메뉴 건너뛰기




Volumn 38, Issue 1, 2015, Pages 32-39

Neuroprotective Effect of Humic Acid on Focal Cerebral Ischemia Injury: an Experimental Study in Rats

Author keywords

cerebrum; humic acid; ischemia

Indexed keywords

AUTACOID; CASPASE 3; CASPASE 9; DRUG THERAPY; HUMIC ACID; HUMIC SUBSTANCE; MALONALDEHYDE; NEUROPROTECTIVE AGENT; NUCLEAR RESPIRATORY FACTOR 1; PHARMACOLOGY; SUPEROXIDE DISMUTASE;

EID: 85027945954     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-0005-0     Document Type: Article
Times cited : (38)

References (42)
  • 1
    • 66049147738 scopus 로고    scopus 로고
    • The complexity of neurological processes in acute ischemic stroke
    • COI: 1:STN:280:DC%2BD1MzotFGltw%3D%3D, PID: 19446389
    • Brouns, R., and P.P. De Deyn. 2009. The complexity of neurological processes in acute ischemic stroke. Clinical Neurology and Neurosurgery 111: 483–495.
    • (2009) Clinical Neurology and Neurosurgery , vol.111 , pp. 483-495
    • Brouns, R.1    De Deyn, P.P.2
  • 2
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • COI: 1:STN:280:DyaK1MvjvVagtw%3D%3D, PID: 10508238
    • Lipton, P. 1999. Ischemic cell death in brain neurons. Physiological Reviews 79: 1431–1568.
    • (1999) Physiological Reviews , vol.79 , pp. 1431-1568
    • Lipton, P.1
  • 3
    • 0030976784 scopus 로고    scopus 로고
    • Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows
    • COI: 1:STN:280:DyaK2szivFGlug%3D%3D, PID: 9186042
    • Kuroda, S., and B.K. Siesjo. 1997. Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clinical Neuroscience 4: 199–212.
    • (1997) Clinical Neuroscience , vol.4 , pp. 199-212
    • Kuroda, S.1    Siesjo, B.K.2
  • 4
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • COI: 1:CAS:528:DC%2BD3MXntFKjtLc%3D, PID: 11149664
    • Chan, P.H. 2001. Reactive oxygen radicals in signaling and damage in the ischemic brain. Journal of Cerebral Blood Flow and Metabolism 21: 2–14.
    • (2001) Journal of Cerebral Blood Flow and Metabolism , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 5
    • 2342540913 scopus 로고    scopus 로고
    • Antioxidant status in acute stroke patients and patients at stroke risk
    • COI: 1:CAS:528:DC%2BD2cXjslOqsL0%3D, PID: 15073440
    • Zimmermann, C., K. Winnefeld, S. Streck, M. Roskos, R.L. Haberl, et al. 2004. Antioxidant status in acute stroke patients and patients at stroke risk. European Neurology 51: 157–61.
    • (2004) European Neurology , vol.51 , pp. 157-161
    • Zimmermann, C.1    Winnefeld, K.2    Streck, S.3    Roskos, M.4    Haberl, R.L.5
  • 6
    • 20344382855 scopus 로고    scopus 로고
    • Polyphenols in cerebral ischemia: novel targets for neuroprotection
    • COI: 1:CAS:528:DC%2BD2MXmtFKltbg%3D, PID: 15953817
    • Simonyi, A., Q. Wang, R.L. Miller, et al. 2005. Polyphenols in cerebral ischemia: novel targets for neuroprotection. Molecular Neurobiology 31(1–3): 135–47.
    • (2005) Molecular Neurobiology , vol.31 , Issue.1-3 , pp. 135-147
    • Simonyi, A.1    Wang, Q.2    Miller, R.L.3
  • 7
    • 0034986361 scopus 로고    scopus 로고
    • Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier
    • COI: 1:CAS:528:DC%2BD3MXkt1Kis70%3D, PID: 11406187
    • Gilgun-Sherki, Y., E. Melamed, and D. Offen. 2001. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology 40: 959–975.
    • (2001) Neuropharmacology , vol.40 , pp. 959-975
    • Gilgun-Sherki, Y.1    Melamed, E.2    Offen, D.3
  • 8
    • 33746533375 scopus 로고    scopus 로고
    • Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia
    • COI: 1:CAS:528:DC%2BD28Xns12ksLc%3D, PID: 16806698
    • Cho, J.Y., I.S. Kim, Y.H. Jang, et al. 2006. Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia. Neuroscience Letters 404: 330–335.
