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Volumn 17, Issue 3, 2010, Pages 162-181

The clinical relevance of molecular genetics in soft tissue sarcomas

Author keywords

Alveolar rhabdomyosarcoma; Bone soft tissue sarcomas; Chondrosarcoma; Clear cell sarcoma; Ewing's sarcoma; Malignant fibrous histiocytoma; Mesenchymal tumors; Round cell myxoid liposarcoma; Sarcomagenesis; Sarcomas; Synovial sarcoma

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; AMG 479; ANTINEOPLASTIC AGENT; ELESCLOMOL; GEFITINIB; HORMONE RECEPTOR AFFECTING AGENT; HSP 70 VACCINE; IMATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; N ACETYLSARCOSYLGLYCYLVALYL DEXTRO ALLOISOLEUCYLTHREONYLNORVALYLISOLEUCYLARGINYLPROLINE ETHYLAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; NVP AEW 541; PACLITAXEL; PAZOPANIB; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; R 1507; RALOXIFENE; RAPAMYCIN; RIDAFOROLIMUS; SMALL INTERFERING RNA; SORAFENIB; SUNITINIB; TANESPIMYCIN; TEMSIROLIMUS; TUMOR VACCINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VITAMIN;

EID: 77951715996     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/PAP.0b013e3181d98cbf     Document Type: Review
Times cited : (28)

References (208)
  • 2
    • 45149090773 scopus 로고    scopus 로고
    • Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up
    • Casali PG, Jost L, Sleijfer S, et al. Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2008;19(suppl 2):ii89-ii93.
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 2
    • Casali, P.G.1    Jost, L.2    Sleijfer, S.3
  • 3
    • 70349753195 scopus 로고    scopus 로고
    • Advances in Ewing's sarcoma research: Where are we now and what lies ahead?
    • Ordonez JL, Osuna D, Herrero D, et al. Advances in Ewing's sarcoma research: where are we now and what lies ahead? Cancer Res. 2009;69:7140-7150.
    • (2009) Cancer Res , vol.69 , pp. 7140-7150
    • Ordonez, J.L.1    Osuna, D.2    Herrero, D.3
  • 4
    • 50649097473 scopus 로고    scopus 로고
    • Synovial sarcoma: From genetics to genetic-based animal modeling
    • Haldar M, Randall RL, Capecchi MR. Synovial sarcoma: from genetics to genetic-based animal modeling. Clin Orthop Relat Res. 2008;466:2156-2167.
    • (2008) Clin Orthop Relat Res , vol.466 , pp. 2156-2167
    • Haldar, M.1    Randall, R.L.2    Capecchi, M.R.3
  • 5
    • 34047146046 scopus 로고    scopus 로고
    • A conditional mouse model of synovial sarcoma: Insights into a myogenic origin
    • Haldar M, Hancock JD, Coffin CM, et al. A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell. 2007;11:375-388.
    • (2007) Cancer Cell , vol.11 , pp. 375-388
    • Haldar, M.1    Hancock, J.D.2    Coffin, C.M.3
  • 6
    • 65949109502 scopus 로고    scopus 로고
    • A CreER-based random induction strategy for modeling translocation- associated sarcomas in mice
    • Haldar M, Hedberg ML, Hockin MF, et al. A CreER-Based Random Induction Strategy for Modeling Translocation- Associated Sarcomas in Mice. Cancer Res. 2009;69:3657-3664.
    • (2009) Cancer Res , vol.69 , pp. 3657-3664
    • Haldar, M.1    Hedberg, M.L.2    Hockin, M.F.3
  • 7
    • 7544243041 scopus 로고    scopus 로고
    • Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: Cooperation of Ink4a/ ARF and Trp53 loss of function
    • Keller C, Arenkiel BR, Coffin CM, et al. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperation of Ink4a/ ARF and Trp53 loss of function. Genes Dev. 2004;18:2614-2626.
    • (2004) Genes Dev , vol.18 , pp. 2614-2626
    • Keller, C.1    Arenkiel, B.R.2    Coffin, C.M.3
  • 8
    • 55349094311 scopus 로고    scopus 로고
    • EWS-FLI1 Induces Developmental Abnormalities and Accelerates Sarcoma Formation in a Transgenic Mouse Model
    • Lin PP, Pandey MK, Jin F, et al. EWS-FLI1 Induces Developmental Abnormalities and Accelerates Sarcoma Formation in a Transgenic Mouse Model. Cancer Res. 2008;68: 8968-8975.
    • (2008) Cancer Res , vol.68 , pp. 8968-8975
    • Lin, P.P.1    Pandey, M.K.2    Jin, F.3
  • 9
    • 0034636584 scopus 로고    scopus 로고
    • The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice
    • Perez-Losada J, Pintado B, Gutierrez-Adan A, et al. The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice. Oncogene. 2000;19:2413-2422.
    • (2000) Oncogene , vol.19 , pp. 2413-2422
    • Perez-Losada, J.1    Pintado, B.2    Gutierrez-Adan, A.3
  • 10
    • 0026686674 scopus 로고
    • Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
    • Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature. 1992;359:162-165.
    • (1992) Nature , vol.359 , pp. 162-165
    • Delattre, O.1    Zucman, J.2    Plougastel, B.3
  • 11
    • 0028307384 scopus 로고
    • A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG
    • Sorensen PH, Lessnick SL, Lopez-Terrada D, et al. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet. 1994;6:146-151.
    • (1994) Nat Genet , vol.6 , pp. 146-151
    • Sorensen, P.H.1    Lessnick, S.L.2    Lopez-Terrada, D.3
  • 12
    • 39449121063 scopus 로고    scopus 로고
    • Complex rearrangement of chromosomes 19, 21, and 22 in Ewing sarcoma involving a novel reciprocal inversion-insertion mechanism of EWS-ERG fusion gene formation: A case analysis and literature review
    • Maire G, Brown CW, Bayani J, et al. Complex rearrangement of chromosomes 19, 21, and 22 in Ewing sarcoma involving a novel reciprocal inversion-insertion mechanism of EWS-ERG fusion gene formation: a case analysis and literature review. Cancer Genet Cytogenet. 2008;181:81-92.
    • (2008) Cancer Genet Cytogenet , vol.181 , pp. 81-92
    • Maire, G.1    Brown, C.W.2    Bayani, J.3
  • 13
    • 0043136766 scopus 로고    scopus 로고
    • FUS/ERG gene fusions in Ewing's tumors
    • Shing DC, McMullan DJ, Roberts P, et al. FUS/ERG gene fusions in Ewing's tumors. Cancer Res. 2003;63:4568-4576.
    • (2003) Cancer Res , vol.63 , pp. 4568-4576
    • Shing, D.C.1    McMullan, D.J.2    Roberts, P.3
  • 14
    • 0028903089 scopus 로고
    • A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1
    • Jeon IS, Davis JN, Braun BS, et al. A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene. 1995;10:1229-1234.
    • (1995) Oncogene , vol.10 , pp. 1229-1234
    • Jeon, I.S.1    Davis, J.N.2    Braun, B.S.3
  • 15
    • 0030028657 scopus 로고    scopus 로고
    • Fusion of an ETSfamily gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy
    • Kaneko Y, Yoshida K, Handa M, et al. Fusion of an ETSfamily gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy. Genes Chromosomes Cancer. 1996;15:115-121.
    • (1996) Genes Chromosomes Cancer , vol.15 , pp. 115-121
    • Kaneko, Y.1    Yoshida, K.2    Handa, M.3
  • 16
    • 0030975975 scopus 로고    scopus 로고
    • A new member of the ETS family fused to EWS in Ewing tumors
    • Peter M, Couturier J, Pacquement H, et al. A new member of the ETS family fused to EWS in Ewing tumors. Oncogene. 1997;14:1159-1164.
    • (1997) Oncogene , vol.14 , pp. 1159-1164
    • Peter, M.1    Couturier, J.2    Pacquement, H.3
  • 17
    • 17644393140 scopus 로고    scopus 로고
    • EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22) (p21;q12)
    • Yamaguchi S, Yamazaki Y, Ishikawa Y, et al. EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22) (p21;q12). Genes Chromosomes Cancer. 2005;43:217-222.
    • (2005) Genes Chromosomes Cancer , vol.43 , pp. 217-222
    • Yamaguchi, S.1    Yamazaki, Y.2    Ishikawa, Y.3
  • 18
    • 0034601373 scopus 로고    scopus 로고
    • A novel zinc finger gene is fused to EWS in small round cell tumor
    • Mastrangelo T, Modena P, Tornielli S, et al. A novel zinc finger gene is fused to EWS in small round cell tumor. Oncogene. 2000;19:3799-3804.
    • (2000) Oncogene , vol.19 , pp. 3799-3804
    • Mastrangelo, T.1    Modena, P.2    Tornielli, S.3
  • 19
    • 34548806398 scopus 로고    scopus 로고
    • Undifferentiated small round cell sarcomas with rare EWS gene fusions: Identification of a novel EWS-SP3 fusion and of additional cases with the EWSETV1 and EWS-FEV fusions
    • Wang L, Bhargava R, Zheng T, et al. Undifferentiated small round cell sarcomas with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWSETV1 and EWS-FEV fusions. J Mol Diagn. 2007;9:498-509.
    • (2007) J Mol Diagn , vol.9 , pp. 498-509
    • Wang, L.1    Bhargava, R.2    Zheng, T.3
  • 20
    • 65249099562 scopus 로고    scopus 로고
    • The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology
    • Szuhai K, Ijszenga M, de Jong D, et al. The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology. Clin Cancer Res. 2009;15:2259-2268.
    • (2009) Clin Cancer Res , vol.15 , pp. 2259-2268
    • Szuhai, K.1    Ijszenga, M.2    De Jong, D.3
  • 21
    • 34548775691 scopus 로고    scopus 로고
    • Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV
    • Ng TL, O'Sullivan MJ, Pallen CJ, et al. Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV. J Mol Diagn. 2007;9:459-463.
    • (2007) J Mol Diagn , vol.9 , pp. 459-463
    • Ng, T.L.1    O'Sullivan, M.J.2    Pallen, C.J.3
  • 22
    • 35648989427 scopus 로고    scopus 로고
    • Successful treatment of a child with t(15;19)-positive tumor
    • Mertens F, Wiebe T, Adlercreutz C, et al. Successful treatment of a child with t(15;19)-positive tumor. Pediatr Blood Cancer. 2007;49:1015-1017.
