Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment

Oncogene

Volumn 34, Issue 4, 2015, Pages 516-524

  Savar, A ^a   Acin, S ^a   Gonzalez, C L ^a   El Sawy, T ^a   Mejia, O ^a   Li, Z ^a   Esmaeli, B ^a   Lacy Hulbert, A ^b   El Naggar, A K ^a   McCarty, J H ^a   Caulin, C ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

integrins; mouse model; p53; squamous cell carcinoma; tumor microenvironment

Indexed keywords

CD51 ANTIGEN; PROTEIN KINASE B; PROTEIN P53;

ANIMAL; CARCINOMA, SQUAMOUS CELL; MOUSE; MOUTH NEOPLASMS; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TUMOR MICROENVIRONMENT;

ANIMALS; CARCINOMA, SQUAMOUS CELL; INTEGRIN ALPHAV; MAP KINASE SIGNALING SYSTEM; MICE; MOUTH NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; SKIN NEOPLASMS; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85028242145     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.585     Document Type: Article

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