The role of homeobox genes in the development of placental insufficiency

Fetal Diagnosis and Therapy

Volumn 32, Issue 4, 2012, Pages 225-230

  Murthi, Padma ^a   Kalionis, Bill ^a   Rajaraman, Gayathri ^a   Keogh, Rosemary J ^a   Da Silva Costa, Fabricio ^a  

^a ROYAL WOMEN'S HOSPITAL   (Australia)

Author keywords

Intrauterine growth restriction; Low birth weight; Perinatal morbidity; Perinatal mortality; Placental insufficiency; Small for gestational age

Indexed keywords

CELL FUNCTION; DISEASE ASSOCIATION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC TRANSCRIPTION; HOMEOBOX; HUMAN; INTRAUTERINE GROWTH RETARDATION; NONHUMAN; PLACENTA DEVELOPMENT; PLACENTA INSUFFICIENCY; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION REGULATION; TROPHOBLAST; VASCULAR DISEASE;

EID: 85027955798     PISSN: 10153837     EISSN: 14219964     Source Type: Journal    
DOI: 10.1159/000339657     Document Type: Review

References (58)

1. Mongelli M, Gardosi J: Fetal growth. Curr Opin Obstet Gynecol 2000; 12: 111-115. (Pubitemid 32250639)
2. Lewit EM, Baker LS, Corman H, Shiono PH: The direct cost of low birth weight. Future Child 1995; 5: 35-56.
3. Godfrey KM, Barker DJ: Fetal nutrition and adult disease. Am J Clin Nutr 2000; 71(5 suppl):1344S-1352S. (Pubitemid 30230539)
4. Baschat AA: Fetal growth restriction -from observation to intervention. J Perinat Med 2010; 38: 239-246.
5. Haram K, Gjelland K: Foetal growth retardation (in Norwegian). Tidsskr Nor Laegeforen 2007; 127: 2665-2669.
6. Mongelli M, Figueras F, Francis A, Gardosi J: A customized birthweight centile calculator developed for an Australian population. Aust NZ J Obstet Gynaecol 2007; 47: 128-131. (Pubitemid 46390189)
7. Carberry AE, Gordon A, Bond DM, Hyett J, Raynes-Greenow CH, Jeffery HE: Customised versus population-based growth charts as a screening tool for detecting small for gestational age infants in low-risk pregnant women. Cochrane Database Syst Rev 2011; 12:CD008549.
8. Anthony RV, Scheaffer AN, Wright CD, Regnault TR: Ruminant models of prenatal growth restriction. Reprod Suppl 2003; 61: 183-194.
9. Chen CP, Bajoria R, Aplin JD: Decreased vascularization and cell proliferation in placentas of intrauterine growth-restricted fetuses with abnormal umbilical artery flow velocity waveforms. Am J Obstet Gynecol 2002; 187: 764-769.
10. Jackson MR, Walsh AJ, Morrow RJ, Mullen JB, Lye SJ, Ritchie JW: Reduced placental villous tree elaboration in small-for-gestational-age pregnancies: relationship with umbilical artery Doppler waveforms. Am J Obstet Gynecol 1995; 172: 518-525.
11. Somerset DA, Li XF, Afford S, Strain AJ, Ahmed A, Sangha RK, Whittle MJ, Kilby MD: Ontogeny of hepatocyte growth factor (HGF) and its receptor (c-met) in human placenta: reduced HGF expression in intrauterine growth restriction. Am J Pathol 1998; 153: 1139-1147. (Pubitemid 28465837)
12. Axt R, Kordina AC, Meyberg R, Reitnauer K, Mink D, Schmidt W: Immunohistochemical evaluation of apoptosis in placentae from normal and intrauterine growth-restricted pregnancies. Clin Exp Obstet Gynecol 1999; 26: 195-198. (Pubitemid 30015410)
13. Smith SC, Baker PN, Symonds EM: Increased placental apoptosis in intrauterine growth restriction. Am J Obstet Gynecol 1997; 177: 1395-1401. (Pubitemid 28040233)
14. Pardi G, Marconi AM, Cetin I: Pathophysiology of intrauterine growth retardation: role of the placenta. Acta Paediatr Suppl 1997; 423: 170-172. (Pubitemid 27511914)
15. Sheppard BL, Bonnar J: An ultrastructural study of utero-placental spiral arteries in hypertensive and normotensive pregnancy and fetal growth retardation. Br J Obstet Gynaecol 1981; 88: 695-705. (Pubitemid 11052966)
16. Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB: Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2. J Clin Endocrinol Metab 2002; 87: 4213-4224.
17. Marzioni D, Capparuccia L, Todros T, Giovannelli A, Castellucci M: Growth factors and their receptors: fundamental molecules for human placental development. Ital J Anat Embryol 2005; 110: 183-187. (Pubitemid 40993974)
