Liposome-Based Models for Membrane Rafts: Methodology and Applications

Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application

Volumn , Issue , 2014, Pages 143-165

  Heberle, Frederick A ^a   Petruzielo, Robin S ^b   Goh, Shih Lin ^b   Konyakhina, Tatyana M ^b   Ackerman, David G ^b   Amazon, Jonathan J ^b   Feigenson, Gerald W ^b  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85028659308     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b16617-12     Document Type: Chapter

References (135)

1. Ackerman, D., Heberle, F. A., and Feigenson, G. W. 2013. Limited perturbation of a DPPC bilayer by fluorescent lipid probes: A molecular dynamics study. Journal of Physical Chemistry B, 117, 4844-4852.
2. Amazon, J. J., Goh, S. L., and Feigenson, G. W. 2013. Competition between line tension and curvature stabilizes modulated phase patterns on the surface of giant unilamellar vesicles: A simulation study. Physical Review E, 87(2), 022708.
3. Anghel, V. N. P. et al. 2007. Scattering from laterally heterogeneous vesicles. II. The form factor. Journal of Applied Crystallography, 40, 513-525.
4. Ariola, F. S. et al. 2009. Membrane fluidity and lipid order in ternary giant unilamellar vesicles using a new bodipy-cholesterol derivative. Biophysical Journal, 96(7), 2696-2708.
5. Ayuyan, A. G. and Cohen, F. S. 2006. Lipid peroxides promote large rafts: Effects of excitation of probes in fluorescence microscopy and electrochemical reactions during vesicle formation. Biophysical Journal, 91(6), 2172-2183.
6. Bagatolli, L. and Kumar, P. B. S. 2009. Phase behavior of multicomponent membranes: Experimental and computational techniques. Soft Matter, 5(17), 3234-3248.
7. Bakht, O. and London, E. 2007. Detecting ordered domain formation (lipid rafts) in model membranes using Tempo. Methods in Molecular Biology, 398, 29-40.
8. Bakht, O., Pathak, P., and London, E. 2007. Effect of the structure of lipids favoring disordered domain formation on the stability of cholesterol-containing ordered domains (lipid rafts): Identification of multiple raft-stabilization mechanisms. Biophysical Journal, 93(12), 4307-4318.
9. Baumgart, T., Hess, S. T., and Webb, W. W. 2003. Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension. Nature, 425(6960), 821-824.
10. Baykal-Caglar, E. et al. 2012. Preparation of giant unilamellar vesicles from damp lipid film for better lipid compositional uniformity. Biochimica et Biophysica Acta, 1818(11), 2598-2604.
11. Bjorkqvist, Y. J. et al. 2005. Domain formation and stability in complex lipid bilayers as reported by cholestatrienol. Biophysical Journal, 88(6), 4054-4063.
12. Boulgaropoulos, B. et al. 2012. Lipid sorting by ceramide and the consequences for membrane proteins. Biophysical Journal, 102(9), 2031-2038.
13. Brown, A. C., Towles, K. B., and Wrenn, S. P. 2007a. Measuring raft size as a function of membrane composition in PC-based systems: Part 1-Binary systems. Langmuir, 23(22), 11180-11187.
14. Brown, A. C., Towles, K. B., and Wrenn, S. P. 2007b. Measuring raft size as a function of membrane composition in PC-based systems: Part II-Ternary systems. Langmuir, 23(22), 11188-11196.
15. Brown, D. A. 2006. Lipid rafts, detergent-resistant membranes, and raft targeting signals. Physiology, 21, 430-439.
16. Buboltz, J. T. 2007. Steady-state probe-partitioning fluorescence resonance energy transfer: A simple and robust tool for the study of membrane phase behavior. Physical Review E, 76(2), 021903.
17. Buboltz, J. T. et al. 2007a. Stern-Volmer modeling of steady-state Forster energy transfer between dilute, freely diffusing membrane-bound fluorophores. Journal of Chemical Physics, 127(21), 215101.
