메뉴 건너뛰기




Volumn 13, Issue 4, 2011, Pages 316-322

Novel approaches to treatment of leiomyosarcomas

Author keywords

Leiomyosarcoma; p53 mutation; Poly ADP Ribose Polymerase (PARP) inhibitors; Sarcoma

Indexed keywords

AROMATASE INHIBITOR; B RAF KINASE; BEVACIZUMAB; BRCA1 PROTEIN; DOCETAXEL; DOXORUBICIN; GEMCITABINE; IFOSFAMIDE; MYOCARDIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PAZOPANIB; PLATELET DERIVED GROWTH FACTOR; PROTEIN P53; RIDAFOROLIMUS; SUNITINIB; TRABECTEDIN; VASCULOTROPIN RECEPTOR;

EID: 85027917596     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-011-0173-0     Document Type: Article
Times cited : (8)

References (58)
  • 2
    • 33751585501 scopus 로고    scopus 로고
    • Incidence patterns of soft tissue sarcomas, regardless of primary site, in the Surveillance, Epidemiology and End Results program, 1978-2001: An analysis of 26,758 cases
    • DOI 10.1002/ijc.22239
    • JR Toro LB Travis HJ Wu, et al. 2006 Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978-2001: an analysis of 26,758 cases Int J Cancer. 119 12 2922 30 17013893 10.1002/ijc.22239 1:CAS:528:DC%2BD28Xht1yqt7nP (Pubitemid 44846246)
    • (2006) International Journal of Cancer , vol.119 , Issue.12 , pp. 2922-2930
    • Toro, J.R.1    Travis, L.B.2    Hongyu, J.W.3    Zhu, K.4    Fletcher, C.D.M.5    Devesa, S.S.6
  • 3
    • 0035876106 scopus 로고    scopus 로고
    • Clinicopathologic re-evaluation of 100 malignant fibrous histiocytomas: Prognostic relevance of subclassification
    • CDM Fletcher P Gustafson A Rydholm, et al. 2001 Clinicopathologic Re-Evaluation of 100 Malignant Fibrous Histiocytomas: Prognostic Relevance of Subclassification J Clin Oncol. 19 12 3045 50 11408500 1:STN:280: DC%2BD3MzksFGhsw%3D%3D This important paper suggests that tumors of myogenic origin have a worse outcome than MFH of nonmyogenic origin; and that 20% of MFH may comprise LMS (Pubitemid 32565442)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.12 , pp. 3045-3050
    • Fletcher, C.D.M.1    Gustafson, P.2    Rydholm, A.3    Willen, H.4    Akerman, M.5
  • 4
    • 41849100978 scopus 로고    scopus 로고
    • Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages i and II: An European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874)
    • 18378136 10.1016/j.ejca.2008.01.019 1:STN:280:DC%2BD1c3kvFWktw%3D%3D
    • NS Reed C Mangioni H Malmstrom, et al. 2008 Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874) Eur J Cancer. 44 6 808 18 18378136 10.1016/j.ejca.2008.01.019 1:STN:280:DC%2BD1c3kvFWktw%3D%3D
    • (2008) Eur J Cancer. , vol.44 , Issue.6 , pp. 808-818
    • Reed, N.S.1    Mangioni, C.2    Malmstrom, H.3
  • 6
    • 0038119913 scopus 로고    scopus 로고
    • The reappraisal of gastrointestinal stromal tumors: From Stout to the KIT revolution
    • AP Dei Tos 2003 The reappraisal of gastrointestinal stromal tumors: from Stout to the KIT revolution Virchows Arch. 442 5 421 8 12759750 (Pubitemid 36718308)
    • (2003) Virchows Archiv , vol.442 , Issue.5 , pp. 421-428
    • Dei Tos, A.P.1
  • 7
    • 0035873187 scopus 로고    scopus 로고
    • Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: A study of 1240 patients from the French Federation of Cancer Centers sarcoma group
    • DOI 10.10 02/1097-01 42(20010515)91:10<191 4::AID-CNCR1214>3.0.C O;2-3
    • JM Coindre P Terrier L Guillou, et al. 2001 Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group Cancer. 91 10 1914 26 11346874 10.1002/1097-0142(20010515)91: 10<1914::AID-CNCR1214>3.0.CO;2-3 1:STN:280:DC%2BD3M3ltVKmsA%3D%3D (Pubitemid 32424119)