    • (2006) Neuroscience Letters , vol.404 , pp. 330-335
    • Cho, J.Y.1    Kim, I.S.2    Jang, Y.H.3
  • 9
    • 0019407212 scopus 로고
    • Sludge decomposition and stabilization
    • COI: 1:CAS:528:DyaL3MXkvVGmtL8%3D, PID: 17752228
    • Hartenstein, R. 1981. Sludge decomposition and stabilization. Science 212(802): 743–749.
    • (1981) Science , vol.212 , Issue.802 , pp. 743-749
    • Hartenstein, R.1
  • 10
    • 0034476713 scopus 로고    scopus 로고
    • Involvement of soluble organic matter in increased plant growth in solarized soils
    • COI: 1:CAS:528:DC%2BD3cXmvFWrsbk%3D
    • Chen, Y., J. Katan, A. Gamliel, et al. 2000. Involvement of soluble organic matter in increased plant growth in solarized soils. Biology and Fertility of Soils 32: 28–34.
    • (2000) Biology and Fertility of Soils , vol.32 , pp. 28-34
    • Chen, Y.1    Katan, J.2    Gamliel, A.3
  • 11
    • 84862009114 scopus 로고    scopus 로고
    • Chemical-pharmaceutical study of native humic acids from peats of Tomsk Oblast, Cand
    • Dissertation: Perm
    • -Gostishcheva M.V.2008. Chemical-pharmaceutical study of native humic acids from peats of Tomsk Oblast, Cand. Sci. Dissertation, Perm
    • (2008) Sci
    • -Gostishcheva, M.V.1
  • 13
    • 0034908107 scopus 로고    scopus 로고
    • Topical application of oxifulvic acid suppresses the cutaneous immune response in mice
    • Van Rensburg, C.E.J., S.C.K. Malfield, and J. Dekker. 2001. Topical application of oxifulvic acid suppresses the cutaneous immune response in mice. Drug Development Research 53: 29–32.
    • (2001) Drug Development Research , vol.53 , pp. 29-32
    • Van Rensburg, C.E.J.1    Malfield, S.C.K.2    Dekker, J.3
  • 14
    • 85172630618 scopus 로고    scopus 로고
    • Cloete T. E, Swart H, Cronje I. J et al.1990. Oxidized coal products as industrial bactericides. Third International Symposium on Gas, Oil, Coal and Environmental Biotechnology, New Orleans, Louisiana, 3–5 December
    • Cloete T. E, Swart H, Cronje I. J et al.1990. Oxidized coal products as industrial bactericides. Third International Symposium on Gas, Oil, Coal and Environmental Biotechnology, New Orleans, Louisiana, 3–5 December.
  • 15
    • 0035986282 scopus 로고    scopus 로고
    • Investigation on the anti-HIV properties of oxihumate
    • PID: 12138330
    • Van Rensburg, C.E.J., J. Dekker, R. Weis, et al. 2002. Investigation on the anti-HIV properties of oxihumate. Chemotherapy 48: 138–143.
    • (2002) Chemotherapy , vol.48 , pp. 138-143
    • Van Rensburg, C.E.J.1    Dekker, J.2    Weis, R.3
  • 16
    • 0019451182 scopus 로고
    • Comparison of the in vitro activities of ammonium humate and of enzymically oxidized chlorogenic and caffeic acids against type 1 and type 2 human herpes virus (author’s transl)
    • COI: 1:CAS:528:DyaL3MXhsFSitLg%3D, PID: 6261267, German
    • Thiel, K.D., B. Helbig, R. Klöcking, et al. 1981. Comparison of the in vitro activities of ammonium humate and of enzymically oxidized chlorogenic and caffeic acids against type 1 and type 2 human herpes virus (author’s transl). Pharmazie 36(1): 50–3. German.
    • (1981) Pharmazie , vol.36 , Issue.1 , pp. 50-53
    • Thiel, K.D.1    Helbig, B.2    Klöcking, R.3
  • 17
    • 78449238678 scopus 로고    scopus 로고
    • Effect of fulvic and humic acids on performance, immune response and thyroid function in rats
    • COI: 1:CAS:528:DC%2BC3cXhsF2ru73N
    • Vucskits, A.V., I. Hullár, A. Bersényi, et al. 2010. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. Journal of Animal Physiology and Animal Nutrition (Berlin) 94(6): 721–8.