    • (2007) Pediatr Blood Cancer , vol.49 , pp. 1015-1017
    • Mertens, F.1    Wiebe, T.2    Adlercreutz, C.3
  • 23
    • 33745283008 scopus 로고    scopus 로고
    • Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation
    • Kawamura-Saito M, Yamazaki Y, Kaneko K, et al. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet. 2006;15:2125-2137.
    • (2006) Hum Mol Genet , vol.15 , pp. 2125-2137
    • Kawamura-Saito, M.1    Yamazaki, Y.2    Kaneko, K.3
  • 24
    • 0028246185 scopus 로고
    • Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor
    • Ladanyi M, Gerald W. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res. 1994;54: 2837-2840.
    • (1994) Cancer Res , vol.54 , pp. 2837-2840
    • Ladanyi, M.1    Gerald, W.2
  • 25
    • 0027227651 scopus 로고
    • Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
    • Crozat A, Aman P, Mandahl N, et al. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature. 1993;363:640-644.
    • (1993) Nature , vol.363 , pp. 640-644
    • Crozat, A.1    Aman, P.2    Mandahl, N.3
  • 26
    • 0030029073 scopus 로고    scopus 로고
    • Fusion of the EWS and CHOP genes in myxoid liposarcoma
    • Panagopoulos I, Hoglund M, Mertens F, et al. Fusion of the EWS and CHOP genes in myxoid liposarcoma. Oncogene. 1996;12:489-494.
    • (1996) Oncogene , vol.12 , pp. 489-494
    • Panagopoulos, I.1    Hoglund, M.2    Mertens, F.3
  • 27
    • 14844283127 scopus 로고    scopus 로고
    • Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript
    • De Cecco L, Gariboldi M, Reid JF, et al. Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript. Histopathology. 2005;46:334-341.
    • (2005) Histopathology , vol.46 , pp. 334-341
    • De Cecco, L.1    Gariboldi, M.2    Reid, J.F.3
  • 28
    • 0030033829 scopus 로고    scopus 로고
    • Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma
    • Clark J, Benjamin H, Gill S, et al. Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Oncogene. 1996; 12:229-235.
    • (1996) Oncogene , vol.12 , pp. 229-235
    • Clark, J.1    Benjamin, H.2    Gill, S.3
  • 29
    • 0033539906 scopus 로고    scopus 로고
    • Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17) (q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma
    • Attwooll C, Tariq M, Harris M, et al. Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17) (q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. Oncogene. 1999;18:7599-7601.
    • (1999) Oncogene , vol.18 , pp. 7599-7601
    • Attwooll, C.1    Tariq, M.2    Harris, M.3
  • 30
    • 0034670380 scopus 로고    scopus 로고
    • Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21)
    • Sjogren H, Wedell B, Meis-Kindblom JM, et al. Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21). Cancer Res. 2000;60:6832-6835.
    • (2000) Cancer Res , vol.60 , pp. 6832-6835
    • Sjogren, H.1    Wedell, B.2    Meis-Kindblom, J.M.3
  • 31
    • 3142654700 scopus 로고    scopus 로고
    • TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma
    • Hisaoka M, Ishida T, Imamura T, et al. TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma. Genes Chromosomes Cancer. 2004;40:325-328.
    • (2004) Genes Chromosomes Cancer , vol.40 , pp. 325-328
    • Hisaoka, M.1    Ishida, T.2    Imamura, T.3
  • 32
    • 0027183108 scopus 로고
    • EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts
    • Zucman J, Delattre O, Desmaze C, et al. EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat Genet. 1993;4:341-345.
    • (1993) Nat Genet , vol.4 , pp. 341-345
    • Zucman, J.1    Delattre, O.2    Desmaze, C.3
  • 33
    • 33749334696 scopus 로고    scopus 로고
    • EWS-CREB1: A recurrent variant fusion in clear cell sarcoma-association with gastrointestinal location and absence of melanocytic differentiation
    • Antonescu CR, Nafa K, Segal NH, et al. EWS-CREB1: a recurrent variant fusion in clear cell sarcoma-association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res. 2006;12:5356-5362.
    • (2006) Clin Cancer Res , vol.12 , pp. 5356-5362
    • Antonescu, C.R.1    Nafa, K.2    Segal, N.H.3
  • 34
    • 23044459407 scopus 로고    scopus 로고
    • Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma
    • Hallor KH, Mertens F, Jin Y, et al. Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 2005;44:97-102.
    • (2005) Genes Chromosomes Cancer , vol.44 , pp. 97-102
    • Hallor, K.H.1    Mertens, F.2    Jin, Y.3
  • 35
    • 37549038654 scopus 로고    scopus 로고
    • EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma
    • Rossi S, Szuhai K, Ijszenga M, et al. EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clin Cancer Res. 2007;13:7322-7328.
    • (2007) Clin Cancer Res , vol.13 , pp. 7322-7328
    • Rossi, S.1    Szuhai, K.2    Ijszenga, M.3
  • 36
    • 0029066330 scopus 로고
    • Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma
    • Crew AJ, Clark J, Fisher C, et al. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J. 1995;14:2333-2340.
    • (1995) EMBO J , vol.14 , pp. 2333-2340
    • Crew, A.J.1    Clark, J.2    Fisher, C.3
  • 37
    • 0027933151 scopus 로고
    • Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma
    • Clark J, Rocques PJ, Crew AJ, et al. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nat Genet. 1994;7:502-508.
    • (1994) Nat Genet , vol.7 , pp. 502-508
    • Clark, J.1    Rocques, P.J.2    Crew, A.J.3
  • 38
    • 0033516270 scopus 로고    scopus 로고
    • A novel fusion gene, SYT-SSX4, in synovial sarcoma
    • Skytting B, Nilsson G, Brodin B, et al. A novel fusion gene, SYT-SSX4, in synovial sarcoma. J Natl Cancer Inst. 1999;91: 974-975.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 974-975
    • Skytting, B.1    Nilsson, G.2    Brodin, B.3
  • 41
    • 0028364374 scopus 로고
    • Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma
    • Davis RJ, D'Cruz CM, Lovell MA, et al. Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. Cancer Res. 1994;54:2869-2872.
    • (1994) Cancer Res , vol.54 , pp. 2869-2872
    • Davis, R.J.1    D'Cruz, C.M.2    Lovell, M.A.3
  • 42
    • 4143150844 scopus 로고    scopus 로고
    • Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1
    • Wachtel M, Dettling M, Koscielniak E, et al. Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1. Cancer Res. 2004;64:5539-5545.
    • (2004) Cancer Res , vol.64 , pp. 5539-5545
    • Wachtel, M.1    Dettling, M.2    Koscielniak, E.3
  • 43
    • 76649129867 scopus 로고    scopus 로고
    • Recurrent t(2;2) and t(2;8) translocations in rhabdomyosarcoma without the canonical PAX-FOXO1 fuse PAX3 to members of the nuclear receptor transcriptional coactivator family
    • Sumegi J, Streblow R, Frayer RW, et al. Recurrent t(2;2) and t(2;8) translocations in rhabdomyosarcoma without the canonical PAX-FOXO1 fuse PAX3 to members of the nuclear receptor transcriptional coactivator family. Genes Chromosomes Cancer. 2009;49:224-236.
    • (2009) Genes Chromosomes Cancer , vol.49 , pp. 224-236
    • Sumegi, J.1    Streblow, R.2    Frayer, R.W.3
  • 44
    • 59649113478 scopus 로고    scopus 로고
    • A novel PAX3 rearrangement in embryonal rhabdomyosarcoma
    • Hosoi H, Kakazu N, Konishi E, et al. A novel PAX3 rearrangement in embryonal rhabdomyosarcoma. Cancer Genet Cytogenet. 2009;189:98-104.
    • (2009) Cancer Genet Cytogenet , vol.189 , pp. 98-104
    • Hosoi, H.1    Kakazu, N.2    Konishi, E.3
  • 45
    • 0031012850 scopus 로고    scopus 로고
    • Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma
    • Simon MP, Pedeutour F, Sirvent N, et al. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet. 1997;15:95-98.
    • (1997) Nat Genet , vol.15 , pp. 95-98
    • Simon, M.P.1    Pedeutour, F.2    Sirvent, N.3
  • 46
    • 0031953233 scopus 로고    scopus 로고
    • A novel ETV6- NTRK3 gene fusion in congenital fibrosarcoma
    • Knezevich SR, McFadden DE, Tao W, et al. A novel ETV6- NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet. 1998;18:184-187.
    • (1998) Nat Genet , vol.18 , pp. 184-187
    • Knezevich, S.R.1    McFadden, D.E.2    Tao, W.3
  • 47
    • 0035804224 scopus 로고    scopus 로고
    • The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25
    • Ladanyi M, Lui MY, Antonescu CR, et al. The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene. 2001;20:48-57.
    • (2001) Oncogene , vol.20 , pp. 48-57
    • Ladanyi, M.1    Lui, M.Y.2    Antonescu, C.R.3
  • 48
    • 14344280487 scopus 로고    scopus 로고
    • Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors
    • Koontz JI, Soreng AL, Nucci M, et al. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Nat Acad Sci U S A. 2001;98:6348-6353.
    • (2001) Proc Nat Acad Sci U S A , vol.98 , pp. 6348-6353
    • Koontz, J.I.1    Soreng, A.L.2    Nucci, M.3
  • 49
    • 0033890820 scopus 로고    scopus 로고
    • TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors
    • Lawrence B, Perez-Atayde A, Hibbard MK, et al. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol. 2000;157:377-384.
    • (2000) Am J Pathol , vol.157 , pp. 377-384
    • Lawrence, B.1    Perez-Atayde, A.2    Hibbard, M.K.3
  • 50
    • 0034879895 scopus 로고    scopus 로고
    • Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor
    • Bridge JA, Kanamori M, Ma Z, et al. Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor. Am J Pathol. 2001;159:411-415.
    • (2001) Am J Pathol , vol.159 , pp. 411-415
    • Bridge, J.A.1    Kanamori, M.2    Ma, Z.3
  • 51
    • 0037402562 scopus 로고    scopus 로고
    • Fusion of ALK to the Ranbinding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor
    • Ma Z, Hill DA, Collins MH, et al. Fusion of ALK to the Ranbinding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor. Genes Chromosomes Cancer. 2003;37:98-105.
    • (2003) Genes Chromosomes Cancer , vol.37 , pp. 98-105
    • Ma, Z.1    Hill, D.A.2    Collins, M.H.3
  • 52
    • 0141702229 scopus 로고    scopus 로고
    • Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma
    • Storlazzi CT, Mertens F, Nascimento A, et al. Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. Hum Mol Genet. 2003;12:2349-2358.
