-
1
-
-
84926669244
-
Metabolism and its sequelae in cancer evolution and therapy
-
PMID 25815848 PubMed Central PMCID PMCPMC4446699
-
Gillies RJ, Gatenby RA. Metabolism and its sequelae in cancer evolution and therapy. Cancer J. 2015; 21(2):88–96. https://doi.org/10.1097/PPO.0000000000000102 PMID: 25815848; PubMed Central PMCID: PMCPMC4446699.
-
(2015)
Cancer J
, vol.21
, Issue.2
, pp. 88-96
-
-
Gillies, R.J.1
Gatenby, R.A.2
-
2
-
-
84856013431
-
Clonal evolution in cancer
-
PMID 22258609 PubMed Central PMCID PMCPMC3367003
-
Greaves M, Maley CC. Clonal evolution in cancer. Nature. 2012; 481(7381):306–13. https://doi.org/10.1038/nature10762 PMID: 22258609; PubMed Central PMCID: PMCPMC3367003.
-
(2012)
Nature
, vol.481
, Issue.7381
, pp. 306-313
-
-
Greaves, M.1
Maley, C.C.2
-
3
-
-
0017167185
-
The clonal evolution of tumor cell populations
-
PMID 959840
-
Nowell PC. The clonal evolution of tumor cell populations. Science. 1976; 194(4260):23–8. PMID: 959840.
-
(1976)
Science
, vol.194
, Issue.4260
, pp. 23-28
-
-
Nowell, P.C.1
-
4
-
-
77249123407
-
Signatures of mutation and selection in the cancer genome
-
PMID 20164919 PubMed Central PMCID PMCPMC3145113
-
Bignell GR, Greenman CD, Davies H, Butler AP, Edkins S, Andrews JM, et al. Signatures of mutation and selection in the cancer genome. Nature. 2010; 463(7283):893–8. https://doi.org/10.1038/ nature08768 PMID: 20164919; PubMed Central PMCID: PMCPMC3145113.
-
(2010)
Nature
, vol.463
, Issue.7283
, pp. 893-898
-
-
Bignell, G.R.1
Greenman, C.D.2
Davies, H.3
Butler, A.P.4
Edkins, S.5
Andrews, J.M.6
-
5
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
PMID 23945592 PubMed Central PMCID PMCPMC3776390
-
Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, et al. Signatures of mutational processes in human cancer. Nature. 2013; 500(7463):415–21. https://doi.org/10.1038/ nature12477 PMID: 23945592; PubMed Central PMCID: PMCPMC3776390.
-
(2013)
Nature
, vol.500
, Issue.7463
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Aparicio, S.A.4
Behjati, S.5
Biankin, A.V.6
-
6
-
-
84938245424
-
Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity
-
PMID 26212640 PubMed Central PMCID PMCPMC4515826
-
Tan H, Bao J, Zhou X. Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity. Sci Rep. 2015; 5:12566. https://doi.org/10.1038/srep12566 PMID: 26212640; PubMed Central PMCID: PMCPMC4515826.
-
(2015)
Sci Rep
, vol.5
, pp. 12566
-
-
Tan, H.1
Bao, J.2
Zhou, X.3
-
7
-
-
84947967335
-
Exploring preferred amino acid mutations in cancer genes: Applications to identify potential drug targets
-
PMID 26581171
-
Anoosha P, Sakthivel R, Michael Gromiha M. Exploring preferred amino acid mutations in cancer genes: Applications to identify potential drug targets. Biochim Biophys Acta. 2016; 1862(2):155–65. https://doi.org/10.1016/j.bbadis.2015.11.006 PMID: 26581171.
-
(2016)
Biochim Biophys Acta
, vol.1862
, Issue.2
, pp. 155-165
-
-
Anoosha, P.1
Sakthivel, R.2
Michael Gromiha, M.3
-
8
-
-
85021961972
-
Mutations in cancer cause gain of cysteine, histidine, and tryptophan at the expense of a net loss of arginine on the proteome level
-
PMID 28671612
-
Tsuber V, Kadamov Y, Brautigam L, Berglund UW, Helleday T. Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level. Bio-molecules. 2017; 7(3). https://doi.org/10.3390/biom7030049 PMID: 28671612.
