Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction

Molecular Human Reproduction

Volumn 12, Issue 12, 2006, Pages 763-769

  Murthi, P ^a,b   Said, J M ^a,b   Doherty, V L ^a   Donath, S ^b   Nowell, C J ^a,b   Brennecke, S P ^a,b   Kalionis, B ^a,b  

^a ROYAL WOMEN'S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

DLX4; Fetal growth restriction; Gene expression; Homeobox; Placenta

Indexed keywords

HOMEODOMAIN PROTEIN; MESSENGER RNA; POLYCLONAL ANTIBODY; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DLX4; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY; CONTROLLED STUDY; CYTOTROPHOBLAST; ENDOTHELIUM CELL; FEMALE; FETUS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IDIOPATHIC DISEASE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRAUTERINE GROWTH RETARDATION; PLACENTA; PREGNANCY COMPLICATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNCYTIOTROPHOBLAST; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; CAPILLARIES; COHORT STUDIES; ENDOTHELIAL CELLS; FEMALE; FETAL GROWTH RETARDATION; GESTATIONAL AGE; HOMEODOMAIN PROTEINS; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; MALE; PLACENTA; PLACENTAL INSUFFICIENCY; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; TROPHOBLASTS;

ORYCTOLAGUS CUNICULUS;

EID: 33751356711     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gal087     Document Type: Article

References (57)

