Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol

Biochimica et Biophysica Acta - Biomembranes

Volumn 1828, Issue 9, 2013, Pages 2204-2214

  Konyakhina, Tatyana M ^a   Wu, Jing ^b   Mastroianni, James D ^a   Heberle, Frederick A ^c   Feigenson, Gerald W ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

4 Component lipid phase diagram; Competing interaction; Lipid raft; Modulated phase 3 Dye method; Quaternary phase diagram

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; CHOLESTEROL; DIOLEOYLPHOSPHATIDYLCHOLINE; DISTEAROYLPHOSPHATIDYLCHOLINE; 1,2 DISTEAROYLLECITHIN; 1,2 OLEOYLPHOSPHATIDYLCHOLINE; 1,2-DISTEAROYLLECITHIN; 1,2-OLEOYLPHOSPHATIDYLCHOLINE; 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; SPHINGOMYELIN;

ARTICLE; FLUORESCENCE MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIPID ANALYSIS; LIPID BILAYER; LIPID COMPOSITION; MOLECULAR DYNAMICS; PHASE DIAGRAM; PHASE TRANSITION; PHYSICAL PARAMETERS; PRIORITY JOURNAL; SOLUBILITY; 1,1′-DIDODECYL-3,3,3′,3′-TETRAMETHYLINDOCARBOCYANINE PERCHLORATE; 1,1′-DIEICOSANYL-3,3,3′,3′-TETRAMETHYLINDOCARBOCYANINE PERCHLORATE; 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1-STEAROYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 2-(4,4-DIFLUORO-5,7-DIMETHYL-4-BORA-3A,4A-DIAZA-S-INDACENE-3-PENTANOYL)-1-HEXADECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 3-DYE METHOD; 4-COMPONENT LIPID PHASE DIAGRAM; BODIPY-PC; C12:0-DII; C20:0-DII; CHEMISTRY; CHOL; COMPETING INTERACTION; DHE; DLPC; DOPC; DPPC; DSPC; ERGOSTA-5,7,9(11),22-TETRAEN-3Β-OL; FÖRSTER RESONANCE ENERGY TRANSFER; FRET; GIANT UNILAMELLAR VESICLE; GUV; LEFT HAND SIDE REFERS TO LEFT SIDE OF PHASE DIAGRAM, I.E. AT LOWER Χ(DSPC); LHS; LIPID RAFT; MODULATED PHASE; PC; POPC; QUATERNARY PHASE DIAGRAM; RAPID SOLVENT EXCHANGE; REE; REGION OF ENHANCED EFFICIENCY; REGION OF REDUCED EFFICIENCY; RHS; RIGHT HAND SIDE, REFERS TO RIGHT SIDE OF PHASE DIAGRAM, I.E.,, AT HIGHER Χ(DSPC); RRE; RSE; SAE; SENSITIZED ACCEPTOR EMISSION; SM; SOPC; T1-T6; THIN LAYER CHROMATOGRAPHY; THIN-LAYER CHROMATOGRAPHY; TOE; TRAJECTORIES 1-6. BSM, SPHINGOMYELIN DERIVED FROM PORCINE BRAIN; TRP-OLEOYL ESTER, N-OLEOYL-DL-TRYPTOPHAN ETHYL ESTER;