    • (2001) Cancer , vol.91 , Issue.10 , pp. 1914-1926
    • Coindre, J.-M.1    Terrier, P.2    Guillou, L.3    Doussal, V.L.4    Collin, F.5    Ranchre, D.6    Sastre, X.7    Vilain, M.-O.8    Bonichon, F.9    Bui, B.N.10
  • 8
    • 0031566814 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: Meta-analysis of individual data
    • DOI 10.1016/S0140-6736(97)08165-8
    • Collaboration SM-a 1997 Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data The Lancet. 350 9092 1647 54 10.1016/S0140-6736(97)08165-8 (Pubitemid 28036824)
    • (1997) Lancet , vol.350 , Issue.9092 , pp. 1647-1654
    • Tierney, J.F.1
  • 9
    • 75149168385 scopus 로고    scopus 로고
    • Outcomes of first-line chemotherapy in patients with advanced or metastatic leiomyosarcoma of uterine and non-uterine origin
    • 20066161 10.1155/2009/348910 1:STN:280:DC%2BC3c%2FhvFWmuw%3D%3D
    • AW Oosten C Seynaeve PI Schmitz, et al. 2009 Outcomes of first-line chemotherapy in patients with advanced or metastatic leiomyosarcoma of uterine and non-uterine origin Sarcoma. 2009 348910 20066161 10.1155/2009/348910 1:STN:280:DC%2BC3c%2FhvFWmuw%3D%3D
    • (2009) Sarcoma. , vol.2009 , pp. 348910
    • Oosten, A.W.1    Seynaeve, C.2    Schmitz, P.I.3
  • 10
    • 0032952928 scopus 로고    scopus 로고
    • Prognostic Factors for the Outcome of Chemotherapy in Advanced Soft Tissue Sarcoma: An Analysis of 2,185 Patients Treated with Anthracycline- Containing First-Line Regimens-A European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study
    • 10458228
    • M Van Glabbeke AT van Oosterom JW Oosterhuis, et al. 1999 Prognostic Factors for the Outcome of Chemotherapy in Advanced Soft Tissue Sarcoma: An Analysis of 2,185 Patients Treated With Anthracycline-Containing First-Line Regimens-A European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study J Clin Oncol. 17 1 150 10458228
    • (1999) J Clin Oncol. , vol.17 , Issue.1 , pp. 150
    • Van Glabbeke, M.1    Van Oosterom, A.T.2    Oosterhuis, J.W.3
  • 11
    • 41149169284 scopus 로고    scopus 로고
    • Significant clinical benefit of first-line palliative chemotherapy in advanced soft-tissue sarcoma: Retrospective analysis and identification of prognostic factors in 488 patients
    • DOI 10.1002/cncr.23332
    • V Karavasilis BM Seddon S Ashley, et al. 2008 Significant clinical benefit of first-line palliative chemotherapy in advanced soft-tissue sarcoma: retrospective analysis and identification of prognostic factors in 488 patients Cancer. 112 7 1585 91 18278813 10.1002/cncr.23332 (Pubitemid 351441172)
    • (2008) Cancer , vol.112 , Issue.7 , pp. 1585-1591
    • Karavasilis, V.1    Seddon, B.M.2    Ashley, S.3    Al-Muderis, O.4    Fisher, C.5    Judson, I.6
  • 12
    • 0027256397 scopus 로고
    • Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas
    • J Edmonson L Ryan R Blum, et al. 1993 Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas J Clin Oncol. 11 7 1269 75 8315424 1:STN:280:DyaK3szgtFKlsg%3D%3D (Pubitemid 23199129)
    • (1993) Journal of Clinical Oncology , vol.11 , Issue.7 , pp. 1269-1275
    • Edmonson, J.H.1    Ryan, L.M.2    Blum, R.H.3    Brooks, J.S.J.4    Shiraki, M.5    Frytak, S.6    Parkinson, D.R.7
  • 13
    • 0023871289 scopus 로고
    • A phase II study of ifosfamide/mesna with doxorubicin for adult soft tissue sarcoma
    • BM Cantwell J Carmichael S Ghani, et al. 1988 A phase II study of ifosfamide/mesna with doxorubicin for adult soft tissue sarcoma Cancer Chemother Pharmacol. 21 1 49 52 3124971 10.1007/BF00262738 1:STN:280:DyaL1c7js1SjtQ%3D%3D (Pubitemid 18050481)
