The neuroprotective effects of carnosine in early stage of focal ischemia rodent model

Journal of Korean Neurosurgical Society

Volumn 55, Issue 3, 2014, Pages 125-130

  Park, Hui Seung ^a   Han, Kyung Hoon ^a   Shin, Jeoung A ^a   Park, Joo Hyun ^a   Song, Kwan Young ^a   Kim, Doh Hee ^a  

^a Seoul Medical Center   (South Korea)

Author keywords

Carnosine; Early stage; Focal ischemia; Neuroprotective effect

Indexed keywords

CARNOSINE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CELL VIABILITY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; NEUROPROTECTION; NONHUMAN; WESTERN BLOTTING;

EID: 84900028320     PISSN: 20053711     EISSN: 15987876     Source Type: Journal    
DOI: 10.3340/jkns.2014.55.3.125     Document Type: Article

References (33)

1. Arundine M, Tymianski M: Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci 61: 657-668, 2004
2. Astrup J, Siesjö BK, Symon L: Thresholds in cerebral ischemia - the ischemic penumbra. Stroke 12: 723-725, 1981
3. Bonfanti L, Peretto P, De Marchis S, Fasolo A: Carnosine-related dipeptides in the mammalian brain. Prog Neurobiol 59: 333-353, 1999
4. Broughton BR, Reutens DC, Sobey CG: Apoptotic mechanisms after cerebral ischemia. Stroke 40: e331-e339, 2009
5. Carmichael ST: Rodent models of focal stroke: size, mechanism, and purpose. NeuroRx 2: 396-409, 2005
6. Chez MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer K, Black C, et al.: Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders. J Child Neurol 17: 833-837, 2002
7. De Marchis S, Melcangi RC, Modena C, Cavaretta I, Peretto P, Agresti C, et al.: Identification of the glial cell types containing carnosine-related peptides in the rat brain. Neurosci Lett 237: 37-40, 1997
8. Decker EA, Ivanov V, Zhu BZ, Frei B: Inhibition of low-density lipoprotein oxidation by carnosine histidine. J Agric Food Chem 49: 511-516, 2001
9. Dobrota D, Fedorova T, Stvolinsky S, Babusikova E, Likavcanova K, Drgova A, et al.: Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: after-stroke-effect. Neurochem Res 30: 1283-1288, 2005
10. Dringen R: Metabolism and functions of glutathione in brain. Prog Neurobiol 62: 649-671, 2000
11. Erecińska M, Silver IA: Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol 128: 263-276, 2001
12. Fridovich I: Superoxide radical and superoxide dismutases. Annu Rev Biochem 64: 97-112, 1995
13. Ginsberg MD: Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture. Stroke 34: 214-223, 2003
14. Hipkiss AR, Preston JE, Himsworth DT, Worthington VC, Keown M, Michaelis J, et al.: Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Ann N Y Acad Sci 854: 37-53, 1998
15. Hossmann KA: Viability thresholds and the penumbra of focal ischemia. Ann Neurol 36: 557-565, 1994
16. Jin CL, Yang LX, Wu XH, Li Q, Ding MP, Fan YY, et al.: Effects of car nosine on amygdaloid-kindled seizures in Sprague-Dawley rats. Neuroscience 135: 939-947, 2005
17. Kim HY, Koh SH, Kim SH: Rat models for ischemic stroke. Korean J Stroke 13: 107-113, 2011
18. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G: Experimental studies of ischemic brain edema. I: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 8: 1-8, 1986
19. Kulik T, Kusano Y, Aronhime S, Sandler AL, Winn HR: Regulation of cerebral vasculature in normal and ischemic brain. Neuropharmacology 55: 281-288, 2008
20. Li F, Omae T, Fisher M: Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats. Stroke 30: 2464-2470; discussion 2470-2471, 1999
21. Longa EZ, Weinstein PR, Carlson S, Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91, 1989
22. Maciel EN, Vercesi AE, Castilho RF: Oxidative stress in Ca(2+)-induced membrane permeability transition in brain mitochondria. J Neurochem 79: 1237-1245, 2001
23. Markus R, Reutens DC, Kazui S, Read S, Wright P, Pearce DC, et al.: Hypoxic tissue in ischaemic stroke: persistence and clinical consequences of spontaneous survival. Brain 127 (Pt 6): 1427-1436, 2004
24. Min J, Senut MC, Rajanikant K, Greenberg E, Bandagi R, Zemke D, et al.: Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia. J Neurosci Res 86: 2984-2991, 2008
25. Niizuma K, Endo H, Chan PH: Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival. J Neurochem 109 Suppl 1: 133-138, 2009
26. Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, et al.: Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta 1802: 92-99, 2010
27. Piantadosi CA, Zhang J: Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. Stroke 27: 327-331; discussion 332, 1996
28. Rahman K: Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging 2: 219-236, 2007
29. Rajanikant GK, Zemke D, Senut MC, Frenkel MB, Chen AF, Gupta R, et al.: Carnosine is neuroprotective against permanent focal cerebral ischemia in mice. Stroke 38: 3023-3031, 2007
30. Reagan-Shaw S, Nihal M, Ahmad N: Dose translation from animal to human studies revisited. FASEB J 22: 659-661, 2008
31. Stellingwerff T, Decombaz J, Harris RC, Boesch C: Optimizing human in vivo dosing and delivery of β-alanine supplements for muscle carnosine synthesis. Amino Acids 43: 57-65, 2012
32. Stvolinsky SL, Dobrota D: Anti-ischemic activity of carnosine. Biochemistry (Mosc) 65: 849-855, 2000
33. Woo KJ: Annual report on the cause of death statistics 2010. Daejeon: Korea National Statistical Office, 2010, pp9