1. Amu S, Hahn-Zoric M, Malik A, Ashraf R, Zaman S, Kjellmer I, Hagberg H, Padyukov L and Hanson LA (2006) Cytokines in the placenta of Pakistani newborns with and without intrauterine growth retardation. Pediatr Res 59(2),254-258.
2. Beanan MJ and Sargent TD (2000) Regulation and function of Dlx3 in vertebrate development. Dev Dyn 218(4),545-553.
3. Berg PE, Williams DM, Qian RL, Cohen RB, Cao SX, Mittelman M and Schechter AN (1989) A common protein binds to two silencers 5′ to the human beta-globin gene. Nucleic Acids Res 17(21),8833-8852.
4. Brodsky D and Christou H (2004) Current concepts in intrauterine growth restriction. J Intensive Care Med 19(6),307-319.
5. Chaddha V, Viero S, Huppertz B and Kingdom J (2004) Developmental biology of the placenta and the origins of placental insufficiency. Semin Fetal Neonatal Med 9(5),357-369.
6. Chang TC, Robson SC, Spencer JA and Gallivan S (1993) Identification of fetal growth retardation: Comparison of Doppler waveform indices and serial ultrasound measurements of abdominal circumference and fetal weight. Obstet Gynecol 82(2),230-236.
7. Chase MB, Fu S, Haga SB, Davenport G, Stevenson H, Do K, Morgan D, Mah AL and Berg PE (2002) BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. Mol Cell Biol 22(8),2505-2514.
8. Chen CP, Bajoria R and Aplin JD (2002) Decreased vascularization and cell proliferation in placentas of intrauterine growth-restricted fetuses with abnormal umbilical artery flow velocity waveforms. Am J Obstet Gynecol 187(3),764-769.
9. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162(1),156-159.
10. Cross JC (2003) The genetics of pre-eclampsia: A feto-placental or maternal problem? Clin Genet 64(2),96-103.
11. Devriendt K (2000) Genetic control of intra-uterine growth. Eur J Obstet Gynecol Reprod Biol 92(1),29-34.
12. Endo H, Okamoto A, Yamada K, Nikaido T and Tanaka T (2005) Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms. Int J Mol Med 16(1),79-84.
13. Ferrari N, Paleari L, Palmisano GL, Tammaro P, Levi G, Albini A and Brigati C (2003a) Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression. Oncol Rep 10(4),973-977.
14. Ferrari N, Palmisano GL, Paleari L, Basso G, Mangioni M, Fidanza V, Albini A, Croce CM, Levi G and Brigati C (2003b) DLX genes as targets of ALL-1: DLX 2,3,4 down-regulation in t(4;11) acute lymphoblastic leukemias. J Leukoc Biol 74(2),302-305.
15. Frisk V, Amsel R and Whyte HE (2002) The importance of head growth patterns in predicting the cognitive abilities and literacy skills of small-forgestational-age children. Dev Neuropsychol 22(3),565-593.
16. Fu S, Stevenson H, Strovel JW, Haga SB, Stamberg J, Do K and Berg PE (2001) Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. Gene 278(1-2),131-139.
17. Gagnon R (2003) Placental insufficiency and its consequences. Eur J Obstet Gynecol Reprod Biol 110(Suppl 1),S99-S107.
18. Gale CR and Martyn CN (2004) Birth weight and later risk of depression in a national birth cohort. Br J Psychiatry 184,28-33.
19. Ghezzi F, Tibiletti MG, Raio L, Di Naro E, Lischetti B, Taborelli M and Franchi M (2003) Idiopathic fetal intrauterine growth restriction: A possible inheritance pattern. Prenat Diagn 23(3),259-264.
20. Godfrey KM and Barker DJ (2000) Fetal nutrition and adult disease. Am J Clin Nutr 71(5 Suppl),1344S-52S.
21. Guaran RL, Wein P, Sheedy M, Walstab J and Beischer NA (1994) Update of growth percentiles for infants born in an Australian population. Aust N Z J Obstet Gynaecol 34(1),39-50.
22. Haga SB, Fu S, Karp JE, Ross DD, Williams DM, Hankins WD, Behm F, Ruscetti FW, Chang M, Smith BD, Becton D et al. (2000) BP1, a new homeobox gene, is frequently expressed in acute leukemias. Leukemia 14(11),1867-1875.
23. Hemberger M and Cross JC (2001) Genes governing placental development. Trends Endocrinol Metab 12(4),162-168.
24. Hollington P, Neufing P, Kalionis B, Waring P, Bentel J, Wattchow D and Tilley WD (2004) Expression and localization of homeodomain proteins DLX4, HB9 and HB24 in malignant and benign human colorectal tissues. Anticancer Res 24(2B),955-962.
25. Illanes S and Soothill P (2004) Management of fetal growth restriction. Semin Fetal Neonatal Med 9(5),395-401.
26. Kingdom J, Huppertz B, Seaward G and Kaufmann P (2000) Development of the placental villous tree and its consequences for fetal growth. Eur J Obstet Gynecol Reprod Biol 92(1),35-43.
27. Knofler M, Saleh L, Bauer S, Vasicek R, Griesinger G, Strohmer H, Helmer H and Husslein P (2000) Promoter elements and transcription factors involved in differentiation-dependent human chorionic gonadotrophin-alpha messenger ribonucleic acid expression of term villous trophoblasts. Endocrinology 141(10),3737-3748.
28. Li H, Xu KL, Pan XY, Wang HY and Li ZY (2004) [Expression of BP1 gene in adult acute leukemia]. Zhonghua Xue Ye Xue Za Zhi 25(1),38-40.
29. Livak KJ and Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4),402-408.
30. Mayhew TM, Charnock-Jones DS and Kaufmann P (2004) Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies. Placenta 25(2-3),127-139.