    • (1988) Cancer Chemotherapy and Pharmacology , vol.21 , Issue.1 , pp. 49-52
    • Cantwell, B.M.J.1    Carmichael, J.2    Ghani, S.3    Harris, A.L.4
  • 15
    • 0023793647 scopus 로고
    • A phase I-II study of ifosfamide in combination with adriamycin in the treatment of adult soft tissue sarcoma
    • 3181268 10.1016/0277-5379(88)90334-3 1:STN:280:DyaL1M%2FjtV2hsA%3D%3D
    • JL Mansi C Fisher E Wiltshaw, et al. 1988 A phase I-II study of ifosfamide in combination with adriamycin in the treatment of adult soft tissue sarcoma Eur J Cancer Clin Oncol. 24 9 1439 43 3181268 10.1016/0277-5379(88) 90334-3 1:STN:280:DyaL1M%2FjtV2hsA%3D%3D
    • (1988) Eur J Cancer Clin Oncol. , vol.24 , Issue.9 , pp. 1439-1443
    • Mansi, J.L.1    Fisher, C.2    Wiltshaw, E.3
  • 17
    • 71049122368 scopus 로고    scopus 로고
    • Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: An exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG)
    • 19853437 10.1016/j.ejca.2009.09.022 1:CAS:528:DC%2BD1MXhsFGrsbvF
    • S Sleijfer M Ouali M van Glabbeke, et al. 2010 Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) Eur J Cancer. 46 1 72 83 19853437 10.1016/j.ejca.2009.09.022 1:CAS:528: DC%2BD1MXhsFGrsbvF
    • (2010) Eur J Cancer. , vol.46 , Issue.1 , pp. 72-83
    • Sleijfer, S.1    Ouali, M.2    Van Glabbeke, M.3
  • 19
    • 77953915132 scopus 로고    scopus 로고
    • Update on gemcitabine and docetaxel combination therapy for primary and metastatic sarcomas
    • 20520541 10.1097/CCO.0b013e32833aafef 1:CAS:528:DC%2BC3cXntF2js70%3D
    • ML Hensley 2010 Update on gemcitabine and docetaxel combination therapy for primary and metastatic sarcomas Curr Opin Oncol. 22 4 356 61 20520541 10.1097/CCO.0b013e32833aafef 1:CAS:528:DC%2BC3cXntF2js70%3D
    • (2010) Curr Opin Oncol. , vol.22 , Issue.4 , pp. 356-361
    • Hensley, M.L.1
  • 23
    • 0035424877 scopus 로고    scopus 로고
    • Phase II clinical investigation of gemcitabine in advanced soft tissue sarcomas and window evaluation of dose rate on gemcitabine triphosphate accumulation
    • SR Patel V Gandhi J Jenkins, et al. 2001 Phase II clinical investigation of gemcitabine in advanced soft tissue sarcomas and window evaluation of dose rate on gemcitabine triphosphate accumulation J Clin Oncol. 19 15 3483 9 11481354 1:CAS:528:DC%2BD3MXmtlGhurY%3D (Pubitemid 32730085)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.15 , pp. 3483-3489
    • Patel, S.R.1    Gandhi, V.2    Jenkins, J.3    Papadopolous, N.4    Burgess, M.A.5    Plager, C.6    Plunkett, W.7    Benjamin, R.S.8
  • 24
    • 0033566150 scopus 로고    scopus 로고
    • Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove
    • DOI 10.1021/jm990241l
    • M Zewail-Foote LH Hurley 1999 Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove J Med Chem. 42 14 2493 7 10411470 10.1021/jm990241l 1:CAS:528:DyaK1MXjvFGiu7k%3D (Pubitemid 29344290)
    • (1999) Journal of Medicinal Chemistry , vol.42 , Issue.14 , pp. 2493-2497
    • Zewail-Foote, M.1    Hurley, L.H.2
  • 28
    • 70249101414 scopus 로고    scopus 로고
    • Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules
    • 19652065 10.1200/JCO.2008.21.0088 1:CAS:528:DC%2BD1MXhtF2jtLrL
    • GD Demetri SP Chawla M von Mehren, et al. 2009 Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules J Clin Oncol. 27 25 4188 96 19652065 10.1200/JCO.2008.21.0088 1:CAS:528:DC%2BD1MXhtF2jtLrL This paper supports the findings of Le Cesne et al. [27•]