18. Buboltz, J. T. et al. 2007b. High-resolution mapping of phase behavior in a ternary lipid mixture: Do lipid-raft phase boundaries depend on the sample preparation procedure? Langmuir, 23(24), 11968-11971.
19. Cao, X., Surma, M. A., and Simons, K. 2012. Polarized sorting and trafficking in epithelial cells. Cell Research, 22(5), 793-805.
20. Chen, L., Yu, Z., and Quinn, P. J. 2007. The partition of cholesterol between ordered and fluid bilayers of phosphatidylcholine: A synchrotron x-ray diffraction study. Biochimica et Biophysica Acta, 1768(11), 2873-2881.
21. Cheng, H. T. and London, E. 2011. Preparation and properties of asymmetric large unilamellar vesicles: Interleaflet coupling in asymmetric vesicles is dependent on temperature but not curvature. Biophysical Journal, 100(11), 2671-2678.
22. Cheng, H. T., Megha, and London, E. 2009. Preparation and properties of asymmetric vesicles that mimic cell membranes: Effect upon lipid raft formation and transmembrane helix orientation. Journal of Biological Chemistry, 284(10), 6079-6092.
23. Chiang, Y. W. et al. 2004. Dynamic molecular structure of DPPC-DLPC-cholesterol ternary lipid system by spin-label electron spin resonance. Biophysical Journal, 87(4), 2483-2496.
24. Chiang, Y. W. et al. 2005. New method for determining tie-lines in coexisting membrane phases using spin-label ESR. Biochimica et Biophysica Acta, 1668(1), 99-105.
25. Collado, M. I. et al. 2005. Domain formation in sphingomyelin/cholesterol mixed membranes studied by spin-label electron spin resonance spectroscopy. Biochemistry, 44(12), 4911-4918.
26. Davis, R., Kumar, P. B. S., Sperotto, M. M., and Laradji, M. 2013. Predictions of phase separation in three-component lipid membranes by the MARTINI force field. The Journal of Physical Chemistry B, 117(15), 4072-4080.
27. Davis, J. H., Clair, J. J., and Juhasz, J. 2009. Phase equilibria in DOPC/DPPC-d62/cholesterol mixtures. Biophysical Journal, 96(2), 521-539.
28. de Almeida, R. F. et al. 2005. Lipid rafts have different sizes depending on membrane composition: A time-resolved fluorescence resonance energy transfer study. Journal of Molecular Biology, 346(4), 1109-1120.
29. de Almeida, R. F. M. et al. 2007. Complexity of lipid domains and rafts in giant unilamellar vesicles revealed by combining imaging and microscopic and macroscopic time-resolved fluorescence. Biophysical Journal, 93(2), 539-553.
30. de Almeida, R. F. M., Fedorov, A., and Prieto, M. 2003. Sphingomyelin/phosphatidylcholine/cholesterol phase diagram: Boundaries and composition of lipid rafts. Biophysical Journal, 85(4), 2406-2416.
31. de Kruyff, B. et al. 1973. The effect of the polar headgroup on the lipid-cholesterol interaction: A monolayer and differential scanning calorimetry study. Biochimica et Biophysica Acta, 307(1), 1-19.
32. de Kruyff, B. et al. 1974. Non-random distribution of cholesterol in phosphatidylcholine bilayers. Biochimica et Biophysica Acta, 356(1), 1-7.
33. Demel, R. A. et al. 1977. Preferential interaction of cholesterol with different classes of phospholipids. Biochimica et Biophysica Acta, 465(1), 1-10.
34. Dietrich, C. et al. 2001. Lipid rafts reconstituted in model membranes. Biophysical Journal, 80(3), 1417-1428.
35. Dimova, R. et al. 2006. A practical guide to giant vesicles. Probing the membrane nanoregime via optical microscopy. Journal of Physics: Condensed Matter, 18(28), S1151-S1176.