31. Meller M, Vadachkoria S, Luthy DA and Williams MA (2005) Evaluation of housekeeping genes in placental comparative expression studies. Placenta 26(8-9),601-607.
32. Merlo GR, Zerega B, Paleari L, Trombino S, Mantero S and Levi G (2000) Multiple functions of Dlx genes. Int J Dev Biol 44(6),619-626.
33. Meyer Zu Schwabedissen HE, Grube M, Heydrich B, Linnemann K, Fusch C, Kroemer HK and Jedlitschky G (2005) Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: Effects of gestational age and cellular differentiation. Am J Pathol 166(1),39-48.
34. Morasso MI and Radoja N (2005) Dlx genes, p63, and ectodermal dysplasias. Birth Defects Res C Embryo Today 75(3),163-171.
35. Morasso MI, Mahon KA and Sargent TD (1995) A Xenopus distal-less gene in transgenic mice: Conserved regulation in distal limb epidermis and other sites of epithelial-mesenchymal interaction. Proc Natl Acad Sci USA 92(9),3968-3972.
36. Morasso MI, Grinberg A, Robinson G, Sargent TD and Mahon KA (1999) Placental failure in mice lacking the homeobox gene Dlx3. Proc Natl Acad Sci USA 96(1),162-167.
37. Murthi P, Kee MW, Gude NM, Brennecke SP and Kalionis B (2005) Fetal growth restriction is associated with increased apoptosis in the chorionic trophoblast cells of human fetal membranes. Placenta 26(4),329-338.
38. Murthi P, Doherty VL, Said JM, Donath S, Brennecke SP and Kalionis B (2006a) Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction. Mol Hum Reprod 12(5),335-340.
39. Murthi P, Doherty V, Said J, Donath S, Brennecke SP and Kalionis B (2006b) Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction. Am J Pathol 168(2),511-518.
40. Nakamura S, Stock DW, Wydner KL, Bollekens JA, Takeshita K, Nagai BM, Chiba S, Kitamura T, Freeland TM, Zhao Z et al. (1996) Genomic analysis of a new mammalian distal-less gene: Dlx7. Genomics 38(3),314-324.
41. Peng L and Payne AH (2002) AP-2 gamma and the homeodomain protein distal-less 3 are required for placental-specific expression of the murine 3 betahydroxysteroid dehydrogenase VI gene, Hsd3b6. J Biol Chem 277(10),7945-7954.
42. Puissant C and Houdebine LM (1990) An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Biotechniques 8(2),148-149.
43. Quinn LM, Johnson BV, Nicholl J, Sutherland GR and Kalionis B (1997a) Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4. Gene 187(1),55-61.
44. Quinn LM, Kilpatrick LM, Latham SE and Kalionis B (1998a) Homeobox genes DLX4 and HB24 are expressed in regions of epithelial-mesenchymal cell interaction in the adult human endometrium. Mol Hum Reprod 4(5),497-501.
45. Quinn LM, Latham SE and Kalionis B (1998b) A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta. Placenta 19(1),87-93.
46. Quint E, Zerucha T and Ekker M (2000) Differential expression of orthologous Dlx genes in zebrafish and mice: Implications for the evolution of the Dlx homeobox gene family. J Exp Zool 288(3),235-241.
47. Roberson MS, Meermann S, Morasso MI, Mulvaney-Musa JM and Zhang T (2001) A role for the homeobox protein Distal-less 3 in the activation of the glycoprotein hormone alpha subunit gene in choriocarcinoma cells. J Biol Chem 276(13),10016-10024.
48. Rossant J and Cross JC (2001) Placental development: Lessons from mouse mutants. Nat Rev Genet 2(7),538-548.
49. Rosso IM, Cannon TD, Huttunen T, Huttunen MO, Lonnqvist J and Gasperoni TL (2000) Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. Am J Psychiatry 157(5),801-807.
50. Sapin V, Blanchon L, Serre AF, Lemery D, Dastugue B and Ward SJ (2001) Use of transgenic mice model for understanding the placentation: Towards clinical applications in human obstetrical pathologies? Transgenic Res 10(5),377-398.
51. Shimamoto T, Nakamura S, Bollekens J, Ruddle FH and Takeshita K (1997) Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and apoptosis. Proc Natl Acad Sci USA 94(7), 3245-3249.
52. Shimamoto T, Ohyashiki K and Takeshita K (2000) Overexpression of the homeobox gene DLX-7 inhibits apoptosis by induced expression of intercellular adhesion molecule-1. Exp Hematol 28(4),433-441.
53. Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K et al. (1994) Cloning and characterization of two members of the vertebrate Dlx gene family. Proc Natl Acad Sci USA 91(6),2250-2254.
54. Steffensen FH, Sorensen HT, Gillman MW, Rothman KJ, Sabroe S, Fischer P and Olsen J (2000) Low birth weight and preterm delivery as risk factors for asthma and atopic dermatitis in young adult males. Epidemiology 11(2),185-188.
55. Straszewski-Chavez SL, Abrahams VM and Mor G (2005) The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy. Endocr Rev 26(7),877-897.
56. Sun Y, Lu X, Yin L, Zhao F and Feng Y (2006) Inhibition of DLX4 promotes apoptosis in choriocarcinoma cell lines. Placenta, 27:375-383.
57. Zhao GQ, Zhao S, Zhou X, Eberspaecher H, Solursh M and de Crombrugghe B (1994) rDlx, a novel distal-less-like homeoprotein is expressed in developing cartilages and discrete neuronal tissues. Dev Biol 164(1),37-51.