    • (2009) J Clin Oncol. , vol.27 , Issue.25 , pp. 4188-4196
    • Demetri, G.D.1    Chawla, S.P.2    Von Mehren, M.3
  • 29
    • 58149186082 scopus 로고    scopus 로고
    • Phase i Combination Study of Trabectedin and Doxorubicin in Patients with Soft-Tissue Sarcoma
    • 18927308 10.1158/1078-0432.CCR-08-0336 1:CAS:528:DC%2BD1cXht1Kgur%2FF
    • J-Y Blay M von Mehren BL Samuels, et al. 2008 Phase I Combination Study of Trabectedin and Doxorubicin in Patients with Soft-Tissue Sarcoma Clin Cancer Res. 14 20 6656 62 18927308 10.1158/1078-0432.CCR-08-0336 1:CAS:528: DC%2BD1cXht1Kgur%2FF
    • (2008) Clin Cancer Res. , vol.14 , Issue.20 , pp. 6656-6662
    • Blay, J.-Y.1    Von Mehren, M.2    Samuels, B.L.3
  • 30
    • 77949493130 scopus 로고    scopus 로고
    • Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53
    • 20046879 10.1371/journal.pone.0008404
    • BA Quinn T Brake X Hua, et al. 2009 Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53 PLoS ONE. 4 12 e8404 20046879 10.1371/journal.pone.0008404
    • (2009) PLoS ONE. , vol.4 , Issue.12 , pp. 8404
    • Quinn, B.A.1    Brake, T.2    Hua, X.3
  • 31
    • 77950965840 scopus 로고    scopus 로고
    • Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
    • 20229506 10.1002/path.2696 1:CAS:528:DC%2BC3cXntFyjsL4%3D
    • AA Ahmed D Etemadmoghadam J Temple, et al. 2010 Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary J Pathol. 221 1 49 56 20229506 10.1002/path.2696 1:CAS:528:DC%2BC3cXntFyjsL4%3D
    • (2010) J Pathol. , vol.221 , Issue.1 , pp. 49-56
    • Ahmed, A.A.1    Etemadmoghadam, D.2    Temple, J.3
  • 33
    • 0036021712 scopus 로고    scopus 로고
    • Expression of estrogen receptors α and β in human lung tissue and cell lines
    • DOI 10.1016/S0169-5002(02)00039-9, PII S0169500202000399
    • S Mollerup K Jørgensen G Berge, et al. 2002 Expression of estrogen receptors [alpha] and [beta] in human lung tissue and cell lines Lung Cancer. 37 2 153 9 12140138 10.1016/S0169-5002(02)00039-9 (Pubitemid 34831807)
    • (2002) Lung Cancer , vol.37 , Issue.2 , pp. 153-159
    • Mollerup, S.1    Jorgensen, K.2    Berge, G.3    Haugen, A.4
  • 34
    • 75749118458 scopus 로고    scopus 로고
    • Treatment of advanced uterine leiomyosarcoma with aromatase inhibitors
    • 19932916 10.1016/j.ygyno.2009.10.064
    • R O'Cearbhaill Q Zhou A Iasonos, et al. 2010 Treatment of advanced uterine leiomyosarcoma with aromatase inhibitors Gynecol Oncol. 116 3 424 9 19932916 10.1016/j.ygyno.2009.10.064
    • (2010) Gynecol Oncol. , vol.116 , Issue.3 , pp. 424-429
    • O'Cearbhaill, R.1    Zhou, Q.2    Iasonos, A.3
  • 35
    • 27244450145 scopus 로고    scopus 로고
    • Phase II Study of Doxorubicin and Bevacizumab for Patients with Metastatic Soft-Tissue Sarcomas
    • 16192597 10.1200/JCO.2005.16.139
    • DR D'Adamo SE Anderson K Albritton, et al. 2005 Phase II Study of Doxorubicin and Bevacizumab for Patients With Metastatic Soft-Tissue Sarcomas J Clin Oncol. 23 28 7135 42 16192597 10.1200/JCO.2005.16.139
    • (2005) J Clin Oncol. , vol.23 , Issue.28 , pp. 7135-7142
    • D'Adamo, D.R.1    Anderson, S.E.2    Albritton, K.3
  • 36
    • 77956395089 scopus 로고    scopus 로고
    • Phase I/II study of docetaxel (D), gemcitabine (G), and bevacizumab (B) in patients (pts) with advanced or recurrent soft tissue sarcoma (STS)
    • CF Verschraegen R Quinn I Rabinowitz, et al. 2008 Phase I/II study of docetaxel (D), gemcitabine (G), and bevacizumab (B) in patients (pts) with advanced or recurrent soft tissue sarcoma (STS) ASCO Meet Abstr. 26 15 suppl 10534
