Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community

Metallomics

Volumn 9, Issue 8, 2017, Pages 1157-1168

  Pedroso, Marcelo Monteiro ^a   Selleck, Christopher ^a   Enculescu, Charmaine ^a   Harmer, Jeffrey R ^a   Mitić, Nataša ^b   Craig, Whitney R ^c   Helweh, Waleed ^d   Hugenholtz, Philip ^a   Tyson, Gene W ^a   Tierney, David L ^c   Larrabee, James A ^d   Schenk, Gerhard ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c MIAMI UNIVERSITY   (United States)

^d MIDDLEBURY COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; METAL IONS; METALS; PROTEINS; SPECTROSCOPIC ANALYSIS;

ACTIVE SITE STRUCTURE; ANTIBIOTIC RESISTANCE; CATALYTIC PROPERTIES; HUMAN POPULATION; RATE-LIMITING STEPS; SPECTROSCOPIC STUDIES; SUBSTRATE PROFILE; TETRAHEDRAL INTERMEDIATES;

ANTIBIOTICS;

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; METAL;

AMINO ACID SEQUENCE; CATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; METAGENOME; MICROBIOLOGY; MOLECULAR MODEL; PERMAFROST; PHENOTYPE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CATALYSIS; HUMANS; METAGENOME; METALS; MODELS, MOLECULAR; PERMAFROST; PHENOTYPE; SEQUENCE HOMOLOGY; SUBSTRATE SPECIFICITY;

EID: 85027469306     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c7mt00195a     Document Type: Article

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