36. Esposito, C. et al. 2007. Flicker spectroscopy of thermal lipid bilayer domain boundary fluctuations. Biophysical Journal, 93(9), 3169-3181.
37. Farkas, E. R. and Webb, W. W. 2010. Precise and millidegree stable temperature control for fluorescence imaging: Application to phase transitions in lipid membranes. Review of Scientific Instruments, 81(9), 093704.
38. Feigenson, G. W. 2007. Phase boundaries and biological membranes. Annual Review of Biophysics and Biomolecular Structure, 36, 63-77.
39. Feigenson, G. W. 2009. Phase diagrams and lipid domains in multicomponent lipid bilayer mixtures. Biochimica et Biophysica Acta, 1788(1), 47-52.
40. Feigenson, G. W. and Buboltz, J. T. 2001. Ternary phase diagram of dipalmitoyl-PC/dilauroyl-PC/cholesterol: Nanoscopic domain formation driven by cholesterol. Biophysical Journal, 80(6), 2775-2788.
41. Fidorra, M. et al. 2006. Absence of fluid-ordered/fluid-disordered phase coexistence in ceramide/POPC mixtures containing cholesterol. Biophysical Journal, 90(12), 4437-4451.
42. Filippov, A., Oradd, G., and Lindblom, G. 2003. The effect of cholesterol on the lateral diffusion of phospholipids in oriented bilayers. Biophysical Journal, 84(5), 3079-3086.
43. Frazier, M. L. et al. 2007. Investigation of domain formation in sphingomyelin/cholesterol/POPC mixtures by fluorescence resonance energy transfer and Monte Carlo simulations. Biophysical Journal, 92(7), 2422-2433.
44. Fuller, D. M. and Zhang, W. 2009. Regulation of lymphocyte development and activation by the LAT family of adapter proteins. Immunological Reviews, 232(1), 72-83.
45. Fung, B. K. K. and Stryer, L. 1978. Surface density determination in membranes by fluorescence energy-transfer. Biochemistry, 17(24), 5241-5248.
46. Goh, S. L., Amazon, J. J., and Feigenson, G. W. 2013. Toward a better raft model: Modulated phases in the four-component bilayer, DSPC/DOPC/POPC/CHOL. Biophysical Journal, 104(4), 853-862.
47. Gullapalli, R. R., Demirel, M. C., and Butler, P. J. 2008. Molecular dynamics simulations of DiI-C18(3) in a DPPC lipid bilayer. Physical Chemistry Chemical Physics, 10(24), 3548-3560.
48. Halling, K. K. et al. 2008. Cholesterol interactions with fluid-phase phospholipids: Effect on the lateral organization of the bilayer. Biophysical Journal, 95(8), 3861-3871.
49. Haluska, C. K. et al. 2008. Combining fluorescence lifetime and polarization microscopy to discriminate phase separated domains in giant unilamellar vesicles. Biophysical Journal, 95(12), 5737-5747.
50. Hammond, A. T. et al. 2005. Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes. Proceedings of the National Academy of Sciences of the United States of America, 102(18), 6320-6325.
51. Hancock, J. F. 2006. Lipid rafts: Contentious only from simplistic standpoints. Nature Reviews Molecular Cell Biology, 7(6), 456-462.
52. Heberle, F. A., 2011. Forster Resonance Energy Transfer in Lipid Bilayers: Theory and Applications for Examining Phase Behavior. (PhD). Cornell University.
53. Heberle, F. A. and Feigenson, G. W. 2011. Phase separation in lipid membranes. Cold Spring Harbor Perspectives in Biology, 3, a004630.
54. Heberle, F. A. et al. 2012. Model-based approaches for the determination of lipid bilayer structure from small-angle neutron and x-ray scattering data. European Biophysical Journal, 41(10), 875-890.