    • (2008) ASCO Meet Abstr. , vol.26 , Issue.15 SUPPL. , pp. 10534
    • Verschraegen, C.F.1    Quinn, R.2    Rabinowitz, I.3
  • 37
    • 67650337802 scopus 로고    scopus 로고
    • Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043)
    • 19451427 10.1200/JCO.2008.21.3223 1:CAS:528:DC%2BD1MXhtFWitb3P
    • S Sleijfer I Ray-Coquard Z Papai, et al. 2009 Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043) J Clin Oncol. 27 19 3126 32 19451427 10.1200/JCO.2008.21.3223 1:CAS:528: DC%2BD1MXhtFWitb3P
    • (2009) J Clin Oncol. , vol.27 , Issue.19 , pp. 3126-3132
    • Sleijfer, S.1    Ray-Coquard, I.2    Papai, Z.3
  • 38
    • 80051631789 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate, a multi-targeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on 3 prevalent histologies: Leiomyosarcoma, liposarcoma, and malignant fibrous histiocytoma
    • doi: 10.1002/ijc.25843
    • Mahmood ST, Agresta S, Vigil C, et al. Phase II study of sunitinib malate, a multi-targeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on 3 prevalent histologies: Leiomyosarcoma, liposarcoma, and malignant fibrous histiocytoma. Int J Cancer. 2011. doi: 10.1002/ijc.25843.
    • (2011) Int J Cancer.
    • Mahmood, S.T.1    Agresta, S.2    Vigil, C.3
  • 39
    • 67650312341 scopus 로고    scopus 로고
    • Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas
    • 19451429 10.1200/JCO.2008.20.9890 1:CAS:528:DC%2BD1MXhtFWitb3E
    • S George P Merriam RG Maki, et al. 2009 Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas J Clin Oncol. 27 19 3154 60 19451429 10.1200/JCO.2008.20.9890 1:CAS:528: DC%2BD1MXhtFWitb3E
    • (2009) J Clin Oncol. , vol.27 , Issue.19 , pp. 3154-3160
    • George, S.1    Merriam, P.2    Maki, R.G.3
  • 40
    • 67650293850 scopus 로고    scopus 로고
    • Phase II Study of Sorafenib in Patients with Metastatic or Recurrent Sarcomas
    • 19451436 10.1200/JCO.2008.20.4495 1:CAS:528:DC%2BD1MXhtFWitb3J
    • RG Maki DR D'Adamo ML Keohan, et al. 2009 Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas Journal of Clinical Oncology. 27 19 3133 40 19451436 10.1200/JCO.2008.20.4495 1:CAS:528:DC%2BD1MXhtFWitb3J
    • (2009) Journal of Clinical Oncology. , vol.27 , Issue.19 , pp. 3133-3140
    • Maki, R.G.1    D'Adamo, D.R.2    Keohan, M.L.3
  • 41
    • 77951715996 scopus 로고    scopus 로고
    • The clinical relevance of molecular genetics in soft tissue sarcomas
    • 20418671 10.1097/PAP.0b013e3181d98cbf
    • JL Ordonez D Osuna DJ Garcia-Dominguez, et al. 2010 The clinical relevance of molecular genetics in soft tissue sarcomas Adv Anat Pathol. 17 3 162 81 20418671 10.1097/PAP.0b013e3181d98cbf
    • (2010) Adv Anat Pathol. , vol.17 , Issue.3 , pp. 162-181
    • Ordonez, J.L.1    Osuna, D.2    Garcia-Dominguez, D.J.3
  • 42
    • 77955880551 scopus 로고    scopus 로고
    • Molecular classification of soft tissue sarcomas and its clinical applications
    • 20490332 1:CAS:528:DC%2BC3cXmtl2ju7k%3D
    • S Jain R Xu VG Prieto, et al. 2010 Molecular classification of soft tissue sarcomas and its clinical applications Int J Clin Exp Pathol. 3 4 416 28 20490332 1:CAS:528:DC%2BC3cXmtl2ju7k%3D
    • (2010) Int J Clin Exp Pathol. , vol.3 , Issue.4 , pp. 416-428
    • Jain, S.1    Xu, R.2    Prieto, V.G.3
  • 43
    • 37149033966 scopus 로고    scopus 로고
    • Survival results with AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas: Update of phase II trial