-
(2017)
Bio-molecules
, vol.7
, Issue.3
-
-
Tsuber, V.1
Kadamov, Y.2
Brautigam, L.3
Berglund, U.W.4
Helleday, T.5
-
9
-
-
1642529511
-
Metagenes and molecular pattern discovery using matrix factorization
-
PMID 15016911 PubMed Central PMCID PMCPMC384712
-
Brunet JP, Tamayo P, Golub TR, Mesirov JP. Metagenes and molecular pattern discovery using matrix factorization. Proc Natl Acad Sci U S A. 2004; 101(12):4164–9. https://doi.org/10.1073/pnas. 0308531101 PMID: 15016911; PubMed Central PMCID: PMCPMC384712.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.12
, pp. 4164-4169
-
-
Brunet, J.P.1
Tamayo, P.2
Golub, T.R.3
Mesirov, J.P.4
-
10
-
-
85016154270
-
COSMIC: Somatic cancer genetics at high-resolution
-
PMID 27899578 PubMed Central PMCID PMCPMC5210583
-
Forbes SA, Beare D, Boutselakis H, Bamford S, Bindal N, Tate J, et al. COSMIC: somatic cancer genetics at high-resolution. Nucleic Acids Res. 2017; 45(D1):D777–D83. https://doi.org/10.1093/nar/ gkw1121 PMID: 27899578; PubMed Central PMCID: PMCPMC5210583.
-
(2017)
Nucleic Acids Res
, vol.45
, Issue.D1
, pp. D777-D783
-
-
Forbes, S.A.1
Beare, D.2
Boutselakis, H.3
Bamford, S.4
Bindal, N.5
Tate, J.6
-
11
-
-
85012922545
-
Cancer cell behaviors mediated by dysregulated pH dynamics at a glance
-
PMID 28202602 PubMed Central PMCID PMCPMC5339414
-
White KA, Grillo-Hill BK, Barber DL. Cancer cell behaviors mediated by dysregulated pH dynamics at a glance. J Cell Sci. 2017; 130(4):663–9. https://doi.org/10.1242/jcs.195297 PMID: 28202602; PubMed Central PMCID: PMCPMC5339414.
-
(2017)
J Cell Sci
, vol.130
, Issue.4
, pp. 663-669
-
-
White, K.A.1
Grillo-Hill, B.K.2
Barber, D.L.3
-
12
-
-
25844528025
-
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
-
PMID 16175178
-
Cardone RA, Casavola V, Reshkin SJ. The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis. Nat Rev Cancer. 2005; 5(10):786–95. https://doi.org/10.1038/nrc1713 PMID: 16175178.
-
(2005)
Nat Rev Cancer
, vol.5
, Issue.10
, pp. 786-795
-
-
Cardone, R.A.1
Casavola, V.2
Reshkin, S.J.3
-
13
-
-
84984908595
-
Increased H(+) efflux is sufficient to induce dyspla-sia and necessary for viability with oncogene expression
-
PMID 25793441 PubMed Central PMCID PMCPMC4392478
-
Grillo-Hill BK, Choi C, Jimenez-Vidal M, Barber DL. Increased H(+) efflux is sufficient to induce dyspla-sia and necessary for viability with oncogene expression. Elife. 2015; 4. https://doi.org/10.7554/eLife. 03270 PMID: 25793441; PubMed Central PMCID: PMCPMC4392478.
-
(2015)
Elife
, vol.4
-
-
Grillo-Hill, B.K.1
Choi, C.2
Jimenez-Vidal, M.3
Barber, D.L.4
-
14
-
-
84883182637
-
Disrupting proton dynamics and energy metabolism for cancer therapy
-
PMID 23969692
-
Parks SK, Chiche J, Pouyssegur J. Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer. 2013; 13(9):611–23. https://doi.org/10.1038/nrc3579 PMID: 23969692.
-
(2013)
Nat Rev Cancer
, vol.13
, Issue.9
, pp. 611-623
-
-
Parks, S.K.1
Chiche, J.2
Pouyssegur, J.3
-
15
-
-
81155159685
-
Dysregulated pH: A perfect storm for cancer progression
-
PMID 21833026
-
Webb BA, Chimenti M, Jacobson MP, Barber DL. Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer. 2011; 11(9):671–7. https://doi.org/10.1038/nrc3110 PMID: 21833026.