    • (2010) Journal of Animal Physiology and Animal Nutrition (Berlin) , vol.94 , Issue.6 , pp. 721-728
    • Vucskits, A.V.1    Hullár, I.2    Bersényi, A.3
  • 18
    • 84868241969 scopus 로고    scopus 로고
    • Antioxidant activity of humic acids in radical-chain oxidation processes
    • COI: 1:CAS:528:DC%2BC38XhsFSlsLfK
    • Efimova, I.V., S.L. Khil’ko, and O.V. Smirnova. 2012. Antioxidant activity of humic acids in radical-chain oxidation processes. Russian Journal of Applied Chemistry 85(9): 1351–54.
    • (2012) Russian Journal of Applied Chemistry , vol.85 , Issue.9 , pp. 1351-1354
    • Efimova, I.V.1    Khil’ko, S.L.2    Smirnova, O.V.3
  • 19
    • 0024494427 scopus 로고
    • Reversible middle cerebral artery occlusion without craniectomy in rats
    • COI: 1:STN:280:DyaL1M7gtFWhuw%3D%3D, PID: 2643202
    • Longa, E.Z., P.R. Weinstein, S. Carlson, et al. 1989. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20(1): 84–91.
    • (1989) Stroke , vol.20 , Issue.1 , pp. 84-91
    • Longa, E.Z.1    Weinstein, P.R.2    Carlson, S.3
  • 20
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • COI: 1:CAS:528:DyaG38XhsVyrsw%3D%3D, PID: 14907713
    • Lowry, O.H., N.J. Rosebrough, A.L. Farr, et al. 1951. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193: 265–75.
    • (1951) Journal of Biological Chemistry , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3
  • 21
    • 0023952554 scopus 로고
    • A simple method for clinical assay of superoxide dismutase
    • COI: 1:CAS:528:DyaL1cXhvVamt7Y%3D, PID: 3349599
    • Sun, Y., L.W. Oberley, and Y. Li. 1988. A simple method for clinical assay of superoxide dismutase. Clinical Chemistry 34: 497–500.
    • (1988) Clinical Chemistry , vol.34 , pp. 497-500
    • Sun, Y.1    Oberley, L.W.2    Li, Y.3
  • 22
    • 0027518384 scopus 로고
    • A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction
    • COI: 1:CAS:528:DyaK3sXhs1ektL8%3D
    • Durak, I., Z. Yurtarslanl, O. Canbolat, et al. 1993. A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clinica Chimica Acta 214: 103–4.
    • (1993) Clinica Chimica Acta , vol.214 , pp. 103-104
    • Durak, I.1    Yurtarslanl, Z.2    Canbolat, O.3
  • 23
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • COI: 1:CAS:528:DyaE1MXltVajsw%3D%3D, PID: 672633
    • Buege, J.A., and S.D. Aust. 1978. Microsomal lipid peroxidation. Methods in Enzymology 52: 302–10.
    • (1978) Methods in Enzymology , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 24
    • 84900028320 scopus 로고    scopus 로고
    • The neuroprotective effects of carnosine in early stage of focal ischemia rodent model
    • PID: 24851146
    • Park, H.S., K.H. Han, J.A. Shin, et al. 2014. The neuroprotective effects of carnosine in early stage of focal ischemia rodent model. Journal of Korean Neurosurgical Society 55(3): 125–30.
    • (2014) Journal of Korean Neurosurgical Society , vol.55 , Issue.3 , pp. 125-130
    • Park, H.S.1    Han, K.H.2    Shin, J.A.3
  • 26
    • 0027265381 scopus 로고
    • Free radicals in brain metabolism and pathology
    • COI: 1:CAS:528:DyaK2cXltFaguw%3D%3D, PID: 8221024
    • Evans, P.H. 1993. Free radicals in brain metabolism and pathology. British Medical Bulletin 49: 577–587.
    • (1993) British Medical Bulletin , vol.49 , pp. 577-587
    • Evans, P.H.1
  • 27
    • 34249852075 scopus 로고    scopus 로고
    • Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia
    • COI: 1:CAS:528:DC%2BD2sXmtlSmsLg%3D
    • Durukan, A., and T. Tatlisumak. 2007. Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacology Biochemistry and Behavior 87: 179–197.
