Obesity-induced endoplasmic reticulum stress causes lung endothelial dysfunction and promotes acute lung injury

American Journal of Respiratory Cell and Molecular Biology

Volumn 57, Issue 2, 2017, Pages 204-215

  Shah, Dilip ^a   Romero, Freddy ^a   Guo, Zhi ^a   Sun, Jianxin ^a   Li, Jonathan ^a   Kallen, Caleb B ^a   Naik, Ulhas P ^b   Summer, Ross ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Endoplasmic reticulum stress; Obesity; Saturated fatty acid

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 6; BETA CATENIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FATTY ACID; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; PROTEIN IRE1; PROTEIN IRE1 ALPHA; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR ENDOTHELIAL CADHERIN; 4-PHENYLBUTYRIC ACID; ARYLBUTYRIC ACID DERIVATIVE; ATF6 PROTEIN, MOUSE; CELL ADHESION MOLECULE; ERN1 PROTEIN, MOUSE; FAT INTAKE; LIPOPOLYSACCHARIDE; MONOUNSATURATED FATTY ACID; PERK KINASE; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; TUNICAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET INDUCED OBESITY; DISEASE PREDISPOSITION; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL DYSFUNCTION; FATTY ACID BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY; LUNG ENDOTHELIUM; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN MISFOLDING; PROTEIN PHOSPHORYLATION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; VASCULAR ENDOTHELIAL CELL; ACUTE LUNG INJURY; AKR MOUSE; ANIMAL; BLOOD; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; ENDOTHELIUM CELL; FAT INTAKE; LUNG; METABOLISM; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SERUM; THERAPEUTIC USE; TOXICITY;

ACTIVATING TRANSCRIPTION FACTOR 6; ACUTE LUNG INJURY; ANIMALS; CELL ADHESION MOLECULES; DIETARY FATS; DISEASE SUSCEPTIBILITY; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; ENDOTHELIAL CELLS; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, NONESTERIFIED; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICE, INBRED AKR; OBESITY; PHENYLBUTYRATES; PROTEIN-SERINE-THREONINE KINASES; SERUM; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE;

EID: 85026384088     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2016-0310OC     Document Type: Article

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