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For an example of a similar reaction sequence, see:.
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The ratio of product 5 and other diastereomers was estimated to be 87:13 by 1H NMR spectroscopy.
-
The ratio of product 5 and other diastereomers was estimated to be 87:13 by 1H NMR spectroscopy.
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81
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One of the major diastereomers was assigned as the one with a rel‐(4R,5S,Sp) configuration, while compound 5 was assigned rel‐(4R,5S,Rp). Two other diastereomers were found in the crude mixture, but the stereostructures were not determined. The ratio of product 5 and diastereomers was estimated to be 66:34.
-
One of the major diastereomers was assigned as the one with a rel‐(4R,5S,Sp) configuration, while compound 5 was assigned rel‐(4R,5S,Rp). Two other diastereomers were found in the crude mixture, but the stereostructures were not determined. The ratio of product 5 and diastereomers was estimated to be 66:34.
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82
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In some cases, this type of intramolecular cyclization is performed in the presence of benzoic acid, see:
-
In some cases, this type of intramolecular cyclization is performed in the presence of benzoic acid, see:.
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-
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83
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72949111039
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Landa, A., Santos, J.I., Vera, S., Oiarbide, M., Palomo, C., Chem. Eur. J. 15 (2009), 11954–11962.
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(2009)
Chem. Eur. J.
, vol.15
, pp. 11954-11962
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Landa, A.1
Santos, J.I.2
Vera, S.3
Oiarbide, M.4
Palomo, C.5
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84
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-
84899936342
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-
Kim, Y.S., Kim, S.M., Wang, B., Companyó, X., Li, J., Moyano, A., Im, S., Tošner, Z., Yang, J.W., Rios, R., Adv. Synth. Catal. 356 (2014), 437–446.
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(2014)
Adv. Synth. Catal.
, vol.356
, pp. 437-446
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-
Kim, Y.S.1
Kim, S.M.2
Wang, B.3
Companyó, X.4
Li, J.5
Moyano, A.6
Im, S.7
Tošner, Z.8
Yang, J.W.9
Rios, R.10
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85
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-
85128689117
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-
See Scheme S1 in the Supporting Information.
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See Scheme S1 in the Supporting Information.
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86
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84885967689
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Akagawa, K., Sen, J., Kudo, K., Angew. Chem. Int. Ed. 52 (2013), 11585–11588.
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(2013)
Angew. Chem. Int. Ed.
, vol.52
, pp. 11585-11588
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-
Akagawa, K.1
Sen, J.2
Kudo, K.3
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87
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-
85128669332
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-
For possible models of enamine intermediates, see Scheme S2 in the Supporting Information.
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For possible models of enamine intermediates, see Scheme S2 in the Supporting Information.
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