Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management

The Lancet Infectious Diseases

Volumn 18, Issue 1, 2018, Pages e1-e13

  Devakumar, Delan ^a   Bamford, Alasdair ^b,d   Ferreira, Marcelo U ^c   Broad, Jonathan ^e   Rosch, Richard E ^d   Groce, Nora ^a   Breuer, Judith ^a   Cardoso, Marly A ^c   Copp, Andrew J ^d   Alexandre, Paula ^d   Rodrigues, Laura C ^f   Abubakar, Ibrahim ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

BRAIN GROWTH; CEPHALOMETRY; CHILD GROWTH; CLINICAL FEATURE; CYTOMEGALOVIRUS; FETUS DEATH; GESTATIONAL AGE; HEAD CIRCUMFERENCE; HERPES SIMPLEX VIRUS; HUMAN; INTRAUTERINE GROWTH RETARDATION; LABORATORY DIAGNOSIS; MICROCEPHALY; NEUROIMAGING; NONHUMAN; POSTNATAL DEVELOPMENT; PREGNANCY; PREGNANT WOMAN; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RUBELLA VIRUS; SCREENING TEST; SEROCONVERSION; TOXOPLASMA GONDII; WORLD HEALTH ORGANIZATION; ZIKA FEVER; ZIKA VIRUS; CENTRAL NERVOUS SYSTEM INFECTION; COMPLICATION; DISEASE MANAGEMENT; PATHOLOGY;

CENTRAL NERVOUS SYSTEM INFECTIONS; DISEASE MANAGEMENT; HUMANS; MICROCEPHALY;

EID: 85028346501     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(17)30398-5     Document Type: Review

References (151)

1. WHO. Zika virus. Fact sheet. http://www.who.int/mediacentre/factsheets/zika/en/, Sept 6, 2016 (accessed July 23, 2017).
2. Schuler-Faccini, L, Ribeiro, EM, Feitosa, IM, et al. Possible association between Zika virus infection and microcephaly—Brazil, 2015. MMWR Morb Mortal Wkly Rep 65 (2016), 59–62.
3. WHO. Screening, assessment and management of neonates and infants with complications associated with Zika virus exposure in utero. Rapid Advice Guideline. Aug 30, 2016, 2016, World Health Organization, Geneva.
4. Ashwal, S, Michelson, D, Plawner, L, Dobyns, WB, Practice parameter: evaluation of the child with microcephaly (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 73 (2009), 887–897.
5. Leviton, A, Holmes, LB, Allred, EN, Vargas, J, Methodologic issues in epidemiologic studies of congenital microcephaly. Early Hum Dev 69 (2002), 91–105.
6. Victora, CG, Schuler-Faccini, L, Matijasevich, A, Ribeiro, E, Pessoa, A, Barros, FC, Microcephaly in Brazil: how to interpret reported numbers?. Lancet 387 (2016), 621–624.
7. WHO. The WHO child growth standards. http://www.who.int/childgrowth/en/ (accessed May 5, 2016).
8. Villar, J, Cheikh Ismail, L, Victora, CG, et al. International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet 384 (2014), 857–868.
9. Morris, JK, Rankin, J, Garne, E, et al. Prevalence of microcephaly in Europe: population based study. BMJ, 354, 2016, i4721.
10. Woods, CG, Human microcephaly. Curr Opin Neurobiol 14 (2004), 112–117.
11. Passemard, S, Kaindl, AM, Verloes, A, Microcephaly. Handb Clin Neurol 111 (2013), 129–141.
12. Barkovich, AJ, Kuzniecky, RI, Jackson, GD, Guerrini, R, Dobyns, WB, A developmental and genetic classification for malformations of cortical development. Neurology 65 (2005), 1873–1887.
13. Szabó, N, Pap, C, Kóbor, J, Svékus, A, Túri, S, Sztriha, L, Primary microcephaly in Hungary: epidemiology and clinical features. Acta Paediatr 99 (2010), 690–693.