55. Heberle, F. A. et al. 2013. Bilayer thickness mismatch controls domain size in model membranes. Journal of the American Chemical Society, 135(18), 6853-6859.
56. Heberle, F. A. et al. 2010. Comparison of three ternary lipid bilayer mixtures: FRET and ESR reveal nanodomains. Biophysical Journal, 99(10), 3309-3318.
57. Heerklotz, H. 2002. Triton promotes domain formation in lipid raft mixtures. Biophysical Journal, 83(5), 2693-2701.
58. Holowka, D. et al. 2005. Lipid segregation and IgE receptor signaling: A decade of progress. Biochimica et Biophysica Acta, 1746(3), 252-259.
59. Holtta-Vuori, M. et al. 2008. BODIPY-cholesterol: A new tool to visualize sterol trafficking in living cells and organisms. Traffic, 9(11), 1839-1849.
60. Honerkamp-Smith, A. R. et al. 2008. Line tensions, correlation lengths, and critical exponents in lipid membranes near critical points. Biophysical Journal, 95(1), 236-246.
61. Ionova, I. V., Livshits, V. A., and Marsh, D. 2012. Phase diagram of ternary cholesterol/palmitoylsphingomyelin/palmitoyloleoyl-phosphatidylcholine mixtures: Spin-label EPR study of lipid-raft formation. Biophysical Journal, 102(8), 1856-1865.
62. Juhasz, J., Sharom, F. J., and Davis, J. H. 2009. Quantitative characterization of coexisting phases in DOPC/DPPC/cholesterol mixtures: Comparing confocal fluorescence microscopy and deuterium nuclear magnetic resonance. Biochimica et Biophysica Acta, 1788(12), 2541-2552.
63. Katsaras, J. 1998. Adsorbed to a rigid substrate, dimyristoylphosphatidylcholine multibilayers attain full hydration in all mesophases. Biophysical Journal, 75(5), 2157-2162.
64. Kiskowski, M. A. and Kenworthy, A. K. 2007. In silico characterization of resonance energy transfer for disk-shaped membrane domains. Biophysical Journal, 92(9), 3040-3051.
65. Klopfenstein, W. E. et al. 1974. Differential scanning calorimetry on mixtures of lecithin, lysolecithin and cholesterol. Chemistry and Physics of Lipids, 13(3), 215-222.
66. Konyakhina, T. M. et al. 2011. Control of a nanoscopic-to-macroscopic transition: Modulated phases in four-component DSPC/DOPC/POPC/Chol giant unilamellar vesicles. Biophysical Journal, 101(2), L8-10.
67. Konyakhina, T. M. et al. 2013. Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol. Biochimica et Biophysica Acta, 1828(9), 2204-2214.
68. Korlach, J. et al. 1999. Characterization of lipid bilayer phases by confocal microscopy and fluorescence correlation spectroscopy. Proceedings of the National Academy of Sciences of the United States of America, 96(15), 8461-8466.
69. Kučerka, N. et al. 2005. Structure of fully hydrated fluid phase DMPC and DLPC lipid bilayers using x-ray scattering from oriented multilamellar arrays and from unilamellar vesicles. Biophysical Journal, 88(4), 2626-2637.
70. Kučerka, N., Nieh, M. P., and Katsaras, J. 2011. Fluid phase lipid areas and bilayer thicknesses of commonly used phosphatidylcholines as a function of temperature. Biochimica et Biophysica Acta, 1808(11), 2761-2771.
71. Kuo, C. and Hochstrasser, R. M. 2011. Super-resolution microscopy of lipid bilayer phases. Journal of the American Chemical Society, 133(13), 4664-4667.
72. Kuzmin, P. I. et al. 2005. Line tension and interaction energies of membrane rafts calculated from lipid splay and tilt. Biophysical Journal, 88(2), 1120-1133.
73. Ladbrooke, B. D. and Chapman, D. 1969. Thermal analysis of lipids, proteins and biological membranes. A review and summary of some recent studies. Chemistry and Physics of Lipids, 3(4), 304-356.
