000), 362–372.
37. Smith, T.J., Insights into the role of fibroblasts in human autoimmune disease. Clin. Exp. Immunol 141 (2005), 388–397.
38. Starkie, R., Ostrowski, S.R., Jauffred, S., Febbraio, M., Pedersen, B.K., Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J. 17 (2003), 884–886.
39. Tanaka, Y., Hirata, S., Saleem, B., Emery, P., Discontinuation of biologics in patients with rheumatoid arthritis. Clin. Exp. Rheumatol. 31:Suppl 78 (2013), S22–S27.
40. Uehleke, B., Brignoli, R., Rostock, M., Saller, R., Melzer, J., Phytodolor(R) in musculoskeletal disorders: re-analysis and meta-analysis. Forschende Komplementarmedizin 18 (2011), 249–256.
41. Ulrich-Merzenich, G., Bhonde, R.R., Donor site, age and health affect fibroblast growth in culture. In vitro Cell Dev. Biol. Anim. 31:7 (1995), 494–496.
42. Ulrich-Merzenich, G., Kelber, O., Koptina, A., Freischmidt, A., Heilmann, J., Muller, J., Zeitler, H., Seidel, M.F., Ludwig, M., Heinrich, E.U., Winterhoff, H., Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. Phytomedicine 19 (2012), 930–939.
43. Ulrich-Merzenich, G., Koptina, A., Kelber, O., Freischmidt, A., Heilmann, J., Muller, J., Sadeghlar, F., Zeitler, H., Wagner, H., Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine. Phytomedicine 19 (2012), 322–329.
44. Ulrich-Merzenich, G., Panek, D., Zeitler, H., Wagner, H., Vetter, H., New perspectives for synergy research with the “omic”-technologies. Phytomedicine 16 (2009), 495–508.
45. Ulrich-Merzenich, G., Zeitler, H., Jobst, D., Panek, D., Vetter, H., Wagner, H., Application of the “-Omic-” technologies in phytomedicine. Phytomedicine 14 (2007), 70–82.
46. Vane, J., The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action. Vane J. 1:33 Suppl (1987), 18–27.
47. von Kruedener, S., Schneider, W., Elstner, E.F., A combination of Populus tremula, Solidago virgaurea and Fraxinus excelsior as an anti-inflammatory and antirheumatic drug. A short review. Arzneimittelforschung 45 (1995), 169–171.
48. Wagner, H., Multitarget Therapy - the Future of Treatment for More than Just Functional Dyspepsia. Wagner, H., Allesscher, H.D., (eds.) Phytomedicine, vol 13, 2006, 122–129.
49. Wang, S.W., Wang, Y.J., Su, Y.J., Zhou, W.W., Yang, S.G., Zhang, R., Zhao, M., Li, Y.N., Zhang, Z.P., Zhan, D.W., Liu, R.T., Rutin inhibits beta-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. Neurotoxicology 33 (2012), 482–490.
50. Whang, W.K., Park, H.S., Ham, I., Oh, M., Namkoong, H., Kim, H.K., Hwang, D.W., Hur, S.Y., Kim, T.E., Park, Y.G., Kim, J.R., Kim, J.W., Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp. Mol. Med. 37 (2005), 436–446.
51. Yadav, V.R., Prasad, S., Sung, B., Kannappan, R., Aggarwal, B.B., Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. Toxins 2 (2010), 2428–2466.
52. Zeilhofer, H.U., Schorr, W., Role of interleukin-8 in neutrophil signaling. Curr. Opin. Hematol. 7 (2000), 178–182.
53. Zhang, S., Qi, Y., Xu, Y., Han, X., Peng, J., Liu, K., Sun, C.K., Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. Neurochem. Int. 63 (2013), 522–532.