14. von der Hagen, M, Pivarcsi, M, Liebe, J, et al. Diagnostic approach to microcephaly in childhood: a two-center study and review of the literature. Dev Med Child Neurol 56 (2014), 732–741.
15. Graham, KA, Fox, DJ, Talati, A, et al. Prevalence and clinical attributes of congenital microcephaly—New York, 2013–2015. MMWR Morb Mortal Wkly Rep 66 (2017), 125–129.
16. França, GV, Schuler-Faccini, L, Oliveira, WK, et al. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet 388 (2016), 891–897.
17. Oliveira Melo, AS, Malinger, G, Ximenes, R, Szejnfeld, PO, Alves Sampaio, S, Bispo de Filippis, AM, Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?. Ultrasound Obstet Gynecol 47 (2016), 6–7.
18. Dolk, H, The predictive value of microcephaly during the first year of life for mental retardation at seven years. Dev Med Child Neurol 33 (1991), 974–983.
19. Heinonen, K, Räikkönen, K, Pesonen, AK, et al. Prenatal and postnatal growth and cognitive abilities at 56 months of age: a longitudinal study of infants born at term. Pediatrics 121 (2008), e1325–e1333.
20. Woods, CG, Parker, A, Investigating microcephaly. Arch Dis Child 98 (2013), 707–713.
21. Krauss, MJ, Morrissey, AE, Winn, HN, Amon, E, Leet, TL, Microcephaly: an epidemiologic analysis. Am J Obstet Gynecol 188 (2003), 1484–1489.
22. O'Rahilly, R, Müller, F, Developmental stages in human embryos, 1987, Carnegie Institution of Washington, Washington.
23. Chenn, A, Walsh, CA, Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297 (2002), 365–369.
24. Sahara, S, O'Leary, DD, Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors. Neuron 63 (2009), 48–62.
25. Buchman, JJ, Tseng, HC, Zhou, Y, Frank, CL, Xie, Z, Tsai, LH, Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron 66 (2010), 386–402.
26. Marthiens, V, Rujano, MA, Pennetier, C, Tessier, S, Paul-Gilloteaux, P, Basto, R, Centrosome amplification causes microcephaly. Nat Cell Biol 15 (2013), 731–740.
27. Chen, JF, Zhang, Y, Wilde, J, Hansen, KC, Lai, F, Niswander, L, Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size. Nat Commun, 5, 2014, 3885.
28. Lancaster, MA, Renner, M, Martin, CA, et al. Cerebral organoids model human brain development and microcephaly. Nature 501 (2013), 373–379.
29. Leruez-Ville, M, Ville, Y, Optimum treatment of congenital cytomegalovirus infection. Expert Rev Anti Infect Ther 14 (2016), 479–488.
30. Pinninti, SG, Kimberlin, DW, Neonatal herpes simplex virus infections. Pediatr Clin North Am 60 (2013), 351–365.
31. Kimberlin, DW, Neonatal herpes simplex infection. Clin Microbiol Rev 17 (2004), 1–13.
32. Kimberlin, DW, Baley, J, Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. Pediatrics 131 (2013), e635–e646.
33. Lee, J, Bowden, DS, Rubella virus replication and links to teratogenicity. Clin Microbiol Rev 13 (2000), 571–587.
34. Silasi, M, Cardenas, I, Kwon, JY, Racicot, K, Aldo, P, Mor, G, Viral infections during pregnancy. Am J Reprod Immunol 73 (2015), 199–213.
35. Montoya, JG, Liesenfeld, O, Toxoplasmosis. Lancet 363 (2004), 1965–1976.
36. SYROCOT (Systematic Review on Congenital Toxoplasmosis) study group, Thiebaut, R, Leproust, S, Chêne, G, Gilbert, R, Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients' data. Lancet 369 (2007), 115–122.
37. McLeod, R, Kieffer, F, Sautter, M, Hosten, T, Pelloux, H, Why prevent, diagnose and treat congenital toxoplasmosis?. Mem Inst Oswaldo Cruz 104 (2009), 320–344.