74. Leslie, M. 2011. Mysteries of the cell. Do lipid rafts exist? Science, 334(6059), 1046-1047.
75. Lin, W. C. et al. 2007. Lipid domains in supported lipid bilayer for atomic force microscopy. Methods in Molecular Biology, 400, 503-513.
76. Loura, L. M. et al. 2009. FRET analysis of domain formation and properties in complex membrane systems. Biochimica et Biophysica Acta, 1788(1), 209-224.
77. Loura, L. M., Fedorov, A., and Prieto, M. 2001. Fluid-fluid membrane microheterogeneity: A fluorescence resonance energy transfer study. Biophysical Journal, 80(2), 776-788.
78. Loura, L. M. et al. 2008. Effects of fluorescent probe NBD-PC on the structure, dynamics and phase transition of DPPC. A molecular dynamics and differential scanning calorimetry study. Biochimica et Biophysica Acta, 1778(2), 491-501.
79. Loura, L. M. and Ramalho, J. P. 2009. Fluorescent membrane probes’ behavior in lipid bilayers: Insights from molecular dynamics simulations. Biophysical Reviews, 1(3), 141-148.
80. Marsh, D. 2009. Cholesterol-induced fluid membrane domains: A compendium of lipid-raft ternary phase diagrams. Biochimica et Biophysica Acta, 1788(10), 2114-2123.
81. Marsh, D. and Smith, I. C. 1973. An interacting spin label study of the fluidizing and condensing effects of cholesterol on lecithin bilayers. Biochimica et Biophysica Acta, 298(2), 133-144.
82. Masui, T., Urakami, N., and Imai, M. 2008. Nano-meter-sized domain formation in lipid membranes observed by small angle neutron scattering. European Physical Journal E, 27(4), 379-389.
83. Mateo, C. R., Acuna, A. U., and Brochon, J. C. 1995. Liquid-crystalline phases of cholesterol lipid bilayers as revealed by the fluorescence of trans-parinaric acid. Biophysical Journal, 68(3), 978-987.
84. McMullen, T. P. W., Lewis, R. N. A. H., and McElhaney, R. N. 2004. Cholesterol-phospholipid interactions, the liquid-ordered phase and lipid rafts in model and biological membranes. Current Opinion in Colloid and Interface Science, 8(6), 459-468.
85. Mills, T. T. et al. 2009. Effects of cholesterol and unsaturated DOPC lipid on chain packing of saturated gel-phase DPPC bilayers. General Physiology and Biophysics, 28(2), 126-139.
86. Mills, T. T. et al. 2008. Liquid-liquid domains in bilayers detected by wide angle x-ray scattering. Biophysical Journal, 95(2), 682-690.
87. Morales-Penningston, N. F. et al. 2010. GUV preparation and imaging: Minimizing artifacts. Biochimica et Biophysica Acta, 1798(7), 1324-1332.
88. Muddana, H. S. et al. 2011. Atomistic simulation of lipid and DiI dynamics in membrane bilayers under tension. Physical Chemistry Chemical Physics, 13(4), 1368-1378.
89. Munro, S. 2003. Lipid rafts: Elusive or illusive? Cell, 115(4), 377-388.
90. Nyholm, T. K. M. et al. 2011. Construction of a DOPC/PSM/cholesterol phase diagram based on the fluorescence properties of trans-parinaric acid. Langmuir, 27(13), 8339-8350.
91. Ono, A. 2010. Relationships between plasma membrane microdomains and HIV-1 assembly. Biology of the Cell, 102(6), 335-350.
92. Pabst, G. et al. 2009. Effect of ceramide on nonraft proteins. Journal of Membrane Biology, 231(2-3), 125-132.
93. Pan, J. et al. 2013. Using small-angle neutron scattering to detect nanoscopic lipid domains. Chemistry and Physics of Lipids, 170-171, 19-32.
