Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 73, Issue 1, 2018, Pages 153-164

  Skaaby, T ^a   Taylor, A E ^b   Thuesen, B H ^a   Jacobsen, R K ^a   Friedrich, N ^a,c   Mollehave L T ^a   Hansen, S ^a   Larsen, S C ^d   Volker U ^c   Nauck, M ^c   Volzke H ^c   Hansen, T ^e   Pedersen, O ^e   Jorgensen T ^a,e,f   Paternoster, L ^b   Munafo M ^b   Grarup, N ^e   Linneberg, A ^a,e,g  

^a The Research Unit for General Practice in Copenhagen   (Denmark)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^d C/L Psychiatry Clinic Bispebjerg   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f AALBORG UNIVERSITY   (Denmark)

^g University of Copenhagen   (Denmark)

Author keywords

allergic disease; allergic sensitization; asthma; hay fever; serum specific IgE

Indexed keywords

BIOLOGICAL MARKER; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY;

ADULT; ARTICLE; ASTHMA; BODY MASS; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC RISK; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MENDELIAN RANDOMIZATION ANALYSIS; OBSERVATIONAL STUDY; POLLEN ALLERGY; PREVALENCE; PRIORITY JOURNAL; SENSITIZATION; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; GENETIC PREDISPOSITION; GENOTYPE; IMMUNOLOGY; LUNG FUNCTION TEST; MIDDLE AGED; ODDS RATIO; PATHOPHYSIOLOGY;

ADULT; ALLELES; ASTHMA; BODY MASS INDEX; FEMALE; FORCED EXPIRATORY VOLUME; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RESPIRATORY FUNCTION TESTS; RHINITIS, ALLERGIC, SEASONAL;

EID: 85026666040     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.13242     Document Type: Article

References (70)

1. Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007;175:661-666.
2. Fenger RV, Gonzalez-Quintela A, Vidal C, et al. The longitudinal relationship of changes of adiposity to changes in pulmonary function and risk of asthma in a general adult population. BMC Pulm Med. 2014;14:208.
3. Chen Y, Rennie D, Cormier Y, Dosman J. Atopy, obesity, and asthma in adults: the Humboldt study. J Agromedicine. 2009;14:222-227.
4. Chen Y, Rennie D, Cormier Y, Dosman J. Association between obesity and atopy in adults. Int Arch Allergy Immunol. 2010;153:372-377.
5. Hersoug LG, Linneberg A. The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy. 2007;62:1205-1213.
6. Jones RL, Nzekwu MM. The effects of body mass index on lung volumes. Chest. 2006;130:827-833.
7. Farah CS, Salome CM. Asthma and obesity: a known association but unknown mechanism. Respirology. 2012;17:412-421.
8. Wang LY, Cerny FJ, Kufel TJ, Grant BJ. Simulated obesity-related changes in lung volume increases airway responsiveness in lean, nonasthmatic subjects. Chest. 2006;130:834-840.
9. Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol. 2008;121:1087-1093.
10. Sismanopoulos N, Delivanis DA, Mavrommati D, Hatziagelaki E, Conti P, Theoharides TC. Do mast cells link obesity and asthma? Allergy. 2013;68:8-15.
11. Payne V, Kam PC. Mast cell tryptase: a review of its physiology and clinical significance. Anaesthesia. 2004;59:695-703.
12. Skaaby T, Vestergaard H, Thomsen S, Knudsen AL, Jorgensen N, Linneberg A. No changes in serum tryptase after bariatric surgery. Ann Epidemiol. 2015;25:800-801.
13. Granell R, Henderson AJ, Evans DM, et al. Effects of BMI, fat mass, and lean mass on asthma in childhood: a mendelian randomization study. PLoS Med. 2014;11:e1001669.
14. Davey Smith G, Timpson N, Ebrahim S. Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization. Ann Med. 2008;40:524-541.
15. Zimmermann E, Angquist LH, Mirza SS, et al. Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obes Rev. 2015;16:327-340.
16. Thorleifsson G, Walters GB, Gudbjartsson DF, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009;41:18-24.
17. Meyre D, Delplanque J, Chevre JC, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet. 2009;41:157-159.
18. Loos RJ, Lindgren CM, Li S, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008;40:768-775.
19. Liu YJ, Liu XG, Wang L, et al. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet. 2008;17:1803-1813.
20. Lindgren CM, Heid IM, Randall JC, et al. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet. 2009;5:e1000508.
21. Heid IM, Jackson AU, Randall JC, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010;42:949-960.
22. Heard-Costa NL, Zillikens MC, Monda KL, et al. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet. 2009;5:e1000539.
23. Benzinou M, Creemers JW, Choquet H, et al. Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet. 2008;40:943-945.
24. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316:889-894.
25. Willer CJ, Speliotes EK, Loos RJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25-34.
26. Speliotes EK, Willer CJ, Berndt SI, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937-948.
27. Scuteri A, Sanna S, Chen WM, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3:e115.
28. Cotsapas C, Speliotes EK, Hatoum IJ, et al. Common body mass index-associated variants confer risk of extreme obesity. Hum Mol Genet. 2009;18:3502-3507.
29. Sandholt CH, Allin KH, Toft U, et al. The effect of GWAS identified BMI loci on changes in body weight among middle-aged Danes during a five-year period. Obesity (Silver Spring). 2014;22:901-908.
30. Larsen SC, Angquist L, Ahluwalia TS, et al. Interaction between genetic predisposition to obesity and dietary calcium in relation to subsequent change in body weight and waist circumference. Am J Clin Nutr. 2014;99:957-965.
31. Skaaby T, Jorgensen T, Linneberg A. Effects of invitation to participate in health surveys on the incidence of cardiovascular disease: a randomized general population study. Int J Epidemiol. 2017;46:603-611.
32. Skaaby T, Husemoen LL, Thuesen BH, Jeppesen J, Linneberg A. The association of atopy with incidence of ischemic heart disease, stroke, and diabetes. Endocrine. 2015;48:541-550.
33. Skaaby T, Husemoen LL, Thuesen BH, Jorgensen T, Linneberg A. Lifestyle-related factors and atopy in seven danish population-based studies from different time periods. PLoS One. 2015;10:e0137406.
34. Skaaby T, Husemoen LL, Thuesen BH, et al. Longitudinal associations between lifestyle and vitamin D: a general population study with repeated vitamin D measurements. Endocrine. 2016;51:342-350.
35. John U, Greiner B, Hensel E, et al. Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design. Soz Praventivmed. 2001;46:186-194.
36. Volzke H, Alte D, Schmidt CO, et al. Cohort profile: the study of health in Pomerania. Int J Epidemiol. 2011;40:294-307.
37. Sudlow C, Gallacher J, Allen N, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12:e1001779.