    • (2003) Hum Mol Genet , vol.12 , pp. 2349-2358
    • Storlazzi, C.T.1    Mertens, F.2    Nascimento, A.3
  • 53
    • 20044366896 scopus 로고    scopus 로고
    • Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene
    • Mertens F, Fletcher CD, Antonescu CR, et al. Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene. Lab Invest. 2005;85:408-415.
    • (2005) Lab Invest , vol.85 , pp. 408-415
    • Mertens, F.1    Fletcher, C.D.2    Antonescu, C.R.3
  • 54
    • 65249144557 scopus 로고    scopus 로고
    • Commonality but diversity in cancer gene fusions
    • Rabbitts TH. Commonality but diversity in cancer gene fusions. Cell. 2009;137:391-395.
    • (2009) Cell , vol.137 , pp. 391-395
    • Rabbitts, T.H.1
  • 55
    • 0033063289 scopus 로고    scopus 로고
    • The Ewing family of tumors and the search for the Achilles' heel
    • Kovar H, Aryee D, Zoubek A. The Ewing family of tumors and the search for the Achilles' heel. Curr Opin Oncol. 1999; 11:275-284.
    • (1999) Curr Opin Oncol , vol.11 , pp. 275-284
    • Kovar, H.1    Aryee, D.2    Zoubek, A.3
  • 56
    • 0031924824 scopus 로고    scopus 로고
    • EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma
    • de Alava E, Kawai A, Healey JH, et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J Clin Oncol. 1998;16:1248-1255.
    • (1998) J Clin Oncol , vol.16 , pp. 1248-1255
    • De Alava, E.1    Kawai, A.2    Healey, J.H.3
  • 57
    • 0033119006 scopus 로고    scopus 로고
    • Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma
    • Lin PP, Brody RI, Hamelin AC, et al. Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma. Cancer Res. 1999;59:1428-1432.
    • (1999) Cancer Res , vol.59 , pp. 1428-1432
    • Lin, P.P.1    Brody, R.I.2    Hamelin, A.C.3
  • 58
    • 0031688631 scopus 로고    scopus 로고
    • Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): Desmoplastic small round-cell tumor and its variants
    • Gerald WL, Ladanyi M, de Alava E, et al. Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants. J Clin Oncol. 1998;16:3028-3036.
    • (1998) J Clin Oncol , vol.16 , pp. 3028-3036
    • Gerald, W.L.1    Ladanyi, M.2    De Alava, E.3
  • 59
    • 0030699247 scopus 로고    scopus 로고
    • The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour
    • Lee SB, Kolquist KA, Nichols K, et al. The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour. Nat Genet. 1997;17:309-313.
    • (1997) Nat Genet , vol.17 , pp. 309-313
    • Lee, S.B.1    Kolquist, K.A.2    Nichols, K.3
  • 60
    • 0038505644 scopus 로고    scopus 로고
    • Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis
    • Palmer RE, Lee SB, Wong JC, et al. Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis. Cancer Cell. 2002;2:497-505.
    • (2002) Cancer Cell , vol.2 , pp. 497-505
    • Palmer, R.E.1    Lee, S.B.2    Wong, J.C.3
  • 61
    • 0032531726 scopus 로고    scopus 로고
    • Skeletal and extraskeletal myxoid chondrosarcoma: A comparative clinicopathologic, ultrastructural, and molecular study
    • Antonescu CR, Argani P, Erlandson RA, et al. Skeletal and extraskeletal myxoid chondrosarcoma: a comparative clinicopathologic, ultrastructural, and molecular study. Cancer. 1998;83:1504-1521.
    • (1998) Cancer , vol.83 , pp. 1504-1521
    • Antonescu, C.R.1    Argani, P.2    Erlandson, R.A.3
  • 62
    • 22644447659 scopus 로고    scopus 로고
    • The gene expression profile of extraskeletal myxoid chondrosarcoma
    • Subramanian S, West RB, Marinelli RJ, et al. The gene expression profile of extraskeletal myxoid chondrosarcoma. J Pathol. 2005;206:433-444.
    • (2005) J Pathol , vol.206 , pp. 433-444
    • Subramanian, S.1    West, R.B.2    Marinelli, R.J.3
  • 63
    • 68249145205 scopus 로고    scopus 로고
    • Pathology of softtissue tumors: Daily diagnosis, molecular cytogenetics and experimental approach
    • Iwasaki H, Nabeshima K, Nishio J, et al. Pathology of softtissue tumors: daily diagnosis, molecular cytogenetics and experimental approach. Pathol Int. 2009;59:501-521.
    • (2009) Pathol Int , vol.59 , pp. 501-521
    • Iwasaki, H.1    Nabeshima, K.2    Nishio, J.3
  • 64
    • 35349023041 scopus 로고    scopus 로고
    • EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma
    • Antonescu CR, Dal Cin P, Nafa K, et al. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 2007;46:1051-1060.
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 1051-1060
    • Antonescu, C.R.1    Dal Cin, P.2    Nafa, K.3
  • 65
    • 0036479960 scopus 로고    scopus 로고
    • Molecular diagnosis of clear cell sarcoma: Detection of EWS-ATF1 and MITF-M transcripts and histopathological and ultrastructural analysis of 12 cases
    • Antonescu CR, Tschernyavsky SJ, Woodruff JM, et al. Molecular diagnosis of clear cell sarcoma: detection of EWS-ATF1 and MITF-M transcripts and histopathological and ultrastructural analysis of 12 cases. J Mol Diagn. 2002;4: 44-52.
    • (2002) J Mol Diagn , vol.4 , pp. 44-52
    • Antonescu, C.R.1    Tschernyavsky, S.J.2    Woodruff, J.M.3
  • 66
    • 0030272143 scopus 로고    scopus 로고
    • Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS
    • Aman P, Panagopoulos I, Lassen C, et al. Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS. Genomics. 1996;37:1-8.
    • (1996) Genomics , vol.37 , pp. 1-8
    • Aman, P.1    Panagopoulos, I.2    Lassen, C.3
  • 67
    • 29744463936 scopus 로고    scopus 로고
    • Frequent alteration of p16(INK4a)/ p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: P53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis
    • Oda Y, Yamamoto H, Takahira T, et al. Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis. J Pathol. 2005;207:410-421.
    • (2005) J Pathol , vol.207 , pp. 410-421
    • Oda, Y.1    Yamamoto, H.2    Takahira, T.3
  • 68
    • 0027534945 scopus 로고
    • Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma
    • DOI 10.1038/ng0293-113
    • Barr FG, Galili N, Holick J, et al. Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. Nat Genet. 1993;3:113-117. (Pubitemid 23079791)
    • (1993) Nature Genetics , vol.3 , Issue.2 , pp. 113-117
    • Barr, F.G.1    Galili, N.2    Holick, J.3    Biegel, J.A.4    Rovera, G.5    Emanuell, B.S.6
  • 69
    • 0030860934 scopus 로고    scopus 로고
    • Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma
    • Davis RJ, Barr FG. Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma. Proc Natl Acad Sci USA. 1997;94:8047-8051.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8047-8051
    • Davis, R.J.1    Barr, F.G.2
  • 70
    • 0036605806 scopus 로고    scopus 로고
    • PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: A report from the children's oncology group
    • Sorensen PH, Lynch JC, Qualman SJ, et al. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. J Clin Oncol. 2002;20:2672-2679.
    • (2002) J Clin Oncol , vol.20 , pp. 2672-2679
    • Sorensen, P.H.1    Lynch, J.C.2    Qualman, S.J.3
  • 72
    • 0036144655 scopus 로고    scopus 로고
    • Impact of SYTSSX fusion type on the clinical behavior of synovial sarcoma: A multi-institutional retrospective study of 243 patients
    • Ladanyi M, Antonescu CR, Leung DH, et al. Impact of SYTSSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res. 2002;62:135-140.
    • (2002) Cancer Res , vol.62 , pp. 135-140
    • Ladanyi, M.1    Antonescu, C.R.2    Leung, D.H.3
  • 73
    • 7044237243 scopus 로고    scopus 로고
    • Molecular prognostication for soft tissue sarcomas: Are we ready yet?
    • Oliveira AM, Fletcher CD. Molecular prognostication for soft tissue sarcomas: are we ready yet? J Clin Oncol. 2004;22: 4031-4034.
    • (2004) J Clin Oncol , vol.22 , pp. 4031-4034
    • Oliveira, A.M.1    Fletcher, C.D.2
  • 74
    • 0031672038 scopus 로고    scopus 로고
    • Dermatofibrosarcoma protuberans with fibrosarcomatous areas. Molecular abnormalities of the p53 pathway in fibrosarcomatous transformation of dermatofibrosarcoma protuberans
    • Hisaoka M, Okamoto S, Morimitsu Y, et al. Dermatofibrosarcoma protuberans with fibrosarcomatous areas. Molecular abnormalities of the p53 pathway in fibrosarcomatous transformation of dermatofibrosarcoma protuberans. Virchows Arch. 1998;433:323-329.
    • (1998) Virchows Arch , vol.433 , pp. 323-329
    • Hisaoka, M.1    Okamoto, S.2    Morimitsu, Y.3
  • 75
    • 19044391610 scopus 로고    scopus 로고
    • Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma
    • Tognon C, Knezevich SR, Huntsman D, et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell. 2002;2:367-376.
    • (2002) Cancer Cell , vol.2 , pp. 367-376
    • Tognon, C.1    Knezevich, S.R.2    Huntsman, D.3
  • 76
    • 25444482607 scopus 로고    scopus 로고
    • Sequencespecific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
    • Hu-Lieskovan S, Heidel JD, Bartlett DW, et al. Sequencespecific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res. 2005;65:8984-8992.
    • (2005) Cancer Res , vol.65 , pp. 8984-8992
    • Hu-Lieskovan, S.1    Heidel, J.D.2    Bartlett, D.W.3
  • 77
    • 70349451845 scopus 로고    scopus 로고
    • Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
    • Italiano A, Bianchini L, Gjernes E, et al. Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas. Clin Cancer Res. 2009;15:5696-5703.
    • (2009) Clin Cancer Res , vol.15 , pp. 5696-5703
    • Italiano, A.1    Bianchini, L.2    Gjernes, E.3
  • 78
    • 34748907274 scopus 로고    scopus 로고
    • Detection of MDM2- CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: Utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR
    • Sirvent N, Coindre JM, Maire G, et al. Detection of MDM2- CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31: 1476-1489.