94. Pan, J. et al. 2012. Molecular structures of fluid phase phosphatidylglycerol bilayers as determined by small angle neutron and x-ray scattering. Biochimica et Biophysica Acta, 1818(9), 2135-2148.
95. Pan, J. et al. 2008. Cholesterol perturbs lipid bilayers nonuniversally. Physical Review Letters, 100(19), 198103.
96. Parton, R. G. and Richards, A. A. 2003. Lipid rafts and caveolae as portals for endocytosis: New insights and common mechanisms. Traffic, 4(11), 724-738.
97. Pathak, P. and London, E. 2011. Measurement of lipid nanodomain (raft) formation and size in sphingomyelin/POPC/cholesterol vesicles shows TX-100 and transmembrane helices increase domain size by coalescing preexisting nanodomains but do not induce domain formation. Biophysical Journal, 101(10), 2417-2425.
98. Pencer, J. et al. 2006. Method of separated form factors for polydisperse vesicles. Journal of Applied Crystallography, 39, 293-303.
99. Pencer, J. et al. 2005. Detection of submicron-sized raft-like domains in membranes by small-angle neutron scattering. European Physical Journal E, 18(4), 447-458.
100. Petruzielo, R. S. et al. 2013. Phase behavior and domain size in sphingomyelin-containing lipid bilayers. Biochimica et Biophysica Acta, 1828(4), 1302-1313.
101. Pokorny, A. et al. 2006. Temperature and composition dependence of the interaction of delta-lysin with ternary mixtures of sphingomyelin/cholesterol/POPC. Biophysical Journal, 91(6), 2184-2197.
102. Rajendran, L. and Simons, K. 2005. Lipid rafts and membrane dynamics. Journal of Cell Science, 118(6), 1099-1102.
103. Repakova, J. et al. 2006. Influence of pyrene-labeling on fluid lipid membranes. Journal of Physical Chemistry B, 110(31), 15403-15410.
104. Sachl, R. et al. 2011. Limitations of electronic energy transfer in the determination of lipid nanodomain sizes. Biophysical Journal, 101(11), L60-L62.
105. Sankaram, M. B. and Thompson, T. E. 1990. Interaction of cholesterol with various glycerophospholipids and sphingomyelin. Biochemistry, 29(47), 10670-10675.
106. Scherfeld, D., Kahya, N., and Schwille, P. 2003. Lipid dynamics and domain formation in model membranes composed of ternary mixtures of unsaturated and saturated phosphatidylcholines and cholesterol. Biophysical Journal, 85(6), 3758-3768.
107. Semrau, S. et al. 2008. Accurate determination of elastic parameters for multicomponent membranes. Physical Review Letters, 100(8), 088101.
108. Shaw, A. S. 2006. Lipid rafts: Now you see them, now you don’t. Nature Immunology, 7(11), 1139-1142.
109. Sheets, E. D., Holowka, D., and Baird, B. 1999. Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. Journal of Cell Biology, 145(4), 877-887.
110. Silvius, J. R. 2003. Fluorescence energy transfer reveals microdomain formation at physiological temperatures in lipid mixtures modeling the outer leaflet of the plasma membrane. Biophysical Journal, 85(2), 1034-1045.
111. Simons, K. and Ikonen, E. 1997. Functional rafts in cell membranes. Nature, 3876633, 569-572.
112. Singer, S. J. and Nicolson, G. L. 1972. The fluid mosaic model of the structure of cell membranes. Science, 1754023, 720-731.
113. Skaug, M. J., Longo, M. L., and Faller, R. 2011. The impact of Texas red on lipid bilayer properties. Journal of Physical Chemistry B, 115(26), 8500-8505.
114. Smith, A. K. and Freed, J. H. 2009. Determination of tie-line fields for coexisting lipid phases: An ESR study. Journal of Physical Chemistry B, 113(12), 3957-3971.