18. Khaliq A, Dunk C, Jiang J, Shams M, Li XF, Acevedo C, Weich H, Whittle M, Ahmed A: Hypoxia down-regulates placenta growth factor, whereas fetal growth restriction upregulates placenta growth factor expression: molecular evidence for 'placental hyperoxia' in intrauterine growth restriction. Lab Invest 1999; 79: 151-170. (Pubitemid 29110646)
19. Ahmed A, Perkins J: Angiogenesis and intrauterine growth restriction. Baillieres Best Pract Res Clin Obstet Gynaecol 2000; 14: 981-998. (Pubitemid 32123685)
20. Spencer JA, Chang TC, Crook D, Proudler A, Felton CV, Robson SC, Hauesler M: Third trimester fetal growth and measures of carbohydrate and lipid metabolism in umbilical venous blood at term. Arch Dis Child Fetal Neonatal Ed 1997; 76:F21-F25. (Pubitemid 28234546)
21. Roh CR, Budhraja V, Kim HS, Nelson DM, Sadovsky Y: Microarray based identification of differentially expressed genes in hypoxic term human trophoblasts and in placental villi of pregnancies with growth restricted fetuses. Placenta 2005; 26: 319-328. (Pubitemid 40485869)
22. Okamoto A, Endo H, Kalionis B, Shinya M, Saito M, Nikaido T, Tanaka T: IGFBP1 and Follistatin-like 3 genes are significantly upregulated in expression profiles of the IUGR placenta. Placenta 2006; 27: 317-321. (Pubitemid 41763473)
23. Aplin JD, Straszewski-Chavez SL, Kalionis B, Dunk C, Morrish D, Forbes K, Baczyk D, Rote N, Malassine A, Knöfler M: Trophoblast differentiation: progenitor cells, fusion and migration -a workshop report. Placenta 2006; 27(suppl A):S141-S143.
24. Knöfler M, Kalionis B, Huelseweh B, Bilban M, Morrish DW: Novel genes and transcription factors in placental development -a workshop report. Placenta 2000; 21(suppl A):S71-S73.
25. Leach L, Badet J, Brownbill P, Harris L, Keogh R, Kalionis B, Whitley G: Endothelium, blood vessels and angiogenesis -a workshop report. Placenta 2006; 27(suppl A):S26-S29.
26. Quinn LM, Latham SE, Kalionis B: Homeobox gene HB24, a regulator of haematopoiesis, is a candidate for regulating differentiation of the extra-embryonic trophoblast cell lineage. Reprod Fertil Dev 1997; 9: 617-623. (Pubitemid 28156735)
27. Quinn LM, Latham SE, Kalionis B: A distalless class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta. Placenta 1998; 19: 87-93. (Pubitemid 28112066)
28. Quinn LM, Johnson BV, Nicholl J, Sutherland GR, Kalionis B: Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4. Gene 1997; 187: 55-61. (Pubitemid 27110434)
29. Gehring WJ, Affolter M, Bürglin T: Homeodomain proteins. Annu Rev Biochem 1994; 63: 487-526. (Pubitemid 24218641)
30. Gellon G, McGinnis W: Shaping animal body plans in development and evolution by modulation of Hox expression patterns. Bioessays 1998; 20: 116-125. (Pubitemid 28132107)
31. Taylor HS: The role of HOX genes in the development and function of the female reproductive tract. Semin Reprod Med 2000; 18: 81-89. (Pubitemid 32182824)
32. Cillo C, Cantile M, Faiella A, Boncinelli E: Homeobox genes in normal and malignant cells. J Cell Physiol 2001; 188: 161-169. (Pubitemid 32622906)
33. Loregger T, Pollheimer J, Knöfler M: Regulatory transcription factors controlling function and differentiation of human trophoblast -a review. Placenta 2003; 24(suppl A):S104-S110. (Pubitemid 37184743)
34. Rossant J, Cross JC: Placental development: lessons from mouse mutants. Nat Rev Genet 2001; 2: 538-548. (Pubitemid 33674027)
35. Sapin V, Blanchon L, Serre AF, Lémery D, Dastugue B, Ward SJ: Use of transgenic mice model for understanding the placentation: towards clinical applications in human obstetrical pathologies? Transgenic Res 2001; 10: 377-398. (Pubitemid 33001692)
36. Hemberger M, Cross JC: Genes governing placental development. Trends Endocrinol Metab 2001; 12: 162-168. (Pubitemid 33713557)
37. Cross JC, Baczyk D, Dobric N, Hemberger M, Hughes M, Simmons DG, Yamamoto H, Kingdom JC: Genes, development and evolution of the placenta. Placenta 2003; 24: 123-130. (Pubitemid 37184707)
38. Li Y, Behringer RR: Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth. Nat Genet 1998; 20: 309-311. (Pubitemid 28507681)
39. Roberson MS, et al: A role for the homeobox protein Distal-less 3 in the activation of the glycoprotein hormone alpha subunit gene in choriocarcinoma cells. J Biol Chem 2001; 276: 10016-10024.