38. Peterson RE, Maes HH, Lin P, et al. On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis. BMC Genom. 2014;15:368.
39. Thuesen BH, Husemoen LL, Ovesen L, et al. Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults. Allergy. 2010;65:1446-1454.
40. Pierce BL, Ahsan H, Vanderweele TJ. Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants. Int J Epidemiol. 2011;40:740-752.
41. Haycock PC, Burgess S, Wade KH, Bowden J, Relton C, Davey SG. Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. Am J Clin Nutr. 2016;103:965-978.
42. Skaaby T, Taylor AE, Jacobsen RK, et al. Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Sci Rep. 2017;7:2224.
43. Haycock PC, Burgess S, Nounu A, et al. Association between telomere length and risk of cancer and non-neoplastic diseases: a mendelian randomization study. JAMA Oncol. 2017;3:636-651.
44. Boulet LP. Obesity and atopy. Clin Exp Allergy. 2015;45:75-86.
45. Flaherman V, Rutherford GW. A meta-analysis of the effect of high weight on asthma. Arch Dis Child. 2006;91:334-339.
46. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9:88.
47. Visness CM, London SJ, Daniels JL, et al. Association of childhood obesity with atopic and nonatopic asthma: results from the National Health and Nutrition Examination Survey 1999-2006. J Asthma. 2010;47:822-829.
48. Byberg KK, Eide GE, Forman MR, Juliusson PB, Oymar K. Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood. Clin Transl Allergy. 2016;6:33-0124.
49. Ronmark EP, Ekerljung L, Mincheva R, et al. Different risk factor patterns for adult asthma, rhinitis and eczema: results from West Sweden Asthma Study. Clin Transl Allergy. 2016;6:28.
50. Lokaj-Berisha V, Gacaferri-Lumezi B, Minci-Bejtullahu G, et al. Gender associated high body mass index in allergic diseases. Open Access Maced J Med Sci. 2015;3:69-74.
51. Sybilski AJ, Raciborski F, Lipiec A, et al. Obesity–a risk factor for asthma, but not for atopic dermatitis, allergic rhinitis and sensitization. Public Health Nutr. 2015;18:530-536.
52. Konno S, Hizawa N, Fukutomi Y, et al. The prevalence of rhinitis and its association with smoking and obesity in a nationwide survey of Japanese adults. Allergy. 2012;67:653-660.
53. Yao TC, Ou LS, Yeh KW, Lee WI, Chen LC, Huang JL. Associations of age, gender, and BMI with prevalence of allergic diseases in children: PATCH study. J Asthma. 2011;48:503-510.
54. Baumann S, Lorentz A. Obesity - a promoter of allergy? Int Arch Allergy Immunol. 2013;162:205-213.
55. Luo X, Xiang J, Dong X, et al. Association between obesity and atopic disorders in Chinese adults: an individually matched case-control study. BMC Public Health. 2013;13:12.
56. Kreissl S, Radon K, Dressel H, et al. Body mass index change and atopic diseases are not always associated in children and adolescents. Ann Allergy Asthma Immunol. 2014;113:440-444.
57. Katebi R, Williams G, Bourke M, Harrison A, Verma A. What factors are associated with the prevalence of atopic symptoms amongst adolescents in Greater Manchester? Eur J Public Health. 2015; pii: ckv139 [Epub ahead of print].
58. Ciprandi G, Schiavetti I, Bellezza FR, Sorbello V, Ricciardolo FL. Overweight and obesity as risk factors for impaired lung function in patients with asthma: a real-life experience. Allergy Asthma Proc. 2014;35:e62-71.
59. Abramson MJ, Schindler C, Schikowski T, et al. Rhinitis in Swiss adults is associated with asthma and early life factors, but not second hand tobacco smoke or obesity. Allergol Int. 2016;65:192-198.
60. Han YY, Forno E, Gogna M, Celedon JC. Obesity and rhinitis in a nationwide study of children and adults in the United States. J Allergy Clin Immunol. 2016;137:1460-1465.
61. Kimura H, Konno S, Isada A, Maeda Y, Musashi M, Nishimura M. Contrasting associations of body mass index and measles with asthma and rhinitis in young adults. Allergy Asthma Proc. 2015;36:293-299.
62. Ciprandi G, Ricciardolo FL, Signori A, et al. Increased body mass index and bronchial impairment in allergic rhinitis. Am J Rhinol Allergy. 2013;27:e195-201.
63. Bhattacharyya N. Associations between obesity and inflammatory sinonasal disorders. Laryngoscope 2013;123:1840-1844.
64. Vieira VJ, Ronan AM, Windt MR, Tagliaferro AR. Elevated atopy in healthy obese women. Am J Clin Nutr. 2005;82:504-509.
65. Xu B, Pekkanen J, Laitinen J, Jarvelin MR. Body build from birth to adulthood and risk of asthma. Eur J Public Health. 2002;12:166-170.
66. Flexeder C, Bruske I, Magnussen H, Heinrich J. Association between obesity and atopy in adults? Int Arch Allergy Immunol. 2011;156:117-118.
67. Schachter LM, Peat JK, Salome CM. Asthma and atopy in overweight children. Thorax. 2003;58:1031-1035.
68. Silverberg JI, Silverberg NB, Lee-Wong M. Association between atopic dermatitis and obesity in adulthood. Br J Dermatol. 2012;166:498-504.
69. Burgess S, Thompson SG. Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol. 2013;42:1134-1144.
70. Burgess S, Thompson SG. Improving bias and coverage in instrumental variable analysis with weak instruments for continuous and binary outcomes. Stat Med. 2012;31:1582-1600.