    • (2007) Pharmacology Biochemistry and Behavior , vol.87 , pp. 179-197
    • Durukan, A.1    Tatlisumak, T.2
  • 28
    • 0024520513 scopus 로고
    • Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation
    • COI: 1:STN:280:DyaL1Mzgs1ymtA%3D%3D, PID: 2663662
    • Braughler, J.M., and E.D. Hall. 1989. Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Radical Biology and Medicine 6: 289–301.
    • (1989) Free Radical Biology and Medicine , vol.6 , pp. 289-301
    • Braughler, J.M.1    Hall, E.D.2
  • 29
    • 0024410139 scopus 로고
    • Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats
    • COI: 1:CAS:528:DyaL1MXltFeisbY%3D, PID: 2749850
    • Bromont, C., C. Marie, and J. Bralet. 1989. Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats. Stroke 20(7): 918–24.
    • (1989) Stroke , vol.20 , Issue.7 , pp. 918-924
    • Bromont, C.1    Marie, C.2    Bralet, J.3
  • 30
    • 84862782562 scopus 로고    scopus 로고
    • Exercise induces mitochondrial biogenesis after brain ischemia in rats
    • Zhang, Q., Y. Wu, P. Zhang, et al. 2012. Exercise induces mitochondrial biogenesis after brain ischemia in rats. Neuroscience 15(205): 10–7.
    • (2012) Neuroscience , vol.15 , Issue.205 , pp. 10-17
    • Zhang, Q.1    Wu, Y.2    Zhang, P.3
  • 31
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    • COI: 1:CAS:528:DC%2BD28XhtFOkt7rM, PID: 17055439
    • St-Pierre, J., S. Drori, M. Uldry, et al. 2006. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127(2): 397–408.
    • (2006) Cell , vol.127 , Issue.2 , pp. 397-408
    • St-Pierre, J.1    Drori, S.2    Uldry, M.3
  • 32
    • 85172621659 scopus 로고    scopus 로고
    • EMEA. Humic acids and their sodium salts, summary report. Committee for Veterinary Medicinal Products. European Agency for the Evaluation of Medicinal Products Available via ; 1999
    • EMEA. Humic acids and their sodium salts, summary report. Committee for Veterinary Medicinal Products. European Agency for the Evaluation of Medicinal Products Available via http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-Report/2009/11/WC500014416.pdf; 1999
  • 33
    • 0028312377 scopus 로고
    • Influence of Tołpa Peat Preparation on gastroprotection and on gastric and duodenal ulcers
    • COI: 1:STN:280:DyaK2M%2Fms12nsQ%3D%3D, PID: 7976431
    • Brzozowski, T., A. Dembiński, and S. Konturek. 1994. Influence of Tołpa Peat Preparation on gastroprotection and on gastric and duodenal ulcers. Acta Poloniae Pharmaceutica 51(1): 103–7.
    • (1994) Acta Poloniae Pharmaceutica , vol.51 , Issue.1 , pp. 103-107
    • Brzozowski, T.1    Dembiński, A.2    Konturek, S.3
  • 34
    • 0026656923 scopus 로고
    • Collagen stabilization induced by natural humic substances
    • COI: 1:STN:280:DyaK3s%2FgtFyrtw%3D%3D, PID: 1389777
    • Riede, U.N., I. Jonas, B. Kirn, et al. 1992. Collagen stabilization induced by natural humic substances. Archives of Orthopaedic and Trauma Surgery 111(5): 259–64.
    • (1992) Archives of Orthopaedic and Trauma Surgery , vol.111 , Issue.5 , pp. 259-264
    • Riede, U.N.1    Jonas, I.2    Kirn, B.3
  • 35
    • 77249103720 scopus 로고    scopus 로고
    • Oxidatively damaged DNA induced by humic acid and arsenic in maternal and neonatal mice
    • COI: 1:CAS:528:DC%2BC3cXis1egtLs%3D, PID: 20079519
    • Hu, C.W., C.C. Yen, Y.L. Huang, et al. 2010. Oxidatively damaged DNA induced by humic acid and arsenic in maternal and neonatal mice. Chemosphere 79(1): 93–9.
    • (2010) Chemosphere , vol.79 , Issue.1 , pp. 93-99
    • Hu, C.W.1    Yen, C.C.2    Huang, Y.L.3
  • 36
    • 40949150267 scopus 로고    scopus 로고
    • Humic acid induced genotoxicity in human peripheral blood lymphocytes using comet and sister chromatid exchange assay
    • COI: 1:CAS:528:DC%2BD1cXjsFyhsbs%3D, PID: 17964718
    • Hseu, Y.C., S.C. Chen, Y.L. Chen, et al. 2008. Humic acid induced genotoxicity in human peripheral blood lymphocytes using comet and sister chromatid exchange assay. Journal of Hazardous Materials 153: 784–791.
