In vitro scan for enhancers at the TCF7L2 locus

Diabetologia

Volumn 56, Issue 1, 2013, Pages 121-125

  Savic, D ^a   Park, S Y ^a   Bailey, K A ^a   Bell, G I ^a   Nobrega, M A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

cis Regulatory elements; GWAS; TCF7L2; Type 2 diabetes

Indexed keywords

TRANSCRIPTION FACTOR 7 LIKE 2;

ALLELE; ARTICLE; CELL STRAIN; CELLULAR DISTRIBUTION; CHROMATIN STRUCTURE; CONTROLLED STUDY; ENHANCER REGION; EPIGENETICS; GENE CONSTRUCT; GENE CONTROL; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRON; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGULATORY SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TCF7L2 GENE;

ALLELES; ANIMALS; BIOLOGICAL MARKERS; CELL LINE; CHROMATIN ASSEMBLY AND DISASSEMBLY; DIABETES MELLITUS, TYPE 2; ENHANCER ELEMENTS, GENETIC; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INSULIN-SECRETING CELLS; MICE; ORGAN SPECIFICITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84871615273     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2730-y     Document Type: Article

References (15)

1. Sakabe NJ, Savic D, Nobrega MA (2012) Transcriptional enhancers in development and disease. Genome Biol 13:238
2. Cauchi S, El Achhab Y, Choquet H et al. (2007) TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med 85:777-782 (Pubitemid 47063530)
3. Savic D, Ye H, Aneas I, Park SY, Bell GI, Nobrega MA (2011) Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res 21:1417-1425
4. Gaulton KJ, Nammo T, Pasquali L et al. (2010) A map of open chromatin in human pancreatic islets. Nat Genet 42:255-259
5. Lyssenko V, Lupi R, Marchetti P et al. (2007) Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155-2163 (Pubitemid 47219560)
6. Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K (2008) Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 57:645-653
7. Loder MK, da Silva XG, McDonald A, Rutter GA (2008) TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells. Biochem Soc Trans 36:357-359 (Pubitemid 351839331)
8. Figeac F, Uzan B, Faro M, Chelali N, Portha B, Movassat J (2010) Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats. Am J Physiol Endocrinol Metab 298:E245-E256
9. Stitzel ML, Sethupathy P, Pearson DS et al. (2010) Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab 12:443-455
10. Savic D, Bell GI, Nobrega MA (2012) An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers. PLoS One 7:e36501
11. Helgason A, Palsson S, Thorleifsson G et al. (2007) Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39:218-225 (Pubitemid 46184353)
12. Sousa AG, Marquezine GF, Lemos PA et al. (2009) TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. PLoS One 4:e7697
13. Hansen T, Ingason A, Djurovic S et al. (2011) At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia. Biol Psychiatry 70:59-63
14. Folsom AR, Pankow JS, Peacock JM, Bielinski SJ, Heiss G, Boerwinkle E (2008) Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care 31:905-909
15. Florez JC (2008) Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia 51:1100-1110