    • (2007) Am J Surg Pathol , vol.31 , pp. 1476-1489
    • Sirvent, N.1    Coindre, J.M.2    Maire, G.3
  • 79
    • 11144355696 scopus 로고    scopus 로고
    • Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma
    • Ragazzini P, Gamberi G, Pazzaglia L, et al. Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. Histol Histopathol. 2004;19:401-411.
    • (2004) Histol Histopathol , vol.19 , pp. 401-411
    • Ragazzini, P.1    Gamberi, G.2    Pazzaglia, L.3
  • 80
    • 34248581595 scopus 로고    scopus 로고
    • Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A
    • Muller CR, Paulsen EB, Noordhuis P, et al. Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A. Int J Cancer. 2007;121:199-205.
    • (2007) Int J Cancer , vol.121 , pp. 199-205
    • Muller, C.R.1    Paulsen, E.B.2    Noordhuis, P.3
  • 81
    • 34547102253 scopus 로고    scopus 로고
    • Gene expression profiling of liposarcoma identifies distinct biological types/ subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma
    • Singer S, Socci ND, Ambrosini G, et al. Gene expression profiling of liposarcoma identifies distinct biological types/ subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma. Cancer Res. 2007;67: 6626-6636.
    • (2007) Cancer Res , vol.67 , pp. 6626-6636
    • Singer, S.1    Socci, N.D.2    Ambrosini, G.3
  • 82
    • 67650079901 scopus 로고    scopus 로고
    • C-Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme
    • Snyder EL, Sandstrom DJ, Law K, et al. c-Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme. J Pathol. 2009;218:292-300.
    • (2009) J Pathol , vol.218 , pp. 292-300
    • Snyder, E.L.1    Sandstrom, D.J.2    Law, K.3
  • 83
    • 35748962309 scopus 로고    scopus 로고
    • Desmoid tumor: A disease opportune for molecular insights
    • Kotiligam D, Lazar AJ, Pollock RE, et al. Desmoid tumor: a disease opportune for molecular insights. Histol Histopathol. 2008;23:117-126.
    • (2008) Histol Histopathol , vol.23 , pp. 117-126
    • Kotiligam, D.1    Lazar, A.J.2    Pollock, R.E.3
  • 84
    • 34548777536 scopus 로고    scopus 로고
    • Immunohistochemistry for b-catenin in the differential diagnosis of spindle cell lesions: Analysis of a series and review of the literature
    • Carlson JW, Fletcher CD. Immunohistochemistry for b-catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature. Histopathology. 2007;51:509-514.
    • (2007) Histopathology , vol.51 , pp. 509-514
    • Carlson, J.W.1    Fletcher, C.D.2
  • 85
    • 55349092046 scopus 로고    scopus 로고
    • Specific mutations in the b-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors
    • Lazar AJ, Tuvin D, Hajibashi S, et al. Specific mutations in the b-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. Am J Pathol. 2008;173:1518-1527.
    • (2008) Am J Pathol , vol.173 , pp. 1518-1527
    • Lazar, A.J.1    Tuvin, D.2    Hajibashi, S.3
  • 86
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev. 2008;8:915-928.
    • (2008) Nat Rev , vol.8 , pp. 915-928
    • Pollak, M.1
  • 87
    • 47249106539 scopus 로고    scopus 로고
    • Targeting insulin-like growth factor 1 receptor in sarcomas
    • Scotlandi K, Picci P. Targeting insulin-like growth factor 1 receptor in sarcomas. Curr Opin Oncol. 2008;20:419-427.
    • (2008) Curr Opin Oncol , vol.20 , pp. 419-427
    • Scotlandi, K.1    Picci, P.2
  • 88
    • 51049098720 scopus 로고    scopus 로고
    • A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: In vitro and in vivo study
    • Martins AS, Ordonez JL, Garcia-Sanchez A, et al. A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study. Cancer Res. 2008;68:6260-6270.
    • (2008) Cancer Res , vol.68 , pp. 6260-6270
    • Martins, A.S.1    Ordonez, J.L.2    Garcia-Sanchez, A.3
  • 89
    • 67649862045 scopus 로고    scopus 로고
    • Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target
    • Herrero-Martin D, Osuna D, Ordonez JL, et al. Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target. Br J Cancer. 2009;101:80-90.
    • (2009) Br J Cancer , vol.101 , pp. 80-90
    • Herrero-Martin, D.1    Osuna, D.2    Ordonez, J.L.3
  • 90
    • 70450182195 scopus 로고    scopus 로고
    • Clinical development of inhibitors of the insulin-like growth factor receptor in oncology
    • Gualberto A, Pollak M. Clinical development of inhibitors of the insulin-like growth factor receptor in oncology. Curr Drug Targets. 2009;10:923-936.
    • (2009) Curr Drug Targets , vol.10 , pp. 923-936
    • Gualberto, A.1    Pollak, M.2
  • 91
    • 69449097339 scopus 로고    scopus 로고
    • Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
    • Gualberto A, Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene. 2009;28:3009-3021.
    • (2009) Oncogene , vol.28 , pp. 3009-3021
    • Gualberto, A.1    Pollak, M.2
  • 92
    • 54249157471 scopus 로고    scopus 로고
    • Addiction to elevated insulin-like growth factor i receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody
    • Cao L, Yu Y, Darko I, et al. Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody. Cancer Res. 2008;68:8039-8048.
    • (2008) Cancer Res , vol.68 , pp. 8039-8048
    • Cao, L.1    Yu, Y.2    Darko, I.3
  • 93
    • 58249101005 scopus 로고    scopus 로고
    • The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
    • Huang F, Greer A, Hurlburt W, et al. The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res. 2009;69:161-170.
    • (2009) Cancer Res , vol.69 , pp. 161-170
    • Huang, F.1    Greer, A.2    Hurlburt, W.3
  • 95
    • 0035141293 scopus 로고    scopus 로고
    • Expression of cadherins and their undercoat proteins (a-, b-, and g-catenins and p120) and accumulation of b-catenin with no gene mutations in synovial sarcoma
    • Sato H, Hasegawa T, Kanai Y, et al. Expression of cadherins and their undercoat proteins (a-, b-, and g-catenins and p120) and accumulation of b-catenin with no gene mutations in synovial sarcoma. Virchows Arch. 2001;438:23-30.
    • (2001) Virchows Arch , vol.438 , pp. 23-30
    • Sato, H.1    Hasegawa, T.2    Kanai, Y.3
  • 96
    • 0042345041 scopus 로고    scopus 로고
    • Classification and subtype prediction of adult soft tissue sarcoma by functional genomics
    • Segal NH, Pavlidis P, Antonescu CR, et al. Classification and subtype prediction of adult soft tissue sarcoma by functional genomics. Am J Pathol. 2003;163:691-700.
    • (2003) Am J Pathol , vol.163 , pp. 691-700
    • Segal, N.H.1    Pavlidis, P.2    Antonescu, C.R.3
  • 97
    • 3543151418 scopus 로고    scopus 로고
    • Wnt/Frizzled signaling in Ewing sarcoma
    • Uren A, Wolf V, Sun YF, et al. Wnt/Frizzled signaling in Ewing sarcoma. Pediatr Blood Cancer. 2004;43:243-249.
    • (2004) Pediatr Blood Cancer , vol.43 , pp. 243-249
    • Uren, A.1    Wolf, V.2    Sun, Y.F.3
  • 98
    • 36049042525 scopus 로고    scopus 로고
    • Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway
    • Matushansky I, Hernando E, Socci ND, et al. Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J Clin Invest. 2007;117:3248-3257.
    • (2007) J Clin Invest , vol.117 , pp. 3248-3257
    • Matushansky, I.1    Hernando, E.2    Socci, N.D.3
  • 99
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with b-catenin, APC, and GSK3b
    • Behrens J, Jerchow BA, Wurtele M, et al. Functional interaction of an axin homolog, conductin, with b-catenin, APC, and GSK3b. Science (NY). 1998;280:596-599.
    • (1998) Science (NY) , vol.280 , pp. 596-599
    • Behrens, J.1    Jerchow, B.A.2    Wurtele, M.3
  • 100
    • 0037604557 scopus 로고    scopus 로고
    • A Wnt-Wnt situation
    • He X. A Wnt-Wnt situation. Dev Cell. 2003;4:791-797.
    • (2003) Dev Cell , vol.4 , pp. 791-797
    • He, X.1
  • 101
    • 0037155691 scopus 로고    scopus 로고
    • Control of b-catenin phosphorylation/ degradation by a dual-kinase mechanism
    • Liu C, Li Y, Semenov M, et al. Control of b-catenin phosphorylation/ degradation by a dual-kinase mechanism. Cell. 2002;108:837-847.
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3
  • 102
    • 0036207723 scopus 로고    scopus 로고
    • APC mutations in synovial sarcoma
    • Saito T, Oda Y, Sakamoto A, et al. APC mutations in synovial sarcoma. J Pathol. 2002;196:445-449.
    • (2002) J Pathol , vol.196 , pp. 445-449
    • Saito, T.1    Oda, Y.2    Sakamoto, A.3
  • 103
    • 27144523169 scopus 로고    scopus 로고
    • Gene expression profiling of human sarcomas: Insights into sarcoma biology
    • Baird K, Davis S, Antonescu CR, et al. Gene expression profiling of human sarcomas: insights into sarcoma biology. Cancer Res. 2005;65:9226-9235.
    • (2005) Cancer Res , vol.65 , pp. 9226-9235
    • Baird, K.1    Davis, S.2    Antonescu, C.R.3
  • 104
    • 0037070754 scopus 로고    scopus 로고
    • Molecular characterisation of soft tissue tumours: A gene expression study
    • Nielsen TO, West RB, Linn SC, et al. Molecular characterisation of soft tissue tumours: a gene expression study. Lancet. 2002;359:1301-1307.
    • (2002) Lancet , vol.359 , pp. 1301-1307
    • Nielsen, T.O.1    West, R.B.2    Linn, S.C.3
  • 105
    • 10744220575 scopus 로고    scopus 로고
    • Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans
    • Linn SC, West RB, Pollack JR, et al. Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans. Am J Pathol. 2003;163:2383-2395.
    • (2003) Am J Pathol , vol.163 , pp. 2383-2395
    • Linn, S.C.1    West, R.B.2    Pollack, J.R.3
  • 106
    • 70350150140 scopus 로고    scopus 로고
    • Critical signaling pathways in bone sarcoma: Candidates for therapeutic interventions
    • Geryk-Hall M, Hughes DP. Critical signaling pathways in bone sarcoma: candidates for therapeutic interventions. Curr Oncol Rep. 2009;11:446-453.