115. Stefl, M. et al. 2012. Dynamics and size of cross-linking-induced lipid nanodomains in model membranes. Biophysical Journal, 102(9), 2104-2113.
116. Stockl, M. et al. 2008. Detection of lipid domains in model and cell membranes by fluorescence lifetime imaging microscopy of fluorescent lipid analogues. Journal of Biological Chemistry, 283(45), 30828-30837.
117. Tayebi, L. et al. 2012. Long-range interlayer alignment of intralayer domains in stacked lipid bilayers. Nature Materials, 11(12), 1074-1080.
118. Towles, K. B. et al. 2007. Effect of membrane microheterogeneity and domain size on fluorescence resonance energy transfer. Biophysical Journal, 93(2), 655-667.
119. Towles, K. B. and Dan, N. 2007. Determination of membrane domain size by fluorescence resonance energy transfer: Effects of domain polydispersity and packing. Langmuir, 23(9), 4737-4739.
120. Uppamoochikkal, P., Tristram-Nagle, S., and Nagle, J. F. 2010. Orientation of tie-lines in the phase diagram of DOPC/DPPC/cholesterol model biomembranes. Langmuir, 26(22), 17363-17368.
121. Veatch, S. L. 2007. From small fluctuations to large-scale phase separation: Lateral organization in model membranes containing cholesterol. Seminars in Cell and Developmental Biology, 18(5), 573-582.
122. Veatch, S. L., Gawrisch, K., and Keller, S. L. 2006. Closed-loop miscibility gap and quantitative tie-lines in ternary membranes containing diphytanoyl PC. Biophysical Journal, 90(12), 4428-4436.
123. Veatch, S. L. and Keller, S. L. 2003. Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. Biophysical Journal, 85(5), 3074-3083.
124. Veatch, S. L. and Keller, S. L. 2005a. Miscibility phase diagrams of giant vesicles containing sphingomyelin. Physical Review Letters, 94(14), 148101.
125. Veatch, S. L. and Keller, S. L. 2005b. Seeing spots: Complex phase behavior in simple membranes. Biochimica et Biophysica Acta, 1746(3), 172-185.
126. Veatch, S. L. et al. 2004. Liquid domains in vesicles investigated by NMR and fluorescence microscopy. Biophysical Journal, 86(5), 2910-2922.
127. Veatch, S. L. et al. 2007a. Fluorescent probes alter miscibility phase boundaries in ternary vesicles. Journal of Physical Chemistry B, 111(3), 502-504.
128. Veatch, S. L. et al. 2007b. Critical fluctuations in domain-forming lipid mixtures. Proceedings of the National Academy of Sciences of the United States of America, 104(45), 17650-17655.
129. Vequi-Suplicy, C. C. et al. 2010. Vesicles with charged domains. Biochimica et Biophysica Acta, 1798(7), 1338-1347.
130. Walde, P. et al. 2010. Giant vesicles: Preparations and applications. ChemBioChem, 11(7), 848-865.
131. Wolber, P. K. and Hudson, B. S. 1979. An analytic solution to the Forster energy transfer problem in two dimensions. Biophysical Journal, 28(2), 197-210.
132. Wu, S. H. W. and McConnell, H. M. 1975. Phase separations in phospholipid membranes. Biochemistry, 14(4), 847-854.
133. Yuan, J. et al. 2009. Solution synchrotron x-ray diffraction reveals structural details of lipid domains in ternary mixtures. Physical Review E, 79(3 Pt 1), 031924.
134. Zhao, J. et al. 2007a. Phase studies of model biomembranes: Complex behavior of DSPC/DOPC/cholesterol. Biochimica et Biophysica Acta, 1768(11), 2764-2776.
135. Zhao, J. et al. 2007b. Phase studies of model biomembranes: Macroscopic coexistence of Lalpha + Lbeta, with light-induced coexistence of Lalpha + Lo phases. Biochimica et Biophysica Acta, 1768(11), 2777-2786.