40. Rajaraman G, Murthi P, Quinn L, Brennecke SP, Kalionis B: Homeodomain protein HLX is expressed primarily in cytotrophoblast cell types in the early pregnancy human placenta. Reprod Fertil Dev 2008; 20: 357-367. (Pubitemid 351363822)
41. Kraus P, Lufkin T: Mammalian Dlx homeobox gene control of craniofacial and inner ear morphogenesis. J Cell Biochem Suppl 1999; 32-33: 133-140. (Pubitemid 30041819)
42. Maas R, Bei M: The genetic control of early tooth development. Crit Rev Oral Biol Med 1997; 8: 4-39. (Pubitemid 27132230)
43. Murthi P, Hiden U, Rajaraman G, Liu H, Borg AJ, Coombes F, Desoye G, Brennecke SP, Kalionis B: Novel homeobox genes are differentially expressed in placental microvascular endothelial cells compared with macrovascular cells. Placenta 2008; 29: 624-630.
44. Murthi P, Doherty V, Said J, Donath S, Brennecke SP, Kalionis B: Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction. Am J Pathol 2006; 168: 511-518. (Pubitemid 43271149)
45. Murthi P, Doherty VL, Said JM, Donath S, Brennecke SP, Kalionis B: Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction. Mol Hum Reprod 2006; 12: 335-340. (Pubitemid 43821796)
46. Murthi P, Said JM, Doherty VL, Donath S, Nowell CJ, Brennecke SP, Kalionis B: Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction. Mol Hum Reprod 2006; 12: 763-769. (Pubitemid 44811655)
47. Murthi P, So M, Gude NM, Doherty VL, Brennecke SP, Kalionis B: Homeobox genes are differentially expressed in macrovascular human umbilical vein endothelial cells and microvascular placental endothelial cells. Placenta 2007; 28: 219-223. (Pubitemid 44914527)
48. Chui A, Evseenko DA, Brennecke SP, Keelan JA, Kalionis B, Murthi P: Homeobox gene Distal-less 3 (DLX3) is a regulator of villous cytotrophoblast differentiation. Placenta 2011; 32: 745-751.
49. Deguchi Y, Moroney JF, Wilson GL, Fox CH, Winter HS, Kehrl JH: Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes. New Biol 1991; 3: 353-363.
50. Kehrl JH, Deguchi Y: Potential roles for two human homeodomain containing proteins in the proliferation and differentiation of human hematopoietic progenitors. Leuk Lymphoma 1993; 10: 173-176. (Pubitemid 23256589)
51. Neufing PJ, Kalionis B, Horsfall DJ, Ricciardelli C, Stahl J, Vivekanandan S, Raymond W, Tilley WD: Expression and localization of homeodomain proteins DLX4/HB9 in normal and malignant human breast tissues. Anticancer Res 2003; 23: 1479-1488. (Pubitemid 36754118)
52. Hollington P, Neufing P, Kalionis B, Waring P, Bentel J, Wattchow D, Tilley WD: Expression and localization of homeodomain proteins DLX4, HB9 and HB24 in malignant and benign human colorectal tissues. Anticancer Res 2004; 24: 955-962. (Pubitemid 38625044)
53. Rajaraman G, Murthi P, Leo B, Brennecke SP, Kalionis B: Homeobox gene HLX1 is a regulator of colony stimulating factor-1 dependent trophoblast cell proliferation. Placenta 2007; 28: 991-998. (Pubitemid 47355229)
54. Rajaraman G, Murthi P, Pathirage N, Brennecke SP, Kalionis B: Downstream targets of homeobox gene HLX show altered expression in human idiopathic fetal growth restriction. Am J Pathol 2010; 176: 278-287.
55. Chui A, Pathirage NA, Johnson B, Cocquebert M, Fournier T, Evain-Brion D, Roald B, Manuelpillai U, Brennecke SP, Kalionis B, Murthi P: Homeobox gene distal-less 3 is expressed in proliferating and differentiating cells of the human placenta. Placenta 2010; 31: 691-697.
56. Graham CH, Hawley TS, Hawley RG, Mac-Dougall JR, Kerbel RS, Khoo N, Lala PK: Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res 1993; 206: 204-211. (Pubitemid 23212937)
57. Ziegelbauer J, Wei J, Tjian R: Myc-interacting protein 1 target gene profile: a link to microtubules, extracellular signal-regulated kinase, and cell growth. Proc Natl Acad Sci USA 2004; 101: 458-463. (Pubitemid 38084658)
58. Morrish DW, Dakour J, Li H: Life and death in the placenta: new peptides and genes regulating human syncytiotrophoblast and extravillous cytotrophoblast lineage formation and renewal. Curr Protein Pept Sci 2001; 2: 245-259. (Pubitemid 32798794)