    • (2009) Curr Oncol Rep , vol.11 , pp. 446-453
    • Geryk-Hall, M.1    Hughes, D.P.2
  • 107
    • 36048942033 scopus 로고    scopus 로고
    • EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice
    • Torchia EC, Boyd K, Rehg JE, et al. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol. 2007;27:7918-7934.
    • (2007) Mol Cell Biol , vol.27 , pp. 7918-7934
    • Torchia, E.C.1    Boyd, K.2    Rehg, J.E.3
  • 108
    • 19644386697 scopus 로고    scopus 로고
    • EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors
    • Hu-Lieskovan S, Zhang J, Wu L, et al. EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res. 2005;65:4633-4644.
    • (2005) Cancer Res , vol.65 , pp. 4633-4644
    • Hu-Lieskovan, S.1    Zhang, J.2    Wu, L.3
  • 109
    • 42049089299 scopus 로고    scopus 로고
    • EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells
    • Riggi N, Suva ML, Suva D, et al. EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells. Cancer Res. 2008;68: 2176-2185.
    • (2008) Cancer Res , vol.68 , pp. 2176-2185
    • Riggi, N.1    Suva, M.L.2    Suva, D.3
  • 110
    • 62449230721 scopus 로고    scopus 로고
    • Identification of cancer stem cells in ewing's sarcoma
    • Suva ML, Riggi N, Stehle JC, et al. Identification of Cancer Stem Cells in Ewing's Sarcoma. Cancer Res. 2009;69: 1776-1781.
    • (2009) Cancer Res , vol.69 , pp. 1776-1781
    • Suva, M.L.1    Riggi, N.2    Stehle, J.C.3
  • 111
    • 0015111921 scopus 로고
    • Dedifferentiation of low-grade chondrosarcomas
    • Dahlin DC, Beabout JW. Dedifferentiation of low-grade chondrosarcomas. Cancer. 1971;28:461-466.
    • (1971) Cancer , vol.28 , pp. 461-466
    • Dahlin, D.C.1    Beabout, J.W.2
  • 112
    • 0031859327 scopus 로고    scopus 로고
    • De-differentiated chondrosarcoma is not a 'de-differentiated' chondrosarcoma
    • Aigner T, Dertinger S, Neureiter D, et al. De-differentiated chondrosarcoma is not a 'de-differentiated' chondrosarcoma. Histopathology. 1998;33:11-19.
    • (1998) Histopathology , vol.33 , pp. 11-19
    • Aigner, T.1    Dertinger, S.2    Neureiter, D.3
  • 113
    • 0020197571 scopus 로고
    • Chondrosarcoma of bone with ''dedifferentiation'
    • Rywlin AM. Chondrosarcoma of bone with ''dedifferentiation''. Hum Pathol. 1982;13:963-964.
    • (1982) Hum Pathol , vol.13 , pp. 963-964
    • Rywlin, A.M.1
  • 114
    • 0022466346 scopus 로고
    • Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). II. An immunohistochemical and electron microscopic study
    • Tetu B, Ordonez NG, Ayala AG, et al. Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). II. An immunohistochemical and electron microscopic study. Cancer. 1986;58:287-298. (Pubitemid 16058604)
    • (1986) Cancer , vol.58 , Issue.2 , pp. 287-298
    • Tetu, B.1    Ordonez, N.G.2    Ayala, A.G.3    Mackay, B.4
  • 115
    • 0028282856 scopus 로고
    • Simultaneous interphase cytogenetic analysis and fluorescence immunophenotyping of dedifferentiated chondrosarcoma. Implications for histopathogenesis
    • Bridge JA, DeBoer J, Travis J, et al. Simultaneous interphase cytogenetic analysis and fluorescence immunophenotyping of dedifferentiated chondrosarcoma. Implications for histopathogenesis. Am J Pathol. 1994;144:215-220.
    • (1994) Am J Pathol , vol.144 , pp. 215-220
    • Bridge, J.A.1    Deboer, J.2    Travis, J.3
  • 116
    • 0032696571 scopus 로고    scopus 로고
    • Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis
    • Bovee JV, Cleton-Jansen AM, Rosenberg C, et al. Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis. J Pathol. 1999;189:454-462.
    • (1999) J Pathol , vol.189 , pp. 454-462
    • Bovee, J.V.1    Cleton-Jansen, A.M.2    Rosenberg, C.3
  • 117
    • 0029075020 scopus 로고
    • P53 expression and DNA ploidy of cartilage lesions
    • Coughlan B, Feliz A, Ishida T, et al. p53 expression and DNA ploidy of cartilage lesions. Hum Pathol. 1995;26:620-624.
    • (1995) Hum Pathol , vol.26 , pp. 620-624
    • Coughlan, B.1    Feliz, A.2    Ishida, T.3
  • 118
    • 0027145013 scopus 로고
    • Possible association of p53 overexpression and mutation with high-grade chondrosarcoma
    • Dobashi Y, Sugimura H, Sato A, et al. Possible association of p53 overexpression and mutation with high-grade chondrosarcoma. Diagn Mol Pathol. 1993;2:257-263.
    • (1993) Diagn Mol Pathol , vol.2 , pp. 257-263
    • Dobashi, Y.1    Sugimura, H.2    Sato, A.3
  • 119
    • 0029764225 scopus 로고    scopus 로고
    • Loss of heterozygosity and tumor suppressor gene mutations in chondrosarcomas
    • Yamaguchi T, Toguchida J, Wadayama B, et al. Loss of heterozygosity and tumor suppressor gene mutations in chondrosarcomas. Anticancer Res. 1996;16:2009-2015.
    • (1996) Anticancer Res , vol.16 , pp. 2009-2015
    • Yamaguchi, T.1    Toguchida, J.2    Wadayama, B.3
  • 120
    • 77950354811 scopus 로고    scopus 로고
    • Soft tissue sarcomas with complex genomic profiles
    • Guillou L, Aurias A. Soft tissue sarcomas with complex genomic profiles. Virchows Arch. 2010;456:201-217.
    • (2010) Virchows Arch. , vol.456 , pp. 201-217
    • Guillou, L.1    Aurias, A.2
  • 121
    • 0018627764 scopus 로고
    • Primary leiomyosarcoma of the bone and its comparison with fibrosarcoma
    • Sanerkin NG. Primary leiomyosarcoma of the bone and its comparison with fibrosarcoma. Cancer. 1979;44:1375-1387.
    • (1979) Cancer , vol.44 , pp. 1375-1387
    • Sanerkin, N.G.1
  • 122
    • 0023304442 scopus 로고
    • Primary leiomyosarcoma in the breast
    • Yamashina M. Primary leiomyosarcoma in the breast. Jpn J Clin Oncol. 1987;17:71-77.
    • (1987) Jpn J Clin Oncol , vol.17 , pp. 71-77
    • Yamashina, M.1
  • 123
    • 0024399859 scopus 로고
    • Prostatic carcinosarcomas. Clinical, histologic, and immunohistochemical data on two cases, with a review of the literature
    • Wick MR, Young RH, Malvesta R, et al. Prostatic carcinosarcomas. Clinical, histologic, and immunohistochemical data on two cases, with a review of the literature. Am J Clin Pathol. 1989;92:131-139.
    • (1989) Am J Clin Pathol , vol.92 , pp. 131-139
    • Wick, M.R.1    Young, R.H.2    Malvesta, R.3
  • 124
    • 21444454631 scopus 로고    scopus 로고
    • Histogenesis of carcinosarcoma and establishment of leiomyosarcoma cell line (HTMMT) derived from human uterine carcinosarcoma
    • Ishiwata I, Ishiwata C, Soma M, et al. Histogenesis of carcinosarcoma and establishment of leiomyosarcoma cell line (HTMMT) derived from human uterine carcinosarcoma. Hum Cell. 2004;17:131-137.
    • (2004) Hum Cell , vol.17 , pp. 131-137
    • Ishiwata, I.1    Ishiwata, C.2    Soma, M.3
  • 125
    • 0030030545 scopus 로고    scopus 로고
    • Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis
    • Thompson L, Chang B, Barsky SH. Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis. Am J Surg Pathol. 1996;20:277-285.
    • (1996) Am J Surg Pathol , vol.20 , pp. 277-285
    • Thompson, L.1    Chang, B.2    Barsky, S.H.3
  • 126
    • 0141569560 scopus 로고    scopus 로고
    • Carcinosarcomas (malignant Mullerian mixed tumors) of the uterus and ovary: A genetic study with special reference to histogenesis
    • Jin Z, Ogata S, Tamura G, et al. Carcinosarcomas (malignant Mullerian mixed tumors) of the uterus and ovary: a genetic study with special reference to histogenesis. Int J Gynecol Pathol. 2003;22:368-373.
    • (2003) Int J Gynecol Pathol , vol.22 , pp. 368-373
    • Jin, Z.1    Ogata, S.2    Tamura, G.3
  • 127
    • 34250013899 scopus 로고    scopus 로고
    • The AKTmTOR pathway plays a critical role in the development of leiomyosarcomas
    • Hernando E, Charytonowicz E, Dudas ME, et al. The AKTmTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med. 2007;13:748-753.
    • (2007) Nat Med , vol.13 , pp. 748-753
    • Hernando, E.1    Charytonowicz, E.2    Dudas, M.E.3
  • 128
    • 33646535436 scopus 로고    scopus 로고
    • Themyxoid/ round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells
    • Engstrom K,Willen H, Kabjorn-Gustafsson C, et al. Themyxoid/ round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells. Am J Pathol. 2006;168:1642-1653.
    • (2006) Am J Pathol , vol.168 , pp. 1642-1653
    • Engstrom, K.1    Willen, H.2    Kabjorn-Gustafsson, C.3
  • 129
    • 58249116717 scopus 로고    scopus 로고
    • The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ
    • Goransson M, Andersson MK, Forni C, et al. The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ. Oncogene. 2009;28:270-278.
    • (2009) Oncogene , vol.28 , pp. 270-278
    • Goransson, M.1    Andersson, M.K.2    Forni, C.3
  • 130
    • 33746924453 scopus 로고    scopus 로고
    • Expression of the FUSCHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma
    • Riggi N, Cironi L, Provero P, et al. Expression of the FUSCHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Cancer Res. 2006;66:7016-7023.
    • (2006) Cancer Res , vol.66 , pp. 7016-7023
    • Riggi, N.1    Cironi, L.2    Provero, P.3
  • 131
    • 0036408963 scopus 로고    scopus 로고
    • TLS-CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas
    • Domoto H, Hosaka T, Oikawa K, et al. TLS-CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas. Pathol Int. 2002;52:497-500.
