The rs7903146 variant in the tcf7l2 gene increases the risk of prediabetes/type 2 diabetes in obese adolescents by impairing b-cell function and hepatic insulin sensitivity

Diabetes Care

Volumn 40, Issue 8, 2017, Pages 1082-1089

  Cropano, Catrina ^a   Santoro, Nicola ^a   Groop, Leif ^b,c   Man, Chiara Dalla ^d   Cobelli, Claudio ^d   Galderisi, Alfonso ^a   Kursawe, Romy ^e   Pierpont, Bridget ^a   Goffredo, Martina ^a   Caprio, Sonia ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^d UNIVERSITY OF PADOVA   (Italy)

^e JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; TCF7L2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR 7 LIKE 2;

ADOLESCENT; ALLELE; ANCESTRY GROUP; BLOOD; BODY MASS; CHILD; CHILDHOOD OBESITY; COHORT ANALYSIS; FEMALE; FOLLOW UP; GENETIC PREDISPOSITION; GENETICS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; LIVER; LONGITUDINAL STUDY; MALE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; RISK FACTOR; SECRETION (PROCESS);

ADOLESCENT; ALLELES; BODY MASS INDEX; CHILD; COHORT STUDIES; CONTINENTAL POPULATION GROUPS; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIVER; LONGITUDINAL STUDIES; MALE; PEDIATRIC OBESITY; PREDIABETIC STATE; RISK FACTORS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 85028062087     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc17-0290     Document Type: Article

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