38. Wikan, N, Smith, DR, Zika virus: history of a newly emerging arbovirus. Lancet Infect Dis 16 (2016), e119–e126.
39. Waddell, LA, Greig, JD, Scoping review of the Zika virus literature. PLoS One, 11, 2016, e0156376.
40. Bharucha, T, Breuer, J, Review: a neglected flavivirus: an update on Zika virus in 2016 and the future direction of research. Neuropathol Appl Neurobiol 42 (2016), 317–325.
41. Petersen, LR, Jamieson, DJ, Powers, AM, Honein, MA, Zika virus. N Engl J Med 374 (2016), 1552–1563.
42. Cooper, LZ, Ziring, PR, Ockerse, AB, Fedun, BA, Kiely, B, Krugman, S, Rubella. Clinical manifestations and management. Am J Dis Child 118 (1969), 18–29.
43. Webster, WS, Teratogen update: congenital rubella. Teratology 58 (1998), 13–23.
44. Driggers, RW, Ho, CY, Korhonen, EM, et al. Zika virus infection with prolonged maternal viremia and fetal brain abnormalities. N Engl J Med 374 (2016), 2142–2151.
45. Mlakar, J, Korva, M, Tul, N, et al. Zika virus associated with microcephaly. N Engl J Med 374 (2016), 951–958.
46. Feldman, B, Yinon, Y, Tepperberg Oikawa, M, Yoeli, R, Schiff, E, Lipitz, S, Pregestational, periconceptional, and gestational primary maternal cytomegalovirus infection: prenatal diagnosis in 508 pregnancies. Am J Obstet Gynecol 4 (2011), e1–e6.
47. Lipitz, S, Yinon, Y, Malinger, G, et al. Risk of cytomegalovirus-associated sequelae in relation to time of infection and findings on prenatal imaging. Ultrasound Obstet Gynecol 41 (2013), 508–514.
48. McAuley, JB, Congenital toxoplasmosis. J Pediatric Infect Dis Soc 3:suppl 1 (2014), S30–S35.
49. Marquez, L, Levy, ML, Munoz, FM, Palazzi, DL, A report of three cases and review of intrauterine herpes simplex virus infection. Pediatr Infect Dis J 30 (2011), 153–157.
50. Hutto, C, Arvin, A, Jacobs, R, et al. Intrauterine herpes simplex virus infections. J Pediatr 110 (1987), 97–101.
51. Barefoot, KH, Little, GA, Ornvold, KT, Fetal demise due to herpes simplex virus: an illustrated case report. J Perinatol 22 (2002), 86–88.
52. Odeberg, J, Wolmer, N, Falci, S, Westgren, M, Seiger, A, Söderberg-Nauclér, C, Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cells. J Virol 80 (2006), 8929–8939.
53. Johansson, AB, Rassart, A, Blum, D, Van Beers, D, Liesnard, C, Lower-limb hypoplasia due to intrauterine infection with herpes simplex virus type 2: possible confusion with intrauterine varicella-zoster syndrome. Clin Infect Dis 38 (2004), 57–62.
54. Lazar, M, Perelygina, L, Martines, R, et al. Immunolocalization and distribution of rubella antigen in fatal congenital rubella syndrome. EBioMedicine 3 (2016), 86–92.
55. Dang, J, Tiwari, SK, Lichinchi, G, et al. Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune teceptor TLR3. Cell Stem Cell 19 (2016), 258–265.
56. Qian, X, Nguyen, HN, Song, MM, et al. Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 165 (2016), 1238–1254.
57. Lafaille, FG, Pessach, IM, Zhang, SY, et al. Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature 491 (2012), 769–773.
58. Garcez, PP, Loiola, EC, Madeiro da Costa, R, et al. Zika virus impairs growth in human neurospheres and brain organoids. Science 352 (2016), 816–818.
59. Luo, MH, Hannemann, H, Kulkarni, AS, Schwartz, PH, O'Dowd, JM, Fortunato, EA, Human cytomegalovirus infection causes premature and abnormal differentiation of human neural progenitor cells. J Virol 84 (2010), 3528–3541.
60. Li, XJ, Liu, XJ, Yang, B, et al. Human cytomegalovirus infection dysregulates the localization and stability of NICD1 and Jag1 in neural progenitor cells. J Virol 89 (2015), 6792–6804.