-
(2011)
Nat Rev Cancer
, vol.11
, Issue.9
, pp. 671-677
-
-
Webb, B.A.1
Chimenti, M.2
Jacobson, M.P.3
Barber, D.L.4
-
16
-
-
85008250438
-
Microscopic mechanisms that govern the titration response and pKa values of buried residues in staphylococcal nuclease mutants
-
PMID 27862310
-
Zheng Y, Cui Q. Microscopic mechanisms that govern the titration response and pKa values of buried residues in staphylococcal nuclease mutants. Proteins. 2017; 85(2):268–81. https://doi.org/10.1002/prot.25213 PMID: 27862310.
-
(2017)
Proteins
, vol.85
, Issue.2
, pp. 268-281
-
-
Zheng, Y.1
Cui, Q.2
-
17
-
-
79956221510
-
On the role of electrostatics in protein-protein interactions
-
PMID 21572182 PubMed Central PMCID PMCPMC3137121
-
Zhang Z, Witham S, Alexov E. On the role of electrostatics in protein-protein interactions. Phys Biol. 2011; 8(3):035001. https://doi.org/10.1088/1478-3975/8/3/035001 PMID: 21572182; PubMed Central PMCID: PMCPMC3137121.
-
(2011)
Phys Biol
, vol.8
, Issue.3
, pp. 035001
-
-
Zhang, Z.1
Witham, S.2
Alexov, E.3
-
18
-
-
20544475665
-
Membrane-protein interactions in cell signaling and membrane trafficking
-
PMID 15869386
-
Cho W, Stahelin RV. Membrane-protein interactions in cell signaling and membrane trafficking. Annu Rev Biophys Biomol Struct. 2005; 34:119–51. https://doi.org/10.1146/annurev.biophys.33.110502. 133337 PMID: 15869386.
-
(2005)
Annu Rev Biophys Biomol Struct
, vol.34
, pp. 119-151
-
-
Cho, W.1
Stahelin, R.V.2
-
19
-
-
66349132474
-
Lipid binding domains: More than simple lipid effectors
-
PMID 19008549 PubMed Central PMCID PMCPMC2674730
-
Stahelin RV. Lipid binding domains: more than simple lipid effectors. J Lipid Res. 2009; 50 Suppl:S299–304. https://doi.org/10.1194/jlr.R800078-JLR200 PMID: 19008549; PubMed Central PMCID: PMCPMC2674730.
-
(2009)
J Lipid Res
, vol.50
, pp. S299-S304
-
-
Stahelin, R.V.1
-
20
-
-
34250878954
-
Mechanisms of specificity in protein phosphorylation
-
PMID 17585314
-
Ubersax JA, Ferrell JE Jr. Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol. 2007; 8(7):530–41. https://doi.org/10.1038/nrm2203 PMID: 17585314.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.7
, pp. 530-541
-
-
Ubersax, J.A.1
Ferrell, J.E.2
-
21
-
-
84861960391
-
Structural reorganization triggered by charging of Lys residues in the hydrophobic interior of a protein
-
PMID 22632835 PubMed Central PMCID PMCPMC3373022
-
Chimenti MS, Khangulov VS, Robinson AC, Heroux A, Majumdar A, Schlessman JL, et al. Structural reorganization triggered by charging of Lys residues in the hydrophobic interior of a protein. Structure. 2012; 20(6):1071–85. https://doi.org/10.1016/j.str.2012.03.023 PMID: 22632835; PubMed Central PMCID: PMCPMC3373022.
-
(2012)
Structure
, vol.20
, Issue.6
, pp. 1071-1085
-
-
Chimenti, M.S.1
Khangulov, V.S.2
Robinson, A.C.3
Heroux, A.4
Majumdar, A.5
Schlessman, J.L.6
-
22
-
-
38749092231
-
Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase
-
PMID 17877460
-
Carson JD, Van Aller G, Lehr R, Sinnamon RH, Kirkpatrick RB, Auger KR, et al. Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase. Biochem J. 2008; 409(2):519–24. https://doi.org/10.1042/BJ20070681 PMID: 17877460.
-
(2008)
Biochem J
, vol.409
, Issue.2
, pp. 519-524
-
-
Carson, J.D.1
Van Aller, G.2
Lehr, R.3
Sinnamon, R.H.4
Kirkpatrick, R.B.5
Auger, K.R.6
-
23
-
-
44349170604
-
Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha
-
PMID 18418043 PubMed Central PMCID PMCPMC3260475
-
Huang CH, Mandelker D, Gabelli SB, Amzel LM. Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle. 2008; 7(9):1151–6. https://doi.org/10.4161/cc.7.9.5817 PMID: 18418043; PubMed Central PMCID: PMCPMC3260475.