1,1′-DIDODECYL-3,3,3′,3′-TETRAMETHYLINDOCARBOCYANINE PERCHLORATE; 1,1′-DIEICOSANYL-3,3,3′,3′-TETRAMETHYLINDOCARBOCYANINE PERCHLORATE; 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1-STEAROYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 2-(4,4-DIFLUORO-5,7-DIMETHYL-4-BORA-3A,4A-DIAZA-S-INDACENE-3-PENTANOYL)-1-HEXADECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 3-DYE METHOD; 4-COMPONENT LIPID PHASE DIAGRAM; BODIPY-PC; C12:0-DII; C20:0-DII; CHOL; CHOLESTEROL; COMPETING INTERACTION; DHE; DLPC; DOPC; DPPC; DSPC; ERGOSTA-5,7,9(11),22-TETRAEN-3Β-OL; FÖRSTER RESONANCE ENERGY TRANSFER; FRET; GIANT UNILAMELLAR VESICLE; GUV; LEFT HAND SIDE REFERS TO LEFT SIDE OF PHASE DIAGRAM, I.E. AT LOWER Χ(DSPC); LHS; LIPID RAFT; MODULATED PHASE; PC; PHOSPHATIDYLCHOLINE; POPC; QUATERNARY PHASE DIAGRAM; RAPID SOLVENT EXCHANGE; REE; REGION OF ENHANCED EFFICIENCY; REGION OF REDUCED EFFICIENCY; RHS; RIGHT HAND SIDE, REFERS TO RIGHT SIDE OF PHASE DIAGRAM, I.E.,, AT HIGHER Χ(DSPC); RRE; RSE; SAE; SENSITIZED ACCEPTOR EMISSION; SM; SOPC; SPHINGOMYELIN; T1-T6; THIN-LAYER CHROMATOGRAPHY; TLC; TOE; TRAJECTORIES 1-6. BSM, SPHINGOMYELIN DERIVED FROM PORCINE BRAIN; TRP-OLEOYL ESTER, N-OLEOYL-DL-TRYPTOPHAN ETHYL ESTER;

CHOLESTEROL; FLUORESCENCE RESONANCE ENERGY TRANSFER; PHASE TRANSITION; PHOSPHATIDYLCHOLINES;

EID: 84879466897     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.05.020     Document Type: Article

References (41)