    • (2002) Pathol Int , vol.52 , pp. 497-500
    • Domoto, H.1    Hosaka, T.2    Oikawa, K.3
  • 132
    • 11144296595 scopus 로고    scopus 로고
    • Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells
    • Boland GM, Perkins G, Hall DJ, et al. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cellular Biochem. 2004; 93:1210-1230.
    • (2004) J Cellular Biochem , vol.93 , pp. 1210-1230
    • Boland, G.M.1    Perkins, G.2    Hall, D.J.3
  • 133
    • 33646241997 scopus 로고    scopus 로고
    • Purified Wnt5a protein activates or inhibits b-catenin-TCF signaling depending on receptor context
    • Mikels AJ, Nusse R. Purified Wnt5a protein activates or inhibits b-catenin-TCF signaling depending on receptor context. PLoS Biol. 2006;4:e115.
    • (2006) PLoS Biol , vol.4
    • Mikels, A.J.1    Nusse, R.2
  • 134
    • 0022646970 scopus 로고
    • A classical osteogenic sarcoma of the breast: Histology, immunohistochemistry and ultrastructure
    • Going JJ, Lumsden AB, Anderson TJ. A classical osteogenic sarcoma of the breast: histology, immunohistochemistry and ultrastructure. Histopathology. 1986;10:631-641.
    • (1986) Histopathology , vol.10 , pp. 631-641
    • Going, J.J.1    Lumsden, A.B.2    Anderson, T.J.3
  • 136
    • 33645454882 scopus 로고    scopus 로고
    • Osteosarcoma of the testis
    • Tazi H, Karmouni T, Ouali M, et al. Osteosarcoma of the testis. Int J Urol. 2006;13:323-324.
    • (2006) Int J Urol , vol.13 , pp. 323-324
    • Tazi, H.1    Karmouni, T.2    Ouali, M.3
  • 137
    • 7544235883 scopus 로고    scopus 로고
    • Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: Implications for alveolar rhabdomyosarcoma cell of origin
    • Keller C, Hansen MS, Coffin CM, et al. Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. Genes Dev. 2004;18: 2608-2613.
    • (2004) Genes Dev , vol.18 , pp. 2608-2613
    • Keller, C.1    Hansen, M.S.2    Coffin, C.M.3
  • 138
    • 0034703978 scopus 로고    scopus 로고
    • Dedifferentiation of mammalian myotubes induced by msx1
    • Odelberg SJ, Kollhoff A, Keating MT. Dedifferentiation of mammalian myotubes induced by msx1. Cell. 2000;103: 1099-1109.
    • (2000) Cell , vol.103 , pp. 1099-1109
    • Odelberg, S.J.1    Kollhoff, A.2    Keating, M.T.3
  • 139
    • 0042121075 scopus 로고    scopus 로고
    • PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells
    • Tiffin N, Williams RD, Shipley J, et al. PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells. Br J Cancer. 2003;89:327-332.
    • (2003) Br J Cancer , vol.89 , pp. 327-332
    • Tiffin, N.1    Williams, R.D.2    Shipley, J.3
  • 140
    • 0028915301 scopus 로고
    • Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xp11.2, with implications for the histologic sub-classification of synovial sarcoma
    • Renwick PJ, Reeves BR, Dal Cin P, et al. Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xp11.2, with implications for the histologic sub-classification of synovial sarcoma. Cytogenet Cell Genet. 1995;70:58-63.
    • (1995) Cytogenet Cell Genet , vol.70 , pp. 58-63
    • Renwick, P.J.1    Reeves, B.R.2    Dal Cin, P.3
  • 141
    • 24644466424 scopus 로고    scopus 로고
    • Epithelioid sarcoma with SYT-SSX1 fusion gene expression: Molecular and cytogenetic analysis
    • de Torres C, Cardesa TM, Rodriguez-Perales S, et al. Epithelioid sarcoma with SYT-SSX1 fusion gene expression: molecular and cytogenetic analysis. Cancer Genet Cytogenet. 2005;162:50-56.
    • (2005) Cancer Genet Cytogenet , vol.162 , pp. 50-56
    • De Torres, C.1    Cardesa, T.M.2    Rodriguez-Perales, S.3
  • 142
    • 33746906998 scopus 로고    scopus 로고
    • SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: A potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma
    • Saito T, Nagai M, Ladanyi M. SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma. Cancer Res. 2006; 66:6919-6927.
    • (2006) Cancer Res , vol.66 , pp. 6919-6927
    • Saito, T.1    Nagai, M.2    Ladanyi, M.3
  • 143
    • 0032873789 scopus 로고    scopus 로고
    • Expression of smooth muscle calponin in synovial sarcoma
    • Ono H, Yoshikawa H, Ueda T, et al. Expression of smooth muscle calponin in synovial sarcoma. Sarcoma. 1999; 3:107-113.
    • (1999) Sarcoma , vol.3 , pp. 107-113
    • Ono, H.1    Yoshikawa, H.2    Ueda, T.3
  • 144
    • 34548052223 scopus 로고    scopus 로고
    • EWS/FLI-1 oncoprotein subtypes impose different requirements for transformation and metastatic activity in a murine model
    • Gonzalez I, Vicent S, de Alava E, et al. EWS/FLI-1 oncoprotein subtypes impose different requirements for transformation and metastatic activity in a murine model. J Mol Med (Berlin, Germany). 2007;85:1015-1029.
    • (2007) J Mol Med (Berlin, Germany) , vol.85 , pp. 1015-1029
    • Gonzalez, I.1    Vicent, S.2    De Alava, E.3
  • 145
    • 33745212417 scopus 로고    scopus 로고
    • Insulin-like growth factor i receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor
    • Martins AS, Mackintosh C, Martin DH, et al. Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor. Clin Cancer Res. 2006;12:3532-3540.
    • (2006) Clin Cancer Res , vol.12 , pp. 3532-3540
    • Martins, A.S.1    MacKintosh, C.2    Martin, D.H.3
  • 146
    • 0035098213 scopus 로고    scopus 로고
    • Establishment of an in vivo model for pediatric Ewing tumors by transplantation into NOD/scid mice
    • Vormoor J, Baersch G, Decker S, et al. Establishment of an in vivo model for pediatric Ewing tumors by transplantation into NOD/scid mice. Pediatr Res. 2001;49:332-341.
    • (2001) Pediatr Res , vol.49 , pp. 332-341
    • Vormoor, J.1    Baersch, G.2    Decker, S.3
  • 147
    • 0034351716 scopus 로고    scopus 로고
    • Murine model for skeletal metastases of Ewing's sarcoma
    • Scotlandi K, Benini S, Manara MC, et al. Murine model for skeletal metastases of Ewing's sarcoma. J Orthop Res. 2000; 18:959-966.
    • (2000) J Orthop Res , vol.18 , pp. 959-966
    • Scotlandi, K.1    Benini, S.2    Manara, M.C.3
  • 148
    • 33947262154 scopus 로고    scopus 로고
    • Preclinical in vivo study of new insulin-like growth factor-I receptor-specific inhibitor in Ewing's sarcoma
    • Manara MC, Landuzzi L, Nanni P, et al. Preclinical in vivo study of new insulin-like growth factor-I receptor-specific inhibitor in Ewing's sarcoma. Clin Cancer Res. 2007;13: 1322-1330.
    • (2007) Clin Cancer Res , vol.13 , pp. 1322-1330
    • Manara, M.C.1    Landuzzi, L.2    Nanni, P.3
  • 149
    • 25444507396 scopus 로고    scopus 로고
    • Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors
    • Castillero-Trejo Y, Eliazer S, Xiang L, et al. Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors. Cancer Res. 2005;65:8698-8705.
    • (2005) Cancer Res , vol.65 , pp. 8698-8705
    • Castillero-Trejo, Y.1    Eliazer, S.2    Xiang, L.3
  • 150
    • 29244447707 scopus 로고    scopus 로고
    • Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells
    • Riggi N, Cironi L, Provero P, et al. Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells. Cancer Res. 2005;65:11459-11468.
    • (2005) Cancer Res , vol.65 , pp. 11459-11468
    • Riggi, N.1    Cironi, L.2    Provero, P.3
  • 151
    • 0034896298 scopus 로고    scopus 로고
    • The expression of the urokinase plasminogen activator system in metastatic murine osteosarcoma: An in vivo mouse model
    • Fisher JL, Mackie PS, Howard ML, et al. The expression of the urokinase plasminogen activator system in metastatic murine osteosarcoma: an in vivo mouse model. Clin Cancer Res. 2001;7:1654-1660.
    • (2001) Clin Cancer Res , vol.7 , pp. 1654-1660
    • Fisher, J.L.1    MacKie, P.S.2    Howard, M.L.3
  • 152
    • 22244439824 scopus 로고    scopus 로고
    • Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases
    • Koshkina NV, Kleinerman ES. Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases. Int J Cancer. 2005;116:458-463.
    • (2005) Int J Cancer , vol.116 , pp. 458-463
    • Koshkina, N.V.1    Kleinerman, E.S.2
  • 153
    • 33846651513 scopus 로고    scopus 로고
    • A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma
    • Dass CR, Ek ET, Contreras KG, et al. A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma. Clin Exp Metastasis. 2006;23:367-380.
    • (2006) Clin Exp Metastasis , vol.23 , pp. 367-380
    • Dass, C.R.1    Ek, E.T.2    Contreras, K.G.3
  • 154
    • 33845680615 scopus 로고    scopus 로고
    • Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis
    • Almog N, Henke V, Flores L, et al. Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis. FASEB J. 2006;20:947-949.
    • (2006) FASEB J , vol.20 , pp. 947-949
    • Almog, N.1    Henke, V.2    Flores, L.3
  • 155
    • 33746924453 scopus 로고    scopus 로고
    • Expression of the FUSCHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma
    • Riggi N, Cironi L, Provero P, et al. Expression of the FUSCHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Cancer Res. 2006;66:7016-7023.
    • (2006) Cancer Res , vol.66 , pp. 7016-7023
    • Riggi, N.1    Cironi, L.2    Provero, P.3
  • 156
    • 34848859978 scopus 로고    scopus 로고
    • Preclinical analysis of tasidotin HCl in Ewing's sarcoma, rhabdomyosarcoma, synovial sarcoma, and osteosarcoma
    • Garg V, Zhang W, Gidwani P, et al. Preclinical analysis of tasidotin HCl in Ewing's sarcoma, rhabdomyosarcoma, synovial sarcoma, and osteosarcoma. Clin Cancer Res. 2007;13: 5446-5454.