61. D'Aiuto, L, Di Maio, R, Heath, B, et al. Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells. PLoS One, 7, 2012, e49700.
62. Rolland, M, Li, X, Sellier, Y, et al. PPARγ is activated during congenital cytomegalovirus infection and inhibits neuronogenesis from human neural stem cells. PLoS Pathog, 12, 2016, e1005547.
63. Braun, E, Zimmerman, T, Hur, TB, et al. Neurotropism of herpes simplex virus type 1 in brain organ cultures. J Gen Virol 87 (2006), 2827–2837.
64. Hu, S, Rotschafer, JH, Lokensgard, JR, Cheeran, MC-J, Activated CD8+ T lymphocytes inhibit neural stem/progenitor cell proliferation: role of interferon-gamma. PLoS One, 9, 2014, e105219.
65. Nguyen, TV, Pham, VH, Abe, K, Pathogenesis of congenital rubella virus infection in human fetuses: viral infection in the ciliary body could play an important role in cataractogenesis. EBioMedicine 2 (2014), 59–63.
66. Rorke, LB, Fabiyi, A, Elizan, TS, Sever, JL, Experimental cerebrovascular lesions in congenital and neonatal rubella-virus infections of ferrets. Lancet 2 (1968), 153–154.
67. Tondury, G, Smith, DW, Fetal rubella pathology. J Pediatr 68 (1966), 867–879.
68. Cugola, FR, Fernandes, IR, Russo, FB, et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 534 (2016), 267–271.
69. Tang, H, Hammack, C, Ogden, SC, et al. Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 18 (2016), 587–590.
70. Hamel, R, Liégeois, F, Wichit, S, et al. Zika virus: epidemiology, clinical features and host-virus interactions. Microbes Infect 18 (2016), 441–449.
71. Nowakowski, TJ, Pollen, AA, Di Lullo, E, Sandoval-Espinosa, C, Bershteyn, M, Kriegstein, AR, Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells. Cell Stem Cell 5 (2016), 591–596.
72. Onorati, M, Li, Z, Liu, F, et al. Zika virus disrupts phospho-TBK1 localization and mitosis in human neuroepithelial stem cells and radial glia. Cell Rep 16 (2016), 2576–2592.
73. Wells, MF, Salick, MR, Wiskow, O, et al. Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection. Cell Stem Cell 19 (2016), 703–708.
74. Pillai, S, Nguyen, J, Johnson, J, Haura, E, Coppola, D, Chellappan, S, Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis. Nat Commun, 6, 2015, 10072.
75. Li, C, Xu, D, Ye, Q, et al. Zika virus disrupts neural progenitor development and leads to microcephaly in mice. Cell Stem Cell 19 (2016), 120–126.
76. Wu, KY, Zuo, GL, Li, XF, et al. Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell Res 26 (2016), 645–654.
77. Adams Waldorf, KM, Stencel-Baerenwald, JE, Kapur, RP, et al. Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nat Med 22 (2016), 1256–1259.
78. Manicklal, S, Emery, VC, Lazzarotto, T, Boppana, SB, Gupta, RK, The “silent” global burden of congenital cytomegalovirus. Clin Microbiol Rev 26 (2013), 86–102.
79. Sheevani, Jindal, N, Aggarwal, A, A pilot seroepidemiological study of cytomegalovirus infection in women of child bearing age. Indian J Med Microbiol 23 (2005), 34–36.
80. Schoenfisch, AL, Dollard, SC, Amin, M, et al. Cytomegalovirus (CMV) shedding is highly correlated with markers of immunosuppression in CMV-seropositive women. J Med Microbiol 60 (2011), 768–774.
81. Cannon, MJ, Schmid, DS, Hyde, TB, Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol 20 (2010), 202–213.
82. Alanen, A, Kahala, K, Vahlberg, T, Koskela, P, Vainionpää, R, Seroprevalence, incidence of prenatal infections and reliability of maternal history of varicella zoster virus, cytomegalovirus, herpes simplex virus and parvovirus B19 infection in South-Western Finland. BJOG 112 (2005), 50–56.