-
(2008)
Cell Cycle
, vol.7
, Issue.9
, pp. 1151-1156
-
-
Huang, C.H.1
Mandelker, D.2
Gabelli, S.B.3
Amzel, L.M.4
-
24
-
-
84885435958
-
Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R
-
PMID 24080956 PubMed Central PMCID PMCPMC3816227
-
Meyer DS, Koren S, Leroy C, Brinkhaus H, Muller U, Klebba I, et al. Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R. Oncogenesis. 2013; 2:e74. https://doi.org/10.1038/oncsis.2013.38 PMID: 24080956; PubMed Central PMCID: PMCPMC3816227.
-
(2013)
Oncogenesis
, vol.2
, pp. e74
-
-
Meyer, D.S.1
Koren, S.2
Leroy, C.3
Brinkhaus, H.4
Muller, U.5
Klebba, I.6
-
25
-
-
84884385851
-
PH sensing by FAK-His58 regulates focal adhesion remodeling
-
PMID 24043700 PubMed Central PMCID PMCPMC3776353
-
Choi CH, Webb BA, Chimenti MS, Jacobson MP, Barber DL. pH sensing by FAK-His58 regulates focal adhesion remodeling. J Cell Biol. 2013; 202(6):849–59. https://doi.org/10.1083/jcb.201302131 PMID: 24043700; PubMed Central PMCID: PMCPMC3776353.
-
(2013)
J Cell Biol
, vol.202
, Issue.6
, pp. 849-859
-
-
Choi, C.H.1
Webb, B.A.2
Chimenti, M.S.3
Jacobson, M.P.4
Barber, D.L.5
-
26
-
-
58149293622
-
Cofilin is a pH sensor for actin free barbed end formation: Role of phosphoinositide binding
-
PMID 19029335 PubMed Central PMCID PMCPMC2592832
-
Frantz C, Barreiro G, Dominguez L, Chen X, Eddy R, Condeelis J, et al. Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. J Cell Biol. 2008; 183(5):865–79. https://doi.org/10.1083/jcb.200804161 PMID: 19029335; PubMed Central PMCID: PMCPMC2592832.
-
(2008)
J Cell Biol
, vol.183
, Issue.5
, pp. 865-879
-
-
Frantz, C.1
Barreiro, G.2
Dominguez, L.3
Chen, X.4
Eddy, R.5
Condeelis, J.6
-
27
-
-
84995450734
-
A histidine cluster in the cytoplasmic domain of the na-h exchanger NHE1 confers pH-sensitive phospholipid binding and regulates transporter activity
-
PMID 27650500 PubMed Central PMCID PMCPMC5104935
-
Webb BA, White KA, Grillo-Hill BK, Schonichen A, Choi C, Barber DL. A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity. J Biol Chem. 2016; 291(46):24096–104. https://doi.org/10.1074/jbc.M116. 736215 PMID: 27650500; PubMed Central PMCID: PMCPMC5104935.
-
(2016)
J Biol Chem
, vol.291
, Issue.46
, pp. 24096-24104
-
-
Webb, B.A.1
White, K.A.2
Grillo-Hill, B.K.3
Schonichen, A.4
Choi, C.5
Barber, D.L.6
-
28
-
-
0036143771
-
A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer
-
PMID 11753428
-
DiGiammarino EL, Lee AS, Cadwell C, Zhang W, Bothner B, Ribeiro RC, et al. A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer. Nat Struct Biol. 2002; 9 (1):12–6. https://doi.org/10.1038/nsb730 PMID: 11753428.
-
(2002)
Nat Struct Biol
, vol.9
, Issue.1
, pp. 12-16
-
-
DiGiammarino, E.L.1
Lee, A.S.2
Cadwell, C.3
Zhang, W.4
Bothner, B.5
Ribeiro, R.C.6
-
29
-
-
79851511414
-
Molecular pathological epidemiology of colorectal neo-plasia: An emerging transdisciplinary and interdisciplinary field
-
PMID 21036793 PubMed Central PMCID PMCPMC3040598
-
Ogino S, Chan AT, Fuchs CS, Giovannucci E. Molecular pathological epidemiology of colorectal neo-plasia: an emerging transdisciplinary and interdisciplinary field. Gut. 2011; 60(3):397–411. https://doi.org/10.1136/gut.2010.217182 PMID: 21036793; PubMed Central PMCID: PMCPMC3040598.