    • SP Chawla AW Tolcher AP Staddon, et al. 2007 Survival results with AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas: Update of phase II trial ASCO Meet Abstr. 25 18 suppl 10076
    • (2007) ASCO Meet Abstr. , vol.25 , Issue.18 SUPPL. , pp. 10076
    • Chawla, S.P.1    Tolcher, A.W.2    Staddon, A.P.3
  • 44
    • 34249946843 scopus 로고    scopus 로고
    • Molecular pathology in sarcomas
    • 17403624 10.1007/s12094-007-0027-2
    • E de Alava 2007 Molecular pathology in sarcomas Clin Transl Oncol. 9 3 130 44 17403624 10.1007/s12094-007-0027-2
    • (2007) Clin Transl Oncol. , vol.9 , Issue.3 , pp. 130-144
    • De Alava, E.1
  • 45
    • 65549111844 scopus 로고    scopus 로고
    • Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas
    • 19276386 10.1158/0008-5472.CAN-08-1443
    • G Pérot J Derré J-M Coindre, et al. 2009 Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas Cancer Res. 69 6 2269 78 19276386 10.1158/0008-5472.CAN-08-1443
    • (2009) Cancer Res. , vol.69 , Issue.6 , pp. 2269-2278
    • Pérot, G.1    Derré, J.2    Coindre, J.-M.3
  • 46
    • 0035062691 scopus 로고    scopus 로고
    • Characterization of chromosome aberrations associated with soft-tissue leiomyosarcomas by twenty-four-color karyotyping and comparative genomic hybridization analysis
    • DOI 10.1002/gcc.1118
    • R Wang YJ Lu C Fisher, et al. 2001 Characterization of chromosome aberrations associated with soft-tissue leiomyosarcomas by twenty-four-color karyotyping and comparative genomic hybridization analysis Genes Chromosom Cancer. 31 1 54 64 11284036 10.1002/gcc.1118 (Pubitemid 32274133)
    • (2001) Genes Chromosomes and Cancer , vol.31 , Issue.1 , pp. 54-64
    • Wang, R.1    Lu, Y.-J.2    Fisher, C.3    Bridge, J.A.4    Shipley, J.5
  • 47
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • 11099028 10.1038/35042675 1:CAS:528:DC%2BD3cXosVemtrY%3D
    • B Vogelstein D Lane AJ Levine 2000 Surfing the p53 network Nature. 408 6810 307 10 11099028 10.1038/35042675 1:CAS:528:DC%2BD3cXosVemtrY%3D
    • (2000) Nature. , vol.408 , Issue.6810 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 48
    • 79551715546 scopus 로고    scopus 로고
    • Comprehensive Mapping of p53 Pathway Alterations Reveals an Apparent Role for Both SNP309 and MDM2 Amplification in Sarcomagenesis
    • 21159888 10.1158/1078-0432.CCR-10-2050 1:CAS:528:DC%2BC3MXhsVers7Y%3D
    • M Ito L Barys T O'Reilly, et al. 2011 Comprehensive Mapping of p53 Pathway Alterations Reveals an Apparent Role for Both SNP309 and MDM2 Amplification in Sarcomagenesis Clin Cancer Res. 17 3 416 26 21159888 10.1158/1078-0432.CCR-10-2050 1:CAS:528:DC%2BC3MXhsVers7Y%3D
    • (2011) Clin Cancer Res. , vol.17 , Issue.3 , pp. 416-426
    • Ito, M.1    Barys, L.2    O'Reilly, T.3
  • 49
    • 79551652531 scopus 로고    scopus 로고
    • The clinical development of inhibitors of poly(ADP-ribose) polymerase
    • 21285153 10.1093/annonc/mdq667
    • H Calvert A Azzariti 2011 The clinical development of inhibitors of poly(ADP-ribose) polymerase Ann. Oncol. 22 suppl 1 i53 i9 21285153 10.1093/annonc/mdq667
    • (2011) Ann. Oncol. , vol.22 , Issue.SUPPL. 1
    • Calvert, H.1    Azzariti, A.2
  • 50
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • 19553641 10.1056/NEJMoa0900212 1:CAS:528:DC%2BD1MXosVKrtrw%3D
    • PC Fong DS Boss TA Yap, et al. 2009 Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers N Engl J Med. 361 2 123 34 19553641 10.1056/NEJMoa0900212 1:CAS:528:DC%2BD1MXosVKrtrw%3D This important paper supports the hypothesis of synthetic lethality when using PARP inhibitors in the context of tumors with mutations in BRCA1