    • (2007) Clin Cancer Res , vol.13 , pp. 5446-5454
    • Garg, V.1    Zhang, W.2    Gidwani, P.3
  • 157
    • 34447249881 scopus 로고    scopus 로고
    • The pediatric preclinical testing program: Description of models and early testing results
    • Houghton PJ, Morton CL, Tucker C, et al. The pediatric preclinical testing program: description of models and early testing results. Pediatr Blood Cancer. 2007;49:928-940.
    • (2007) Pediatr Blood Cancer , vol.49 , pp. 928-940
    • Houghton, P.J.1    Morton, C.L.2    Tucker, C.3
  • 158
    • 33745633851 scopus 로고    scopus 로고
    • Molecular determinants of differential sensitivity to docetaxel and paclitaxel in human pediatric cancer models
    • Izbicka E, Campos D, Marty J, et al. Molecular determinants of differential sensitivity to docetaxel and paclitaxel in human pediatric cancer models. Anticancer Res. 2006;26:1983-1988.
    • (2006) Anticancer Res , vol.26 , pp. 1983-1988
    • Izbicka, E.1    Campos, D.2    Marty, J.3
  • 159
    • 34548217651 scopus 로고    scopus 로고
    • Maximizing mouse cancer models
    • Frese KK, Tuveson DA. Maximizing mouse cancer models. Nature Rev. 2007;7:645-658.
    • (2007) Nature Rev , vol.7 , pp. 645-658
    • Frese, K.K.1    Tuveson, D.A.2
  • 160
    • 0034619768 scopus 로고    scopus 로고
    • Liposarcoma initiated by FUS/TLS-CHOP: The FUS/ TLS domain plays a critical role in the pathogenesis of liposarcoma
    • Perez-Losada J, Sanchez-Martin M, Rodriguez-Garcia MA, et al. Liposarcoma initiated by FUS/TLS-CHOP: the FUS/ TLS domain plays a critical role in the pathogenesis of liposarcoma. Oncogene. 2000;19:6015-6022.
    • (2000) Oncogene , vol.19 , pp. 6015-6022
    • Perez-Losada, J.1    Sanchez-Martin, M.2    Rodriguez-Garcia, M.A.3
  • 161
    • 18744412961 scopus 로고    scopus 로고
    • The invertor knockin conditional chromosomal translocation mimic
    • Forster A, Pannell R, Drynan LF, et al. The invertor knockin conditional chromosomal translocation mimic. Nat Methods. 2005;2:27-30.
    • (2005) Nat Methods , vol.2 , pp. 27-30
    • Forster, A.1    Pannell, R.2    Drynan, L.F.3
  • 162
    • 15844394270 scopus 로고    scopus 로고
    • An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
    • Corral J, Lavenir I, Impey H, et al. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell. 1996;85:853-861.
    • (1996) Cell , vol.85 , pp. 853-861
    • Corral, J.1    Lavenir, I.2    Impey, H.3
  • 163
    • 0345582392 scopus 로고    scopus 로고
    • Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer
    • Forster A, Pannell R, Drynan LF, et al. Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell. 2003;3:449-458.
    • (2003) Cancer Cell , vol.3 , pp. 449-458
    • Forster, A.1    Pannell, R.2    Drynan, L.F.3
  • 164
    • 0036463950 scopus 로고    scopus 로고
    • Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia
    • Higuchi M, O'Brien D, Kumaravelu P, et al. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell. 2002;1:63-74.
    • (2002) Cancer Cell , vol.1 , pp. 63-74
    • Higuchi, M.1    O'Brien, D.2    Kumaravelu, P.3
  • 165
    • 0035342464 scopus 로고    scopus 로고
    • Murine models for experimental therapy of pediatric solid tumors with poor prognosis
    • Beltinger C, Debatin KM. Murine models for experimental therapy of pediatric solid tumors with poor prognosis. Int J Cancer. 2001;92:313-318.
    • (2001) Int J Cancer , vol.92 , pp. 313-318
    • Beltinger, C.1    Debatin, K.M.2
  • 166
    • 0035057571 scopus 로고    scopus 로고
    • An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential
    • Khanna C, Prehn J, Yeung C, et al. An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential. Clin Exp Metastasis. 2000;18:261-271.
    • (2000) Clin Exp Metastasis , vol.18 , pp. 261-271
    • Khanna, C.1    Prehn, J.2    Yeung, C.3
  • 168
    • 33744498623 scopus 로고    scopus 로고
    • Effect of interleukin-18 on metastasis of mouse osteosarcoma cells
    • Nakamura Y, Yamada N, Ohyama H, et al. Effect of interleukin-18 on metastasis of mouse osteosarcoma cells. Cancer Immunol Immunother. 2006;55:1151-1158.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 1151-1158
    • Nakamura, Y.1    Yamada, N.2    Ohyama, H.3
  • 169
    • 0033964052 scopus 로고    scopus 로고
    • Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene
    • Manara MC, Baldini N, Serra M, et al. Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene. Bone. 2000;26:215-220.
    • (2000) Bone , vol.26 , pp. 215-220
    • Manara, M.C.1    Baldini, N.2    Serra, M.3
  • 170
    • 0033504341 scopus 로고    scopus 로고
    • A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies
    • Jia SF, Worth LL, Kleinerman ES. A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies. Clin Exp Metastasis. 1999;17:501-506.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 501-506
    • Jia, S.F.1    Worth, L.L.2    Kleinerman, E.S.3
  • 171
    • 0036191644 scopus 로고    scopus 로고
    • Eradication of osteosarcoma lung metastasis using intranasal gemcitabine
    • Jia SF, Worth LL, Turan M, et al. Eradication of osteosarcoma lung metastasis using intranasal gemcitabine. Anticancer Drugs. 2002;13:155-161.
    • (2002) Anticancer Drugs , vol.13 , pp. 155-161
    • Jia, S.F.1    Worth, L.L.2    Turan, M.3
  • 172
    • 0033817517 scopus 로고    scopus 로고
    • Intranasal therapy with an adenoviral vector containing the murine interleukin-12 gene eradicates osteosarcoma lung metastases
    • Worth LL, Jia SF, Zhou Z, et al. Intranasal therapy with an adenoviral vector containing the murine interleukin-12 gene eradicates osteosarcoma lung metastases. Clin Cancer Res. 2000;6:3713-3718.
    • (2000) Clin Cancer Res , vol.6 , pp. 3713-3718
    • Worth, L.L.1    Jia, S.F.2    Zhou, Z.3
  • 173
    • 33748312291 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor: A multimodal tumor inhibitor
    • Ek ET, Dass CR, Choong PF. Pigment epithelium-derived factor: a multimodal tumor inhibitor. Mol Cancer Ther. 2006; 5:1641-1646.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1641-1646
    • Ek, E.T.1    Dass, C.R.2    Choong, P.F.3
  • 174
    • 34247621392 scopus 로고    scopus 로고
    • Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor
    • Ek ET, Dass CR, Contreras KG, et al. Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. Clin Exp Metastasis. 2007;24:93-106.
    • (2007) Clin Exp Metastasis , vol.24 , pp. 93-106
    • Ek, E.T.1    Dass, C.R.2    Contreras, K.G.3
  • 175
    • 33846458609 scopus 로고    scopus 로고
    • Human xenograft osteosarcoma models with spontaneous metastasis in mice: Clinical relevance and applicability for drug testing
    • Dass CR, Ek ET, Choong PF. Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing. J Cancer Res Clin Oncol. 2007;133:193-198.
    • (2007) J Cancer Res Clin Oncol , vol.133 , pp. 193-198
    • Dass, C.R.1    Ek, E.T.2    Choong, P.F.3
  • 176
    • 25444481809 scopus 로고    scopus 로고
    • An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis
    • Luu HH, Kang Q, Park JK, et al. An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis. Clin Exp Metastasis. 2005;22:319-329.
    • (2005) Clin Exp Metastasis , vol.22 , pp. 319-329
    • Luu, H.H.1    Kang, Q.2    Park, J.K.3
  • 177
    • 24744454198 scopus 로고    scopus 로고
    • New genetic tactics to model alveolar rhabdomyosarcoma in the mouse
    • Keller C, Capecchi MR. New genetic tactics to model alveolar rhabdomyosarcoma in the mouse. Cancer Res. 2005;65: 7530-7532.
    • (2005) Cancer Res , vol.65 , pp. 7530-7532
    • Keller, C.1    Capecchi, M.R.2
  • 178
    • 0031837454 scopus 로고    scopus 로고
    • Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
    • Hahn H, Wojnowski L, Zimmer AM, et al. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med. 1998;4:619-622.
    • (1998) Nat Med , vol.4 , pp. 619-622
    • Hahn, H.1    Wojnowski, L.2    Zimmer, A.M.3
  • 179
    • 0036851869 scopus 로고    scopus 로고
    • Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis
    • Sharp R, Recio JA, Jhappan C, et al. Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis. Nat Med. 2002;8:1276-1280.
    • (2002) Nat Med , vol.8 , pp. 1276-1280
    • Sharp, R.1    Recio, J.A.2    Jhappan, C.3
  • 180
    • 0347628826 scopus 로고    scopus 로고
    • Rhabdomyosarcoma development in mice lacking Trp53 and Fos: Tumor suppression by the Fos protooncogene
    • Fleischmann A, Jochum W, Eferl R, et al. Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene. Cancer Cell. 2003;4: 477-482.
    • (2003) Cancer Cell , vol.4 , pp. 477-482
    • Fleischmann, A.1    Jochum, W.2    Eferl, R.3
  • 181
    • 0037601793 scopus 로고    scopus 로고
    • Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice
    • Nanni P, Nicoletti G, De Giovanni C, et al. Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice. Cancer Res. 2003;63:2728-2732.
    • (2003) Cancer Res , vol.63 , pp. 2728-2732
    • Nanni, P.1    Nicoletti, G.2    De Giovanni, C.3
  • 182
    • 33845684374 scopus 로고    scopus 로고
    • Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice
    • Tsumura H, Yoshida T, Saito H, et al. Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice. Oncogene. 2006; 25:7673-7679.
    • (2006) Oncogene , vol.25 , pp. 7673-7679
    • Tsumura, H.1    Yoshida, T.2    Saito, H.3
  • 183
    • 73949110181 scopus 로고    scopus 로고
    • Molecular pathology in contemporary diagnostic pathology laboratory: An opinion for the active role of surgical pathologists
    • Lauwers GY, Black-Schaffer S, Salto-Tellez M. Molecular pathology in contemporary diagnostic pathology laboratory: an opinion for the active role of surgical pathologists. Am J Surg Pathol. 2010;34:115-117.