83. Seo, S, Cho, Y, Park, J, Serologic screening of pregnant Korean women for primary human cytomegalovirus infection using IgG avidity test. Korean J Lab Med 29 (2009), 557–562.
84. Kenneson, A, Cannon, MJ, Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 17 (2007), 253–276.
85. Ornoy, A, Diav-Citrin, O, Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod Toxicol 21 (2006), 399–409.
86. Picone, O, Vauloup-Fellous, C, Cordier, AG, et al. A series of 238 cytomegalovirus primary infections during pregnancy: description and outcome. Prenat Diagn 33 (2013), 751–758.
87. Britt, W, Controversies in the natural history of congenital human cytomegalovirus infection: the paradox of infection and disease in offspring of women with immunity prior to pregnancy. Med Microbiol Immunol 204 (2015), 263–271.
88. Society for Maternal-Fetal Medicine, Hughes, BL, Gyamfi-Bannerman, C, Diagnosis and antenatal management of congenital cytomegalovirus infection. Am J Obstet Gynecol 214 (2016), B5–B11.
89. Khamduang, W, Jourdain, G, Sirirungsi, W, et al. The interrelated transmission of HIV-1 and cytomegalovirus during gestation and delivery in the offspring of HIV-infected mothers. J Acquir Immune Defic Syndr 58 (2011), 188–192.
90. Looker, KJ, Garnett, GP, Schmid, GP, An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ 86 (2008), 805–812.
91. Looker, KJ, Magaret, AS, Turner, KM, Vickerman, P, Gottlieb, SL, Newman, LM, Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012. PLoS One, 10, 2015, e114989.
92. Vynnycky, E, Adams, EJ, Cutts, FT, et al. Using seroprevalence and immunisation coverage data to estimate the global burden of congenital rubella syndrome, 1996–2010: a systematic review. PloS One, 11, 2016, e0149160.
93. WHO. Rubella. http://www.who.int/mediacentre/factsheets/fs367/en/, March, 2016 (accessed June 18, 2016).
94. Pandolfi, E, Gesualdo, F, Rizzo, C, et al. Global seroprevalence of rubella among pregnant and childbearing age women: a meta-analysis. Eur J Public Health 27 (2017), 530–537.
95. Tenter, AM, Heckeroth, AR, Weiss, LM, Toxoplasma gondii: from animals to humans. Int J Parasitol 30 (2000), 1217–1258.
96. Jones, JL, Kruszon-Moran, D, Wilson, M, McQuillan, G, Navin, T, McAuley, JB, Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidemiol 154 (2001), 357–365.
97. Torgerson, PR, Mastroiacovo, P, The global burden of congenital toxoplasmosis: a systematic review. Bull World Health Organ 91 (2013), 501–508.
98. Wang ZD, Wang SC, Liu HH, et al. Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis. Lancet HIV; 4: e177–88.
99. Duffy, MR, Chen, TH, Hancock, WT, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 360 (2009), 2536–2543.
100. Aubry, M, Teissier, A, Huart, M, et al. Zika virus seroprevalence, French Polynesia, 2014–2015. Emerging Infect Dis 23 (2017), 669–672.
101. WHO. Zika situation report. http://www.who.int/emergencies/zika-virus/situation-report/10-march-2017/en/, March 10, 2017 (accessed March 31, 2017).
102. Coelho, FC, Durovni, B, Saraceni, V, et al. Sexual transmission causes a marked increase in the incidence of Zika in women in Rio de Janeiro, Brazil. Int J Infect Dis 51 (2016), 128–132.
103. Health Protection Agency. Guidance on viral rash in pregnancy. Investigation, diagnosis and management of viral rash illness, or exposure to viral rash illness, in pregnancy, 2011, HPA, London.
104. Pass, RF, Boppana, S, Jeffries, DJ, Hudson, CN, Viral infection in obstetrics and gynaecology, 1999, Arnold, New York.
