Expression and localization of homeodomain proteins DLX4/HB9 in normal and malignant human breast tissues

Anticancer Research

Volumn 23, Issue 2 B, 2003, Pages 1479-1488

  Neufing, Petra J ^a   Kalionis, Bill ^b   Horsfall, David J ^a   Ricciardelli, Carmela ^a   Stahl, Juergen ^c   Vivekanandan, Suchindra ^a   Raymond, Wendy ^c   Tilley, Wayne D ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b ROYAL WOMEN'S HOSPITAL   (Australia)

^c FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Breast cancer; Homeodomain proteins; Immunohistochemistry

Indexed keywords

HOMEODOMAIN PROTEIN; PROTEIN DLX 4; PROTEIN HB 9; UNCLASSIFIED DRUG;

ARTICLE; BREAST; BREAST CANCER; BREAST CARCINOMA; CANCER GRADING; CELL NUCLEUS; CLINICAL ARTICLE; COMPARATIVE STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, NEOPLASM; BREAST; BREAST NEOPLASMS; CARCINOMA; CELL NUCLEUS; DISEASE PROGRESSION; DNA PROBES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNE SERA; IMMUNOENZYME TECHNIQUES; LYMPHATIC METASTASIS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SHEEP; TRANSCRIPTION FACTORS;