-
(2011)
Gut
, vol.60
, Issue.3
, pp. 397-411
-
-
Ogino, S.1
Chan, A.T.2
Fuchs, C.S.3
Giovannucci, E.4
-
30
-
-
84955176253
-
Integration of molecular pathology, epidemiology and social science for global precision medicine
-
PMID 26636627 PubMed Central PMCID PMCPMC4713314
-
Nishi A, Milner DA Jr., Giovannucci EL, Nishihara R, Tan AS, Kawachi I, et al. Integration of molecular pathology, epidemiology and social science for global precision medicine. Expert Rev Mol Diagn. 2016; 16(1):11–23. https://doi.org/10.1586/14737159.2016.1115346 PMID: 26636627; PubMed Central PMCID: PMCPMC4713314.
-
(2016)
Expert Rev Mol Diagn
, vol.16
, Issue.1
, pp. 11-23
-
-
Nishi, A.1
Milner, D.A.2
Giovannucci, E.L.3
Nishihara, R.4
Tan, A.S.5
Kawachi, I.6
-
31
-
-
84937028711
-
Resistance to cancer chemotherapy: Failure in drug response from ADME to P-gp
-
PMID 26180516 PubMed Central PMCID PMCPMC4502609
-
Alfarouk KO, Stock CM, Taylor S, Walsh M, Muddathir AK, Verduzco D, et al. Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp. Cancer Cell Int. 2015; 15:71. https://doi.org/10.1186/s12935-015-0221-1 PMID: 26180516; PubMed Central PMCID: PMCPMC4502609.
-
(2015)
Cancer Cell Int
, vol.15
, pp. 71
-
-
Alfarouk, K.O.1
Stock, C.M.2
Taylor, S.3
Walsh, M.4
Muddathir, A.K.5
Verduzco, D.6
-
32
-
-
84937027274
-
Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question
-
PMID 25621294 PubMed Central PMCID PMCPMC4303887
-
Alfarouk KO, Verduzco D, Rauch C, Muddathir AK, Adil HH, Elhassan GO, et al. Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question. Oncoscience. 2014; 1(12):777–802. https://doi.org/10.18632/oncoscience.109 PMID: 25621294; PubMed Central PMCID: PMCPMC4303887.
-
(2014)
Oncoscience
, vol.1
, Issue.12
, pp. 777-802
-
-
Alfarouk, K.O.1
Verduzco, D.2
Rauch, C.3
Muddathir, A.K.4
Adil, H.H.5
Elhassan, G.O.6
-
33
-
-
84862757952
-
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
-
PMID 22695393 PubMed Central PMCID PMCPMC4122506
-
Gillies RJ, Verduzco D, Gatenby RA. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer. 2012; 12(7):487–93. https://doi.org/10.1038/nrc3298 PMID: 22695393; PubMed Central PMCID: PMCPMC4122506.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.7
, pp. 487-493
-
-
Gillies, R.J.1
Verduzco, D.2
Gatenby, R.A.3
-
34
-
-
77951640946
-
A method and server for predicting damaging missense mutations
-
PMID 20354512 PubMed Central PMCID PMCPMC2855889
-
Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, et al. A method and server for predicting damaging missense mutations. Nat Methods. 2010; 7(4):248–9. https://doi.org/10.1038/ nmeth0410-248 PMID: 20354512; PubMed Central PMCID: PMCPMC2855889.
-
(2010)
Nat Methods
, vol.7
, Issue.4
, pp. 248-249
-
-
Adzhubei, I.A.1
Schmidt, S.2
Peshkin, L.3
Ramensky, V.E.4
Gerasimova, A.5
Bork, P.6
-
35
-
-
77954069195
-
A flexible R package for nonnegative matrix factorization
-
PMID 20598126 PubMed Central PMCID PMCPMC2912887
-
Gaujoux R, Seoighe C. A flexible R package for nonnegative matrix factorization. BMC Bioinformatics. 2010; 11:367. https://doi.org/10.1186/1471-2105-11-367 PMID: 20598126; PubMed Central PMCID: PMCPMC2912887.
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 367
-
-
Gaujoux, R.1
Seoighe, C.2
|