105. Best, JM, Rubella. Semin Fetal Neonatal Med 12 (2007), 182–192.
106. Mendelson, E, Aboudy, Y, Smetana, Z, Tepperberg, M, Grossman, Z, Laboratory assessment and diagnosis of congenital viral infections: rubella, cytomegalovirus (CMV), varicella-zoster virus (VZV), herpes simplex virus (HSV), parvovirus B19 and human immunodeficiency virus (HIV). Reprod Toxicol 21 (2006), 350–382.
107. Lazzarotto, T, Guerra, B, Lanari, M, Gabrielli, L, Landini, MP, New advances in the diagnosis of congenital cytomegalovirus infection. J Clin Virol 41 (2008), 192–197.
108. Centers for Disease Control and Prevention. DPDx—laboratory identification of parasitic diseases of public health concern. Toxoplasmosis. http://www.cdc.gov/dpdx/toxoplasmosis/dx.html, 2015 (accessed Oct 26, 2017).
109. Petersen, E, Toxoplasmosis. Semin Fetal Neonatal Med 12 (2007), 214–223.
110. Dard, C, Fricker-Hidalgo, H, Brenier-Pinchart, MP, Pelloux, H, Relevance of and new developments in serology for toxoplasmosis. Trends Parasitol 32 (2016), 492–506.
111. Rorman, E, Zamir, CS, Rilkis, I, Ben-David, H, Congenital toxoplasmosis—prenatal aspects of Toxoplasma gondii infection. Reprod Toxicol 21 (2006), 458–472.
112. Alanen, A, Hukkanen, V, Herpes simplex virus DNA in amniotic fluid without neonatal infection. Clin Infect Dis 30 (2000), 363–367.
113. Calvet, G, Aguiar, RS, Melo, AS, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis 16 (2016), 653–660.
114. World Health Organization. Immunization coverage. Fact sheet. http://www.who.int/mediacentre/factsheets/fs378/en/, March, 2017 (accessed March 31, 2017).
115. Klein, JO, Remington, JS, Current concepts of infections of the fetus and newborn infant. Remington, JS, Klein, JO, (eds.) Infectious disease of the fetus and newborn infant, 4th edn., 1995, WB Saunders Co, Philadelphia, 1–16.
116. Johnson, KE, Overview of TORCH infections. https://www.uptodate.com/contents/overview-of-torch-infections, 2015 (accessed May 17, 2016).
117. Kimberlin, DW, Jester, PM, Sánchez, PJ, et al. Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med 372 (2015), 933–943.
118. Kimberlin, DW, Lin, CY, Sánchez, PJ, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr 143 (2003), 16–25.
119. Shah, T, Luck, S, Sharland, M, Kadambari, S, Heath, P, Lyall, H, Fifteen-minute consultation: diagnosis and management of congenital CMV. Arch Dis Child Educ Pract Ed 101 (2016), 232–235.
120. Kimberlin, DW, Lin, CY, Jacobs, RF, et al. Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. Pediatrics 108 (2001), 230–238.
121. Plotkin, SA, Reef, SE, Cooper, LZ, Alford, CA, Rubella. Remington, JS, Klein, JO, Wilson, CB, Baker, CJ, (eds.) Infectious diseases of the fetus and newborn infant, 7th edn., 2011, Elsevier Saunders, Philadelphia, PA, 861.
122. Daffos, F, Forestier, F, Capella-Pavlovsky, M, et al. Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis. N Engl J Med 318 (1988), 271–275.
123. Cheeran, MC, Lokensgard, JR, Schleiss, MR, Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev 22 (2009), 99–126.
124. Dollard, SC, Grosse, SD, Ross, DS, New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol 17 (2007), 355–363.
125. Dreher, AM, Arora, N, Fowler, KB, et al. Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr 164 (2014), 855–859.
126. Miller, E, Cradock-Watson, JE, Pollock, TM, Consequences of confirmed maternal rubella at successive stages of pregnancy. Lancet 2 (1982), 781–784.
127. Givens, KT, Lee, DA, Jones, T, Ilstrup, DM, Congenital rubella syndrome: ophthalmic manifestations and associated systemic disorders. Br J Ophthalmol 77 (1993), 358–363.
