Structural flexibility enhances the reactivity of the bioremediator glycerophosphodiesterase by fine-tuning its mechanism of hydrolysis

Journal of the American Chemical Society

Volumn 131, Issue 33, 2009, Pages 11900-11908

  Hadler, Kieran S ^a   Mitić, Nataša ^a   Ely, Fernanda ^a   Hanson, Graeme R ^a   Gahan, Lawrence R ^a   Larrabee, James A ^b   Ollis, David L ^c   Schenk, Gerhard ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MIDDLEBURY COLLEGE   (United States)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINUCLEAR CENTER; CATALYTIC TURNOVER; CONCENTRATION OF; COORDINATION SPHERE; ENTEROBACTER AEROGENES; FLUORESCENCE MEASUREMENTS; H-BOND NETWORK; HYDROGEN BOND NETWORKS; INDUCED FIT; MAXIMUM VALUES; PARAMAGNETIC PROPERTIES; STOPPED FLOW; STRUCTURAL CHANGE; STRUCTURAL FLEXIBILITIES; STRUCTURAL REARRANGEMENT; SUBSTRATE BINDING; THREE PHASIS;

BINDING SITES; BIOREMEDIATION; CATALYSIS; COORDINATION REACTIONS; HYDROGEN; HYDROLYSIS; MANGANESE; MANGANESE COMPOUNDS; METAL IONS;

SUBSTRATES;

4 NITROPHENYL PHOSPHATE; GLYCEROPHOSPHODIESTERASE; HISTIDINE; HYDROGEN; MANGANESE; PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOREMEDIATION; CATALYSIS; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; ENTEROBACTER AEROGENES; FLUORESCENCE; HYDROGEN BOND; HYDROLYSIS; MUTATION; NONHUMAN;

BIOCATALYSIS; BIODEGRADATION, ENVIRONMENTAL; CATALYTIC DOMAIN; ENTEROBACTER AEROGENES; HYDROGEN BONDING; HYDROLYSIS; MAGNETICS; MANGANESE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHATES; PHOSPHORIC DIESTER HYDROLASES; SPECTROMETRY, FLUORESCENCE;

EID: 69049087726     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja903534f     Document Type: Article

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