    • (2008) Journal of Hazardous Materials , vol.153 , pp. 784-791
    • Hseu, Y.C.1    Chen, S.C.2    Chen, Y.L.3
  • 37
    • 0034809489 scopus 로고    scopus 로고
    • Induction of oxidative stress by humic acid through increasing intracellular iron: a possible mechanism leading to atherothrombotic vascular disorder in blackfoot disease
    • COI: 1:CAS:528:DC%2BD3MXjtlOrur0%3D, PID: 11350046
    • Gau, R.J., H.L. Yang, J.L. Suen, et al. 2001. Induction of oxidative stress by humic acid through increasing intracellular iron: a possible mechanism leading to atherothrombotic vascular disorder in blackfoot disease. Biochemical and Biophysical Research Communications 283: 743–749.
    • (2001) Biochemical and Biophysical Research Communications , vol.283 , pp. 743-749
    • Gau, R.J.1    Yang, H.L.2    Suen, J.L.3
  • 38
    • 0141792629 scopus 로고    scopus 로고
    • Humic acid induces oxidative DNA damage, growth retardation, and apoptosis in human primary fibroblasts
    • COI: 1:CAS:528:DC%2BD3sXls1Wkt7g%3D
    • Cheng, M.L., H.Y. Ho, Y.W. Huang, et al. 2003. Humic acid induces oxidative DNA damage, growth retardation, and apoptosis in human primary fibroblasts. Experimental Biology and Medicine (Maywood, N.J.) 228(4): 413–23.
    • (2003) Experimental Biology and Medicine (Maywood, N.J.) , vol.228 , Issue.4 , pp. 413-423
    • Cheng, M.L.1    Ho, H.Y.2    Huang, Y.W.3
  • 39
    • 0032818705 scopus 로고    scopus 로고
    • Humic acid-mediated oxidative damages to human erythrocytes: a possible mechanism leading to anemia in blackfoot disease
    • COI: 1:CAS:528:DyaK1MXltlKrtr4%3D, PID: 10468224
    • Cheng, M.L., H.Y. Ho, D.T. Chiu, et al. 1999. Humic acid-mediated oxidative damages to human erythrocytes: a possible mechanism leading to anemia in blackfoot disease. Free Radical Biology and Medicine 27(3–4): 470–477.
    • (1999) Free Radical Biology and Medicine , vol.27 , Issue.3-4 , pp. 470-477
    • Cheng, M.L.1    Ho, H.Y.2    Chiu, D.T.3
  • 40
    • 36248942591 scopus 로고    scopus 로고
    • Antitumor effect of humus extract on murine transplantable L1210 leukemia
    • Kodama, H., and Denso. 2007. Antitumor effect of humus extract on murine transplantable L1210 leukemia. Journal of Veterinary Sciences and Medicine 69: 1069–1071.
    • (2007) Journal of Veterinary Sciences and Medicine , vol.69 , pp. 1069-1071
    • Kodama, H.1    Denso2
  • 41
    • 57349093782 scopus 로고    scopus 로고
    • Protective effect of humus extract against Trypanosoma brucei infection in mice
    • PID: 19057136
    • Kodama, H., Okazaki F. Denso, and S. Ishida. 2008. Protective effect of humus extract against Trypanosoma brucei infection in mice. Journal of Veterinary Medical Science 70(11): 1185–90.
    • (2008) Journal of Veterinary Medical Science , vol.70 , Issue.11 , pp. 1185-1190
    • Kodama, H.1    Denso, O.F.2    Ishida, S.3
  • 42
    • 0346665574 scopus 로고    scopus 로고
    • Investigation of the immunostimulatory properties of oxihumate
    • COI: 1:CAS:528:DC%2BD3sXitlOrsbs%3D
    • Joone, G.K., J. Dekker, and C.E. Van Rensburg. 2003. Investigation of the immunostimulatory properties of oxihumate. Zeitschrift fu¨ r Naturforschung. C 58: 263–267.
    • (2003) Zeitschrift fu¨ r Naturforschung. C , vol.58 , pp. 263-267
    • Joone, G.K.1    Dekker, J.2    Van Rensburg, C.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.