The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling

ACS Infectious Diseases

Volumn 3, Issue 8, 2017, Pages 564-574

  Sogi, Kimberly M ^a   Lien, Katie A ^a   Johnson, Jeffrey R ^b   Krogan, Nevan J ^b   Stanley, Sarah A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

epidermal growth factor receptor (EGFR); host directed therapeutic; lysosomal biogenesis; Mycobacterium tuberculosis; signal transducer and activator of transcription 3 (STAT3)

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GAMMA INTERFERON; GEFITINIB; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE; PHOSPHOTYROSINE; STAT3 PROTEIN; EGFR PROTEIN, MOUSE; PHOSPHOPROTEIN; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; STAT3 PROTEIN, MOUSE; TUBERCULOSTATIC AGENT;

ANIMAL CELL; ARTICLE; AUTOPHAGY; BACTERIAL GROWTH; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; LYSOSOME; MACROPHAGE; MAMMAL CELL; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ORGANELLE BIOGENESIS; PHOSPHOPROTEOMICS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUBERCULOSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE MARROW CELL; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PRIMARY CELL CULTURE; PROCEDURES; PROTEOMICS;

ANIMALS; ANTITUBERCULAR AGENTS; BONE MARROW CELLS; CYTOKINES; GENE EXPRESSION REGULATION; LYSOSOMES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOBACTERIUM TUBERCULOSIS; ORGANELLE BIOGENESIS; PHOSPHOPROTEINS; PRIMARY CELL CULTURE; PROTEIN KINASE INHIBITORS; PROTEOMICS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 85027255374     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.7b00046     Document Type: Article

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