    • (2009) N Engl J Med. , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 52
    • 78649601369 scopus 로고    scopus 로고
    • How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation
    • 20853319 10.1002/ijc.25683 1:CAS:528:DC%2BC3cXhsVGrur3J
    • A Mangerich A Burkle 2011 How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation Int J Cancer. 128 2 251 65 20853319 10.1002/ijc.25683 1:CAS:528:DC%2BC3cXhsVGrur3J
    • (2011) Int J Cancer. , vol.128 , Issue.2 , pp. 251-265
    • Mangerich, A.1    Burkle, A.2
  • 53
    • 77649131406 scopus 로고    scopus 로고
    • Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
    • 20177395 10.1038/nrm2851 1:CAS:528:DC%2BC3cXitlaisbg%3D
    • ME Moynahan M Jasin 2010 Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis Nat Rev Mol Cell Biol. 11 3 196 207 20177395 10.1038/nrm2851 1:CAS:528:DC%2BC3cXitlaisbg%3D
    • (2010) Nat Rev Mol Cell Biol. , vol.11 , Issue.3 , pp. 196-207
    • Moynahan, M.E.1    Jasin, M.2
  • 54
    • 77954057957 scopus 로고    scopus 로고
    • Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas
    • 20046869 10.1371/journal.pone.0008534 This paper provides the first evidence that mutations in Brca1 and p53 co-operate in the development of LMS in the mouse
    • KV Clark-Knowles MK Senterman O Collins, et al. 2009 Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas PLoS One 4 12 e8534 20046869 10.1371/journal.pone.0008534 This paper provides the first evidence that mutations in Brca1 and p53 co-operate in the development of LMS in the mouse
    • (2009) PLoS One , vol.4 , Issue.12 , pp. 8534
    • Clark-Knowles, K.V.1    Senterman, M.K.2    Collins, O.3
  • 55
    • 19744368302 scopus 로고    scopus 로고
    • Cancer of the ovary
    • DOI 10.1056/NEJMra041842
    • SA Cannistra 2004 Cancer of the ovary N Engl J Med. 351 24 2519 29 15590954 10.1056/NEJMra041842 1:CAS:528:DC%2BD2cXhtVGksbbM (Pubitemid 39603165)
    • (2004) New England Journal of Medicine , vol.351 , Issue.24
    • Cannistra, S.A.1
  • 56
    • 78649456369 scopus 로고    scopus 로고
    • BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations
    • 21118481 10.1186/1471-2407-10-654 1:CAS:528:DC%2BC3cXhsFCgsrfF
    • H Holstege HM Horlings A Velds, et al. 2010 BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations BMC Cancer. 10 654 21118481 10.1186/1471-2407-10-654 1:CAS:528:DC%2BC3cXhsFCgsrfF
    • (2010) BMC Cancer. , vol.10 , pp. 654
    • Holstege, H.1    Horlings, H.M.2    Velds, A.3
  • 57
    • 77953291328 scopus 로고    scopus 로고
    • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    • 20453858 10.1038/nsmb.1831 1:CAS:528:DC%2BC3cXlslyqtLo%3D
    • P Bouwman A Aly JM Escandell, et al. 2010 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers Nat Struct Mol Biol. 17 6 688 95 20453858 10.1038/nsmb.1831 1:CAS:528:DC%2BC3cXlslyqtLo%3D
    • (2010) Nat Struct Mol Biol. , vol.17 , Issue.6 , pp. 688-695
    • Bouwman, P.1    Aly, A.2    Escandell, J.M.3
  • 58
    • 77950958141 scopus 로고    scopus 로고
    • 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
    • 20362325 10.1016/j.cell.2010.03.012 1:CAS:528:DC%2BC3cXmtVWnsL0%3D
    • SF Bunting E Callen N Wong, et al. 2010 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks Cell. 141 2 243 54 20362325 10.1016/j.cell.2010.03.012 1:CAS:528:DC%2BC3cXmtVWnsL0%3D
    • (2010) Cell. , vol.141 , Issue.2 , pp. 243-254
    • Bunting, S.F.1    Callen, E.2    Wong, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.