    • (2010) Am J Surg Pathol. , vol.34 , pp. 115-117
    • Lauwers, G.Y.1    Black-Schaffer, S.2    Salto-Tellez, M.3
  • 184
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher AW, Sarantopoulos J, Patnaik A, et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol. 2009;27:5800-5807.
    • (2009) J Clin Oncol , vol.27 , pp. 5800-5807
    • Tolcher, A.W.1    Sarantopoulos, J.2    Patnaik, A.3
  • 185
    • 70149105476 scopus 로고    scopus 로고
    • Ewing's sarcoma: Standard and experimental treatment options
    • Subbiah V, Anderson P, Lazar AJ, et al. Ewing's sarcoma: standard and experimental treatment options. Curr Treat Options Oncol. 2009;10:126-140.
    • (2009) Curr Treat Options Oncol , vol.10 , pp. 126-140
    • Subbiah, V.1    Anderson, P.2    Lazar, A.J.3
  • 186
    • 34548844748 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and platelet-derived growth factor receptors as potential targets in treating aggressive fibromatosis
    • Signoroni S, Frattini M, Negri T, et al. Cyclooxygenase-2 and platelet-derived growth factor receptors as potential targets in treating aggressive fibromatosis. Clin Cancer Res. 2007;13: 5034-5040.
    • (2007) Clin Cancer Res , vol.13 , pp. 5034-5040
    • Signoroni, S.1    Frattini, M.2    Negri, T.3
  • 187
    • 42249087305 scopus 로고    scopus 로고
    • Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells
    • Ambrosini G, Cheema HS, Seelman S, et al. Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells. Mol Cancer Ther. 2008;7:890-896.
    • (2008) Mol Cancer Ther , vol.7 , pp. 890-896
    • Ambrosini, G.1    Cheema, H.S.2    Seelman, S.3
  • 188
    • 67650293850 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with metastatic or recurrent sarcomas
    • Maki RG, D'Adamo DR, Keohan ML, et al. Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol. 2009;27:3133-3140.
    • (2009) J Clin Oncol , vol.27 , pp. 3133-3140
    • Maki, R.G.1    D'Adamo, D.R.2    Keohan, M.L.3
  • 189
    • 77949535841 scopus 로고    scopus 로고
    • Pharmacological management of gastrointestinal stromal tumours: An update on the role of sunitinib
    • Blay JY. Pharmacological management of gastrointestinal stromal tumours: an update on the role of sunitinib. Ann Oncol. 2010;21:208-215.
    • (2010) Ann Oncol. , vol.21 , pp. 208-215
    • Blay, J.Y.1
  • 190
    • 67650309276 scopus 로고    scopus 로고
    • Soft tissue sarcoma trials: One size no longer fits all
    • Verweij J. Soft tissue sarcoma trials: one size no longer fits all. J Clin Oncol. 2009;27:3085-3087.
    • (2009) J Clin Oncol , vol.27 , pp. 3085-3087
    • Verweij, J.1
  • 191
    • 14144256775 scopus 로고    scopus 로고
    • Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225
    • McArthur GA, Demetri GD, van Oosterom A, et al. Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225. J Clin Oncol. 2005;23:866-873.
    • (2005) J Clin Oncol , vol.23 , pp. 866-873
    • McArthur, G.A.1    Demetri, G.D.2    Van Oosterom, A.3
  • 192
    • 33644977853 scopus 로고    scopus 로고
    • Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumor)
    • Heinrich MC,McArthur GA, Demetri GD, et al. Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumor). J Clin Oncol. 2006; 24:1195-1203.
    • (2006) J Clin Oncol , vol.24 , pp. 1195-1203
    • Heinrich, M.C.1    McArthur, G.A.2    Demetri, G.D.3
  • 193
    • 70350569370 scopus 로고    scopus 로고
    • Sunitinib malate in the treatment of recurrent or persistent uterine leiomyosarcoma: A Gynecologic Oncology Group phase II study
    • Hensley ML, Sill MW, Scribner DR Jr, et al. Sunitinib malate in the treatment of recurrent or persistent uterine leiomyosarcoma: a Gynecologic Oncology Group phase II study. Gynecol Oncol. 2009;115:460-465.
    • (2009) Gynecol Oncol , vol.115 , pp. 460-465
    • Hensley, M.L.1    Sill, M.W.2    Scribner Jr., D.R.3
  • 194
    • 67650312341 scopus 로고    scopus 로고
    • Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas
    • George S, Merriam P, Maki RG, et al. Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas. J Clin Oncol. 2009;27:3154-3160.
    • (2009) J Clin Oncol , vol.27 , pp. 3154-3160
    • George, S.1    Merriam, P.2    Maki, R.G.3
  • 195
    • 72849150434 scopus 로고    scopus 로고
    • Targeting tumorigenesis: Development and use of mTOR inhibitors in cancer therapy
    • Yuan R, Kay A, Berg WJ, et al. Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy. J Hematol Oncol. 2009;2:45.
    • (2009) J Hematol Oncol , vol.2 , pp. 45
    • Yuan, R.1    Kay, A.2    Berg, W.J.3
  • 196
    • 53749094926 scopus 로고    scopus 로고
    • Targeting sarcomas: Therapeutic targets and their rational
    • Ordonez JL, Martins AS, Osuna D, et al. Targeting sarcomas: therapeutic targets and their rational. Semin Diagn Pathol. 2008;25:304-316.
    • (2008) Semin Diagn Pathol , vol.25 , pp. 304-316
    • Ordonez, J.L.1    Martins, A.S.2    Osuna, D.3
  • 197
    • 34247849277 scopus 로고    scopus 로고
    • Evaluation of antitumor effects of tumor cell lysate enriched by HSP-70 against fibrosarcoma tumor in BALB/c mice
    • Hashemi SM, Hassan ZM, Soudi S, et al. Evaluation of antitumor effects of tumor cell lysate enriched by HSP-70 against fibrosarcoma tumor in BALB/c mice. Int Immunopharmacol. 2007;7:920-927.
    • (2007) Int Immunopharmacol , vol.7 , pp. 920-927
    • Hashemi, S.M.1    Hassan, Z.M.2    Soudi, S.3
  • 198
    • 57149111052 scopus 로고    scopus 로고
    • Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma
    • Baker LH, Rowinsky EK, Mendelson D, et al. Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma. J Clin Oncol. 2008;26:5583-5588.
    • (2008) J Clin Oncol , vol.26 , pp. 5583-5588
    • Baker, L.H.1    Rowinsky, E.K.2    Mendelson, D.3
  • 199
    • 70449369322 scopus 로고    scopus 로고
    • The role of angiocidin in sarcomas
    • Liebig C, Wilks JA, Feig BW, et al. The role of angiocidin in sarcomas. Cancer. 2009;115:5251-5262.
    • (2009) Cancer , vol.115 , pp. 5251-5262
    • Liebig, C.1    Wilks, J.A.2    Feig, B.W.3
  • 200
    • 28844448329 scopus 로고    scopus 로고
    • Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas
    • Nagayama S, Fukukawa C, Katagiri T, et al. Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas. Oncogene. 2005;24:6201-6212.
    • (2005) Oncogene , vol.24 , pp. 6201-6212
    • Nagayama, S.1    Fukukawa, C.2    Katagiri, T.3
  • 201
    • 84864277344 scopus 로고    scopus 로고
    • EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells
    • Miyagawa Y, Okita H, Itagaki M, et al. EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells. PLoS ONE. 2009;4:e4634.
    • (2009) PLoS ONE , vol.4
    • Miyagawa, Y.1    Okita, H.2    Itagaki, M.3
  • 202
    • 64549109015 scopus 로고    scopus 로고
    • Targeted therapy of human osteosarcoma with 17AAG or rapamycin: Characterization of induced apoptosis and inhibition of mTOR and Akt/ MAPK/Wnt pathways
    • Gazitt Y, Kolaparthi V, Moncada K, et al. Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/ MAPK/Wnt pathways. Int J Oncol. 2009;34:551-561.
    • (2009) Int J Oncol , vol.34 , pp. 551-561
    • Gazitt, Y.1    Kolaparthi, V.2    Moncada, K.3
  • 203
    • 58449131239 scopus 로고    scopus 로고
    • The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene
    • Filion C, Motoi T, Olshen AB, et al. The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene. J Pathol. 2009; 217:83-93.
    • (2009) J Pathol , vol.217 , pp. 83-93
    • Filion, C.1    Motoi, T.2    Olshen, A.B.3
  • 204
    • 70249100296 scopus 로고    scopus 로고
    • MI-63: A novel smallmolecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wildtype p53
    • Canner JA, Sobo M, Ball S, et al. MI-63: a novel smallmolecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wildtype p53. Br J Cancer. 2009;101:774-781.
    • (2009) Br J Cancer , vol.101 , pp. 774-781
    • Canner, J.A.1    Sobo, M.2    Ball, S.3
  • 205
    • 67650337802 scopus 로고    scopus 로고
    • Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043)
    • Sleijfer S, Ray-Coquard I, Papai Z, et al. Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol. 2009;27:3126-3132.
    • (2009) J Clin Oncol , vol.27 , pp. 3126-3132
    • Sleijfer, S.1    Ray-Coquard, I.2    Papai, Z.3
  • 206
    • 49849098245 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models
    • Liu S, Cheng H, Kwan W, et al. Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models. Mol Cancer Ther. 2008;7: 1751-1761.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1751-1761
    • Liu, S.1    Cheng, H.2    Kwan, W.3
  • 207
    • 66649122272 scopus 로고    scopus 로고
    • Cyclooxygenase 2 mediates the antiangiogenic effect of rapamycin in Ewing sarcoma
    • discussion 1146
    • Lipskar AM, Glick RD, Huang J, et al. Cyclooxygenase 2 mediates the antiangiogenic effect of rapamycin in Ewing sarcoma. J Pediatr Surg. 2009;44:1139-1146; discussion 1146.
    • (2009) J Pediatr Surg , vol.44 , pp. 1139-1146
    • Lipskar, A.M.1    Glick, R.D.2    Huang, J.3
  • 208
    • 29144462140 scopus 로고    scopus 로고
    • Targeting CD99 in association with doxorubicin: An effective combined treatment for Ewing's sarcoma
    • Scotlandi K, Perdichizzi S, Bernard G, et al. Targeting CD99 in association with doxorubicin: an effective combined treatment for Ewing's sarcoma. Eur J Cancer. 2006;42:91-96.
    • (2006) Eur J Cancer , vol.42 , pp. 91-96
    • Scotlandi, K.1    Perdichizzi, S.2    Bernard, G.3


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