EID: 0038238128     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Gehring WJ: On the Hbx and its significance. Bioessays 5: 3-4, 1986.
2. Sco P, Tamkun JW, Hartzell GW: The structure and function of the Hdm. Biochim Biophys Acta 989: 25-48, 1989.
3. Gehring WJ and Hiromi Y: Homeotic genes and the Hbx. Annu Rev Genet 20: 147-73, 1986.
4. Grapin-Botton A and Melton DA: Endoderm development: from patterning to organogenesis. Trends Genet 16: 124-30, 2000.
5. Cillo C, Faiella A, Cantile M and Boncinelli E: Hbx genes and cancer. Exp Cell Res 248: 1-9, 1999.
6. Deguchi Y, Yamanaka Y, Theodossiou C, Najfeld V and Kehrl JH: High expression of two diverged Hbx genes, HB24 and HB9, in acute leukemias: molecular markers of hematopoietic cell immaturity. Leukemia 7: 446-51, 1993.
7. Naora H, Yang YQ, Montz FJ, Seidman JD, Kurman RJ and Roden RB: A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells. Proc Natl Acad Sci USA 98: 4060-5, 2001.
8. Imoto 1, Pimkhaokham A, Watanabe T, Saito-Ohara F, Soeda E and Inazawa J: Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines. Biochem Biophys Res Commun 276: 264-70, 2000.
9. Bowen C, Bubendorf L, Voeller HJ, Slack R, Willi N, Sauter G et al: Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression. Cancer Res 60: 6111-5, 2000.
10. Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M et al: Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 Hbx. Down- regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 74: 35-44, 1997.
11. Chawengsaksophak K, James R, Hammond VE, Kontgen F and Beck F: Homeosis and intestinal tumors in Cdx2 mutant mice. Nature 386: 84-7, 1997.
12. Tanaka M, Komuro I, Inagaki H, Jenkins NA, Copeland NG and Izumo S: Nkx3.1, a murine homolog of Drosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands. Dev Dyn 219: 248-60, 2000.
13. Bhatia-Gaur R, Donjacour AA, Sciavolino PJ, Kim M, Desai N, Young P, Norton CR, Gridley T, Cardiff RD, Cunha GR, Abate-Shen C and Shen MM: Roles for Nkx3.1 in prostate development and cancer. Genes Dev 13(8): 966-77, 1999.
14. Soubeyran P, Mallo GV, Moucadel V, Dagorn JC and Iovanna JL: Overexpression of Cdx1 and Cdx2 homeogenes enhances expression of the HLA-I in HT-29 cells. Mol Cell Biol Res Commun 3: 271-6, 2000.
15. Lorentz O, Dulue I, Arcangelis AD, Simon-Assmann P, Kedinger M and Freund JN: Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation. J Cell Biol 139: 1553-65, 1997.
16. Jin T, Branch DR, Zhang X, Qi S, Youngson B and Goss PE: Examination of POU Hbx gene expression in human breast cancer cells. Int J Cancer 81: 104-12, 1999.
17. Ford HL, Kabingu EN, Bump EA, Mutter GL and Pardee AB: Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis. Proc Natl Acad Sci USA 95: 12608-13, 1998.
18. Lewis MT, Ross S, Strickland PA, Snyder CJ and Daniel CW: Regulated expression patterns of IRX-2, an Iroquois-class Hbx gene, in the human breast. Cell Tissue Res 296: 549-54, 1999.
19. Raman V, Martensen SA, Reisman D, Evron E, Odenwald WF, Jaffee E et al: Compromised HOXA5 function can limit p53 expression in human breast tumors. Nature 405: 974-8, 2000.
20. Bodey B, Bodey B Jr, Siegel SE and Kaiser HE: Immunocytochemical detection of the Hbx B3, B4, and C6 gene products in breast carcinomas. Anticancer Res 20: 3281-6, 2000.
21. Elston CW and Ellis IO: Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19: 403-10, 1991.
22. Maniatis T, Fritsch EF and Sambrook J: Molecular Cloning. New York: Cold Spring Harbor Lab Press, Inc 7.19-7.22, 1989.
23. Moretti P, Simmons P, Thomas P, Haylock D, Rathjen P, Vadas M, et al: Identification of Hbx genes expressed in human hematopoietic progenitor cells. Gene 144: 213-9, 1994.
24. Buettner R, Yim SO, Hong YS, Boncinelli E and Tainsky MA: Alteration of Hbx gene expression by N-ras transformation of PA-1 human teratocarcinoma cells. Mol Cell Biol 11: 3573-83, 1991.
25. Odenwald VvT, Garbern J, Arnheiter H, Tournier-Lasserve E and Lazzarini RA: The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein. Genes Dev 3: 158-72, 1989.
26. Acampora D, DEsposito M, Faiella A, Pannese M, Migliaccio E, Morelli F et al: The human HOX gene family. Nucleic Acids Res 17: 10385-402, 1989.
27. Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Care A et al: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. Differentiation 40: 191-7, 1989.
28. Price JA, Bowden DW, Wright JT, Pettenati MJ and Hart TC: Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome. Hum Mol Genet 7: 563-9, 1989.
29. Quinn LM, Johnson BV, Nicholl J, Sutherland GR and Kalionis B: Isolation and identification of Hbx genes from the human placenta including a novel member of the Distal-less family, DLX4. Gene. 187: 55-61, 1997.
30. Harrison KA, Druey KM, Deguchi Y, Tuscano JM and Kehrl JH: A novel human Hbx gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues. J Biol Chem 269: 19968-75, 1994.
31. Deguchi Y, Moroney JF, Wilson GL, Fox CH, Winter HS and Kehrl JH: Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes. New Biol 3(4): 353-63, 1991.
32. Arcari P, Martinelli R and Salvatore F: Human glyceraldehyde-3-phosphate dehydrogenase pseudogenes: molecular evolution and a possible mechanism for amplification. Biochem Genet 27(7-8): 439-50, 1989.
33. Kolaskar AS and Tongaonkar PC: A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett 276: 172-4, 1990.
34. Puchtler H, Waldrop FS, Meloan SN, Terry MS and Conner HM: Methacarn (methanol-Camoy) fixation. Practical and theoretical considerations. Histochemie 21(2): 97-116, 1970.
35. Shimamoto T, Nakamura S, Bollekens J, Ruddle FH and Takeshita K: Inhibition of DLX-7 Hbx gene causes decreased expression of GATA- I and c-myc genes and apoptosis. Proc Natl Acad Sci USA. 94: 3245-9, 1997.
36. Quinn LM, Kilpatrick LM, Latham SE and Kalionis B: Hbx genes DLX4 and HB24 are expressed in regions of epithelial-mesenchymal cell interaction in the adult human endometrium. Mol Hum Reprod 4: 497-501, 1998.
37. Friedmann Y and Daniel CW: Regulated expression of Hbx genes Msx-1 and Msx-2 in mouse mammary gland development suggests a role in hormone action and epithelial-stromal interactions. Dev Biol 177: 347-55, 1996.
38. Morasso MI, Mahon KA and Sargent TD: A Xenopus distal-less gene in transgenic mice: conserved regulation in distal limb epidermis and other sites of epithelial-mesenchymal interaction. Proc Natl Acad Sci USA 92: 3968-72, 1995.
39. Weiss KM and Ruddle FH: Bollekens J: Dlx and other Hbx genes in the morphological development of the dentition. Connect Tissue Res 132: 35-40, 1995.
40. Barrow JR and Capecchi MR: Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4, Development 122: 3817-28, 1996.
41. Shimamoto T, Ohyashiki K and Takeshita K: Overexpressioa of the Hbx gene DLX-7 inhibits apoptosis by induced expression of intercellular adhesion molecule-1. Exp Hematol 28: 433, 2000.
42. Harrison KA, Thaler J, Pfaff SL, Gu H and Kehrl JH: Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet 23: 71-5, 1999.
43. Li H, Arber S, Jessel TM and Edlund H: Selective agenesis of the dorsal pancreas in mice lacking Hbx gene Hlxb9. Nature Genetics 23: 67-70, 1999.
44. Thaler J, Harrison K, Sharma K, Lettieri K, Kehrl J and Pfaff SL: Active suppression of interneuron programs within developing motor neurons revealed by analysis of Hdm factor HB9. Neuron 23: 675-87, 1999.
45. Arber S, Han B, Mendelsohn M, Smith M, Jessell TM and Sockanathan S: Requirement for the Hbx gene Hb9 in the consolidation of motor neuron identity. Neuron 23: 659-74, 1999.
46. Beverloo HB, Panagopoulos I, Isaksson M, van Wering E, van Drunen E, de Klein A, Johansson B and Slater R: Fusion of the homeobox gene HLXB9 and the ETV6 gene in infant acute myeloid leukemias with the t(7; 12)(q36;pl 3). Cancer Res 61(14): 5374-7, 2001.
47. Ross AJ, Ruiz-Perez V, Wang Y, Hagan DM, Scherer S, Lynch SA et al: A Hbx gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. Nat Genet 20: 358-61, 1998.
48. Lynch SA, Wang Y, Strachan T, Burn J and Lindsay S: Autosomal dominant sacral agenesis: Currarino syndrome. J Med Genet 37: 561-6, 2000.