1. D. Lingwood, and K. Simons Lipid rafts as a membrane-organizing principle Science 327 5961 2010 46 50
2. S.L. Veatch, K. Gawrisch, and S.L. Keller Closed-loop miscibility gap and quantitative tie-lines in ternary membranes containing diphytanoyl PC Biophys. J. 90 2006 4428 4436 (Pubitemid 43830889)
3. S.L. Veatch, and S.L. Keller Seeing spots: complex phase behavior in simple mixtures Biochim. Biophys. Acta 1746 2005 172 185 (Pubitemid 41815014)
4. J. Zhao, J. Wu, F.A. Heberle, T.T. Mills, P. Klawitter, G. Huang, G. Costanza, and G.W. Feigenson Phase studies of model biomembranes: complex behavior of DSPC/DOPC/Cholesterol Biochim. Biophys. Acta 1768 2007 2764 2776 (Pubitemid 350060870)
5. J. Zhao, J. Wu, H. Shao, F. Kong, N. Jain, G. Hunt, and G.W. Feigenson Phase studies of model biomembranes: macroscopic coexistence of Lα + Lβ, with light-induced coexistence of Lα + Lo phases Biochim. Biophys. Acta 1768 2007 2777 2788
6. G.W. Feigenson, and J.T. Buboltz Ternary phase diagram of dipalmitoyl-PC/dilauroyl-PC/cholesterol: nanoscopic domain formation driven by cholesterol Biophys. J. 80 2001 2775 2788 (Pubitemid 32521651)
7. F.A. Heberle, J. Wu, S.L. Goh, R.S. Petruzielo, and G.W. Feigenson Comparison of three ternary lipid bilayer mixtures: FRET and ESR reveal nanodomains Biophys. J. 99 2010 3309 3318
8. R.S. Petruzielo, F.A. Heberle, P. Drazba, J. Katsaras, and G.W. Feigenson Phase behavior and domain size in sphingomyelin-containing lipid bilayers Biochim. Biophys. Acta 1828 2013 1302 1313
9. F.A. Heberle, R.S. Petruzielo, J. Pan, P. Drazba, N. Kučerka, R.F. Standaert, G.W. Feigenson, and J. Katsaras Bilayer thickness mismatch controls domain size in model membranes J. Am. Chem. Soc. 135 18 2013 6853 6859
10. A. Pokorny, L.E. Yandek, A.L. Elegbede, A. Hinderliter, and P.F. Almeida Temperature and composition dependence of the interaction of d-lysin with ternary mixtures of sphingomyelin/cholesterol/POPC Biophys. J. 91 2006 2184 2197 (Pubitemid 44352401)
11. R.F.M. de Almeida, A. Fedorov, and M. Prieto Sphingomyelin/ phosphatidylcholine/cholesterol phase diagram: boundaries and composition of lipid rafts Biophys. J. 85 2003 2406 2416 (Pubitemid 37210789)
12. J.R. Silvius Fluorescence energy transfer reveals microdomain formation at physiological temperatures in lipid mixtures modeling the outer leaflet of the plasma membrane Biophys. J. 85 2003 1034 1045 (Pubitemid 36909667)
13. J.F. Hancock Lipid rafts: contentious only from simplistic standpoints Nat. Rev. Mol. Cell Biol. 7 2006 456 462 (Pubitemid 44050099)
14. P.F.F. Almeida, A. Pokorny, and A. Hinderliter Thermodynamics of membrane domains Biochim. Biophys. Acta 1720 2005 1 13 (Pubitemid 43202129)
15. E.L. Elson, E. Fried, J.E. Dolbrow, and G.M. Genin Phase separation in biological membranes: integration of theory and experiment Annu. Rev. Biophys. 39 2010 207 226
16. N. Vyas, D. Goswami, A. Manonmani, P. Sharma, H.A. Ranganath, K. VijayRaghavan, L.S. Shashidhara, R. Sowdhamini, and S. Mayor Nanoscale organization of hedgehog is essential for long-range signaling Cell 133 2008 1214 1227 (Pubitemid 351852915)
17. D. Meder, M.J. Moreno, P. Verkade, W.L. Vaz, and K. Simons Phase coexistence and connectivity in the apical membrane of polarized epithelial cells PNAS 103 2006 329 334 (Pubitemid 43122400)
18. M. Ge, A. Gidwani, H.A. Brown, D. Holowka, B. Baird, and J.H. Freed Ordered and disordered phases coexist in plasma membrane vesicles of RBL-2H3 Mast Cells. An ESR study Biophys. J. 85 2003 1278 1288 (Pubitemid 36909688)
19. C. Eggeling, C. Ringemann, R. Medda, G. Schwarzmann, K. Sandhoff, S. Polyakova, V.N. Belov, B. Hein, C. von Middendorf, A. Schönle, and S.W. Hell Direct observation of the nanoscale dynamics of membrane lipids in a living cell Nature 457 2009 1159 1162
20. S.J. Sahl, M. Leutenegger, M. Hilbert, S.W. Hell, and C. Eggeling Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids PNAS 107 15 2010 6829 6834
