Prediction of adverse events by in vivo gene expression profiling exemplified for phytopharmaceuticals containing salicylates and the antidepressant imipramine

Phytomedicine

Volumn 19, Issue 3-4, 2012, Pages 322-329

  Ulrich Merzenich, G ^a   Koptina, A ^a,b   Kelber, O ^c   Freischmidt, A ^d   Heilmann, J ^d   Muller J ^c   Sadeghlar, F ^a   Zeitler, H ^a   Wagner, H ^e  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b VOLGA STATE UNIVERSITY OF TECHNOLOGY   (Russian Federation)

^c Steigerwald Arzneimittelwerk GmbH   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

Adverse events; Antidepressant; Gene microarray; Imipramine; Multitarget; Salicylates (Salicin)

Indexed keywords

ALCOHOL; ALKALINE PHOSPHATASE; ALPHA 1D ADRENERGIC RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE; ERYTHROPOIETIN; IMIPRAMINE; NITRIC OXIDE SYNTHASE; PLANT EXTRACT; SALICIN; SALICYLIC ACID; UNCLASSIFIED DRUG; VASCULOTROPIN; WILLOW BARK EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY DISEASE; ARTICLE; BLOOD; CHEMICAL COMPOSITION; COMPARATIVE STUDY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DISEASE CLASSIFICATION; DRUG SAFETY; GENE EXPRESSION PROFILING; GLOMERULAR DYSFUNCTION; HEART ARRHYTHMIA; HEART BLOCK; HEART FAILURE; HEART INFARCTION; HEART INJURY; HEART PALPITATION; HEART VENTRICLE HYPERTROPHY; KIDNEY FAILURE; KIDNEY TUBULE NECROSIS; MALE; MICROARRAY ANALYSIS; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; TACHYCARDIA; URINE RETENTION; WILLOW;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BENZYL ALCOHOLS; DRUG-INDUCED LIVER INJURY; ETHANOL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUCOSIDES; HEART DISEASES; HYPERTENSION, PULMONARY; IMIPRAMINE; MALE; NEPHRITIS; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SALICYLATES;

RATTUS; SALIX;

EID: 84857039368     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.09.078     Document Type: Article

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