128. Reef, SE, Plotkin, S, Cordero, JF, et al. Preparing for elimination of congenital Rubella syndrome (CRS): summary of a workshop on CRS elimination in the United States. Clin Infect Dis 31 (2000), 85–95.
129. Sabin, AH, Toxoplasmosis. A recently recognized disease of human beings. Adv Pediatr 1 (1942), 1–53.
130. Cortina-Borja, M, Tan, HK, Wallon, M, et al. Prenatal treatment for serious neurological sequelae of congenital toxoplasmosis: an observational prospective cohort study. PLoS Med, 7, 2010, e1000351.
131. Capobiango, JD, Breganó, RM, Navarro, IT, et al. Congenital toxoplasmosis in a reference center of Parana, Southern Brazil. Braz J Infect Dis 18 (2014), 364–371.
132. Cauchemez, S, Besnard, M, Bompard, P, et al. Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study. Lancet 387 (2016), 2125–2132.
133. Brasil, P, Pereira, JP Jr, Moreira, ME, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med 375 (2016), 2321–2334.
134. Moore, CA, Staples, JE, Dobyns, WB, et al. Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians. JAMA Pediatr 171 (2017), 288–295.
135. Melo, AS, Aguiar, RS, Amorim, MM, et al. Congenital Zika virus infection: beyond neonatal microcephaly. JAMA Neurol 73 (2016), 1407–1416.
136. Ventura, CV, Maia, M, Dias, N, Ventura, LO, Belfort, R Jr, Zika: neurological and ocular findings in infant without microcephaly. Lancet, 387, 2016, 2502.
137. Reynolds, MR, Jones, AM, Petersen, EE, et al. Vital signs: update on Zika virus-associated birth defects and evaluation of all U.S. infants with congenital Zika virus exposure—U.S. Zika pregnancy registry, 2016. MMWR Morb Mortal Wkly Rep 66 (2017), 366–373.
138. Noyola, DE, Demmler, GJ, Nelson, CT, et al. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr 138 (2001), 325–331.
139. Abdel Razek, AA, Kandell, AY, Elsorogy, LG, Elmongy, A, Basett, AA, Disorders of cortical formation: MR imaging features. AJNR Am J Neuroradiol 30 (2009), 4–11.
140. WHO. Psychosocial support for pregnant women and for families with microcephaly and other neurological complications in the context of Zika virus. Interim guidance for health-care providers, 2016, World Health Organization, Geneva.
141. Centers for Disease Control. Facts about microcephaly. http://www.cdc.gov/ncbddd/birthdefects/microcephaly.html, 2016 (accessed July 15, 2016).
142. Holt, RL, Mikati, MA, Care for child development: basic science rationale and effects of interventions. Pediatr Neurol 44 (2011), 239–253.
143. Britto, PR, Lye, SJ, Proulx, K, et al. Nurturing care: promoting early childhood development. Lancet 389 (2016), 91–102.
144. The United Nations Children's Fund. Violence against disabled children. UN Secretary Generals report on violence against children. Thematic group on violence against disabled children. Findings and recommendations, 2005, UNICEF, New York, NY.
145. WHO, World Bank. World report on disability, 2011, World Health Organization, Geneva.
146. The United Nations Children's Fund. The state of the world's children 2013. Children with Disabilities, 2013, UNICEF, New York, NY.
147. Groce, N, Disability, public health and social injustice. Levy, B, Sidel, V, (eds.) Social injustice and public health, 2nd edn., 2014, Oxford University Press, Oxford.
148. Yamin, A, Health, human rights and the Zika virus. https://fxb.harvard.edu/4941-2/, 2016 (accessed July 27, 2016).
149. Palmer, M, Disability and poverty: a conceptual review. J Disabil Policy Stud 21 (2011), 210–218.
150. Mitra, S, Posarac, A, Vick, B, Disability and poverty in developing countries: a multidimensional study. World Development 41 (2013), 1–18.
151. UN. UN Convention on the Rights of Persons with Disabilities, 2006, United Nations, New York, NY.