21. T.S. van Zanten, J. Gómez, C. Manzo, A. Cambi, J. Buceta, R. Reigada, and M.F. Garcia-Parajo Direct mapping of nanoscale compositional connectivity on intact cell membranes PNAS 107 35 2010 15437 15442
22. F.A. Heberle, and G.W. Feigenson Phase separation in lipid membranes Cold Spring Harbor Perspect. Biol. 2011 10.1101/cshperspect.a004630
23. T.M. Konyakhina, S.L. Goh, J. Amazon, F.A. Heberle, J. Wu, and G.W. Feigenson Control of a nanoscopic-to-macroscopic transition: modulated phases in 4-component DSPC/DOPC/POPC/chol giant unilamellar vesicles Biophys. J. Lett. 101 2 2011 L8 L10
24. S.L. Goh, J. Amazon, and G.W. Feigenson Towards a better raft model: Modulated phases in the 4-component bilayer, DSPC/DOPC/POPC/CHOL Biophys. J. 104 2013 853 862
25. C. Esposito, A. Tian, S. Melamed, C. Johnson, S.Y. Tee, and T. Baumgart Flicker spectroscopy of thermal bilayer domain boundary fluctuations Biophys. J. 93 2007 3169 3181 (Pubitemid 350097107)
26. S.L. Veatch, P. Cicuta, P. Sengupta, A. Honerkamp-Smith, D. Holowka, and B. Baird Critical fluctuations in plasma membrane vesicles ACS Chem. Biol. 3 2008 287 293
27. A.R. Honerkamp-Smith, S.L. Veatch, and S.L. Keller An introduction to critical points for biophysicists; observations in lipid membranes Biochim. Biophys. Acta 1788 1 2009 53 63
28. J.T. Buboltz, and G.W. Feigenson A novel strategy for the preparation of liposomes: rapid solvent exchange Biochim. Biophys. Acta 1417 1999 232 245 (Pubitemid 29114912)
29. M.I. Angelova, S. Soleau, P. Meleard, J.F. Faucon, and P. Bothorel Preparation of giant vesicles by external AC electric fields. Kinetics and applications Progr Colloid Polym. Sci. 89 1992 127 131
30. N.F. Morales-Penningston, J. Wu, E.R. Farkas, S.L. Goh, T.M. Konyakhina, J.Y. Zheng, W.W. Webb, and G.W. Feigenson GUV preparation and imaging: minimizing artifacts Biochim. Biophys. Acta 1798 7 2010 1324 1332
31. J.T. Buboltz Steady-state probe-partitioning fluorescence resonance energy transfer: a simple and robust tool for the study of membrane phase behavior Phys. Rev. E 76 2007 021903
32. P. Ceppi, S. Colombo, M. Francolini, F. Raimondo, N. Borgese, and M. Masserini Two tail-anchored protein variants, differing in transmembrane domain length and intracellular sorting, interact differently with lipids PNAS 102 45 2005 16269 16274 (Pubitemid 41688903)
33. J.S. Marsh Principles of Phase Diagrams 1935 McGraw-Hill New York 122 170
34. The AOCS Lipid Library, http://lipidlibrary.aocs.org/, the joint Editors-in-Chief J. L. Harwood, R. J. Weselake, technical Editor W. W. Christie. Last updated 12/21/2012.
35. J. Huang, J.T. Buboltz, and G.W. Feigenson Maximum solubility of cholesterol in phosphatidylcholine and phosphatidylethanolamine bilayers Biochim. Biophys. Acta 1417 1999 89 100 (Pubitemid 29078589)
36. T.T. Mills, J. Huang, G.W. Feigenson, and J.F. Nagle Effects of cholesterol and unsaturated DOPC lipid on chain packing of saturated gel-phase DPPC bilayers Gen. Physiol. Biophys. 28 2 2009 126 139
37. J.J. Amazon, S.L. Goh, and G.W. Feigenson Competition between line tension and curvature stabilizes modulated phase patterns on the surface of giant unilamellar vesicles: a simulation study Phys. Rev. E 87 2013 022708
38. M. Schick Membrane heterogeneity: manifestation of a curvature-induced microemulsion Phys. Rev. E 85 2012 031902
39. L.S. Palatnik, and A.I. Landau Phase Equilibria in Multicomponent Systems J. Jaffe, 1964 Holt, Rinehart & Winston New York
40. J. Huang, and G.W. Feigenson A microscopic interaction model of maximum solubility of cholesterol in lipid bilayers Biophys. J. 76 4 1999 2142 2157 (Pubitemid 29266367)
41. J.T. Buboltz, C. Bwalya, S. Reyes, and D. Kamburov Stern-Volmer modeling of steady-state Förster energy transfer between dilute, freely diffusing membrane-bound fluorophores J. Chem. Phys. 127 2007 215101